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  1. Article ; Online: Open disclosure.

    Philpot, S / Sherwin, A / Allen, S

    BJA education

    2024  Volume 24, Issue 5, Page(s) 147–154

    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2888911-3
    ISSN 2058-5357 ; 2058-5349
    ISSN (online) 2058-5357
    ISSN 2058-5349
    DOI 10.1016/j.bjae.2024.02.001
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    Zs.A 6459: Show issues Location:
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  2. Article ; Online: Autonomy vs. the environment: nitrous oxide use in obstetrics, an ongoing challenge.

    Murphy, C / Sherwin, A / Lavelle, A

    Anaesthesia

    2023  Volume 78, Issue 5, Page(s) 654–655

    MeSH term(s) Pregnancy ; Female ; Humans ; Obstetrics ; Nitrous Oxide ; Anesthesia, Obstetrical ; Longitudinal Studies ; Anesthetics, Inhalation
    Chemical Substances Nitrous Oxide (K50XQU1029) ; Anesthetics, Inhalation
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15976
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  3. Article ; Online: Sixty years of conjecture over a urinary biomarker: a step closer to understanding the proposed link between anxiety and urinary pyrroles.

    Sherwin, Angela / Shaw, Ian C

    Laboratory medicine

    2023  Volume 55, Issue 3, Page(s) 334–340

    Abstract: Objective: For over 60 years there has been conjecture about the identity of an Ehrlich's test positive pyrrole (Mauve Factor) reputed to be a biomarker for psychological disorders, including anxiety. We reviewed studies that attempt to identify Mauve ... ...

    Abstract Objective: For over 60 years there has been conjecture about the identity of an Ehrlich's test positive pyrrole (Mauve Factor) reputed to be a biomarker for psychological disorders, including anxiety. We reviewed studies that attempt to identify Mauve Factor and subjected authentic standards of the 2 main candidates, kryptopyrrole and hydroxypyrrole, to the Ehrlich's reaction.
    Methods: Modified Ehrlich's test for kryptopyrrole and hydroxypyrrole were applied to urine samples from 10 volunteers, anxious and nonanxious.
    Results: Based on the mechanistic chemistry of Ehrlich's reaction and reactions of the 2 compounds, Mauve Factor cannot be hydroxypyrrole. Analyses of urine samples from volunteers, identified by the Generalized Anxiety Disorder - 7 item scale (GAD-7 ≥10; n = 5) and control urine samples (GAD-7 <10; n = 5) using a kryptopyrrole calibration graph, show that concentrations are similar in both groups.
    Conclusion: Kryptopyrrole may be the elusive Mauve Factor. Its possible origin from stercobilin via gut microbiome-mediated metabolism, its link to gut-mediated neurological effects via γ-aminobutyric acid (GABA) receptors, and its predicted interaction with Zn2+ and consequent impact on zinc homeostasis are discussed. The GAD-7 scale does not differentiate between state and trait anxiety and as such, the minimal difference in pyrrole levels between volunteer groups requires further study.
    MeSH term(s) Humans ; Pyrroles/urine ; Biomarkers/urine ; Anxiety/urine
    Chemical Substances Pyrroles ; Biomarkers
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmad086
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  4. Article ; Online: Anaesthesia for breast surgery.

    Sherwin, A / Buggy, D J

    BJA education

    2018  Volume 18, Issue 11, Page(s) 342–348

    Language English
    Publishing date 2018-09-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2888911-3
    ISSN 2058-5357 ; 2058-5349
    ISSN (online) 2058-5357
    ISSN 2058-5349
    DOI 10.1016/j.bjae.2018.08.002
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  5. Article ; Online: Bilateral cerebellopontine angle lipomas in an infant with encephalocele: illustrative case.

    Zhao, Xiaochun / Prather, Kiana Y / Tavakol, Sherwin A / Gernsback, Joanna E

    Journal of neurosurgery. Case lessons

    2023  Volume 6, Issue 13

    Abstract: Background: Bilateral cerebellopontine angle (CPA) lipomas are extremely rare. Herein the authors present a case of bilateral CPA lipomas in an infant along with a literature review of bilateral CPA lipomas.: Observations: A newborn girl was ... ...

    Abstract Background: Bilateral cerebellopontine angle (CPA) lipomas are extremely rare. Herein the authors present a case of bilateral CPA lipomas in an infant along with a literature review of bilateral CPA lipomas.
    Observations: A newborn girl was incidentally found to have bilateral CPA lipomas during the workup for an occipital encephalocele. The encephalocele was repaired primarily on day 2 after birth. The patient demonstrated no symptoms associated with the bilateral CPA lipomas. Eight cases of bilateral CPA lipomas were identified in the literature review and are summarized. Conservative management is the consensus strategy, given minimum growth of the tumor and the high risk of surgical intervention.
    Lessons: This is the first reported case of bilateral CPA lipomas in an infant as well as the first with a coexisting intracranial malformation. Intracranial lipomas share an extremely low growth rate and typically do not cause severe symptoms. The management of asymptomatic or mildly symptomatic bilateral CPA lipomas is usually conservative.
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23315
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  6. Article ; Online: The evolution of stereoelectroencephalography: symbiotic progress in medical imaging and procedural technologies.

    Parrott, Aaron / Tavakol, Sherwin A / Zieles, Kristin / Jea, Andrew / Desai, Virendra R

    Journal of neurosurgery. Pediatrics

    2023  Volume 32, Issue 5, Page(s) 545–552

    Abstract: Stereoelectroencephalography (sEEG) was pioneered in France, at a time when cerebral anatomy was invisible to contemporaneous imaging modalities. Epilepsy surgeons relied on indirect targeting techniques to identify epileptogenic tissue. Since then, ... ...

    Abstract Stereoelectroencephalography (sEEG) was pioneered in France, at a time when cerebral anatomy was invisible to contemporaneous imaging modalities. Epilepsy surgeons relied on indirect targeting techniques to identify epileptogenic tissue. Since then, alongside the rapid rise of medical imaging technology, sEEG has experienced dramatic stepwise progress. A flurry of advancements has pushed this technique to its current-day standards, enabling neurosurgeons to access any intracranial location in a safe, highly precise, and expeditious manner. Presently, epilepsy surgeons throughout the world apply robot-assisted sEEG. Herein, the authors chronicle this incredible evolution.
    MeSH term(s) Humans ; Electroencephalography/methods ; Stereotaxic Techniques ; Epilepsy/diagnostic imaging ; Epilepsy/surgery ; Brain Mapping/methods ; Radiography ; Electrodes, Implanted ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2023.7.PEDS2344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135 -Pediatrics-: Show issues Location:
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  7. Article ; Online: Open Surgical Approaches for Meningiomas.

    Zhao, Xiaochun / Tavakol, Sherwin A / Pelargos, Panayiotis E / Palejwala, Ali H / Dunn, Ian F

    Neurosurgery clinics of North America

    2023  Volume 34, Issue 3, Page(s) 381–391

    Abstract: Meningiomas are the most common intracranial extra-axial primary tumor. Although most are low grade and slow growing, resection can be technically challenging, particularly when located at the skull base. Appropriate craniotomy and approach selection are ...

    Abstract Meningiomas are the most common intracranial extra-axial primary tumor. Although most are low grade and slow growing, resection can be technically challenging, particularly when located at the skull base. Appropriate craniotomy and approach selection are of paramount importance to minimize brain retraction, optimize exposure, and achieve complete resection. This article summarizes various craniotomies and their approaches to meningiomas, and illustrates some nuances in performing these techniques with cadaveric dissection and operative videos.
    MeSH term(s) Humans ; Meningioma/surgery ; Meningeal Neoplasms/surgery ; Neurosurgical Procedures/methods ; Skull Base/surgery ; Craniotomy/methods ; Skull Base Neoplasms/pathology
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2023.02.004
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  8. Article ; Online: Influence of perioperative anaesthetic and analgesic interventions on oncological outcomes: a narrative review.

    Wall, T / Sherwin, A / Ma, D / Buggy, D J

    British journal of anaesthesia

    2019  Volume 123, Issue 2, Page(s) 135–150

    Abstract: Surgery is an important treatment modality for the majority of solid organ cancers. Unfortunately, cancer recurrence following surgery of curative intent is common, and typically results in refractory disease and patient death. Surgery and other ... ...

    Abstract Surgery is an important treatment modality for the majority of solid organ cancers. Unfortunately, cancer recurrence following surgery of curative intent is common, and typically results in refractory disease and patient death. Surgery and other perioperative interventions induce a biological state conducive to the survival and growth of residual cancer cells released from the primary tumour intraoperatively, which may influence the risk of a subsequent metastatic disease. Evidence is accumulating that anaesthetic and analgesic interventions could affect many of these pathophysiological processes, influencing risk of cancer recurrence in either a beneficial or detrimental way. Much of this evidence is from experimental in vitro and in vivo models, with clinical evidence largely limited to retrospective observational studies or post hoc analysis of RCTs originally designed to evaluate non-cancer outcomes. This narrative review summarises the current state of evidence regarding the potential effect of perioperative anaesthetic and analgesic interventions on cancer biology and clinical outcomes. Proving a causal link will require data from prospective RCTs with oncological outcomes as primary endpoints, a number of which will report in the coming years. Until then, there is insufficient evidence to recommend any particular anaesthetic or analgesic technique for patients undergoing tumour resection surgery on the basis that it might alter the risk of recurrence or metastasis.
    MeSH term(s) Analgesia/methods ; Anesthesia/methods ; Humans ; Neoplasms/surgery ; Patient Outcome Assessment ; Perioperative Care/methods
    Language English
    Publishing date 2019-06-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2019.04.062
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  9. Article: Risk of Avascular Necrosis with The Modified Dunn Procedure in SCFE Patients: A Meta-Analysis.

    Jauregui, Julio J / Shaw, Nichole M / Weir, Tristan B / Barvarz, Sherwin A / McClure, Philip K

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 11

    Abstract: In situ stabilization is a widely accepted treatment for slipped capital femoral epiphysis (SCFE) despite risks of avascular necrosis (AVN) and femoroacetabular impingement (FAI). The modified Dunn procedure with surgical hip dislocation attempts to ... ...

    Abstract In situ stabilization is a widely accepted treatment for slipped capital femoral epiphysis (SCFE) despite risks of avascular necrosis (AVN) and femoroacetabular impingement (FAI). The modified Dunn procedure with surgical hip dislocation attempts to maintain epiphyseal perfusion and allows anatomic epiphyseal repositioning, theoretically reducing AVN and FAI risks. We systematically evaluated the literature, elucidating overall and stability-stratified rates of AVN following the modified Dunn procedure, and revision rates in non-AVN patients. Using Ovid and MEDLINE (PubMed), studies involving the modified Dunn procedure were evaluated for age, stability, preoperative slip (Southwick) angle, ROM at follow-up, outcome metrics, and revisions. Utilizing a random effect model of proportions, we determined overall and stability-stratified AVN rates, and revision rates in patients without AVN.673 patients (688 SCFEs) who underwent modified Dunn procedure were included. Overall AVN rate was 14.3% with a 95% Confidence Interval (CI) of 9.3 to 20.2%. AVN rate in stable slips was 10.9% (95% CI: 6.0 to 17.1%) and 19.9% (95% CI: 12.8% to 28.1%) in unstable slips. Revision rate in non-AVN patients was 13.3% (95% CI: 8.3% to 19.2%). Fixation failures occurred following K-wire or small-caliber (<6.5 mm) screw fixation. Overall mean Harris Hip Score (HHS) was excellent (>90 points). Mean HHS was 98.9 points (range of means: 86 to 99 points) in stable cases, and 90.5 points (range of means: 73 to 98 points) in unstable cases. Patients undergoing modified Dunn procedure had excellent clinical outcomes and low incidences of AVN. Further studies are needed to determine if modified Dunn osteotomy with surgical hip dislocation is a viable alternative to in situ pinning for treatment of severe SCFE.
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9111680
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  10. Article: Specific gene expression signatures of low grade meningiomas.

    Tsitsikov, Erdyni N / Hameed, Sanaa / Tavakol, Sherwin A / Stephens, Tressie M / Tsytsykova, Alla V / Garman, Lori / Bi, Wenya Linda / Dunn, Ian F

    Frontiers in oncology

    2023  Volume 13, Page(s) 1126550

    Abstract: Introduction: Meningiomas are the most common primary central nervous system (CNS) tumors in adults, representing approximately one-third of all primary adult CNS tumors. Although several recent publications have proposed alternative grading systems of ... ...

    Abstract Introduction: Meningiomas are the most common primary central nervous system (CNS) tumors in adults, representing approximately one-third of all primary adult CNS tumors. Although several recent publications have proposed alternative grading systems of meningiomas that incorporate genomic and/or epigenomic data to better predict meningioma recurrence and progression-free survival, our understanding of driving forces of meningioma development is still limited.
    Objective: To define gene expression signatures of the most common subtypes of meningiomas to better understand cellular processes and signaling pathways specific for each tumor genotype.
    Methods: We used RNA sequencing (RNA-seq) to determine whole transcriptome profiles of twenty meningiomas with genomic alterations including
    Results: The analysis revealed that meningiomas with
    Conclusions: Each group of meningiomas displayed a unique gene expression signature suggesting signaling pathways potentially implicated in tumorigenesis. These findings will improve our understanding of meningioma tumorigenesis and prognosis.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1126550
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