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  1. Article ; Online: Promising Lead Compounds in the Development of Potential Clinical Drug Candidate for Drug-Resistant Tuberculosis.

    Alghamdi, Saad / Rehman, Shaheed Ur / Shesha, Nashwa Talaat / Faidah, Hani / Khurram, Muhammad / Rehman, Sabi Ur

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 23

    Abstract: According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen, ...

    Abstract According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities with HIV and diabetes are present. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. As a better understanding of tuberculosis, microanatomy has discovered an extended range of new promising antitubercular targets and diagnostic biomarkers. However, there are still no new approved antitubercular drugs of routine therapy for several decades, except for bedaquiline, delamanid, and pretomanid approved tentatively. Despite this, innovative methods are also urgently needed to find potential new antitubercular drug candidates, which potentially decimate both latent state and active state
    MeSH term(s) Animals ; Antitubercular Agents/pharmacology ; Coumarins/chemistry ; Drug Design ; Humans ; Isoniazid/chemistry ; Mycobacterium tuberculosis/drug effects ; Peptides, Cyclic/chemistry ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/chemistry ; Pore Forming Cytotoxic Proteins/chemistry ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology
    Chemical Substances Antitubercular Agents ; Coumarins ; Peptides, Cyclic ; Pharmaceutical Preparations ; Pore Forming Cytotoxic Proteins ; griselimycin ; coumarin (A4VZ22K1WT) ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2020-12-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25235685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article: Biomarkers for Breast Adenocarcinoma Using In Silico Approaches.

    Pandi, Jhansi / Arulprakasam, Ajucarmelprecilla / Dhandapani, Ranjithkumar / Ramanathan, Saikishore / Thangavelu, Sathiamoorthi / Chinnappan, Jayaprakash / Vidhya Rajalakshmi, V / Alghamdi, Saad / Shesha, Nashwa Talaat / Prasath, S

    publication RETRACTED

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7825272

    Abstract: This work elucidates the idea of finding probable critical genes linked to breast adenocarcinoma. In this study, the GEO database gene expression profile data set (GSE70951) was retrieved to look for genes that were expressed variably across breast ... ...

    Abstract This work elucidates the idea of finding probable critical genes linked to breast adenocarcinoma. In this study, the GEO database gene expression profile data set (GSE70951) was retrieved to look for genes that were expressed variably across breast adenocarcinoma samples and healthy tissue samples. The genes were confirmed to be part of the PPI network for breast cancer pathogenesis and prognosis. In Cytoscape, the CytoHubba module was used to discover the hub genes. For correlation analysis, the predictive biomarker of these hub genes, as well as GEPIA, was used. A total of 155 (85 upregulated genes and 70 downregulated genes) were identified. By integrating the PPI and CytoHubba data, the major key/hub genes were selected from the results. The KM plotter is employed to find the prognosis of those major pivot genes, and the outcome shows worse prognosis in breast adenocarcinoma patients. Further experimental validation will show the predicted expression levels of those hub genes. The overall result of our study gives the consequences for the identification of a critical gene to ease the molecular targeting therapy for breast adenocarcinoma. It could be used as a prognostic biomarker and could lead to therapy options for breast adenocarcinoma.
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7825272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies.

    Jamal, Qazi Mohammad Sajid / Ahmad, Varish / Alharbi, Ali H / Ansari, Mohammad Azam / Alzohairy, Mohammad A / Almatroudi, Ahmad / Alghamdi, Saad / Alomary, Mohammad N / AlYahya, Sami / Shesha, Nashwa Talaat / Rehman, Suriya

    Saudi journal of biological sciences

    2021  Volume 28, Issue 8, Page(s) 4560–4568

    Abstract: The human-to-human transmitted respiratory illness in COVID-19 affected by the pathogenic Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which appeared in the last of December 2019 in Wuhan, China, and rapidly spread in many countries. ... ...

    Abstract The human-to-human transmitted respiratory illness in COVID-19 affected by the pathogenic Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which appeared in the last of December 2019 in Wuhan, China, and rapidly spread in many countries. Thereon, based on the urgent need for therapeutic molecules, we conducted
    Language English
    Publishing date 2021-04-28
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2021.04.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

    Coll, Francesc / Phelan, Jody / Hill-Cawthorne, Grant A / Nair, Mridul B / Mallard, Kim / Ali, Shahjahan / Abdallah, Abdallah M / Alghamdi, Saad / Alsomali, Mona / Ahmed, Abdallah O / Portelli, Stephanie / Oppong, Yaa / Alves, Adriana / Bessa, Theolis Barbosa / Campino, Susana / Caws, Maxine / Chatterjee, Anirvan / Crampin, Amelia C / Dheda, Keertan /
    Furnham, Nicholas / Glynn, Judith R / Grandjean, Louis / Ha, Dang Minh / Hasan, Rumina / Hasan, Zahra / Hibberd, Martin L / Joloba, Moses / Jones-López, Edward C / Matsumoto, Tomoshige / Miranda, Anabela / Moore, David J / Mocillo, Nora / Panaiotov, Stefan / Parkhill, Julian / Penha, Carlos / Perdigão, João / Portugal, Isabel / Rchiad, Zineb / Robledo, Jaime / Sheen, Patricia / Shesha, Nashwa Talaat / Sirgel, Frik A / Sola, Christophe / Sousa, Erivelton Oliveira / Streicher, Elizabeth M / Van Helden, Paul / Viveiros, Miguel / Warren, Robert M / McNerney, Ruth / Pain, Arnab / Clark, Taane G

    Nature genetics

    2018  Volume 50, Issue 5, Page(s) 764

    Abstract: In the version of this article initially published, the URL listed for TubercuList was incorrect. The correct URL is https://mycobrowser.epfl.ch/. The error has been corrected in the HTML and PDF versions of the article. ...

    Abstract In the version of this article initially published, the URL listed for TubercuList was incorrect. The correct URL is https://mycobrowser.epfl.ch/. The error has been corrected in the HTML and PDF versions of the article.
    Language English
    Publishing date 2018-04-19
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-018-0074-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3613: Show issues Location:
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    Zs.MG 46: Show issues

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  5. Article ; Online: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

    Coll, Francesc / Phelan, Jody / Hill-Cawthorne, Grant A / Nair, Mridul B / Mallard, Kim / Ali, Shahjahan / Abdallah, Abdallah M / Alghamdi, Saad / Alsomali, Mona / Ahmed, Abdallah O / Portelli, Stephanie / Oppong, Yaa / Alves, Adriana / Bessa, Theolis Barbosa / Campino, Susana / Caws, Maxine / Chatterjee, Anirvan / Crampin, Amelia C / Dheda, Keertan /
    Furnham, Nicholas / Glynn, Judith R / Grandjean, Louis / Minh Ha, Dang / Hasan, Rumina / Hasan, Zahra / Hibberd, Martin L / Joloba, Moses / Jones-López, Edward C / Matsumoto, Tomoshige / Miranda, Anabela / Moore, David J / Mocillo, Nora / Panaiotov, Stefan / Parkhill, Julian / Penha, Carlos / Perdigão, João / Portugal, Isabel / Rchiad, Zineb / Robledo, Jaime / Sheen, Patricia / Shesha, Nashwa Talaat / Sirgel, Frik A / Sola, Christophe / Oliveira Sousa, Erivelton / Streicher, Elizabeth M / Helden, Paul Van / Viveiros, Miguel / Warren, Robert M / McNerney, Ruth / Pain, Arnab / Clark, Taane G

    Nature genetics

    2018  Volume 50, Issue 2, Page(s) 307–316

    Abstract: To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed- ... ...

    Abstract To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described resistance-associated genes, novel mutations were discovered for resistance to cycloserine, ethionamide and para-aminosalicylic acid. The capacity to detect mutations associated with resistance to ethionamide, pyrazinamide, capreomycin, cycloserine and para-aminosalicylic acid was enhanced by inclusion of insertions and deletions. Odds ratios for mutations within candidate genes were found to reflect levels of resistance. New epistatic relationships between candidate drug-resistance-associated genes were identified. Findings also suggest the involvement of efflux pumps (drrA and Rv2688c) in the emergence of resistance. This study will inform the design of new diagnostic tests and expedite the investigation of resistance and compensatory epistatic mechanisms.
    MeSH term(s) Antitubercular Agents/therapeutic use ; DNA, Bacterial/analysis ; Drug Resistance, Multiple, Bacterial/genetics ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Extensively Drug-Resistant Tuberculosis/microbiology ; Genetic Variation ; Genome, Bacterial ; Genome-Wide Association Study ; Geography ; Humans ; Microbial Sensitivity Tests ; Mutation ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Phylogeny ; Sequence Analysis, DNA ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/microbiology
    Chemical Substances Antitubercular Agents ; DNA, Bacterial
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-017-0029-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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