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  1. Article ; Online: Reactive arthritis following treatment with intravesical Bacillus Calmette-Guerin for papillary carcinoma of bladder.

    Singh, Yogesh Preet / Roy, Debaditya / Jois, Bhargavi / Shetti, Mohit

    BMJ case reports

    2022  Volume 15, Issue 4

    Abstract: A man in his 60s developed reactive arthritis following treatment with intravesical Bacillus Calmette-Guerin (iBCG) for papillary carcinoma of bladder. Evaluation revealed leucocytosis and raised inflammatory markers. HLA B27 was positive. Based on the ... ...

    Abstract A man in his 60s developed reactive arthritis following treatment with intravesical Bacillus Calmette-Guerin (iBCG) for papillary carcinoma of bladder. Evaluation revealed leucocytosis and raised inflammatory markers. HLA B27 was positive. Based on the temporal relationship, it was attributed to BCG-related reactive arthritis. iBCG was stopped. Treatment with non-steroidal anti-inflammatory drugs (NSAIDS) and glucocorticoids were ineffective. Prolonged course of disease-modifying antirheumatic drugs (DMARDS) was required which aided in alleviation of symptoms and sustained remission. Intravesical BCG therapy is a treatment for bladder cancer. It is rarely associated with reactive arthritis, which responds to discontinuation of iBCG and treatment with NSAIDS and/or short-term glucocorticoids. iBCG-related reactive arthritis commonly has an acute/subacute course. Chronic arthritis as observed in our case requiring prolonged treatment with DMARDS is rare.
    MeSH term(s) Administration, Intravesical ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Reactive/chemically induced ; Arthritis, Reactive/diagnosis ; Arthritis, Reactive/drug therapy ; BCG Vaccine/adverse effects ; Carcinoma, Papillary/drug therapy ; Female ; Glucocorticoids/therapeutic use ; Humans ; Male ; Mycobacterium bovis ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antirheumatic Agents ; BCG Vaccine ; Glucocorticoids
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-249208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MEASUREMENT OF CONTROLLED ATTENUATION PARAMETER: A SURROGATE MARKER OF HEPATIC STEATOSIS IN PATIENTS OF NONALCOHOLIC FATTY LIVER DISEASE ON LIFESTYLE MODIFICATION - A PROSPECTIVE FOLLOW-UP STUDY.

    Paul, Jayanta / Venugopal, Raj Vigna / Peter, Lorance / Shetty, Kula Naresh Kumar / Shetti, Mohit P

    Arquivos de gastroenterologia

    2018  Volume 55, Issue 1, Page(s) 7–13

    Abstract: Background: Liver biopsy is a gold standard method for hepatic steatosis assessment. However, liver biopsy is an invasive and painful procedure and can cause severe complications therefore it cannot be frequently used in case of follow-up of patients. ... ...

    Abstract Background: Liver biopsy is a gold standard method for hepatic steatosis assessment. However, liver biopsy is an invasive and painful procedure and can cause severe complications therefore it cannot be frequently used in case of follow-up of patients. Non-invasive assessment of steatosis and fibrosis is of growing relevance in non-alcoholic fatty liver disease (NAFLD). To evaluate hepatic steatosis, transient elastography with controlled attenuation parameter (CAP) measurement is an option now days.
    Objective: Aim of this study is to evaluate role of measurement of controlled attenuation parameter, a surrogate marker of hepatic steatosis in patients of nonalcoholic fatty liver disease on lifestyle modification.
    Methods: In this study, initially 37 participants were included who were followed up after 6 months with transient elastography, blood biochemical tests and anthropometric measurements. The results were analyzed by Multivariate linear regression analysis and paired samples t-test (Dependent t-test) with 95% confidence interval. Correlation is calculated by Pearson correlation coefficients.
    Results: Mean CAP value for assessing hepatic steatosis during 1st consultation (278.57±49.13 dB/m) was significantly improved (P=0.03) after 6 months of lifestyle modification (252.91±62.02 dB/m). Only fasting blood sugar (P=0.008), weight (P=0.000), body mass index (BMI) (P=0.000) showed significant positive correlation with CAP. Only BMI (P=0.034) and weight (P=0.035) were the independent predictor of CAP value in NAFLD patients.
    Conclusion: Lifestyle modification improves the hepatic steatosis, and CAP can be used to detect the improvement of hepatic steatosis during follow-up in patients with NAFLD on lifestyle modification. There is no relation between CAP and Fibroscan score in NAFLD patients. Only BMI and weight can predict CAP value independently.
    MeSH term(s) Adolescent ; Adult ; Alanine Transaminase/blood ; Biomarkers ; Biopsy ; Blood Glucose/analysis ; Blood Pressure ; Body Mass Index ; Elasticity Imaging Techniques ; Fasting/blood ; Fatty Liver/blood ; Fatty Liver/diagnostic imaging ; Female ; Follow-Up Studies ; Humans ; Insulin/blood ; Insulin Resistance/physiology ; Life Style ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/pathology ; Prospective Studies ; Ultrasonography ; Young Adult
    Chemical Substances Biomarkers ; Blood Glucose ; Insulin ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2018-01
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.201800000-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Incision therapy for an unusual esophageal stricture.

    Bassan, Milan S / Shetti, Mohit / Edwards, Paul / Abi-Hanna, David / Koo, Jenn

    Gastrointestinal endoscopy

    2016  Volume 83, Issue 2, Page(s) 451

    MeSH term(s) Esophageal Stenosis/surgery ; Esophagoscopy/methods ; Humans ; Male ; Treatment Outcome
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2015.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effects of lifestyle modification on liver enzyme and Fibroscan in Indian patients with non-alcoholic fatty liver disease.

    Paul, Jayanta / Venugopal, Raj Vigna / Peter, Lorance / Hussain, Shihaz / Naresh Kumar Shetty, Kula / Shetti, Mohit P

    Gastroenterology report

    2017  Volume 6, Issue 1, Page(s) 49–53

    Abstract: Background and aims: Non-alcoholic fatty liver disease (NAFLD) is remarkably increasing in developing countries like India, in parallel with the increasing incidence of obesity. Lifestyle modification is a recommended treatment for NAFLD. In most of the ...

    Abstract Background and aims: Non-alcoholic fatty liver disease (NAFLD) is remarkably increasing in developing countries like India, in parallel with the increasing incidence of obesity. Lifestyle modification is a recommended treatment for NAFLD. In most of the previous studies, improvement after lifestyle modification was assessed by liver fibrosis through liver biopsy, but we cannot do a serial liver biopsy in every NAFLD patient. Liver fibrosis can also be assessed by fibroscan non-invasively in NAFLD. This study was designed to evaluate the effect of lifestyle modification on liver enzymes and Fibroscan values in a population with NAFLD.
    Methods: Initially, 50 NAFLD patients were included in this prospective follow-up study; however, after 6 months of lifestyle modification, only 39 participants were studied. During both the first and second consultations, Fibroscan was carried out. All participants underwent a careful interview, anthropometry measurements and radiological and biochemical tests during every consultation.
    Results: After 6 months of lifestyle modification, Fibroscan values improved significantly (8.31 ± 0.11kPa vs 7.87 ± 0.12kPa,
    Conclusion: Measured by Fibroscan and liver enzymes, it has been found that lifestyle modification is an effective therapy to downgrade hepatic injury in NAFLD patients. Serial Fibroscan can be used to assess the treatment response in NAFLD patients due to its non-invasive nature.
    Language English
    Publishing date 2017-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/gox020
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  5. Article ; Online: Listeria monocytogenes infection in Crohn's disease treated with adalimumab.

    Willson, Kaspar J / Jacob, Antony / Shetti, Mohit P / Bhatia, Rajesh / Yee, Kwang / Osler, William

    The Medical journal of Australia

    2011  Volume 197, Issue 8, Page(s) 466–467

    MeSH term(s) Adalimumab ; Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Crohn Disease/drug therapy ; Humans ; Listeria monocytogenes/isolation & purification ; Listeriosis/etiology ; Listeriosis/microbiology ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Monoclonal, Humanized ; Tumor Necrosis Factor-alpha ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2011-03-28
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja11.10521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is narrow band imaging superior to high-definition white light endoscopy in the assessment of diminutive colorectal polyps?

    Singh, Rajvinder / Bhat, Yasser Maqbool / Thurairajah, Prem Harichander / Shetti, Mohit Pramod / Jayanna, Mahesh / Nind, Garry / Tam, William / Walmsey, Russell / Bourke, Micheal / Moss, Alan / Chen, Robert / Bampton, Peter / Roberts-Thomson, Ian / Schoeman, Mark / Tucker, Graeme

    Journal of gastroenterology and hepatology

    2013  Volume 28, Issue 3, Page(s) 472–478

    Abstract: Background and aim: Diminutive polyps measuring ≤ 5 mm in size constitute 80% of polyps in the colon. We prospectively assessed the performance of high-definition white light endoscopy (hWLE) and narrow band imaging (NBI) in differentiating diminutive ... ...

    Abstract Background and aim: Diminutive polyps measuring ≤ 5 mm in size constitute 80% of polyps in the colon. We prospectively assessed the performance of high-definition white light endoscopy (hWLE) and narrow band imaging (NBI) in differentiating diminutive colorectal polyps.
    Methods: In this prospective, multicenter study, videos of 50 diminutive polyps (31 hyperplastic, 19 adenomatous) in hWLE followed by NBI (total 100 videos) were initially obtained and placed in random order into five separate folders (each folder 20 videos). Eight endoscopists were then invited to predict the histology (each endoscopist 100 videos, 800 video assessments in all). Polyps were classified into types 1-3 (hyperplastic) and type 4 (adenoma). Feedback on individual performance was given after each folder (20 videos) was assessed.
    Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in differentiating hyperplastic from adenomatous polyps by hWLE (400 videos) and NBI (400 videos) were 67.8%, 90.7%, 81.7%, 82.1%, and 82.0%; and 82.2%, 81.5%, 73.1%, 88.2%, and 81.8%, respectively. In the pretest and post-test analysis, the accuracy with NBI improved markedly from 68.8% to 91.3% (P = 0.001) compared with hWLE, 76.3-78.8% (P = 0.850). Overall, the interobserver agreement was 0.46 for hWLE (moderate) and 0.64 for NBI (good).
    Conclusions: NBI was as accurate as hWLE in differentiating diminutive colorectal polyps. Once a learning curve was reached, NBI achieved significantly higher accuracies with good interobserver agreement. Using a simplified classification, a didactic learning session and feedback on performance, diminutive colorectal polyps could be predicted with high accuracies with NBI.
    MeSH term(s) Adenomatous Polyps/diagnosis ; Adult ; Aged ; Aged, 80 and over ; Colon/pathology ; Colonic Polyps/diagnosis ; Colonoscopy/methods ; Colorectal Neoplasms/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hyperplasia/diagnosis ; Intestinal Polyps/diagnosis ; Learning Curve ; Male ; Middle Aged ; Narrow Band Imaging ; Observer Variation ; Rectum/pathology ; Sensitivity and Specificity ; Video Recording
    Language English
    Publishing date 2013-03
    Publishing country Australia
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.12098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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