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Book ; Online: Chapter Sorption Detoxification as an Addition to Conventional Therapy of Acute Radiation Sickness and Iatrogenic Leukopenia

Sarnatskaya, V. V. / Snezhkova, E. A. / Chekhun, Vasyl F. / Vg, Nikolaev / Bilous, Anatoliy G. / Shevchuk, O. O. / Badakhivska, Kvitoslava I. / Sakhno, L. A.

2019

Keywords	Medical microbiology & virology ; leukopenia, ionizing irradiation, anti-cancer chemotherapy, granulocyte colony stimulating factor, hemosorption, enterosorption, application-sorption therapy
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047889
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: [Morphological aspects of protective influence of carbonic enterosorbent and granulocyte colony stimulating factor on small intestine in case of Melphalan administration]

Shevchuk O.O.

Морфологія, Vol 9, Iss 3, Pp 117-

2015 Volume 121

Abstract: Background. High toxicity of anti-cancer drugs limits the efficacy of the treatment of malignant tumors. The most frequent side effects are the injury of highly proliferative cell and tissues: hematologic and gastrointestinal toxicity. Our previous study ...

Abstract	Background. High toxicity of anti-cancer drugs limits the efficacy of the treatment of malignant tumors. The most frequent side effects are the injury of highly proliferative cell and tissues: hematologic and gastrointestinal toxicity. Our previous study showed high myeloprotective activity of combination of carbonic enterosorbent and granulocyte colony stimulating factor. The objective of this investigation is to study the morphologic characteristic of small intestine in case of melphalan injection and pharmacocorrection with carbonic granulated enterosorbent C2 and filgrastim. Methods. Histologic structure of jejunum of healthy male inbred rats, after the melphalan injection (4 mg/kg) and its correction with enterosorption and filgrastim apart, and in combination was investigated. Results. Cytostatic melphalan caused the dilation of microcirculatory vessels and expressed perivasal edema leading to enlargement of intestinal villi. It was revealed a large amount of lymphocytes and histiocytes in stroma and signs of increasing secretory activity of glandular cells. Dystrophic changes of the epithelium were seen. The enteral sorptive therapy showed prominent improvement of morphologic characteristic of jejunum. But sighs of increased mucus production were still seen. The granulocyte colony stimulating factor has no effects on small intestine structures. The combination of carbonic enterosorbent and filgrastim improved the histologic picture maximally. Conclusion. Combination of enterosorption and granulocyte colony stimulating factor is a prospective approach to diminish the gastrointestinal toxicity of cytostatic therapy. Citation: Shevchuk OO. [Morphological aspects of protective influence of carbonic enterosorbent and granulocyte colony stimulating factor on small intestine in case of Melphalan administration]. Morphologia. 2015;9(3):117-21. Ukrainian.
Keywords	small intestine ; melphalan ; carbonic enterosorbent ; granulocyte colony stimulating factor ; Biology (General) ; QH301-705.5
Subject code	610
Language	Russian
Publishing date	2015-09-01T00:00:00Z
Publisher	Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Adsorptive therapy as a modificator for tumor-host interaction.

Sakhno, L A / Sarnatskaya, V V / Yushko, L A / Snezhkova, E A / Bardakhivskaya, K I / Shevchuk, O O / Sidorenko, A S / Nikolaev, V G

Experimental oncology

2019 Volume 41, Issue 3, Page(s) 254–257

Abstract: The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic ... ...

Abstract	The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic toxicity of chemo- and radiation therapy, is discussed. The ES influence on the development of PNS was demonstrated in C57/BL6 mice with transplanted Lewis lung carcinoma. Two-week administration of carbon enterosorbents resulted in a significant suppression of metastasis and correction of tumor-related anemia, activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of its mitotic activity. ES exerted a positive influence on the structural-morphologic indexes and regenerative potential of kidneys and liver, mitigated manifestations of oxidative stress, decreased the level of endogenous intoxication, increased resistance of erythrocyte membranes and decreased ligand loading of blood plasma transport proteins. The effect of ES on anticancer activity and toxic reactions of cisplatin (CP) was evaluated in Guerin carcinoma-bearing rats. ES reduced significantly creatinine and other kidney biochemical indexes elevated in the blood plasma of rats after CP treatment. ES attenuated dystrophic changes in the histological structure of internal organs (kidney, liver, spleen), caused by tumor growth and significantly aggravated under the influence of CP. Such changes were specially traced in the kidneys and well reflect the nephroprotective potential of ES. In rats irradiated with X-ray in sublethal dose, highly activated granulated carbonic enterosorbents facilitated the restoration of white blood cells and lymphocyte count. The results obtained confirm the insights of academician R.E. Kavetsky predicting the future of adsorptive detoxification with activated carbons in the treatment of cancer patients.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Disease Models, Animal ; Enterosorption/adverse effects ; Enterosorption/methods ; Humans ; Male ; Mice ; Neoplasms/complications ; Neoplasms/diagnosis ; Neoplasms/therapy ; Paraneoplastic Syndromes/therapy ; Treatment Outcome
Language	English
Publishing date	2019-09-27
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
DOI	10.32471/exp-oncology.2312-8852.vol-41-no-3.13576
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Article: Theoretical ground for adsorptive therapy of anthracyclines cardiotoxicity.

Shevchuk, O O / Posokhova, E A / Sakhno, L A / Nikolaev, V G

Experimental oncology

2012 Volume 34, Issue 4, Page(s) 314–322

Abstract: Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and ... ...

Abstract	Anthracyclines play an important role in treatment of variety types of cancer due to their high effectiveness and broad spectrum of activity. However, a major limitation of their use is the dose-limiting cardiotoxicity. The inability to predict and prevent anthracycline cardiotoxicity is in part due to the fact that the molecular and cellular mechanisms remain controversial and incompletely understood. This review focuses on the biochemical basis of the anthracyclines toxic cardiac effects and pharmacological measures to their treatment and preventing. We describe the theoretical substantiation of the enterosorption abilities for diminishing of cardiac damage.
MeSH term(s)	Animals ; Anthracyclines/adverse effects ; Anthracyclines/chemistry ; Heart/drug effects ; Heart Diseases/chemically induced ; Heart Diseases/therapy ; Humans
Chemical Substances	Anthracyclines
Language	English
Publishing date	2012-12
Publishing country	Ukraine
Document type	Journal Article ; Review
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
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Article: Enterosorption combined with granulocyte colony stimulating factor decreases melphalan gonadal toxicity.

Shevchuk, O O / Bodnar, Ya Ya / Bardakhivskaya, K I / Datsko, T V / Volska, A S / Posokhova, К А / Chekhun, V F / Nikolaev, V G

Experimental oncology

2016 Volume 38, Issue 3, Page(s) 172–175

Abstract: Unlabelled: Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause ... ...

Abstract	Unlabelled: Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology. The aim of our investigation was to study the efficiency of combined use of enterosorption and G-CSF to decrease gonadal toxicity of chemotherapy. Materials and methods: Melphalan (L-PAM) injected i.v. at a single dose of 4 mg/kg to white inbred rats was used as gonadotoxic and myelosuppressing agent. Carbon enterosorbent C2 was administered by intragastric route as a suspension in saline at a dose of 5 ml per 1 kg of rats' body weight (or 900 mg/kg of the dry mass of enterosorbent) daily for 3 days before and for 7 days after L-PAM injection. G-CSF was injected once a day for 4 days starting from the next day after L-PAM administration at a dose of 50 µg/kg. Histological preparations of testicular tissues were examined by light microscopy. Results: Our findings have shown that melphalan caused marked damage of testicular tissues and seminiferous, especially spermatogenic epithelium. The most expressed protection of the histological structure of testes was observed when enterosorbent and G-CSF were used in combination. Conclusion: Gonadal toxicity of chemotherapy could be efficiently decreased by the combined use of enterosorption and G-CSF.
Language	English
Publishing date	2016-09
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
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Article: Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor.

Shevchuk, O O / Posokhova, К А / Todor, I N / Lukianova, N Yu / Nikolaev, V G / Chekhun, V F

Experimental oncology

2015 Volume 37, Issue 2, Page(s) 135–138

Abstract: Unlabelled: Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that ... ...

Abstract	Unlabelled: Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous administration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy.
MeSH term(s)	Animals ; Antineoplastic Agents, Alkylating/adverse effects ; Antineoplastic Agents, Alkylating/therapeutic use ; Bone Marrow/drug effects ; Bone Marrow/pathology ; Carbon/pharmacology ; Enterosorption ; Female ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hematopoiesis/drug effects ; Male ; Melphalan/adverse effects ; Melphalan/therapeutic use ; Neoplasm Transplantation ; Neoplasms, Experimental/drug therapy ; Neutropenia/chemically induced ; Neutropenia/prevention & control ; Rats, Wistar
Chemical Substances	Antineoplastic Agents, Alkylating ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Carbon (7440-44-0) ; Melphalan (Q41OR9510P)
Language	English
Publishing date	2015-06
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
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Article: The influence of enterosorption on some haematological and biochemical indices of the normal rats after single injection of melphalan.

Shevchuk, O O / Posokhova, K A / Sidorenko, A S / Bardakhivskaya, K I / Maslenny, V M / Yushko, L A / Chekhun, V F / Nikolaev, V G

Experimental oncology

2014 Volume 36, Issue 2, Page(s) 94–100

Abstract: Aim: One of the most prominent side effects of intensive cancer chemotherapy is bone marrow suppression which is an independent negative prognostic factor for the time to tumor progression. The aim of the study was to evaluate the myeloprotective ... ...

Abstract	Aim: One of the most prominent side effects of intensive cancer chemotherapy is bone marrow suppression which is an independent negative prognostic factor for the time to tumor progression. The aim of the study was to evaluate the myeloprotective possibilities of carbon enterosorbents in the case of usage of alkilating drug melphalan (L-PAM). Materials and methods: L-PAM was injected intravenously to healthy inbred rats to cause the myelosuppression. 3 days before and 7 days after this, suspension of two types of carbon granulated enterosorbents were administered per os one time per day. On 8(th) day after L-PAM injection, the rats were weighted and blood and liver tissue were taken under Ketamine general anesthesia for biochemical examination. Peripheral blood smears were made also. Results: Melphalan at a dose of 3 mg/kg causes expressed myelotoxic reaction: leucopenia, decreasing of erythrocytes, hemoglobin and platelets counts. Even on 8(th) day after single injection of this cytostatic we can detect expressed signs of oxidative stress like increasing of hydroperoxides, TBA-reactive substances, and decreasing of activity and level of main endogenic antioxidants - superoxide dismutase (SOD), catalase and reduced glutathione. L-PAM causes also the violation of kidney function such as increase of urea and creatinine level; and rising of endogenic intoxication with elevation of middle mass molecules level. In a dose of 3 mg/kg melphalan has no negative influence on liver function on 8(th) day of experiment. Enterosorption with carbon enterosorbents C1 (bulk density γ = 0.28 g/cm(3), granules diameter 0.15-0.25 mm, BET pore surface 1719 m(2)/g, therapeutic dosage 1400 mg/kg) and C2 (bulk density γ = 0.18 g/cm(3), granules diameter 0.15-0.25 mm, BET pore surface 2162 m(2)/g, therapeutic dosage 900 mg/kg) diminishes and mitigates negative side effects caused by single intravenous injection of melphalan. Carbon enterosorbent C2 have rather more expressed positive effect than C1 for practically all indices. The most important curative effect due to C2 administration is prominent myeloprotection of bone marrow of experimental animals. Conclusion: Carbon enterosorbent C2 is promising and perspective sorbent for prophylaxis and treatment of side effects of cytostatic chemotherapy including myelotoxicity, mucositis, kidney injuries, gonadotoxicity, etc.
MeSH term(s)	Animals ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/toxicity ; Carbon/chemistry ; Carbon/metabolism ; Enterosorption ; Erythrocyte Indices/drug effects ; Hematopoiesis/drug effects ; Leukocyte Count ; Leukocytes/drug effects ; Melphalan/administration & dosage ; Melphalan/pharmacology ; Melphalan/toxicity ; Oxidative Stress/drug effects ; Rats ; Reactive Oxygen Species/metabolism
Chemical Substances	Antineoplastic Agents, Alkylating ; Reactive Oxygen Species ; Carbon (7440-44-0) ; Melphalan (Q41OR9510P)
Language	English
Publishing date	2014-06
Publishing country	Ukraine
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
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Article ; Online: Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts.

Yost, A J / Shevchuk, O O / Gooch, R / Gusscott, S / You, M J / Ince, T A / Aster, J C / Weng, A P

Leukemia

2012 Volume 27, Issue 6, Page(s) 1437–1440

MeSH term(s)	Culture Media ; Culture Media, Serum-Free ; Humans ; In Vitro Techniques ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology
Chemical Substances	Culture Media ; Culture Media, Serum-Free
Language	English
Publishing date	2012-11-21
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/leu.2012.337
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Article: Enterosorption as a method to decrease the systemic toxicity of cisplatin.

Sakhno, L A / Yurchenko, O V / Maslenniy, V N / Bardakhivskaya, K I / Nikolaeva, V V / Ivanyuk, A A / Shevchuk, O O / Korotich, V G / Nikolaev, V G

Experimental oncology

2013 Volume 35, Issue 1, Page(s) 45–52

Abstract: Unlabelled: A perspective adsorptive method to minimize systemic toxic effects of chemotherapy is enterosorption (ES). However, the capabilities of this method are far from being completely studied. The question remains opened - should ES be initiated ... ...

Abstract	Unlabelled: A perspective adsorptive method to minimize systemic toxic effects of chemotherapy is enterosorption (ES). However, the capabilities of this method are far from being completely studied. The question remains opened - should ES be initiated in the first hours on completing cytostatic infusion without the risk of their anticancer activity to be decreased. Aim: to analyze ES influence on anticancer activity and toxic reactions of cisplatin (CP) upon the use of carbon enterosorbent in 1 h after intravenous administration of cytostatic. Methods: CP at the dose of 1 mg/kg body weigh (BW) was administered to Guerin carcinoma-bearing rats each second day for two weeks. Enterosorbents on the basis of highly activated carbon fibers were administered by per os daily 1 h after CP injection. 3 days after the last CP administration the rats were weighted and blood under ether narcosis has been taken for biochemical examination. Tumors and innate organs were isolated, weighted, and fixed in 4% buffered formalin for morphologic examination. Results: In rats administered with CP at the background of ES, BW loss was in 1.6 times lower than in animals after CP session. Relative kidney weight in CP-treated rats was 33.9% higher than in normal ones (p ≤ 0.05). No significant differences were detected between relative kidney weights in the CP + ES-treated and intact animals. Introduction of ES allowed prevent an 30% increase of creatinin content observed in blood plasma after CP treatment (р ≤ 0.05). Urea content was 1.7 times lower in blood plasma of CP + ES-treated rats than after CP treatment. CP caused significant toxic injuries in kidneys, liver, and spleen tissues. Morphologic structure of organs in rats treated with CP at the background of ES was affected at much lower degree. In tumors, large areas of newly formed connective tissue and blood vessels have been fixed after the CP+ES action instead of large necrotic area observed after CP treatment. ES caused insignificant suppression of Guerin carcinoma growth and had additional impact to inhibitory action of CP. Conclusion: Active carbon enterosorbents which are administrated just 1 h after CP administration possesses detoxicating potential sufficient for significant elimination of toxic effect of the cytostatic at the background of complete preservation of its antitumor activity.
MeSH term(s)	Animals ; Antineoplastic Agents/adverse effects ; Body Weight/drug effects ; Carbon/administration & dosage ; Carbon/chemistry ; Cisplatin/adverse effects ; Creatinine/blood ; Enterosorption ; Kidney/drug effects ; Neoplasms/drug therapy ; Rats ; Uric Acid/blood
Chemical Substances	Antineoplastic Agents ; Uric Acid (268B43MJ25) ; Carbon (7440-44-0) ; Creatinine (AYI8EX34EU) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2013-03
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	2176927-8
ISSN	1812-9269 ; 0204-3564
ISSN	1812-9269 ; 0204-3564
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