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Article ; Online: Complementary sensors for rapid and sensitive detection of wound bacteria.

Sheybani, Roya / Shukla, Anita

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2017 Volume 2016, Page(s) 1902–1905

Abstract: Dual sensors for timely wound bacterial infection detection through the measurement of pH and bacterial cell attachment were developed. A high sensitivity of -57.98 ± 7.08 mV/pH (pH 1-13; over 14 days) and a minimum detectable bacteria concentration of ... ...

Abstract	Dual sensors for timely wound bacterial infection detection through the measurement of pH and bacterial cell attachment were developed. A high sensitivity of -57.98 ± 7.08 mV/pH (pH 1-13; over 14 days) and a minimum detectable bacteria concentration of 103 CFU/mL was achieved for the pH and cell-based sensors, respectively. Sensors were capable of successfully monitoring growth of bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) over time with and without antibiotics in simulated would fluid.
MeSH term(s)	Anti-Bacterial Agents ; Bacteria/growth & development ; Equipment and Supplies ; Sensitivity and Specificity ; Wound Infection/diagnosis
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2017-03-08
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2016.7591093
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Article ; Online: Highly sensitive label-free dual sensor array for rapid detection of wound bacteria.

Sheybani, Roya / Shukla, Anita

Biosensors & bioelectronics

2017 Volume 92, Page(s) 425–433

Abstract: Wound infections are a critical healthcare concern worldwide. Rapid and effective antibiotic treatments that can mitigate infection severity and prevent the spread of antibiotic resistance are contingent upon timely infection detection. In this work, ... ...

Abstract	Wound infections are a critical healthcare concern worldwide. Rapid and effective antibiotic treatments that can mitigate infection severity and prevent the spread of antibiotic resistance are contingent upon timely infection detection. In this work, dual electrochemical pH and cell-attachment sensor arrays were developed for the real-time spatial and temporal monitoring of potential wound infections. Biocompatible polymeric device coatings were integrated to stabilize the sensors and promote bacteria attachment while preventing non-specific cell and protein fouling. High sensitivity (bacteria concentration of 10
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/growth & development ; Bacteria/isolation & purification ; Biosensing Techniques/economics ; Biosensing Techniques/instrumentation ; Electrochemical Techniques/economics ; Electrochemical Techniques/instrumentation ; Equipment Design ; Escherichia coli/drug effects ; Escherichia coli/growth & development ; Escherichia coli/isolation & purification ; Humans ; Hydrogen-Ion Concentration ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/growth & development ; Pseudomonas aeruginosa/isolation & purification ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/isolation & purification ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/growth & development ; Streptococcus pyogenes/isolation & purification ; Wound Infection/diagnosis ; Wound Infection/drug therapy ; Wound Infection/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2017-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2016.10.084
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Article: Highly sensitive label-free dual sensor array for rapid detection of wound bacteria

Sheybani, Roya / Anita Shukla

Biosensors & bioelectronics. 2017 June 15, v. 92

2017

Abstract	Wound infections are a critical healthcare concern worldwide. Rapid and effective antibiotic treatments that can mitigate infection severity and prevent the spread of antibiotic resistance are contingent upon timely infection detection. In this work, dual electrochemical pH and cell-attachment sensor arrays were developed for the real-time spatial and temporal monitoring of potential wound infections. Biocompatible polymeric device coatings were integrated to stabilize the sensors and promote bacteria attachment while preventing non-specific cell and protein fouling. High sensitivity (bacteria concentration of 102 colony forming units (CFU)/mL and −88.1±6.3mV/pH over a pH range of 1–13) and stability over 14 days were achieved without the addition of biological recognition elements. The dual sensor array was demonstrated to successfully monitor the growth of both gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) over time through lag and log growth phases and following antibiotic administration and in simulated shallow wounds conditions. The versatile fabrication methods utilized in sensor development, superior sensitivity, prolonged stability, and lack of non-specific sensor fouling may enable long-term in situ sensor array operation in low resource settings.
Keywords	antibiotic resistance ; antibiotics ; biosensors ; coatings ; electrochemistry ; Escherichia coli ; fouling ; Gram-negative bacteria ; health services ; monitoring ; pH ; Pseudomonas aeruginosa ; rapid methods ; Staphylococcus aureus ; Streptococcus pyogenes
Language	English
Dates of publication	2017-0615
Size	p. 425-433.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2016.10.084
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Article ; Online: Cellular host response sepsis test for risk stratification of patients in the emergency department: A pooled analysis.

O'Neal, Hollis R / Sheybani, Roya / Kraus, Chadd K / Self, Wesley H / Shah, Ajay M / Thomas, Christopher B / Tse, Henry T K / Scoggins, Robert

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

2024

Abstract: Objectives: Sepsis is one of the most common, costly, and misdiagnosed conditions in U.S. emergency departments (EDs). ED providers often treat on nonspecific signs, subjective suspicion, or presumption of infection, resulting in over- and ... ...

Abstract	Objectives: Sepsis is one of the most common, costly, and misdiagnosed conditions in U.S. emergency departments (EDs). ED providers often treat on nonspecific signs, subjective suspicion, or presumption of infection, resulting in over- and undertreatment. An increased understanding of host response has opened a new direction for sepsis diagnostics. The IntelliSep test is a U.S. Food and Drug Administration-cleared cellular host response diagnostic that could help distinguish sepsis in ED settings. Our objective was to evaluate the potential of the cellular host response test to expedite appropriate care for patients who present with signs of infection. Methods: We performed a pooled analysis of five adult (≥18 years) cohorts enrolled at seven geographically diverse U.S. sites in separate studies. Structured blinded adjudication was used to classify presence or absence of sepsis, and only patients with high confidence in the adjudicated label were included (n = 1002), defined as patients for whom there was consensus in the determination of sepsis per the Sepsis-3 and severe sepsis per the Sepsis-2 definitions between both the independent adjudication panel and the site-level physician. Results: Among patients with signs or suspicion of infection, the test achieved similar or better performance compared to other indicators in identifying patients at high risk for sepsis (specificity > 83%) and significantly superior performance in identifying those at low risk (sensitivity > 92%; 0% sepsis-associated mortality). The test also stratified severity of illness, as shown by 30-day in-hospital mortality (p < 0.001), hospital length of stay (p < 0.01), and use of hospital resources (p < 0.001). Conclusions: Our data suggest that the cellular host response test provides clinically actionable results for patients at both high and low risk for sepsis and provides a rapid, objective means for risk stratification of patients with signs of infection. If integrated into standard of care, the test may help improve outcomes and reduce unnecessary antibiotic use.
Language	English
Publishing date	2024-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329813-6
ISSN	1553-2712 ; 1069-6563
ISSN (online)	1553-2712
ISSN	1069-6563
DOI	10.1111/acem.14923
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Article ; Online: The impact of a peer-based education on fruits and vegetables intake among housewives.

Sheybani, Roya / Hosseini, Zahra / Davoodi, Sayed Hossein / Aghamolaei, Teamur / Ghanbarnejad, Amin

Journal of health, population, and nutrition

2021 Volume 40, Issue 1, Page(s) 53

Abstract: Background: Evidence indicates the lower intake of fruits and vegetables than the recommended daily amount. Study aimed at determining the effects of peer education intervention on the consumption of fruits and vegetable in housewives.: Methods: A ... ...

Abstract	Background: Evidence indicates the lower intake of fruits and vegetables than the recommended daily amount. Study aimed at determining the effects of peer education intervention on the consumption of fruits and vegetable in housewives. Methods: A quasi-experimental was conducted with 130 housewives referring to health care centers in Bandar Abbas, Iran. Sixty-five subjects were recruited in each of the intervention and the control groups. Intervention group were divided into three subgroups each receiving a seven-sessions educational programs (lecturing and group discussion) through peers about the importance of benefits of fruits and vegetables consumption. Participants were followed for two months. Data were collected using a questionnaire in two stages of pre- and post-intervention. Differences in the outcome before and after the intervention were tested using T-test and paired T-test. Results: The daily servings of fruits and vegetables in the intervention group increased from 1.73 to 4.20 and in the control group from 1.96 to 2.16; a statistically significant difference was also observed between the groups (P < 0.001). After the intervention benefits and self-efficacy of fruits and vegetables consumption significantly increased and perceived barriers of fruits and vegetables consumption significantly decreased in the intervention group (P < 0.001). Conclusion: Peer education improves benefits and self-efficacy, reduces barriers, and increases the daily servings of fruits and vegetables in housewives.
MeSH term(s)	Educational Status ; Fruit ; Humans ; Iran ; Self Efficacy ; Vegetables
Language	English
Publishing date	2021-12-13
Publishing country	Bangladesh
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-021-00278-3
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Article ; Online: On-demand wireless infusion rate control in an implantable micropump for patient-tailored treatment of chronic conditions.

Sheybani, Roya / Meng, Ellis

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2015 Volume 2014, Page(s) 882–885

Abstract: Wireless infusion rate control and programmability for an implantable, low power, electrochemical micropump is presented. Flow rate control was achieved through adjustment of the wiper position of a current potentiometer in the wireless receiver (0.6-3.2 ...

Abstract	Wireless infusion rate control and programmability for an implantable, low power, electrochemical micropump is presented. Flow rate control was achieved through adjustment of the wiper position of a current potentiometer in the wireless receiver (0.6-3.2 mA output current with a resolution of 0.2 mA per step). An off-the-shelf Bluetooth module and Basic Stamp microcontroller kit was used to initiate amplitude-shift keying (ASK) modulation of the inductive power signal. Accurate flow control of two model regimens was achieved on benchtop. Wireless transmission (power transfer and control) was not affected by simulated tissue material placed between the transmitter and receiver.
MeSH term(s)	Animals ; Chronic Disease/therapy ; Equipment Design ; Humans ; Models, Theoretical ; Prostheses and Implants ; Reproducibility of Results ; Wireless Technology/instrumentation
Language	English
Publishing date	2015-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2014.6943732
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Article: Acceleration Techniques for Recombination of Gases in Electrolysis Microactuators with Nafion®-Coated Electrocatalyst.

Sheybani, Roya / Meng, Ellis

Sensors and actuators. B, Chemical

2015 Volume 221, Page(s) 914–922

Abstract: Recombination of electrolysis gases (oxidation of hydrogen and reduction of oxygen) is an important factor in operation efficiency of devices employing electrolysis such as actuators and also unitized regenerative fuel cells. Several methods of improving ...

Abstract	Recombination of electrolysis gases (oxidation of hydrogen and reduction of oxygen) is an important factor in operation efficiency of devices employing electrolysis such as actuators and also unitized regenerative fuel cells. Several methods of improving recombination speed and repeatability were developed for application to electrolysis microactuators with Nafion®-coated catalytic electrodes. Decreasing the electrolysis chamber volume increased the speed, consistency, and repeatability of the gas recombination rate. To further improve recombination performance, methods to increase the catalyst surface area, hydrophobicity, and availability were developed and evaluated. Of these, including in the electrolyte pyrolyzed-Nafion®-coated Pt segments contained in the actuator chamber accelerated recombination by increasing the catalyst surface area and decreasing the gas transport diffusion path. This approach also reduced variability in recombination encountered under varying actuator orientation (resulting in differing catalyst/gas bubble proximity) and increased the rate of recombination by 2.3 times across all actuator orientations. Repeatability of complete recombination for different generated gas volumes was studied through cycling.
Language	English
Publishing date	2015-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1021505-0
ISSN	0925-4005
ISSN	0925-4005
DOI	10.1016/j.snb.2015.07.026
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Article: Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis.

Sorrells, Matt G / Seo, Yurim / Magnen, Melia / Broussard, Bliss / Sheybani, Roya / Shah, Ajay M / O'Neal, Hollis R / Tse, Henry T K / Looney, Mark R / Di Carlo, Dino

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 8

Abstract: Sepsis, the leading cause of mortality in hospitals, currently lacks effective early diagnostics. A new cellular host response test, the IntelliSep test, may provide an indicator of the immune dysregulation characterizing sepsis. The objective of this ... ...

Abstract	Sepsis, the leading cause of mortality in hospitals, currently lacks effective early diagnostics. A new cellular host response test, the IntelliSep test, may provide an indicator of the immune dysregulation characterizing sepsis. The objective of this study was to examine the correlation between the measurements performed using this test and biological markers and processes associated with sepsis. Phorbol myristate acetate (PMA), an agonist of neutrophils known to induce neutrophil extracellular trap (NET) formation, was added to whole blood of healthy volunteers at concentrations of 0, 200, and 400 nM and then evaluated using the IntelliSep test. Separately, plasma from a cohort of subjects was segregated into Control and Diseased populations and tested for levels of NET components (citrullinated histone (cit-H3) DNA and neutrophil elastase (NE) DNA) using customized ELISA assays and correlated with ISI scores from the same patient samples. Significant increases in IntelliSep Index (ISI) scores were observed with increasing concentrations of PMA in healthy blood (0 and 200:
Language	English
Publishing date	2023-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13081435
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Article: Micro- and nano-fabricated implantable drug-delivery systems: current state and future perspectives.

Meng, Ellis / Sheybani, Roya

Therapeutic delivery

2014 Volume 5, Issue 11, Page(s) 1167–1170

MeSH term(s)	Drug Delivery Systems/instrumentation ; Drug Delivery Systems/methods ; Drug Delivery Systems/trends ; Equipment Design ; Forecasting ; Infusion Pumps, Implantable/trends ; Membranes, Artificial ; Miniaturization ; Nanomedicine/instrumentation ; Nanomedicine/methods ; Nanomedicine/trends ; Nanopores ; Porosity ; Technology, Pharmaceutical/instrumentation ; Technology, Pharmaceutical/methods ; Technology, Pharmaceutical/trends
Chemical Substances	Membranes, Artificial
Language	English
Publishing date	2014-11
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	2041-5990
ISSN	2041-5990
DOI	10.4155/tde.14.90
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Article: A Wireless Implantable Micropump for Chronic Drug Infusion Against Cancer.

Cobo, Angelica / Sheybani, Roya / Tu, Heidi / Meng, Ellis

Sensors and actuators. A, Physical

2016 Volume 239, Page(s) 18–25

Abstract: We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as ... ...

Abstract	We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling. Micropump performance was demonstrated using a model anti-cancer application in which daily doses of 30 μL were supplied for several weeks with less than 6% variation in flow rate within a single pump and less than 8% variation across different pumps. Pumping under different back pressure, viscosity, and temperature conditions were investigated; parameters were chosen so as to mimic
Language	English
Publishing date	2016-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1500729-7
ISSN	0924-4247
ISSN	0924-4247
DOI	10.1016/j.sna.2016.01.001
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