Article: The protective effect and mechanism of sevoflurane on LPS-induced acute lung injury in mice.
American journal of translational research
2017 Volume 9, Issue 4, Page(s) 1732–1742
Abstract: Acute lung injury (ALI) is a disturbance caused by infectious or non-infectious inflammation and lipopolysaccharide (LPS) could induce an artificial pathological ALI process. Sevoflurane has been demonstrated to be an inhaled anesthetic having anti- ... ...
| Abstract | Acute lung injury (ALI) is a disturbance caused by infectious or non-infectious inflammation and lipopolysaccharide (LPS) could induce an artificial pathological ALI process. Sevoflurane has been demonstrated to be an inhaled anesthetic having anti-inflammatory and protective effects on inflammatory injury. To study the protective effects and mechanisms of sevoflurane on LPS-induced acute lung injury in mice. By assessing W/D ratio, sevofluranecan counteract the edema induced by LPS. The ELISA results showed that sevoflurane reduced IFN-γ production and increased IL-10 level. Elevation of PGE2 induced by sevofluraneand LPS in peritoneal macrophages was inhibited by NS-398, an inhibitor of the PGE2 regulator COX-2, indicating that NS-398 blocked COX-2 mediated PGE |
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| Language | English |
| Publishing date | 2017-04-15 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2471058-1 |
| ISSN | 1943-8141 |
| ISSN | 1943-8141 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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