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Article ; Online: CAR‐NK cells from engineered pluripotent stem cells

Shi‐Jiang Lu / Qiang Feng

Stem Cells Translational Medicine, Vol 10, Iss S2, Pp S10-S

Off‐the‐shelf therapeutics for all patients

2021 Volume 17

Abstract: Abstract Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for treating hematological malignancies has revolutionized the field of cellular immunotherapy. However, due to the nature of utilizing autologous T cells, ... ...

Abstract	Abstract Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for treating hematological malignancies has revolutionized the field of cellular immunotherapy. However, due to the nature of utilizing autologous T cells, affordability and availability are major hurdles, in addition to scientific challenges relating to CAR‐T therapy optimization. Natural killer (NK) cell is a specialized immune effector cell type that recognizes and kills targets without human leukocyte antigen (HLA) restriction and prior sensitization. CAR‐NK cells do not cause graft vs host disease and can be obtained from unrelated donors as well as pluripotent stem cells (PSC), representing an ideal off‐the‐shelf therapeutics readily available for patients. Furthermore, unlike cytotoxic T cells, NK cells specifically target and eliminate cancer stem cells, which are the cells causing relapse and metastasis. PSCs can be genetically manipulated and engineered with CARs at the pluripotent stage, which allows the establishment of permanent, stable, and clonal PSC‐CAR lines for the manufacture of unlimited homogenous CAR‐NK cells. Multiple master PSC‐CAR cell banks targeting a variety of antigens for cancer, viral infection, and autoimmune diseases provide inexhaustible cell sources for all patients. Development of a next‐generation 3D bioreactor platform for PSC expansion and NK cell production overcomes major barriers related to cost and scalability for CAR‐NK product.
Keywords	CAR‐T ; CAR‐NK ; cellular immunotherapy ; off‐the‐shelf therapeutics ; pluripotent stem cells ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Oxford University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diversified Synthesis of All-Carbon Quaternary

Li, Bin / Shi, Jiang-Ling / Xia, Ying

Organic letters

2023 Volume 25, Issue 15, Page(s) 2674–2679

Abstract: The construction of all-carbon quaternary centers in small-ring systems is important but challenging in organic synthesis. Herein, by ... ...

Abstract	The construction of all-carbon quaternary centers in small-ring systems is important but challenging in organic synthesis. Herein, by taking
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c00751
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 over the last 3 years in China, what we've learned.

Shi, Jiang / Chen, Fenghua / Chen, Shugong / Ling, Haoqing

Frontiers in public health

2023 Volume 11, Page(s) 1209343

MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Quarantine ; China/epidemiology ; Learning
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1209343
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Article ; Online: Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.

Hao, Dexun / Li, Yanshuang / Shi, Jiang / Jiang, Junguang

Thoracic cancer

2023 Volume 14, Issue 7, Page(s) 662–672

Abstract: Background: Circular RNAs (circRNAs) play vital roles in non-small cell lung cancer (NSCLC) progression. Our research analyzed the role of circ_0110498 on the cisplatin (DDP) resistance of NSCLC.: Methods: Cell glycolysis was analyzed by measuring ... ...

Abstract	Background: Circular RNAs (circRNAs) play vital roles in non-small cell lung cancer (NSCLC) progression. Our research analyzed the role of circ_0110498 on the cisplatin (DDP) resistance of NSCLC. Methods: Cell glycolysis was analyzed by measuring glucose consumption and lactate production. Protein expression was determined by western blot analysis. The expression of circ_0110498, microRNA (miR)-1287-5p and RBBP4 was detected by RT-qPCR assay. Cell counting kit-8, colony formation and transwell assays, together with flow cytometry were conducted to analyze cell DDP resistance, proliferation, metastasis and apoptosis. Results: Circ_0110498 expression was elevated in DDP-resistant NSCLC tissues and cells. Circ_0110498 silencing not only suppressed the DDP resistance of NSCLC cells by inhibiting cell growth, metastasis and glycolysis, but also enhanced the DDP sensitivity of NSCLC tumors. MiR-1287-5p was sponged by circ_0110498, and its inhibitor also reversed the effect of circ_0110498 silencing on the DDP resistance of NSCLC cells. MiR-1287-5p interacted with RBBP4, and RBBP4 overexpression partly reversed the inhibitory effect of miR-1287-5p on the DDP resistance of NSCLC cells. Conclusion: Circ_0110498 facilitated DDP resistance partly through mediating the miR-1287-5p/RBBP4 signaling in NSCLC.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Lactic Acid ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Retinoblastoma-Binding Protein 4/genetics ; Retinoblastoma-Binding Protein 4/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Lactic Acid (33X04XA5AT) ; MicroRNAs ; MIRN1287 microRNA, human ; RBBP4 protein, human ; Retinoblastoma-Binding Protein 4 ; RNA, Circular
Language	English
Publishing date	2023-01-23
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14787
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Article ; Online: Multimedia Character Modeling Design and Modeling of Cartoon Animation Based on Bayesian Sequence Recommendation Algorithm

Hao Wu / Shi-Jiang Wen / Jong-Hoon Yang

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: With the continuous development of the social economy, cartoon animation and other multimedia and streaming media forms are becoming more and more popular and are loved by all kinds of people, such as monkey king and Nezha. However, the multimedia of ... ...

Abstract	With the continuous development of the social economy, cartoon animation and other multimedia and streaming media forms are becoming more and more popular and are loved by all kinds of people, such as monkey king and Nezha. However, the multimedia of these cartoon animation needs to conform to mainstream values and transmit positive energy. In view of these needs and shortcomings, this study relies on the Bayesian sequence recommendation algorithm, combs the three-tier architecture diagram of multimedia character modeling, analyzes it, respectively, from the perspectives of hierarchy, behavior, and interactive process, and tries to build corresponding animation design management documents, so as to provide corresponding decision-making basis to produce animation and develop corresponding results, provide corresponding reference mode for cartoon animation multimedia character manufacturing, complete corresponding cartoon animation multimedia characters faster, and improve cartoon animation multimedia works and efficiency. The simulation results show that the Bayesian sequence recommendation algorithm is effective and can support the design and modeling of cartoon animation multimedia characters.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	629
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Voice-Driven Facial Expression Film and Television Animation Based on Compromised Node Detection in Wireless Sensor Networks

Shi-Jiang Wen / Hao Wu / Jong-Hoon Yang

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: With the continuous development of social economy, film and television animation, as the spiritual needs of ordinary people, is more and more popular. Especially for the development of emerging technologies, the corresponding voice can be used to change ... ...

Abstract	With the continuous development of social economy, film and television animation, as the spiritual needs of ordinary people, is more and more popular. Especially for the development of emerging technologies, the corresponding voice can be used to change AI expression. But at the same time, how to ensure the synchronization of language sound and facial expression is one of the difficulties in animation transformation. Relying on the compromised node detection of wireless sensor networks, this paper combs the synchronous traffic flow between the speech signals and facial expressions, finds the pattern distribution of facial motion based on unsupervised classification, realizes training and learning through neural networks, and realizes one-to-one mapping to facial expressions by using the rhyme distribution of speech features. It avoids the defect of robustness of speech recognition, improves the learning ability of speech recognition, and realizes the driving analysis of facial expression film and television animation. The simulation results show that the compromised node detection in wireless sensor networks is effective and can support the analysis and research of speech-driven facial expression film and television animation.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	410
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CAR-NK cells from engineered pluripotent stem cells: Off-the-shelf therapeutics for all patients.

Lu, Shi-Jiang / Feng, Qiang

Stem cells translational medicine

2021 Volume 10 Suppl 2, Page(s) S10–S17

Abstract: Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for treating hematological malignancies has revolutionized the field of cellular immunotherapy. However, due to the nature of utilizing autologous T cells, ... ...

Abstract	Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for treating hematological malignancies has revolutionized the field of cellular immunotherapy. However, due to the nature of utilizing autologous T cells, affordability and availability are major hurdles, in addition to scientific challenges relating to CAR-T therapy optimization. Natural killer (NK) cell is a specialized immune effector cell type that recognizes and kills targets without human leukocyte antigen (HLA) restriction and prior sensitization. CAR-NK cells do not cause graft vs host disease and can be obtained from unrelated donors as well as pluripotent stem cells (PSC), representing an ideal off-the-shelf therapeutics readily available for patients. Furthermore, unlike cytotoxic T cells, NK cells specifically target and eliminate cancer stem cells, which are the cells causing relapse and metastasis. PSCs can be genetically manipulated and engineered with CARs at the pluripotent stage, which allows the establishment of permanent, stable, and clonal PSC-CAR lines for the manufacture of unlimited homogenous CAR-NK cells. Multiple master PSC-CAR cell banks targeting a variety of antigens for cancer, viral infection, and autoimmune diseases provide inexhaustible cell sources for all patients. Development of a next-generation 3D bioreactor platform for PSC expansion and NK cell production overcomes major barriers related to cost and scalability for CAR-NK product.
MeSH term(s)	Humans ; Immunotherapy, Adoptive ; Killer Cells, Natural ; Neoplasms/therapy ; Pluripotent Stem Cells/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2021-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2642270-0
ISSN	2157-6580 ; 2157-6580
ISSN (online)	2157-6580
ISSN	2157-6580
DOI	10.1002/sctm.21-0135
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Article: Current advances and future directions in combined hepatocellular and cholangiocarcinoma.

Zhang, Yu-Zhu / Liu, Yu-Chen / Su, Tong / Shi, Jiang-Nan / Huang, Yi / Liang, Bo

Gastroenterology report

2024 Volume 12, Page(s) goae031

Abstract: The low incidence of combined hepatocellular cholangiocarcinoma (cHCC-CCA) is an important factor limiting research progression. Our study extensively included nearly three decades of relevant literature and assembled the most comprehensive database ... ...

Abstract	The low incidence of combined hepatocellular cholangiocarcinoma (cHCC-CCA) is an important factor limiting research progression. Our study extensively included nearly three decades of relevant literature and assembled the most comprehensive database comprising 5,742 patients with cHCC-CCA. We summarized the characteristics, tumor markers, and clinical features of these patients. Additionally, we present the evolution of cHCC-CCA classification and explain the underlying rationale for these classification standards. We reviewed cHCC-CCA diagnostic advances using imaging features, tumor markers, and postoperative pathology, as well as treatment options such as surgical, adjuvant, and immune-targeted therapies. In addition, recent advances in more effective chemotherapeutic regimens and immune-targeted therapies were explored. Furthermore, we described the molecular mutation features and potential specific markers of cHCC-CCA. The prognostic value of Nestin has been proven, and we speculate that Nestin will also play a role in classification and diagnosis. However, further research is needed. Moreover, we believe that the possibility of using machine learning liquid biopsy for preoperative diagnosis and establishing a scoring system are directions for future research.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2710871-5
ISSN	2052-0034
ISSN	2052-0034
DOI	10.1093/gastro/goae031
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Article ; Online: Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq.

Zhang, Yang / Shi, Jiang / Luo, Junfang / Liu, Cong / Zhu, Lixu

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2023 Volume 25, Issue 6, Page(s) 1844–1855

Abstract: Purpose: Cancer cells maintain cell growth, division, and survival through altered energy metabolism. However, research on metabolic reprogramming in lung adenocarcinoma (LUAD) is limited METHODS: We downloaded TCGA and GEO sequencing data. Consistent ... ...

Abstract	Purpose: Cancer cells maintain cell growth, division, and survival through altered energy metabolism. However, research on metabolic reprogramming in lung adenocarcinoma (LUAD) is limited METHODS: We downloaded TCGA and GEO sequencing data. Consistent clustering with the ConsensusClusterPlus package was employed to detect the scores for four metabolism-related pathways. The LUAD samples in the TCGA dataset were clustered with ConsensusClusterPlus, and the optimal number of clusters was determined according to the cumulative distribution function (CDF). The cell score for each sample in the TCGA dataset was calculated using the MCPcounter estimate function of the MCPcounter package. Results: We identified two subtypes by scoring the samples based on the 4 metabolism-related pathways and cluster dimensionality reduction. The prognosis of cluster B was obviously poorer than that of cluster A in patients with LUAD. The analysis of single-nucleotide variation (SNV) data showed that the top 15 genes in the four metabolic pathways with the most mutations were TKTL2, PGK2, HK3, EHHADH, GLUD2, PKLR, TKTL1, HADHB, CPT1C, HK1, HK2, PFKL, SLC2A3, PFKFB1, and CPT1A. The IFNγ score of cluster B was significantly higher than that of cluster A. The immune T-cell lytic activity score of cluster B was significantly higher than that of cluster A. We further identified 5 immune cell subsets from single-cell sequencing data. The top 5 marker genes of B cells were IGHM, JCHAIN, IGLC3, IGHA1, and IGKC. The C0 subgroup of monocytes had a higher pentose phosphate pathway (PPP) score than the C6 subgroup. Conclusions: Metabolism-related subtypes could be potential biomarkers in the prognosis prediction and treatment of LUAD.
MeSH term(s)	Humans ; RNA-Seq ; Single-Cell Gene Expression Analysis ; Energy Metabolism ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Prognosis ; Transketolase
Chemical Substances	TKTL1 protein, human (EC 2.2.1.1) ; Transketolase (EC 2.2.1.1)
Language	English
Publishing date	2023-01-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-023-03082-z
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Article ; Online: A study of the role of myeloid-derived growth factor on acute lung injury in vitro and In vivo

Wenhui Gong / Shi Jiang / Jianbo Wang / Qian Gong / Chengxin Zhang / Shenglin Ge

European Journal of Inflammation, Vol

2023 Volume 21

Abstract: Objectives: Bone marrow-derived mesenchymal stem cells (BMSCs) are considered to have potential clinical application value in the treatment of acute lung injury (ALI). Myeloid-derived growth factor (MYDGF) can promote the proliferation of stem cell. We ... ...

Abstract	Objectives: Bone marrow-derived mesenchymal stem cells (BMSCs) are considered to have potential clinical application value in the treatment of acute lung injury (ALI). Myeloid-derived growth factor (MYDGF) can promote the proliferation of stem cell. We hypothesized that MYDGF may play a role in reducing lung injury in vitro and in vivo through bone marrow mesenchymal stem cells. Methods: An in vitro model of lipopolysaccharide (LPS)(MLE-12) was established, which was divided into five groups: A: MLE-12; B: MLE-12+LPS; C: MLE-12+LPS + BMSCs; D: MLE-12+LPS + MYDGF; and E: MLE-12+LPS + BMSCs + MYDGF. A Cell Counting Kit-8 was used to detect the OD value. And an ALI model was constructed by inducing mice with a lipopolysaccharide. Forty male Balb/c mice were randomly divided into five groups: A control group; B: model group; C: LPS + BMSCs; D: LPS + MYDGF; E: LPS +BMSCs +MYDGF. Specimens were collected after 24 h. Hematoxylin-eosin (HE)-staining was performed on the tissue sections. The protein concentration in the alveolar lavage fluid was measure by bicinchoninic acid (BCA). The NF-κB, p-Akt, Bax, and Bcl-2 protein expression was detected through Western blotting, and Enzyme linked immunosorbent assay (ELISA) was used to measure the expression of serum interleukin-6, interleukin-10, and TNF-α. Results: Compared with the model group, BMSCs and MYDGF can alleviate the ALI induced by lipopolysaccharide in vitro and vivo ( p < .05). Conclusion: We found that the combined treatment effect of MYDGF and BMSCs was better than using MYDGF or BMSCs alone. We speculate that a pretreatment with MYDGF after ALI in mice may improve the survival and growth of transplanted MSCs, thereby improving the curative effect of cell transplantation.
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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