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  1. Article ; Online: Editorial: Innate and adaptive immunity against tuberculosis infection: diagnostics, vaccines, and therapeutics.

    Hu, Zhidong / Shi, Lanbo / Xie, Jianping / Fan, Xiao-Yong

    Frontiers in immunology

    2024  Volume 15, Page(s) 1366976

    MeSH term(s) Humans ; Tuberculosis ; Adaptive Immunity ; Latent Tuberculosis ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1366976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coordination of the Uptake and Metabolism of Amino Acids in

    Jiang, Qingkui / Shi, Lanbo

    Frontiers in immunology

    2021  Volume 12, Page(s) 711462

    Abstract: Macrophage polarization to the M1-like phenotype, which is critical for the pro-inflammatory and antimicrobial responses of macrophages against intracellular pathogens, is associated with metabolic reprogramming to the Warburg effect and a high output of ...

    Abstract Macrophage polarization to the M1-like phenotype, which is critical for the pro-inflammatory and antimicrobial responses of macrophages against intracellular pathogens, is associated with metabolic reprogramming to the Warburg effect and a high output of NO from increased expression of NOS2. However, there is limited understanding about the uptake and metabolism of other amino acids during M1 polarization. Based on functional analysis of a group of upregulated transporters and enzymes involved in the uptake and/or metabolism of amino acids in
    MeSH term(s) Amino Acids/metabolism ; Arginine/metabolism ; Cell Polarity ; Humans ; Macrophage Activation ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Mycobacterium tuberculosis/immunology ; Oxidation-Reduction
    Chemical Substances Amino Acids ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2021-07-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.711462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diabetes as a potential compounding factor in COVID-19-mediated male subfertility.

    Jiang, Qingkui / Linn, Thomas / Drlica, Karl / Shi, Lanbo

    Cell & bioscience

    2022  Volume 12, Issue 1, Page(s) 35

    Abstract: Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and Leydig ... ...

    Abstract Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and Leydig cells. Indirect effects on testis and concentrations of male reproductive hormones derive from (1) virus-stimulated inflammation; (2) viral-induced diabetes, and (3) an interaction between diabetes and inflammation that exacerbates the deleterious effect of each perturbation. Reproductive hormones affected include testosterone, luteinizing hormone, and follicle-stimulating hormone. Reduction of male fertility is also observed with other viral infections, but the global pandemic of COVID-19 makes demographic and public health implications of reduced male fertility of major concern, especially if it occurs in the absence of serious symptoms that would otherwise encourage vaccination. Clinical documentation of COVID-19-associated male subfertility is now warranted to obtain quantitative relationships between infection severity and subfertility; mechanistic studies using animal models may reveal ways to mitigate the problem. In the meantime, the possibility of subfertility due to COVID-19 should enter considerations of vaccine hesitancy by reproductive-age males.
    Language English
    Publishing date 2022-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-022-00766-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Imaging Architecture of Granulomas Induced by

    Kumar, Ranjeet / Kolloli, Afsal / Subbian, Selvakumar / Kaushal, Deepak / Shi, Lanbo / Tyagi, Sanjay

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Granulomas are an important hallmark ... ...

    Abstract Granulomas are an important hallmark of
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.02.526702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mycorrhiza formation and elevated CO

    Loewe, Anja / Einig, Werner / Shi, Lanbo / Dizengremel, Pierre / Hampp, Rüdiger

    The New phytologist

    2021  Volume 145, Issue 3, Page(s) 565–574

    Abstract: The effects of mycorrhiza formation in combination with elevated ... ...

    Abstract The effects of mycorrhiza formation in combination with elevated CO
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1046/j.1469-8137.2000.00598.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  6. Article ; Online: Glutamine Is Required for M1-like Polarization of Macrophages in Response to Mycobacterium tuberculosis Infection.

    Jiang, Qingkui / Qiu, Yunping / Kurland, Irwin J / Drlica, Karl / Subbian, Selvakumar / Tyagi, Sanjay / Shi, Lanbo

    mBio

    2022  Volume 13, Issue 4, Page(s) e0127422

    Abstract: In response to Mycobacterium tuberculosis infection, macrophages mount proinflammatory and antimicrobial responses similar to those observed in M1 macrophages activated by lipopolysaccharide (LPS) and interferon gamma (IFN-γ). A metabolic reprogramming ... ...

    Abstract In response to Mycobacterium tuberculosis infection, macrophages mount proinflammatory and antimicrobial responses similar to those observed in M1 macrophages activated by lipopolysaccharide (LPS) and interferon gamma (IFN-γ). A metabolic reprogramming to hypoxia-inducible-factor 1 (HIF-1)-mediated uptake of glucose and its metabolism by glycolysis is required for M1-like polarization, but little is known about other metabolic programs driving the M1-like polarization during infection. We report that glutamine serves as a carbon and nitrogen source for the metabolic reprogramming to M1-like macrophages. Widely targeted metabolite screening identified an association of glutamine and/or glutamate with highly affected metabolic pathways of M1-like macrophages. Moreover, stable isotope-assisted metabolomics of U
    MeSH term(s) Aspartic Acid/metabolism ; Carbon/metabolism ; Glucose/metabolism ; Glutamine/metabolism ; Glycolysis ; Humans ; Hypoxia/metabolism ; Macrophages/microbiology ; Mycobacterium tuberculosis/metabolism ; Nitrogen/metabolism ; Tuberculosis/microbiology
    Chemical Substances Glutamine (0RH81L854J) ; Aspartic Acid (30KYC7MIAI) ; Carbon (7440-44-0) ; Glucose (IY9XDZ35W2) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01274-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biphasic Dynamics of Macrophage Immunometabolism during

    Shi, Lanbo / Jiang, Qingkui / Bushkin, Yuri / Subbian, Selvakumar / Tyagi, Sanjay

    mBio

    2019  Volume 10, Issue 2

    Abstract: Macrophages are the primary targets ... ...

    Abstract Macrophages are the primary targets of
    MeSH term(s) Aerobiosis ; Animals ; Glycolysis ; Host-Pathogen Interactions ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/microbiology ; Mycobacterium tuberculosis/immunology ; Oxidative Phosphorylation ; Tuberculosis/immunology
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02550-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Transcriptional and Physiological Changes during Mycobacterium tuberculosis Reactivation from Non-replicating Persistence.

    Du, Peicheng / Sohaskey, Charles D / Shi, Lanbo

    Frontiers in microbiology

    2016  Volume 7, Page(s) 1346

    Abstract: Mycobacterium tuberculosis can persist for years in the hostile environment of the host in a non-replicating or slowly replicating state. While active disease predominantly results from reactivation of a latent infection, the molecular mechanisms of M. ... ...

    Abstract Mycobacterium tuberculosis can persist for years in the hostile environment of the host in a non-replicating or slowly replicating state. While active disease predominantly results from reactivation of a latent infection, the molecular mechanisms of M. tuberculosis reactivation are still poorly understood. We characterized the physiology and global transcriptomic profiles of M. tuberculosis during reactivation from hypoxia-induced non-replicating persistence. We found that M. tuberculosis reactivation upon reaeration was associated with a lag phase, in which the recovery of cellular physiological and metabolic functions preceded the resumption of cell replication. Enrichment analysis of the transcriptomic dynamics revealed changes to many metabolic pathways and transcription regulons/subnetworks that orchestrated the metabolic and physiological transformation in preparation for cell division. In particular, we found that M. tuberculosis reaeration lag phase is associated with down-regulation of persistence-associated regulons/subnetworks, including DosR, MprA, SigH, SigE, and ClgR, as well as metabolic pathways including those involved in the uptake of lipids and their catabolism. More importantly, we identified a number of up-regulated transcription regulons and metabolic pathways, including those involved in metal transport and remobilization, second messenger-mediated responses, DNA repair and recombination, and synthesis of major cell wall components. We also found that inactivation of the major alternative sigma factors SigE or SigH disrupted exit from persistence, underscoring the importance of the global transcriptional reprogramming during M. tuberculosis reactivation. Our observations suggest that M. tuberculosis lag phase is associated with a global gene expression reprogramming that defines the initiation of a reactivation process.
    Language English
    Publishing date 2016-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2016.01346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Immunometabolism in Tuberculosis.

    Shi, Lanbo / Eugenin, Eliseo A / Subbian, Selvakumar

    Frontiers in immunology

    2016  Volume 7, Page(s) 150

    Abstract: Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation. In response to infection, activation of the host innate and adaptive immune cells is ... ...

    Abstract Immunometabolism, the study of the relationship between bioenergetic pathways and specific functions of immune cells, has recently gained increasing appreciation. In response to infection, activation of the host innate and adaptive immune cells is accompanied by a switch in the bioenergetic pathway from oxidative phosphorylation to glycolysis, a metabolic remodeling known as the Warburg effect, which is required for the production of antimicrobial and pro-inflammatory effector molecules. In this review, we summarize the current understanding of the Warburg effect and discuss its association with the expression of host immune responses in tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb). We also discuss potential mechanisms underlying the Warburg effect with a focus on the expression and regulation of hypoxia-inducible factor 1 alpha (HIF-1α), the regulatory subunit of HIF-1, a major transcription regulator involved in cellular stress adaptation processes, including energy metabolism and antimicrobial responses. We also propose a novel hypothesis that Mtb perturbs the Warburg effect of immune cells to facilitate its survival and persistence in the host. A better understanding of the dynamics of metabolic states of immune cells and their specific functions during TB pathogenesis can lead to the development of immunotherapies capable of promoting Mtb clearance and reducing Mtb persistence and the emergence of drug resistant strains.
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2016.00150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Immunometabolism of Phagocytes During

    Kumar, Ranjeet / Singh, Pooja / Kolloli, Afsal / Shi, Lanbo / Bushkin, Yuri / Tyagi, Sanjay / Subbian, Selvakumar

    Frontiers in molecular biosciences

    2019  Volume 6, Page(s) 105

    Abstract: Tuberculosis (TB), caused ... ...

    Abstract Tuberculosis (TB), caused by
    Language English
    Publishing date 2019-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2019.00105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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