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Article ; Online: Layered Double Hydroxide Nanosheets: Synthesis Strategies and Applications in the Field of Energy Conversion.

Wang, Yindong / Ying, Zhixuan / Gao, Yushuan / Shi, Le

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 30, Issue 6, Page(s) e202303025

Abstract: In recent years, layered double hydroxides (LDH) nanosheets have garnered substantial attention as intriguing inorganic anionic layered clay materials. These nanosheets have captured the attention of researchers due to their unique physicochemical ... ...

Abstract	In recent years, layered double hydroxides (LDH) nanosheets have garnered substantial attention as intriguing inorganic anionic layered clay materials. These nanosheets have captured the attention of researchers due to their unique physicochemical properties. This review aims to showcase the latest advancements in laboratory research concerning LDH nanosheets, with a specific emphasis on their methods of preparation. This review provides detailed insights into the factors influencing the anionic conductivity of LDH, along with delineating the applications of LDH nanosheets in the realm of energy conversion. Notably, the review highlights the crucial role of LDH nanosheets in the oxygen evolution reaction (OER), a vital process in water splitting and diverse electrochemical applications. The review emphasizes the significant potential of LDH nanosheets in enhancing supercapacitor technology, owing to their high surface area and exceptional charge storage capacity. Additionally, it elucidates the prospective application of LDH nanosheets as anion exchange membranes in anion exchange membrane fuel cells, potentially revolutionizing fuel cell performance through improved efficiency and stability facilitated by enhanced ion transport properties.
Language	English
Publishing date	2023-11-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303025
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Article: Civic-Moral Education Research in China (1992-2022): A Scoping Review.

Shi, Le / Chen, Lingjun / Gong, Rui

Behavioral sciences (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: Civic-moral education is a topic that has been widely discussed globally. In China, civic-moral education has a long history and presents different characteristics and methods from other countries due to political, economic, and cultural factors. To ... ...

Abstract	Civic-moral education is a topic that has been widely discussed globally. In China, civic-moral education has a long history and presents different characteristics and methods from other countries due to political, economic, and cultural factors. To summarize the current status of research on civic-moral education in China, we identified 715 papers in 30 years (1992-2022) under related topics and selected a total of 72 papers for further analysis. To show the study trend more clearly, we divided the result section into three parts: the historical and cultural resources of education, the current educational approaches, and the existing challenges in civic-moral education. China is rich in historical resources for civic-moral education, which had an impact across generations. Currently, Chinese educators employ many approaches to improve civic-moral education: building a civic-moral curriculum system, transforming the social climate, and making the most use of the campus. The emphasis on intelligence over morality and the emphasis on knowledge over action, however, may undermine the effectiveness of civic-moral education. To conclude, China attaches great importance to civic-moral education and has come up with many approaches inspired by ancient cultural resources.
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs13100819
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Article ; Online: Histone Deacetylases (HDACs) Are Potential Biochemical Targets for Insecticide Development.

Yang, Jing-Fang / Shi, Le-Rong / Zhang, Zhong-Kai / Zhou, Zhong-Shi / Wan, Fang-Hao

Journal of agricultural and food chemistry

2024 Volume 72, Issue 2, Page(s) 953–955

MeSH term(s)	Histone Deacetylases/genetics ; Insecticides/pharmacology ; Histone Deacetylase Inhibitors
Chemical Substances	Histone Deacetylases (EC 3.5.1.98) ; Insecticides ; Histone Deacetylase Inhibitors
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c09348
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Article ; Online: Edaravone for patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Huang, Shi-Le / Shen, Yin-Li / Peng, Wen-Yan / Ye, Kun / Zheng, Hui

Acta neurologica Belgica

2024

Abstract: Background and objective: The effectiveness and long-term efficacy of edaravone, a recommended treatment for amyotrophic lateral sclerosis (ALS), has not been examined in real-world settings. This study aims to evaluate the effectiveness and long-term ... ...

Abstract	Background and objective: The effectiveness and long-term efficacy of edaravone, a recommended treatment for amyotrophic lateral sclerosis (ALS), has not been examined in real-world settings. This study aims to evaluate the effectiveness and long-term efficacy of edaravone. Methods: The OVID Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science databases were searched for articles published between January 1, 2000, and May 1, 2023. Two investigators independently screened the retrieved articles for randomized controlled trials (RCTs), cohort studies, or single-arm trials that evaluated the effect of edaravone on amyotrophic lateral sclerosis (ALS). The risk of bias was evaluated using the revised Cochrane Risk-of-Bias (RoB 2.0) tool for randomized controlled trials (RCTs) and the Risk-of-Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies. The primary outcome was the ALSFRS-R score assessed at month 6, with secondary outcomes including the ALSFRS-R scores evaluated at months 9, 12, and 18, forced vital capacity (FVC), and adverse events. The certainty of evidence was assessed using the GRADE approach. Results: The analysis included 16 studies with a total of 4828 participants. Among these, four were randomized controlled trials (RCTs) and 12 were observational studies. Of the RCTs, four were rated as having a low risk of bias, while six of the observational studies were rated as having a low risk of bias. Edaravone was associated with slightly slower progression in the reduction of ALSFRS-R score at month 6 compared to placebo (mean difference 1.01, 95%CI -0.87 to 3.09, p = 0.293), as shown by evidence from RCTs. However, observational studies did not show any benefit of adding edaravone to routine practice (mean difference 1.85, 95%CI -2.05 to 5.75, p = 0.352). The change from baseline in ALSFRS-R score was -2.1, -4.04, -7.5, -6.82, and -7.9 at months 3, 6, 9, 12, and 18, respectively. The GRADE assessment indicated moderate certainty for evidence from RCTs, while evidence from observational studies had very low certainty. Conclusion: Due to the limited number of studies and confounding issues in observational studies, further examination of the added benefits of edaravone to routine practice is necessary through RCTs, particularly regarding its long-term efficacy.
Language	English
Publishing date	2024-02-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-024-02476-2
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Article: [Evaluation of red and white aesthetic effects of porcelain veneers in the restoration of developmental anterior dental gaps].

Deng, Xiao-Lin / Yuan, Shuang / Zhu, Dan-Ting / Shi, Le

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2023 Volume 32, Issue 3, Page(s) 276–279

Abstract: Purpose: To evaluate the red and white aesthetic effect of porcelain veneer in the restoration of developmental anterior interdental spaces.: Methods: A total of 152 anterior teeth in 64 patients with developmental anterior dental gaps were restored ... ...

Abstract	Purpose: To evaluate the red and white aesthetic effect of porcelain veneer in the restoration of developmental anterior interdental spaces. Methods: A total of 152 anterior teeth in 64 patients with developmental anterior dental gaps were restored using porcelain veneers, the aesthetic effects before and after restoration were evaluated by pink aesthetic index (PES) and white aesthetic index(WES), the aesthetic effect of gingival papilla filling and reconstruction was evaluated by interdental gingival papilla index (PIS), and visual analogue score (VAS) was used to compare the satisfaction of patients before and after restoration. SPSS 203.0 software package was used for statistical analysis. Results: The overall mean scores of PES before and after restoration of 152 developmental anterior interdental teeth were 9.63±2.23 and 13.64±0.88, respectively. The average scores of WES before and after restoration were 6.85±1.87 and 9.81±0.58, respectively. There were significant differences of PES and WES scores before and after restoration(P＜0.01). According to the requirements of "near" perfect restoration(PES≥13 points, WES≥9 points), the red and white aesthetic effect after restoration was near the standard. The scores of PIS before and after restoration were 1.86±0.67 and 2.97±0.18, the interdental gingival papilla was completely filled with space, and the shape was ideal, there were significant statistical differences before and after restoration(P＜0.01). Patients were more satisfied with the smile curve and morphology of the restored anterior teeth than other parameters. Conclusions: The aesthetic effect of using porcelain veneers to repair developmental anterior interdental gaps is ideal, among which the filling of the papillae between the teeth can meet the expectations of patients, and the aesthetic effect evaluation of PIS and PES/WES applied to porcelain veneers to repair developmental anterior interdental spaces has practical guiding significance in clinical practice.
MeSH term(s)	Humans ; Dental Porcelain ; Esthetics, Dental ; Dental Materials ; Dental Veneers
Chemical Substances	Dental Porcelain (12001-21-7) ; Dental Materials
Language	Chinese
Publishing date	2023-09-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article ; Online: Rational design of stable functional metal-organic frameworks.

Chen, Zhijie / Kirlikovali, Kent O / Shi, Le / Farha, Omar K

Materials horizons

2023 Volume 10, Issue 9, Page(s) 3257–3268

Abstract: Functional porous metal-organic frameworks (MOFs) have been explored for a number of potential applications in catalysis, chemical sensing, water capture, gas storage, and separation. MOFs are among the most promising candidates to address challenges ... ...

Abstract	Functional porous metal-organic frameworks (MOFs) have been explored for a number of potential applications in catalysis, chemical sensing, water capture, gas storage, and separation. MOFs are among the most promising candidates to address challenges facing our society related to energy and environment, but the successful implementation of functional porous MOF materials are contingent on their stability; therefore, the rational design of stable MOFs plays an important role towards the development of functional porous MOFs. In this Focus article, we summarize progress in the rational design and synthesis of stable MOFs with controllable pores and functionalities. The implementation of reticular chemistry allows for the rational top-down design of stable porous MOFs with targeted topological networks and pore structures from the pre-selected building blocks. We highlight the reticular synthesis and applications of stable MOFs: (1) MOFs based on high valent metal ions (
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh00541k
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Article ; Online: lncRNA FR215775 Regulates Th2 Differentiation in Murine Allergic Rhinitis.

Ma, Yue / Shi, Le / Zhao, Keqing / Zheng, Chunquan

Journal of immunology research

2022 Volume 2022, Page(s) 7783481

Abstract: To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression ... ...

Abstract	To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression of lncRNA FR215775 via Sh-FR215775-Ads, Cell Counting Kit-8, cytometric bead array, and fluorescence-activated cell sorting were performed to determine its functions in vitro. Moreover, lncRNA FR215775-silencing or nonsilencing cells were injected intravenously into AR mice. Then, hematoxylin and eosin, Alcian blue-periodic acid Schiff, and toluidine blue staining were performed, and the levels of IL-2, IL-4, IL-5, IL-6, IL-10, IL-17A, IFN-
MeSH term(s)	Animals ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/pathology ; Interleukin-4/genetics ; Interleukin-4/pharmacology ; Interleukin-5/genetics ; Interleukin-5/immunology ; Mice ; Mice, Inbred BALB C ; Nasal Mucosa/pathology ; Ovalbumin ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/immunology ; Rhinitis, Allergic/genetics ; Rhinitis, Allergic/immunology ; Th2 Cells/immunology ; Th2 Cells/pathology
Chemical Substances	Cytokines ; Interleukin-5 ; RNA, Long Noncoding ; Interleukin-4 (207137-56-2) ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2022-06-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/7783481
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Article ; Online: Comprehensive analysis of circRNA-miRNA-mRNA in oral squamous cell carcinoma.

Cheng, Yong / Shi, Le / Yu, YouCheng

Archives of oral biology

2022 Volume 138, Page(s) 105346

Abstract: Objectives: The aim of the present study was to explore expression profiles of circular RNAs (circRNAs) and potential molecular mechanisms in oral squamous cell carcinoma (OSCC).: Design: In this study, high-throughput microarray was used to detect ... ...

Abstract	Objectives: The aim of the present study was to explore expression profiles of circular RNAs (circRNAs) and potential molecular mechanisms in oral squamous cell carcinoma (OSCC). Design: In this study, high-throughput microarray was used to detect the expression profiles of circRNAs in OSCC. Reverse transcription quantitative PCR (RT-qPCR) was used to quantify the expression of dysregulated circRNAs in microarray. The validated microRNAs sponged by circRNAs and targeted mRNA were collected from literatures and miRTarBase database. and Gene Ontologypathways were analyzed on DAVID platform. Furthermore, network of circRNA-miRNA-mRNA and protein-protein interaction were constructed by Cytoscape 6.0 software. Results: The results revealed that 1540 circRNAs were differentially expressed in 4 paired OSCC tissues and adjacent tissues significantly. Among them, 6 abundant circRNAs which have been reported in literatures were identified through RT-qPCR. According to the hypothesis of competing endogenous RNAs, 14 miRNAs sponged by the validated circRNAs and 62 downstream target protein coding genes were identified. Upon Gene Ontologyanalysis, 62 target genes were found to play roles in positively regulation of cell migration, cell division, angiogenesis and response to hypoxia. For Kyoto Encyclopedia of Genes and Genomes pathways, target genes were found to be involved in oncogenic signaling pathways (hsa05200), PI3K-Akt signaling pathway (hsa04151), focal adhesion (hsa04510), microRNAs in cancer (hsa05206), ECM-receptor interaction (hsa04512). These results suggested that circRNAs may participate in the tumorigenesis and development of OSCC via sponging miRNAs. Conclusions: This study indicated that circRNA may play vital role in tumorigenesis and metastasis in OSCC.
MeSH term(s)	Carcinogenesis ; Gene Expression Profiling/methods ; Humans ; MicroRNAs/genetics ; Mouth Neoplasms/genetics ; RNA, Circular/genetics ; RNA, Messenger/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics
Chemical Substances	MicroRNAs ; RNA, Circular ; RNA, Messenger
Language	English
Publishing date	2022-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	80227-x
ISSN	1879-1506 ; 0003-9969
ISSN (online)	1879-1506
ISSN	0003-9969
DOI	10.1016/j.archoralbio.2022.105346
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Article ; Online: Electrochemical and hydraulic analysis of thin-film composite and cellulose triacetate membranes for seawater electrolysis applications

Taylor, Rachel / Shi, Le / Zhou, Xuechen / Rossi, Ruggero / Picioreanu, C. / Logan, Bruce E.

Journal of Membrane Science. 2023 Aug., v. 679 p.121692-

2023

Abstract: Polymeric filtration membranes could be a cost-effective alternative to cation exchange membranes (CEMs) in electrolysis with a contained anolyte and saltwater catholyte because they size selectively hinder salt ion transport between compartments while ... ...

Abstract	Polymeric filtration membranes could be a cost-effective alternative to cation exchange membranes (CEMs) in electrolysis with a contained anolyte and saltwater catholyte because they size selectively hinder salt ion transport between compartments while facilitating proton and hydroxide transport. Optimizing membrane performance requires a better understanding of membrane properties that impact electrical resistances and ion retention. Twelve reverse osmosis (RO) membranes, one nanofiltration (NF) membrane, and one cellulose triacetate forward osmosis (FO) membrane were examined for their electrical resistances under conditions typically used for characterization of CEMs. Resistances measured at low current densities (0.07–0.3 mA cm⁻²) varied between different membranes by over an order of magnitude in 1 M NaCl at neutral pH, from 6.1 ± 0.1 Ω cm² to 70 ± 30 Ω cm². There was no significant correlation between membrane resistance and applied potential during saltwater electrolysis at 20 mA cm⁻² (p = 0.44), or between membrane resistance and water permeability (p = 0.35). These results indicate that traditional CEM resistance characterization methods do not predict polymeric filtration membrane electrolysis performance because proton and hydroxide transport, which is important during electrolysis when large pH gradients develop, must be considered separately from salt ion and water molecule transport through size selective RO, NF, and FO membranes during water electrolysis.
Keywords	cation exchange ; cellulose ; cost effectiveness ; electrochemistry ; electrolysis ; nanofiltration ; pH ; permeability ; polymers ; reverse osmosis ; saline water ; seawater ; Seawater electrolysis ; Thin film composite ; Cellulose triacetate ; Electrical resistance ; Ion transport
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2023.121692
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Article ; Online: AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice

Wu, Xingwen / Zhu, Danting / Shi, Le / Tu, Qisheng / Yu, Youcheng / Chen, Jake

Heliyon. 2023 Mar., v. 9, no. 3 p.e13975-

2023

Abstract: To investigate the role of AdipoRon in bone wound healing of calvaria critical-sized defects (CSD) in diet-induced obesity (DIO) mice. After establishing the calvaria CSD in normal-chow (NC), DIO and Adiponectin knockout (APNKO) mice, AdipoRon or vehicle ...

Abstract	To investigate the role of AdipoRon in bone wound healing of calvaria critical-sized defects (CSD) in diet-induced obesity (DIO) mice. After establishing the calvaria CSD in normal-chow (NC), DIO and Adiponectin knockout (APNKO) mice, AdipoRon or vehicle was orally gavaged for 3 weeks. The bone defects were analyzed by micro-CT and H&E staining. The expression of osteogenesis-related factor in the defect area, and the chemotactic gradient of SDF-1 between bone marrow and bone defect area were further analyzed. AdipoRon downregulated body weight and alleviated fasting blood glucose level of DIO mice after treatment with AdipoRon in 14 and 21 days. Newly formed bone was significantly increased in the defect area of DIO and APNKO mice after treatment with AdipoRon compared with vehicle treatment. No significant difference was shown in NC mice. Furthermore, compared with NC mice, a significant decrease of BV/TV%, Tb.N value and formed bone percentage were shown in DIO and APNKO mice. The treatment with AdipoRon could reverse of decreased value and increase the newly formed bone in those mice. AdipoRon promoted col-1α expression in wound sites in DIO and APNKO mice. AdipoRon nearly quadrupled the chemotactic gradient of SDF-1 by decreasing SDF-1 expression in bone marrow and increasing it in the bone defect area in APNKO and DIO treated mice. AdipoRon alleviates the obesity status in DIO mice with calvarial defect and increase new bone formation in calvarial defects in DIO and APNKO mice by modulating chemotactic gradient of SDF-1.
Keywords	adiponectin ; blood glucose ; bone formation ; bone marrow ; chemotaxis ; micro-computed tomography ; obesity ; skull ; AdipoRon ; Diet-induced obesity mice ; Adiponectin knockout mice ; Calvaria critical-sized defects ; Bone wound healing
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13975
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