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  1. Article: Airway clearance technique in the modern era of bronchiectasis management.

    Pan, Cui-Xia / Shi, Ming-Xin / Guan, Wei-Jie

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: There is a need and further room to strengthen airway clearance among patients with bronchiectasis in the modern era of clinical ... ...

    Abstract There is a need and further room to strengthen airway clearance among patients with bronchiectasis in the modern era of clinical management
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00674-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bacteria and viruses and clinical outcomes of asthma-bronchiectasis overlap syndrome: A cohort study.

    Zhang, Xiao-Xian / He, Jia-Hui / Pan, Cui-Xia / He, Zhen-Feng / Li, Hui-Min / Lin, Zhen-Hong / Zhang, Xiao-Fen / Cen, Lai-Jian / Zhang, Ri-Lan / Shi, Ming-Xin / Guan, Wei-Jie

    Clinical and translational allergy

    2024  Volume 14, Issue 1, Page(s) e12331

    Abstract: Background: Despite the high prevalence of co-existing bronchiectasis and asthma (asthma-bronchiectasis overlap syndrome [ABOS]), little is known regarding the dominant pathogens and clinical correlates.: Objective: To investigate the bacteria and ... ...

    Abstract Background: Despite the high prevalence of co-existing bronchiectasis and asthma (asthma-bronchiectasis overlap syndrome [ABOS]), little is known regarding the dominant pathogens and clinical correlates.
    Objective: To investigate the bacteria and viruses which differentially dominate in ABOS (including its subtypes) compared with bronchiectasis alone, and determine their relevance with bronchiectasis severity and exacerbations.
    Methods: This was a prospective observational cohort study conducted between March 2017 and August 2023. We included 81 patients with ABOS and 107 patients with bronchiectasis alone. At steady-state baseline, patients underwent comprehensive assessments and sputum collection for bacterial culture and viral detection (quantitative polymerase-chain-reaction). Patients were followed-up to record exacerbation and spirometry.
    Results: Patients with ABOS had significantly higher symptom burden and exacerbation frequency than those with bronchiectasis alone. Despite similar pathogen spectrum, the rate of bacteria-virus co-detection increased less substantially at acute exacerbations (AE) onset than at steady-state compared with bronchiectasis alone. Pathogenic bacteria (particularly Pseudomonas aeruginosa) were detected fairly common (exceeding 50%) in ABOS and were associated with greater severity of bronchiectasis when stable and conferred greater exacerbation risks at follow-up. Viral but not bacterial compositions changed substantially at AE onset compared with clinical stability. Higher blood eosinophil count, moderate-to-severe bronchiectasis and non-atopy were associated with higher odds of bacterial, but not viral, detection (all p < 0.05).
    Conclusion: Detection of bacteria or virus is associated with bronchiectasis severity or clinical outcomes in ABOS. This highlights the importance of integrating sputum microbial assessment for ascertaining the dominant pathophysiology (atopy vs. infection) and longitudinal trajectory prediction in ABOS.
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sputum pathogen spectrum and clinical outcomes of upper respiratory tract infection in bronchiectasis exacerbation: a prospective cohort study.

    Huang, Yan / Chen, Chun-Lan / Cen, Lai-Jian / Li, Hui-Min / Lin, Zhen-Hong / Zhu, Si-Yu / Duan, Chong-Yang / Zhang, Ri-Lan / Pan, Cui-Xia / Zhang, Xiao-Fen / Zhang, Xiao-Xian / He, Zhen-Feng / Shi, Ming-Xin / Zhong, Nan-Shan / Guan, Wei-Jie

    Emerging microbes & infections

    2023  Volume 12, Issue 1, Page(s) 2202277

    Abstract: Upper respiratory tract infection (URTI) is common in humans. We sought to profile sputum pathogen spectrum and impact of URTI on acute exacerbation of bronchiectasis (AE). Between March 2017 and December 2021, we prospectively collected sputum from ... ...

    Abstract Upper respiratory tract infection (URTI) is common in humans. We sought to profile sputum pathogen spectrum and impact of URTI on acute exacerbation of bronchiectasis (AE). Between March 2017 and December 2021, we prospectively collected sputum from adults with bronchiectasis. We stratified AEs into events related (URTI-AE) and unrelated to URTI (non-URTI-AE). We captured URTI without onset of AE (URTI-non-AE). We did bacterial culture and viral detection with polymerase chain reaction, and explored the pathogen spectrum and clinical impacts of URTI-AE via longitudinal follow-up. Finally, we collected 479 non-AE samples (113 collected at URTI-non-AE and 225 collected at clinically stable) and 170 AE samples (89 collected at URTI-AE and 81 collect at non-URTI-AE). The viral detection rate was significantly higher in URTI-AE (46.1%) than in non-URTI-AE (4.9%) and URTI-non-AE (11.5%) (both
    MeSH term(s) Adult ; Humans ; Prospective Studies ; Sputum/microbiology ; Respiratory Tract Infections ; Bronchiectasis/complications ; Bronchiectasis/microbiology ; Rhinovirus/genetics
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2202277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Pharmacokinetics of Curcumin Ethosomes in Rats

    Zhao, Jing / Li, Yuan / Shi, Ming-Xin / Wang, Xue / Zhang, Jing-Qing

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2017  Volume 48, Issue 2, Page(s) 290–294

    Abstract: Objectives: To study the oral phamacokinetics of curcumin ethosomes in rats.: Methods: Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of ... ...

    Abstract Objectives: To study the oral phamacokinetics of curcumin ethosomes in rats.
    Methods: Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats.
    Results: Analyzed by non-compartmental method, the area under concentration-time curve from 0 to last time [
    Conclusion: The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.
    MeSH term(s) Administration, Oral ; Animals ; Area Under Curve ; Biological Availability ; Chromatography, High Pressure Liquid ; Curcumin/pharmacokinetics ; Liposomes/pharmacokinetics ; Rats
    Chemical Substances Liposomes ; Curcumin (IT942ZTH98)
    Language Chinese
    Publishing date 2017-06-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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