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Article ; Online: Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Shi Su / Peter M. Kang

Nanomaterials, Vol 10, Iss 656, p

2020 Volume 656

Abstract: Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of ... ...

Abstract	Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.
Keywords	biodegradable ; nanomaterials ; nanomedicine ; Chemistry ; QD1-999
Subject code	339
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimizing modeling windows to better capture the long-term variation of PM2.5 concentrations in China during 2005–2019

Shi, Su / Wang, Weidong / Li, Xinyue / Hang, Yun / Lei, Jian / Kan, Haidong / Meng, Xia

Science of the Total Environment. 2023 Jan., v. 854 p.158624-

2023

Abstract: Including data of different time intervals during model development influences the predicting accuracy of PM₂.₅ but has not been widely discussed. Therefore, we included modeling data with multiple time windows to identify optimized modeling time windows ...

Abstract	Including data of different time intervals during model development influences the predicting accuracy of PM₂.₅ but has not been widely discussed. Therefore, we included modeling data with multiple time windows to identify optimized modeling time windows for capturing the long-term variation of PM₂.₅ in China during 2005–2019. In general, we incorporated PM₂.₅ measurements, aerosol optical depth (AOD), meteorological parameters, land use data, and other predictors to train random forest models. The study period was separated into two phases (2013–2019 and 2005–2012) according to the availability of PM₂.₅ measurements. First, we trained models with two strategies of choosing time windows to compare model performance in predicting PM₂.₅ from 2013 to 2019, when measurements were available. Strategy 1a (ST1a) refers to training one model with all available data, and Strategy 1b (ST1b) refers to training multiple models each with one-year data. Second, we trained models with additional ten strategies (ST2a-ST2j) based on data from different time windows during 2013–2019 to compare the accuracy in predicting PM₂.₅ before 2013, when measurements were unavailable. The internal and external cross-validation (CV) indicated that the model performance of ST1b was better than ST1a. Predictions based on ST1a tended to underestimate PM₂.₅ levels in 2013 and 2014 when PM₂.₅ concentrations were high, and overestimate after 2017 when PM₂.₅ dropped dramatically. The external CV of predicting historical PM₂.₅ was the most robust in ST2i (averaged predictions from two models developed by 2013 and 2014 data, respectively). Models with data closer to historical years and PM₂.₅ levels performed better in predicting historical PM₂.₅ concentrations. Our results suggested that training models with data of current-years performed better during 2013–2019, and with data of 2013 and 2014 performed better in predicting historical PM₂.₅ before 2013 in China. The comparison provided evidence for choosing optimized time windows when predicting long-term PM₂.₅ concentrations in China.
Keywords	aerosols ; environment ; land use ; model validation ; models ; China ; Fine particulate matter ; Random forest ; Model evaluation ; Optimized time window ; Historical estimation
Language	English
Dates of publication	2023-01
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158624
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Circulating Proteins and IgA Nephropathy.

Tang, Chen / Chen, Pei / Xu, Lin-Lin / Lv, Ji-Cheng / Shi, Su-Fang / Zhou, Xu-Jie / Liu, Li-Jun / Zhang, Hong

Journal of the American Society of Nephrology : JASN

2024

Abstract: Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early diagnosis and targeted treatment remain challenging. We aimed to identify circulating plasma proteins associated with IgA nephropathy by proteome-wide mendelian ... ...

Abstract	Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early diagnosis and targeted treatment remain challenging. We aimed to identify circulating plasma proteins associated with IgA nephropathy by proteome-wide mendelian randomization studies across multiple ancestry populations. Methods: In this study, we applied Mendelian randomization and colocalization analyses to estimate the putative causal effects of 2615 proteins on IgA nephropathy in Europeans and 235 proteins in East Asians. Following two-stage network Mendelian randomization, multi-trait colocalization analysis and protein-altering variant annotation were performed to strengthen the reliability of the results. A protein-protein interaction network was constructed to investigate the interactions between the identified proteins and the targets of existing medications. Results: Putative causal effects of 184 and 13 protein-disease pairs in European and East Asian ancestries were identified, respectively. Two protein-disease pairs showed shared causal effects across them (CFHR1 and FCRL2). Supported by the evidence from colocalization analysis, potential therapeutic targets were prioritized and four drug-repurposing opportunities were suggested. The protein-protein interaction network further provided strong evidence for existing medications and pathways that are known to be therapeutically important. Conclusions: Our study identified a number of circulating proteins associated with IgA nephropathy and prioritized several potential drug targets that require further investigation.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.0000000000000379
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Article ; Online: Epigenome-wide association study on ambient PM

Cai, Xiyang / Song, Qinglin / Meng, Xia / Li, Kaixuan / Shi, Su / Jin, Li / Kan, Haidong / Wang, Sijia

Environmental research

2024 Volume 247, Page(s) 118276

Abstract: ... Ambient ... ...

Abstract	Ambient PM
MeSH term(s)	Humans ; Air Pollutants/toxicity ; Air Pollutants/analysis ; Particulate Matter/toxicity ; Particulate Matter/analysis ; Epigenome ; DNA Methylation ; China
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118276
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Article ; Online: Stark Effects of Rydberg Excitons in a Monolayer WSe

Lian, Zhen / Li, Yun-Mei / Yan, Li / Ma, Lei / Chen, Dongxue / Taniguchi, Takashi / Watanabe, Kenji / Zhang, Chuanwei / Shi, Su-Fei

Nano letters

2024

Abstract: The enhanced Coulomb interaction in two-dimensional semiconductors leads to tightly bound electron-hole pairs known as excitons. The large binding energy of excitons enables the formation of Rydberg excitons with high principal quantum numbers (n), ... ...

Abstract	The enhanced Coulomb interaction in two-dimensional semiconductors leads to tightly bound electron-hole pairs known as excitons. The large binding energy of excitons enables the formation of Rydberg excitons with high principal quantum numbers (n), analogous to Rydberg atoms. Rydberg excitons possess strong interactions among themselves as well as sensitive responses to external stimuli. Here, we probe Rydberg exciton resonances through photocurrent spectroscopy in a monolayer WSe
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.4c00134
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Article ; Online: Time-Varying Proteinuria and Progression of IgA Nephropathy: A Cohort Study.

Tang, Chen / Chen, Pei / Si, Feng-Lei / Lv, Ji-Cheng / Shi, Su-Fang / Zhou, Xu-Jie / Liu, Li-Jun / Zhang, Hong

American journal of kidney diseases : the official journal of the National Kidney Foundation

2024

Abstract: Rationale & objective: Proteinuria is a surrogate end point for predicting long-term kidney outcomes in IgA nephropathy (IgAN) with levels<1g/day identified as a therapeutic target. However, this threshold has not been sufficiently studied. We ... ...

Abstract	Rationale & objective: Proteinuria is a surrogate end point for predicting long-term kidney outcomes in IgA nephropathy (IgAN) with levels<1g/day identified as a therapeutic target. However, this threshold has not been sufficiently studied. We quantified the associations of progression of IgAN with various levels of proteinuria. Study design: Observational cohort study. Setting & participants: 1,530 patients with IgAN and at least 12 months of follow-up at Peking University First Hospital. Exposure: Proteinuria levels updated over time (time-varying proteinuria, TVP). Outcome: A composite kidney outcome of a 50% reduction in the estimated glomerular filtration rate or end-stage kidney disease. Analytical approach: Marginal structural models. Results: After a median follow-up period of 43.5 (IQR, 27.2-72.8) months, 254 patients (16.6%) developed the composite kidney outcome. A graded association was observed between TVP and composite kidney outcomes with higher risk among those with proteinuria of≥0.5g/day. Compared with TVP<0.3g/day, the HRs for proteinuria levels of 0.3 to<0.5g/day, 0.5 to<1.0g/day, 1.0 to<2.0g/day, and≥2.0g/day were 2.22 (95% CI, 0.88-5.58), 4.04 (95% CI, 1.93-8.46), 8.46 (95% CI, 3.80-18.83), and 38.00 (95% CI, 17.62-81.95), respectively. The trend was more pronounced in patients with baseline proteinuria of≥1.0g/day, among whom a higher risk was observed with TVP of 0.3 to<0.5g/day compared with TVP<0.3g/day (HR, 3.26 [95% CI, 1.07-9.92], P=0.04). However, in patients with baseline proteinuria levels of<1g/day, the risk of composite kidney outcome only began to increase when TVP was≥1.0g/day (HR, 3.25 [95% CI, 1.06-9.90]). Limitations: Single-center observational study, selection bias, and unmeasured confounders. Conclusions: This study showed that patients with IgAN and proteinuria levels of>0.5g/day, have an elevated risk of kidney failure especially among patients with proteinuria levels≥1.0g/day before initiating treatment. These data may serve to inform the selection of proteinuria targets in the treatment of IgAN. Plain-language summary: The presence of proteinuria has often been considered a surrogate end point and a possible therapeutic target in clinical trials in IgA nephropathy (IgAN). Some guidelines recommend a reduction in proteinuria to<1g/day as a treatment goal based on the results of previous longitudinal studies. However, these findings may have been biased because they did not properly adjust for time-dependent confounders. Using marginal structural models to appropriately account for these confounding influences, we observed that patients with IgAN and proteinuria levels≥0.5g/day have an elevated risk of kidney failure, especially among patients who had proteinuria levels of≥1.0g/day before initiating treatment. These data may serve to inform the selection of proteinuria targets in the treatment of IgAN.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2023.12.016
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Assessment of TUFT1 and Rac1-GTP levels in triple-negative breast cancer patients: clinical and pathological correlations.

Shi, Su-Fang / Cai, Rui-Xi / Ren, Yan-Fei / Li, Yong / Li, Shuo / Yin, Tian-Lu / Jia, Dong-Xiao / Li, Yong-Jun

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2024

Abstract: Objective: The primary goal of this study was to investigate the expressions of TUFT1 (Tuftelin) and Rac1-GTP in the cancerous tissues of individuals with triple-negative breast cancer (TNBC). Additionally, we aimed to explore the correlation between ... ...

Abstract	Objective: The primary goal of this study was to investigate the expressions of TUFT1 (Tuftelin) and Rac1-GTP in the cancerous tissues of individuals with triple-negative breast cancer (TNBC). Additionally, we aimed to explore the correlation between TUFT1 and Rac1-GTP expressions and examine the associations of TUFT1 and Rac1-GTP expressions with the clinical and pathological indicators of the patients. Methods: Ninety-six patients diagnosed with TNBC, scheduled for surgery between May 2022 and November 2022, were enrolled in this study. Cancerous tissue specimens were collected from these patients, and immunohistochemistry was employed to evaluate the levels of TUFT1 and Rac1-GTP expressions in the cancerous tissues. Subsequent to data collection, a comprehensive analysis was conducted to examine the correlation between TUFT1 and Rac1-GTP expressions. Furthermore, we sought to assess the associations of TUFT1 and Rac1-GTP expressions with the clinical and pathological indicators of the patients. Results: The TUFT1 protein was expressed in both the membrane and cytoplasm of TNBC cancer cells, with notably higher expression observed in the cytoplasm. Rac1-GTP was primarily expressed in the cytoplasm. There was a positive correlation between the levels of TUFT1 and Rac1-GTP expressions (χ Conclusion: A significant correlation was identified between the levels of TUFT1 and Rac1-GTP expressions in the cancerous tissues of patients with TNBC, suggesting a close association with the progression of TNBC. The two molecules play significant roles in facilitating an early diagnosis and treatment of TNBC.
Language	English
Publishing date	2024-03-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-024-03426-3
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Article ; Online: Analysis of clinicopathologic features and gene mutations in gastrointestinal stromal tumor: a series of 58 patients.

Cheng, Hao / Qiu, Tian / Shi, Su-Sheng

International journal of clinical and experimental pathology

2021 Volume 14, Issue 12, Page(s) 1128–1137

Abstract: Background: In gastrointestinal stromal tumor (GIST), mutually exclusive gain-of-function mutations of c-kit and PDGFRα are associated with different mutation-dependent clinical features. We analyzed clinico-pathologic features and genotypes of GIST ... ...

Abstract	Background: In gastrointestinal stromal tumor (GIST), mutually exclusive gain-of-function mutations of c-kit and PDGFRα are associated with different mutation-dependent clinical features. We analyzed clinico-pathologic features and genotypes of GIST among patients in China. Methods: Adult patients with GIST in the stomach, small intestine, colorectum, or extra-gastrointestinal areas were enrolled in this study. These patients had been subjected to surgical resection without imatinib (Gleevec) treatment at the Cancer Hospital, Chinese Academy of Medical Sciences from January 2009 to January 2019. Samples were obtained for histopathologic examination. Mutations in c-kit and PDGFRα genes were analyzed by PCR and next generation sequencing (NGS). Clinico-pathologic characteristics of each gene were also analyzed. Results: A total of 58 GIST patients was enrolled in this study. In terms of genotypes, there were 51 (87.9%) c-kit mutations, 5 (8.6%) PDGFRα mutations, and 2 (3.4%) wild-type mutations. In terms of cell types, there were 40 cases (69.0%) with spindle cell type, 3 cases (5.2%) with epithelioid cell type and 3 cases (5.2%) with mixed spindle-epithelioid cell type. Among the 4 mutant forms of c-kit exon-11, the most common were point mutations in 16 cases (38.1%), deletion mutations in 13 cases (31.0%), insertion mutations in 4 cases (9.5%), and mixed mutations in 9 cases (21.4%). Based on risk grade classification of the National Institutes of Health (NIH), 3 cases (5.2%) were very-low risk, 9 cases (15.5%) were low risk, 19 cases (32.8%) were medium risk, and 23 cases (39.7%) were high risk. Significant differences in cell type were identified across different gene types ( Conclusion: With c-kit mutations, spindle cell type prevalence exceeded that of the epithelioid cell type and mixed spindle-epithelioid cell type. Spindle and mixed spindle-epithelioid cell types were the most prevalent in the category of PDGFRα mutations. In wild type cases, spindle and epithelioid cell types were the most common. A high risk of deletion and mixed mutations, and intermediate risk of point and insertion mutations were observed in c-kit exon-11 mutation type.
Language	English
Publishing date	2021-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article ; Online: Excitonic Complexes in Two-Dimensional Transition Metal Dichalcogenides.

Chen, Xiaotong / Lian, Zhen / Meng, Yuze / Ma, Lei / Shi, Su-Fei

Nature communications

2023 Volume 14, Issue 1, Page(s) 8233

Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44119-9
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Article ; Online: Six-Body and Eight-Body Exciton States in Monolayer WSe_{2}.

Van Tuan, Dinh / Shi, Su-Fei / Xu, Xiaodong / Crooker, Scott A / Dery, Hanan

Physical review letters

2022 Volume 129, Issue 7, Page(s) 76801

Abstract: In the archetypal monolayer semiconductor WSe_{2}, the distinct ordering of spin-polarized valleys (low-energy pockets) in the conduction band allows for studies of not only simple neutral excitons and charged excitons (i.e., trions), but also more ... ...

Abstract	In the archetypal monolayer semiconductor WSe_{2}, the distinct ordering of spin-polarized valleys (low-energy pockets) in the conduction band allows for studies of not only simple neutral excitons and charged excitons (i.e., trions), but also more complex many-body states that are predicted at higher electron densities. We discuss magneto-optical measurements of electron-rich WSe_{2} monolayers and interpret the spectral lines that emerge at high electron doping as optical transitions of six-body exciton states ("hexcitons") and eight-body exciton states ("oxcitons"). These many-body states emerge when a photoexcited electron-hole pair interacts simultaneously with multiple Fermi seas, each having distinguishable spin and valley quantum numbers. In addition, we explain the relations between dark trions and satellite optical transitions of hexcitons in the photoluminescence spectrum.
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.129.076801
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