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Article ; Online: Analysis of Pollution Characteristics and Emissions Reduction Measures in the Main Cotton Area of Xinjiang.

Fang, Chunsheng / Li, Zhuoqiong / Shi, Weihao / Wang, Ju

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: With cotton production in Xinjiang increasing annually, the impact on the environment of agricultural waste produced to improve production has been reflected. This study selected Bozhou of Xinjiang, the main cotton producing region in northern Xinjiang, ... ...

Abstract	With cotton production in Xinjiang increasing annually, the impact on the environment of agricultural waste produced to improve production has been reflected. This study selected Bozhou of Xinjiang, the main cotton producing region in northern Xinjiang, as the research object, and collected hourly concentration data of six pollutants from 2017 to 2021, and analyzed the spatial and temporal distribution characteristics of each pollutant. At the same time, Morlet wavelet analysis was used to further analyze the variation period of PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; Carbon Monoxide/analysis ; Particulate Matter/analysis ; Environmental Pollutants/analysis ; Gossypium ; Environmental Monitoring/methods ; China
Chemical Substances	Air Pollutants ; Carbon Monoxide (7U1EE4V452) ; Particulate Matter ; Environmental Pollutants
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20032273
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Article ; Online: Progress of Research on Urban Growth Boundary and Its Implications in Chinese Studies Based on Bibliometric Analysis.

Liu, Xiaoyang / Shi, Weihao / Zhang, Sen

International journal of environmental research and public health

2022 Volume 19, Issue 24

Abstract: Urban sprawl is a development theme of cities all over the world, especially in developing countries with rapid urbanization, and the long-established rough and outward urban growth pattern has brought about a series of social and ecological problems. As ...

Abstract	Urban sprawl is a development theme of cities all over the world, especially in developing countries with rapid urbanization, and the long-established rough and outward urban growth pattern has brought about a series of social and ecological problems. As an important tool in controlling urban sprawl in western countries, the urban growth boundary (UGB) has become one of the three major policy tools in the national spatial planning system since it was introduced into China. Combined with a bibliometric analysis, this literature review summarizes UGB studies on development and evolution, delimitation means, and implementation management and provides references for studying UGB adaptability in China. The results show that: (1) Originating from Howard's garden city concept, UGB studies have formed a relatively complete system of "theoretical basis, technical methods, supporting policies, and implementation management" through long-term empirical research in foreign countries. With a relatively late start in China, UGB research currently focuses on different situations between China and abroad and the adaptation of China's localization. (2) UGB delimitation mainly includes two aspects: forward expansion, which, from the urban development perspective, is mainly supported by cellular automata (CA) urban growth simulation; and reverse restriction, which, from the ecological protection perspective, is supported by ecological security pattern construction, ecological sensitivity evaluation, and land suitability evaluation. (3) Many foreign UGB implementations have different forms and more flexible and comprehensive corresponding supporting policies. However, the current state of research in China in this area is still insufficient. Against the background of the national spatial planning system reform, the findings of this review provide references for delineating UGB that considers ecological protection and urban development under the scenarios of planning, formulating a supporting mechanism for multi-subject participation and multi-party coordination, and establishing an adjustment system based on implementation effect evaluation.
MeSH term(s)	Humans ; Bibliometrics ; China ; Cities ; Conservation of Natural Resources ; Ecosystem ; Urbanization
Language	English
Publishing date	2022-12-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192416644
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Article ; Online: Spatial-Temporal Evolution and Driving Factors of the Coupling Coordination between Urbanization and Urban Resilience: A Case Study of the 167 Counties in Hebei Province.

Shi, Weihao / Tian, Jian / Namaiti, Aihemaiti / Xing, Xiaoxu

International journal of environmental research and public health

2022 Volume 19, Issue 20

Abstract: Urban resilience, as an important ability to deal with disasters in the process of urbanization, has been paid more and more attention as the result of the increasing risks that are caused by rapid urbanization. China is taking the county level as the ... ...

Abstract	Urban resilience, as an important ability to deal with disasters in the process of urbanization, has been paid more and more attention as the result of the increasing risks that are caused by rapid urbanization. China is taking the county level as the basic unit to promote new-type urbanization and constructing resilient cities has become one of the development strategies. However, to achieve this strategy researchers need to analyze the interaction between county urbanization and urban resilience and its driving mechanism, which have been paid little attention. Therefore, this paper selected 167 counties in Hebei Province as the investigation subject. Based on the statistical data from 2010 to 2020, a comprehensive index system was developed to quantify the degree of coupling coordination between urbanization and urban resilience, and the spatial Durbin model was used to analyze the driving mechanism of it. The study shows that: Firstly, the urbanization level of counties rose year after year, with there being a geographical distribution that was "lower from southeast to northwest". The level of urban resilience increased year after year, showing a geographical distribution that was "higher from south to north" and a "core-edge" feature that was localized. Secondly, the coupling coordination degree increased steadily, and the overall level changed from a basic imbalance to a mild imbalance. In space, it is bounded by "Pingquan City-Pingshan County", which showed the distribution of "high in the east and low in the west, high in the center and low on the outskirts". Thirdly, the coupling coordination degree has spatial spillover effect. Government financial expenditure, innovation level, industrial upgrading level and urban shape index all influence the coupling coordination degree positively, with a successively decreasing impact, while the urban compactness has significant negative impacts. This study indicates that the regional differences exist in the coupling coordination degree, and the counties in different development stages need to adopt different strategies to promote the coordinated development of urbanized and resilient cities. Inter-regional support is also necessary in this process. Meanwhile, it is necessary for the government to govern various urban elements, especially in terms of their urban form.
MeSH term(s)	Urbanization ; Cities ; China ; Industry ; Disasters ; Economic Development
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192013128
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Article ; Online: Debris generated by laser and/or balloon cause cerebral infarction with different severity.

Yang, Kai / Tan, Jinyun / Deng, Ying / Jiang, Shuai / Tang, Jingdong / Shi, Weihao / Yu, Bo

Lasers in medical science

2023 Volume 39, Issue 1, Page(s) 15

Abstract: The purpose of this study is to determine the effects that debris generated by laser and/or balloon on the brain. Debris generated by laser, balloon, and laser combined with balloon were collected and then injected into rats' left common carotid artery. ... ...

Abstract	The purpose of this study is to determine the effects that debris generated by laser and/or balloon on the brain. Debris generated by laser, balloon, and laser combined with balloon were collected and then injected into rats' left common carotid artery. Rats were divided into five groups: sham, saline, laser (L), balloon (B), and laser combined with balloon (LB). The cognition ability of rats was evaluated by Morris water maze. Cerebral blood flow (CBF) was examined by laser speckle. TTC staining and MRI scan were conducted to detect cerebral ischemic infarction. Intracranial arteries in rats were visualized by MRI angiography via contrast medium injected via tail vein. Immunohistologic staining for NeuN and Iba1 and hematoxylin-eosin staining were performed to assess brain infarction. White matter demyelination was assessed by Luxol fast blue staining. Long-term memory and CBF of rats in different groups exhibited no significant difference. No obstruction sign in intracranial artery tree was noticed in each group. Debris generated by different treatments all caused brain infarction. Infarction lesion caused by debris produced by balloon was much more severe than the one caused by debris generated by laser. While the LB group lay in between. The thickness of white matter decreased in the B group, but not in the L and LB groups. Rat brain has a tolerance for debris as cognition ability and cerebral blood flow are not significantly declined. The severity of cerebral infarction varies by debris generated by different treatments.
MeSH term(s)	Rats ; Animals ; Brain Ischemia/pathology ; Cerebral Infarction/etiology ; Cerebral Infarction/complications ; Brain/blood supply ; Arteries/pathology ; Lasers
Language	English
Publishing date	2023-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-023-03904-0
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Article: Analysis of the anatomic eligibility for transcarotid artery revascularization in Chinese patients who underwent carotid endarterectomy and transfemoral carotid artery stenting.

Fan, Weijian / Shi, Weihao / Lu, Shuangshuang / Guo, Wencheng / Tong, Jindong / Tan, Jinyun / Yu, Bo

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1045598

Abstract: Objective: Transcarotid artery revascularization (TCAR) is thought to be a promising technique and instrument for treating carotid stenosis with favorable outcomes. Since there remain several differences in anatomic characteristics among races, this ... ...

Abstract	Objective: Transcarotid artery revascularization (TCAR) is thought to be a promising technique and instrument for treating carotid stenosis with favorable outcomes. Since there remain several differences in anatomic characteristics among races, this study was conducted to investigate the anatomic eligibility of TCAR in Chinese patients who underwent carotid revascularization. Methods: A retrospective review of patients with carotid stenosis from 2019 to 2021 was conducted. The anatomic eligibility of TCAR was based on the instruction of the ENROUTE Transcarotid Neuroprotection System. The carotid artery characteristics and configuration of the circle of Willis (CoW) were evaluated by CT angiography. The demographic and clinical characteristics and procedure-related complications were recorded. Logistic regression was used to analyze the independent factors for TCAR eligibility. Results: Of 289 consecutive patients [222 for carotid endarterectomy (CEA) and 67 for transfemoral carotid artery stenting (TF-CAS)] identified, a total of 215 patients (74.4%) met TCAR anatomic eligibility. Specifically, 83.7% had mild common carotid artery (CCA) puncture site plaque, 95.2% had 4-9 mm internal carotid artery diameters, 95.8% had >6 mm CCA diameter, and 98.3% had >5 cm clavicle to carotid bifurcation distance. Those who were female (OR, 5.967; 95% CI: 2.545-13.987; Conclusion: A significant proportion of Chinese patients meet the anatomic criteria of TCAR, making TCAR a feasible treatment option in China. Anatomic and some demographic factors play key roles in TCAR eligibility. Further analysis indicates a potential reduction of procedure-related complications in patients with high-risk carotid stenosis under the TCAR procedure.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1045598
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Article ; Online: The Impact of Balloon Pre-dilatation Techniques on Drug-Coated Balloon Therapy for Femoropopliteal Artery Disease: Six-Month Results From the CIVILIAN Registry.

Ye, Meng / Ni, Qihong / He, Chunshui / Shi, Zhenyu / Shi, Weihao / Zhu, Jingpu / Li, Lin / Wu, Ziheng

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

2024 , Page(s) 15266028241231036

Abstract: Objective: The purpose of this study is to compare the initial outcomes of using the Chocolate balloon pre-dilatation (CLP) and sequential enlarging angioplasty pre-dilatation (sequential balloon pre-dilation [SP]) techniques versus the conventional ... ...

Abstract	Objective: The purpose of this study is to compare the initial outcomes of using the Chocolate balloon pre-dilatation (CLP) and sequential enlarging angioplasty pre-dilatation (sequential balloon pre-dilation [SP]) techniques versus the conventional balloon pre-dilatation (CP) method prior to drug-coated balloon (DCB) treatment for femoropopliteal (FP) lesions. Methods: This was a retrospective analysis of prospectively collected data from the CIVILIAN (Clinical InVestigation of different lesIon preparation modaLIty followed by DCB in femoropopliteal Artery occlusioN disease) registry. Between March 2021 and November 2022, 3 pre-dilation techniques used prior to the DCB angioplasty were included. The study endpoint included intraoperative finial severe dissection after provisional stent placement, bailout stenting rate, the diameter of the largest pre-dilation balloon and DCB, as well as major adverse events (MAEs), including death, major limb amputation, or target vessel revascularization at 6 months. Results: During the study period, 435 limbs (429 patients) were pre-dilated before DCB treatment in FP lesions, 166 limbs were pre-dilated with Chocolate balloons, 93 limbs with sequential enlarging balloon pre-dilation technique, and 176 limbs with CP. The largest pre-dilation balloon was significantly larger in CLP and SP groups than that in the CP group (CLP 4.74±0.52 mm vs CP 4.36±0.64 mm, p<0.001; SP 4.82±0.69 mm vs CP 4.36±0.63 mm, p<0.001). A consistent result was shown in DCB diameter (CLP 4.86±0.44 mm vs CP 4.71±0.51 mm, p=0.003; SP 4.90±0.58 mm vs CP 4.71±0.51 mm, p=0.006). The bailout stenting rate was significantly lower in the CLP group than that in the CP group (18.1% vs 30.1%, p=0.011). The rates of MAEs at 6 months in the CLP and SP groups were comparable to those in the CP group (7.2% and 8.6% vs 6.3%, p>0.05). The risk for intraoperative bailout stenting rate was related to TASC D classification (3.59, 95% CI: 1.83-7.05, p<0.001), chronic total occlusion (CTO) lesion (1.82, 95% CI: 1.07-3.10, p=0.028), as well as pre-dilated with the conventional balloon (1.64, 95% CI: 1.00-2.69, p=0.048). Conclusions: By utilizing chocolate balloon and sequential enlarging angioplasty, it becomes possible to use larger pre-dilation balloons and DCBs. In addition, the use of the chocolate balloon can significantly reduce the need for bailout stenting when compared with conventional balloons. Clinical impact: The utilization of a chocolate balloon and sequential enlarging angioplasty has emerged as a promising technique for angioplasty procedures. This approach allows for the use of larger pre-dilation balloons and drug-coated balloons. The use of the chocolate balloon can significantly reduce the need for bail-out stenting when compared to conventional balloons. Further research is required to determine the impact of vessel preparation techniques on the primary patency.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006618-1
ISSN	1545-1550 ; 1526-6028
ISSN (online)	1545-1550
ISSN	1526-6028
DOI	10.1177/15266028241231036
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Article ; Online: Ambient RNAs removal of cortex-specific snRNA-seq reveals Apoe

Zhang, Yuan / Tan, Jinyun / Yang, Kai / Fan, Weijian / Yu, Bo / Shi, Weihao

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 152

Abstract: Background: Ambient RNAs contamination in single-nuclei RNA sequencing (snRNA-seq) is a challenging problem, but the consequences of ambient RNAs contamination of damaged and/or diseased tissues are poorly understood. Cognitive impairments and white/ ... ...

Abstract	Background: Ambient RNAs contamination in single-nuclei RNA sequencing (snRNA-seq) is a challenging problem, but the consequences of ambient RNAs contamination of damaged and/or diseased tissues are poorly understood. Cognitive impairments and white/gray matter injuries are characteristic of deeper cerebral hypoperfusion mouse models induced by bilateral carotid artery stenosis (BCAS), but the molecular mechanisms still need to be further explored. More importantly, the BCAS mice can also offer an excellent model to examine the signatures of ambient RNAs contamination in damaged tissues when performing snRNA-seq. Methods: After the sham and BCAS mice were established, cortex-specific single-nuclei libraries were constructed. Single-nuclei transcriptomes were described informatically by the R package Seurat, and ambient RNA markers of were identified in each library. Then, after removing ambient RNAs in each sample using the in silico approaches, the combination of CellBender and subcluster cleaning, single-nuclei transcriptomes were reconstructed. Next, the comparison of ambient RNA contamination was performed using irGSEA analysis before and after the in silico approaches. Finally, further bioinformatic analyses were performed. Results: The ambient RNAs are more predominant in the BCAS group than the sham group. The contamination mainly originated from damaged neuronal nuclei, but could be reduced largely using the in silico approaches. The integrative analysis of cortex-specific snRNA-seq data and the published bulk transcriptome revealed that microglia and other immune cells were the primary effectors. In the sequential microglia/immune subgroups analysis, the subgroup of Apoe Conclusions: Taken together, our current study unravels the features of ambient RNAs in snRNA-seq datasets under diseased conditions, and the in silico approaches can effectively eliminate the incorrected cell annotation and following misleading analysis. In the future, snRNA-seq data analysis should be carefully revisited, and ambient RNAs removal needs to be taken into consideration, especially for those diseased tissues. To our best knowledge, our study also offers the first cortex-specific snRNA-seq data of deeper cerebral hypoperfusion, which provides with novel therapeutic targets.
MeSH term(s)	Animals ; Mice ; Microglia/metabolism ; RNA, Small Nuclear/metabolism ; RNA, Small Nuclear/pharmacology ; RNA, Small Nuclear/therapeutic use ; Macrophages ; Carotid Stenosis/complications ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Mice, Inbred C57BL
Chemical Substances	RNA, Small Nuclear ; Apolipoproteins E
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02831-9
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Article ; Online: Antiferroptosis therapy alleviated the development of atherosclerosis.

Yang, Zhou / He, Yue / Wu, Dejun / Shi, Weihao / Liu, Ping / Tan, Jinyun / Wang, Rui / Yu, Bo

MedComm

2024 Volume 5, Issue 4, Page(s) e520

Abstract: Ferroptosis has been confirmed to be associated with various diseases, but the relationship between ferroptosis and atherosclerosis (AS) remains unclear. Our research detailly clarified the roles of ferroptosis in three continuous and main pathological ... ...

Abstract	Ferroptosis has been confirmed to be associated with various diseases, but the relationship between ferroptosis and atherosclerosis (AS) remains unclear. Our research detailly clarified the roles of ferroptosis in three continuous and main pathological stages of AS respectively (injury of endothelial cells [ECs], adhesion of monocytes, and formation of foam cells). We confirmed that oxidized low-density lipoprotein (ox-LDL), the key factor in the pathogenesis of AS, strongly induced ferroptosis in ECs. Inhibition of ferroptosis repressed the adhesion of monocytes to ECs by inhibiting inflammation of ECs. Ferroptosis also participated in the formation of foam cells and lipids by regulating the cholesterol efflux of macrophages. Further research confirmed that ox-LDL repressedthe activity of glutathione peroxidase 4 (GPX4), the classic lipid peroxide scavenger. Treatment of a high-fat diet significantly induced ferroptosis in murine aortas and aortic sinuses, which was accompanied by AS lesions and hyperlipidemia. Treatment with ferroptosis inhibitors significantly reduced ferroptosis, hyperlipidemia, and AS lesion development. In conclusion, our research determined that ox-LDL induced ferroptosis by repressing the activity of GPX4. Antiferroptosis treatment showed promising treatment effects in vivo. Ferroptosis-associated indexes also showed promising diagnostic potential in AS patients.
Language	English
Publishing date	2024-04-04
Publishing country	China
Document type	Journal Article
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.520
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Article ; Online: A Systematic Review of Total Thoracic Endovascular Aortic Repair in Treatment of Kommerell Diverticulum Combined with Right-Sided Aortic Arch.

Fan, Weijian / Tan, Jinyun / Shi, Weihao / Rong, Jianjie / Yu, Bo

Medical science monitor : international medical journal of experimental and clinical research

2021 Volume 27, Page(s) e930031

Abstract: Kommerell diverticulum (KD) combined with right-sided aortic arch (RAA) and aberrant left subclavian artery (ALSA) are rare and limited to a few case reports and small series. Thoracic endovascular aortic repair (TEVAR), which is mini-invasive, is widely ...

Abstract	Kommerell diverticulum (KD) combined with right-sided aortic arch (RAA) and aberrant left subclavian artery (ALSA) are rare and limited to a few case reports and small series. Thoracic endovascular aortic repair (TEVAR), which is mini-invasive, is widely utilized in complicated aortic disease. We performed a systematic review of the literature to identify all patients who underwent endovascular repair for KD in terms of technical feasibility and procedural outcomes. Published and accepted studies only in English as well as article reference lists were searched and extracted to assess case series reporting solely TEVAR in KD patients. There were 28 patients with KD/RAA identified from 19 studies. All of them underwent endovascular technique for KD exclusion and the median age was 69 years (range 39-83 years). Hypertension (n=17) was the most common comorbidity in this cohort, followed by diabetes mellitus (n=3), hyperlipidemia (n=3), and smoking (n=3). The presenting symptoms were dysphagia (n=8, 29%), intermittent back pain (n=4, 14%), and acute aortic dissection (n=6, 21%), while asymptomatic was found in 9 patients (n=9, 32%). A technical success rate of 100% was reported associated with various managements of ALSA, proximal embolization (n=19, 68%), in-situ revascularization (n=3, 11%), and left carotid-subclavian bypass (n=3, 11%). All patients survived without severe complications and were discharged home within less than 14 days. The mean follow-up time was 9.3 months, patency was found in all patients, thrombosis and distinct shrinkage of KD aneurysm as indicated by CT-scans were noted (n=20, 71%), and type II endoleak was found in only 4 patients (n=4, 14%). TEVAR appears to be safe and offers favorable results, but it still needs substantial evidence to support routine use in KD. TEVAR is an alternative to open repair in selected cases, but it needs further investigation in a large cohort.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/surgery ; Aortic Diseases/etiology ; Aortic Diseases/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Diverticulum/surgery ; Embolization, Therapeutic ; Endovascular Procedures/methods ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Stents ; Treatment Outcome
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.930031
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Article: Endovascular Debulking of Human Carotid Plaques by Using an Excimer Laser Combined With Balloon Angioplasty: An

Yang, Kai / Tan, Jinyun / Deng, Ying / Shi, Weihao / Yu, Bo

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 700497

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2021-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.700497
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