Article ; Online: Research advances in cochlear pericytes and hearing loss.
2023 Volume 438, Page(s) 108877
Abstract: Pericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and ... ...
Abstract | Pericytes are specialized mural cells surrounding endothelial cells in microvascular beds. They play a role in vascular development, blood flow regulation, maintenance of blood-tissue barrier integrity, and control of angiogenesis, tissue fibrosis, and wound healing. In recent decades, understanding of the critical role played by pericytes in retina, brain, lung, and kidney has seen significant progress. The cochlea contains a large population of pericytes. However, the role of cochlear pericytes in auditory pathophysiology is, by contrast, largely unknown. The present review discusses recent progress in identifying cochlear pericytes, mapping their distribution, and defining their role in regulating blood flow, controlling the blood-labyrinth barrier (BLB) and angiogenesis, and involvement in different types of hearing loss. |
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MeSH term(s) | Humans ; Pericytes ; Endothelial Cells ; Hearing Loss ; Deafness ; Cochlea |
Language | English |
Publishing date | 2023-08-19 |
Publishing country | Netherlands |
Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural |
ZDB-ID | 282629-x |
ISSN | 1878-5891 ; 0378-5955 |
ISSN (online) | 1878-5891 |
ISSN | 0378-5955 |
DOI | 10.1016/j.heares.2023.108877 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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