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Article: Clinical effect of high-flow nasal cannula oxygen therapy combined with naloxone on severe respiratory failure in older adult patients: a randomized controlled trial.

Zhou, Yaqing / Shi, Xiaoyan / Pu, Zunguo / Liu, Aiming

American journal of translational research

2023 Volume 15, Issue 11, Page(s) 6613–6620

Abstract: Objective: To analyze the clinical effect of high-flow nasal cannula (HFNC) oxygen therapy combined with naloxone on severe respiratory failure (SRF) in older adult patients.: Methods: We enrolled 96 older adult patients with SRF who were admitted to ...

Abstract	Objective: To analyze the clinical effect of high-flow nasal cannula (HFNC) oxygen therapy combined with naloxone on severe respiratory failure (SRF) in older adult patients. Methods: We enrolled 96 older adult patients with SRF who were admitted to Hai'an People's Hospital between February 2019 and March 2022. The patients were divided into two groups: the control group (treated with non-invasive positive pressure ventilation combined with naloxone) and the observation group (treated with HFNC oxygen therapy combined with naloxone). The blood gas measurement, respiratory rate (RR), St. George's Respiratory Questionnaire (SGRQ) score, Clara cell secreted protein (CC16) level, tumor necrosis factor-alpha (TNF-α) level, interleukin-1 (IL-1) level, length of intensive care unit (ICU) stay, tracheal intubation rate, and 28-day mortality rate were compared between the groups. Results: Blood gas measurement or RR did not differ significantly between the groups ( Conclusions: HFNC oxygen therapy combined with naloxone in older adult patients with SRF could improve blood gas results, disease duration, tracheal intubation rate, and 28-day mortality rate. This may occur through regulation of TNF-α, IL-1, and CC16 expression.
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Numerical simulation study on optimization of ventilation airflow organization of a raw coal bunker

Zhang Qianru / Yang Luying / Shi Xiaoyan / Wang Xin

E3S Web of Conferences, Vol 356, p

2022 Volume 01061

Abstract: For the problem of gas accumulation in the product bunker of a company’s coal processing plant, three different ventilation schemes are proposed. The first one opens rectangular air inlet louvers on the wall of the product bunker and adds fans on the top ...

Abstract	For the problem of gas accumulation in the product bunker of a company’s coal processing plant, three different ventilation schemes are proposed. The first one opens rectangular air inlet louvers on the wall of the product bunker and adds fans on the top for exhaust; the second one sets six ventilation windows evenly on the top of the product bunker for natural ventilation; the third one sends air to the interior of the bunker through small holes evenly distributed on the ventilation pipes and opens six exhaust ports on the wall. Finally, the effect of gas accumulation management of the ventilation scheme is simulated and analyzed through numerical simulation. The ventilation scheme is applicable to the gas accumulation management of raw coal bunkers with different coal storage heights, and provides a technical reference for the gas accumulation management of product bunkers in coal processing plants.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway.

Zhou, Min / Ma, Xiaolin / Gao, Menglong / Wu, Hongfei / Liu, Yarong / Shi, Xiaoyan / Dai, Min

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 1

Abstract: Atherosclerosis is a chronic inflammatory disease leading to various vascular diseases. Vascular smooth muscle cell (VSMC) senescence promotes atherosclerotic inflammation and the formation of plaque necrosis core, in part through telomere damage ... ...

Abstract	Atherosclerosis is a chronic inflammatory disease leading to various vascular diseases. Vascular smooth muscle cell (VSMC) senescence promotes atherosclerotic inflammation and the formation of plaque necrosis core, in part through telomere damage mediated by a high-fat diet. Our previous research found that paeonol, a potential anti-inflammatory agent extracted from Cortex Moutan, could significantly improve VSMCs dysfunction. However, the impact of paeonol on the senescence of VSMCs remains unexplored. This study presents the protective effects of paeonol on VSMCs senescence, and its potential activity in inhibiting the progression of atherosclerosis in vivo and in vitro. Sirtuin 1 (SIRT1) is a nuclear deacetylase involved in cell proliferation, senescence, telomere damage, and inflammation. Here, SIRT1 was identified as a potential target of paeonol having anti-senescence and anti-atherosclerosis activity. Mechanistic studies revealed that paeonol binds directly to SIRT1 and then activates the SIRT1/P53/TRF2 pathway to inhibit VSMCs senescence. Our results suggested that SIRT1-mediated VSMCs senescence is a promising druggable target for atherosclerosis, and that pharmacological modulation of the SIRT1/P53/TRF2 signaling pathway by paeonol is of potential benefit for patients with atherosclerosis.
MeSH term(s)	Humans ; Sirtuins ; Sirtuin 1 ; Muscle, Smooth, Vascular ; Tumor Suppressor Protein p53 ; Atherosclerosis/drug therapy ; Inflammation ; Signal Transduction ; Acetophenones
Chemical Substances	Sirtuins (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; paeonol (3R834EPI82) ; Tumor Suppressor Protein p53 ; SIRT1 protein, human (EC 3.5.1.-) ; Acetophenones
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29010261
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Article: Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes.

Feng, Jun / Zhang, Liya / Tang, Jihong / Zhang, Bingbing / Xiao, Xiao / Shi, Xiaoyan

Neuropsychiatric disease and treatment

2024 Volume 20, Page(s) 459–467

Abstract: Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS).: Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in ... ...

Abstract	Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS). Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children's Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video EEG during slow-wave sleep were evaluated before and after treatment. The role of LCM monotherapy in improving SWI, controlling clinical seizures and improving cognition was analyzed, and corresponding adverse reactions were documented. Results: There were 52 males and 37 females in this group, with an average age of 7.6 ± 2.1 years. The total effective rate was 93.83% and at 18 months of treatment, the cumulative control rate was 85.19%, the retention rate was 91.01% and the effective rate in terms of EEG spike index was 72.92%, all of which showed a high rate; there was no statistically significant difference in intelligence quotient before and after treatment ( Conclusion: LCM monotherapy had curative effect and adverse reactions for SeLECTS, with no negative impact on cognition. These significant findings indicate that LCM is likely to become a widely prescribed ASM for the treatment of SeLECTS. Meanwhile, the onset age and baseline seizure frequency had certain value in judging prognosis and predicting curative effect.
Language	English
Publishing date	2024-03-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S452784
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Article ; Online: Creating Atomically Iridium-Doped PdO

Wang, Yingjie / Xu, Guangyan / Sun, Yanwei / Shi, Wei / Shi, Xiaoyan / Yu, Yunbo / He, Hong

Environmental science & technology

2024

Abstract: The urgent environmental concern of methane abatement, attributed to its high global warming potential, necessitates the development of methane oxidation catalysts (MOC) with enhanced low-temperature activity and durability. Herein, an iridium-doped ... ...

Abstract	The urgent environmental concern of methane abatement, attributed to its high global warming potential, necessitates the development of methane oxidation catalysts (MOC) with enhanced low-temperature activity and durability. Herein, an iridium-doped PdO
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.4c00868
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Article ; Online: MicroRNA let-7g links foam cell formation and adipogenic differentiation: A key regulator of Paeonol treating atherosclerosis-osteoporosis.

Yan, Jinjin / Yang, Yulong / Liu, Yarong / Shi, Xiaoyan / Wu, Hongfei / Dai, Min

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 126, Page(s) 155447

Abstract: Backgroud: High comorbidity rates have been reported in patients with atherosclerosis and osteoporosis, posing a serious risk to the health and well-being of elderly patients. To improve and update clinical practice regarding the joint treatment of ... ...

Abstract	Backgroud: High comorbidity rates have been reported in patients with atherosclerosis and osteoporosis, posing a serious risk to the health and well-being of elderly patients. To improve and update clinical practice regarding the joint treatment of these two diseases, the common mechanisms of atherosclerosis and osteoporosis need to be clarified. MicroRNAs (miRNAs), are importance molecules in the pathogenesis of human diseases, including in cardiovascular and orthopedic fields. They have garnered interest as potential targets for novel therapeutic strategies. However, the key miRNAs involved in atherosclerosis and osteoporosis and their precise regulation mechanisms remain unknown. Paeonol (Pae), an active ingredient in Cortex Moutan, has shown promising results in improving both lipid and bone metabolic abnormalities. However, it is uncertain whether this agent can exert a cotherapeutic effect on atherosclerosis and osteoporosis. Objective: This study aimed to screen important shared miRNAs in atherosclerotic and osteoporotic complications, and explore the mechanism of the protective effects of Pae against atherosclerosis and osteoporosis in high-fat diet (HFD)-fed ApoE Methods: An experimental atherosclerosis and osteoporosis model was established in 40-week-old HFD ApoE Results: miR let-7g identified using bioinformatics was assessed to evaluate its participation in atherosclerosis-osteoporosis. Experimental analysis showed reduced miR let-7g levels in the atherosclerosis-osteoporosis mice model. Moreover, miR let-7g was required for BMSC - Raw 264.7 cell crosstalk, thereby promoting foam cell formation and adipocyte differentiation. Treatment with Pae significantly reduced plaque accumulation and foam cell number in the aorta while increasing bone density and improving trabecular bone microarchitecture in HFD ApoE Conclusion: The study results suggested that miR let-7g participates in atherosclerosis -osteoporosis regulation and that Pae acts as a potential therapeutic agent for preventing atherosclerosis-osteoporosis through regulatory effects on the miR let-7g/HMGA2/CEBPβ pathway to hinder foam cell formation and adipocyte differentiation.
MeSH term(s)	Humans ; Animals ; Mice ; Aged ; Foam Cells ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Cell Differentiation ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Apolipoproteins E/genetics ; Acetophenones
Chemical Substances	paeonol (3R834EPI82) ; MicroRNAs ; Apolipoproteins E ; Acetophenones
Language	English
Publishing date	2024-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155447
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Article ; Online: Metallophilic Interactions Drive Supramolecular Chirality Evolution and Amplify Circularly Polarized Luminescence.

Wang, Ya-Jie / Shi, Xiao-Yan / Xing, Pengyao / Zang, Shuang-Quan

JACS Au

2023 Volume 3, Issue 2, Page(s) 565–574

Abstract: Metallophilic interactions, which are ubiquitous among ... ...

Abstract	Metallophilic interactions, which are ubiquitous among d
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.2c00653
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Article: Effect of PDCA circulation nursing intervention on prognosis of patients with severe pneumonia.

Bai, Ling / Yang, Likun / Shi, Xiaoyan / Huang, Wan

American journal of translational research

2022 Volume 14, Issue 1, Page(s) 252–263

Abstract: Objectives: To investigate the effect of a new nursing method combining Plan-Do-Check-Act (PDCA) circulation management and nursing on the prognosis of patients with severe pneumonia.: Methods: The clinical records of 98 patients treated in the ... ...

Abstract	Objectives: To investigate the effect of a new nursing method combining Plan-Do-Check-Act (PDCA) circulation management and nursing on the prognosis of patients with severe pneumonia. Methods: The clinical records of 98 patients treated in the Second Affiliated Hospital of Xi'an Jiaotong University from January 2019 to January 2021 were retrospectively analyzed. Patients were divided into the control group (n=49) and the PDCA group (n=49), which were intervened by routine nursing and PDCA nursing based on routine nursing, respectively, by the same group of nursing staff. Results: After PDCA care, the nutritional status (body weight; total protein, TP; albumin, ALB) and immune function (immunoglobulin A, IgA; immunoglobulin G, IgG) in the PDCA group were significantly higher than those in the control group. Compared with routine nursing, PDCA care significantly increased the levels of PaO Conclusions: PDCA care can effectively improve the nursing quality and patients' satisfaction, and better alleviate patients' poor psychological emotions, which is conducive to building a harmonious doctor-patient relationship.
Language	English
Publishing date	2022-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Metal-Organic Framework-Derived NiSe Embedded into a Porous Multi-Heteroatom Self-Doped Carbon Matrix as a Promising Anode for Sodium-Ion Battery.

Shi, Xiaoyan / Fang, Lujun / Peng, Handong / Deng, Xizhan / Sun, Zhipeng

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 19

Abstract: A self-doping strategy is applied to prepare a multi-heteroatom-doped carbonaceous nickel selenide NiSe@C composite by introducing N and P-containing ligand hexa(4-carboxyl-phenoxy)-cyclotriphosphazene (HCTP-COOH) into a Ni-based MOF precursor. The MOF- ... ...

Abstract	A self-doping strategy is applied to prepare a multi-heteroatom-doped carbonaceous nickel selenide NiSe@C composite by introducing N and P-containing ligand hexa(4-carboxyl-phenoxy)-cyclotriphosphazene (HCTP-COOH) into a Ni-based MOF precursor. The MOF-derived NiSe@C composite is characterized as NiSe particles nested in a multi-heteroatom-doped carbon matrix. The multi-heteroatom-doped NiSe@C composite with a unique structure shows an excellent sodium-ion storage property. The Na-ion battery from the NiSe@C electrode exhibits a capacity of 447.8 mA h g
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12193345
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Article: Research Progress on Radiotherapy Combined with Immunotherapy for Associated Pneumonitis During Treatment of Non-Small Cell Lung Cancer.

Zhang, Anqi / Yang, Fuyuan / Gao, Lei / Shi, Xiaoyan / Yang, Jiyuan

Cancer management and research

2022 Volume 14, Page(s) 2469–2483

Abstract: Radiation pneumonitis is a common and serious complication of radiotherapy for thoracic tumours. Although radiotherapy technology is constantly improving, the incidence of radiation pneumonitis is still not low, and severe cases can be life-threatening. ... ...

Abstract	Radiation pneumonitis is a common and serious complication of radiotherapy for thoracic tumours. Although radiotherapy technology is constantly improving, the incidence of radiation pneumonitis is still not low, and severe cases can be life-threatening. Once radiation pneumonitis develops into radiation fibrosis (RF), it will have irreversible consequences, so it is particularly important to prevent the occurrence and development of radiation pneumonitis. Immune checkpoint inhibitors (ICIs) have rapidly altered the treatment landscape for multiple tumour types, providing unprecedented survival in some patients, especially for the treatment of non-small cell lung cancer (NSCLC). However, in addition to its remarkable curative effect, ICls may cause immune-related adverse events. The incidence of checkpoint inhibitor pneumonitis (CIP) is 3% to 5%, and its mortality rate is 10% to 17%. In addition, the incidence of CIP in NSCLC is higher than in other tumour types, reaching 7%-13%. With the increasing use of immune checkpoint inhibitors (ICls) and thoracic radiotherapy in the treatment of patients with NSCLC, ICIs may induce delayed radiation pneumonitis in patients previously treated with radiation therapy, or radiation activation of the systemic immune system increases the toxicity of adverse reactions, which may lead to increased pulmonary toxicity and the incidence of pneumonitis. In this paper, the data about the occurrence of radiation pneumonitis, immune pneumonitis, and combined treatment and the latest related research results will be reviewed.
Language	English
Publishing date	2022-08-13
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S374648
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