LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 66

Search options

  1. Book ; Online: A Privacy-preserving Distributed Training Framework for Cooperative Multi-agent Deep Reinforcement Learning

    Shi, Yimin

    2021  

    Abstract: Deep Reinforcement Learning (DRL) sometimes needs a large amount of data to converge in the training procedure and in some cases, each action of the agent may produce regret. This barrier naturally motivates different data sets or environment owners to ... ...

    Abstract Deep Reinforcement Learning (DRL) sometimes needs a large amount of data to converge in the training procedure and in some cases, each action of the agent may produce regret. This barrier naturally motivates different data sets or environment owners to cooperate to share their knowledge and train their agents more efficiently. However, it raises privacy concerns if we directly merge the raw data from different owners. To solve this problem, we proposed a new Deep Neural Network (DNN) architecture with both global NN and local NN, and a distributed training framework. We allow the global weights to be updated by all the collaborator agents while the local weights are only updated by the agent they belong to. In this way, we hope the global weighs can share the common knowledge among these collaborators while the local NN can keep the specialized properties and ensure the agent to be compatible with its specific environment. Experiments show that the framework can efficiently help agents in the same or similar environments to collaborate in their training process and gain a higher convergence rate and better performance.
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2021-09-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Inference for Inverse Power Lomax Distribution with Progressive First-Failure Censoring.

    Shi, Xiaolin / Shi, Yimin

    Entropy (Basel, Switzerland)

    2021  Volume 23, Issue 9

    Abstract: This paper investigates the statistical inference of inverse power Lomax distribution parameters under progressive first-failure censored samples. The maximum likelihood estimates (MLEs) and the asymptotic confidence intervals are derived based on the ... ...

    Abstract This paper investigates the statistical inference of inverse power Lomax distribution parameters under progressive first-failure censored samples. The maximum likelihood estimates (MLEs) and the asymptotic confidence intervals are derived based on the iterative procedure and asymptotic normality theory of MLEs, respectively. Bayesian estimates of the parameters under squared error loss and generalized entropy loss function are obtained using independent gamma priors. For Bayesian computation, Tierney-Kadane's approximation method is used. In addition, the highest posterior credible intervals of the parameters are constructed based on the importance sampling procedure. A Monte Carlo simulation study is carried out to compare the behavior of various estimates developed in this paper. Finally, a real data set is analyzed for illustration purposes.
    Language English
    Publishing date 2021-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e23091099
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Statistical Analysis for Competing Risks' Model with Two Dependent Failure Modes from Marshall-Olkin Bivariate Gompertz Distribution.

    Wu, Min / Zhang, Fode / Shi, Yimin / Wang, Yan

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 3988225

    Abstract: The bivariate or multivariate distribution can be used to account for the dependence structure between different failure modes. This paper considers two dependent competing failure modes from Gompertz distribution, and the dependence structure of these ... ...

    Abstract The bivariate or multivariate distribution can be used to account for the dependence structure between different failure modes. This paper considers two dependent competing failure modes from Gompertz distribution, and the dependence structure of these two failure modes is handled by the Marshall-Olkin bivariate distribution. We obtain the maximum likelihood estimates (MLEs) based on classical likelihood theory and the associated bootstrap confidence intervals (CIs). The posterior density function based on the conjugate prior and noninformative (Jeffreys and Reference) priors are studied; we obtain the Bayesian estimates in explicit forms and construct the associated highest posterior density (HPD) CIs. The performance of the proposed methods is assessed by numerical illustration.
    MeSH term(s) Bayes Theorem ; Likelihood Functions ; Models, Statistical ; Research Design
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/3988225
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Evidential Estimation of an Uncertain Mixed Exponential Distribution under Progressive Censoring.

    Zhou, Kuang / Shi, Yimin

    Entropy (Basel, Switzerland)

    2020  Volume 22, Issue 10

    Abstract: In this paper, the evidential estimation method for the parameters of the mixed exponential distribution is considered when a sample is obtained from Type-II progressively censored data. Different from the traditional statistical inference methods for ... ...

    Abstract In this paper, the evidential estimation method for the parameters of the mixed exponential distribution is considered when a sample is obtained from Type-II progressively censored data. Different from the traditional statistical inference methods for censored data from mixture models, here we consider a very general form where there is some uncertain information about the sub-class labels of units. The partially specified label information, as well as the censored data are represented in a united frame by mass functions within the theory of belief functions. Following that, the evidential likelihood function is derived based on the completely observed failures and the uncertain information included in the data. Then, the optimization method using the evidential expectation maximization algorithm (E2M) is introduced. A general form of the maximal likelihood estimates (MLEs) in the sense of the evidential likelihood, named maximal evidential likelihood estimates (MELEs), can be obtained. Finally, some Monte Carlo simulations are conducted. The results show that the proposed estimation method can incorporate more information than traditional EM algorithms, and this confirms the interest in using uncertain labels for the censored data from finite mixture models.
    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e22101106
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Volatile carbonyl metabolites analysis of nanoparticle exposed lung cells in an organ-on-a-chip system.

    Liu, Jinlong / Qin, Meiyan / Shi, Yimin / Jiang, Rui / Wang, Zizhen / Zhang, Lingqian / Zhao, Yang / Gao, Hang / Li, Mingxiao / Huang, Chengjun

    Talanta

    2024  Volume 274, Page(s) 126066

    Abstract: The evaluation of nanoparticles (NPs) cytotoxicity is crucial for advancing nanotechnology and assessing environmental pollution. However, existing methods for NPs cytotoxicity evaluation suffer from limited accuracy and inadequate information content. ... ...

    Abstract The evaluation of nanoparticles (NPs) cytotoxicity is crucial for advancing nanotechnology and assessing environmental pollution. However, existing methods for NPs cytotoxicity evaluation suffer from limited accuracy and inadequate information content. In the study, we developed a novel detection platform that enables the identification of cellular carbonyl metabolites at the organ level. The platform is integrated with a cell co-culture lung organ chip (LOC) and a micropillar concentrator. Notably, our work represents the successful measurement of the amounts of cellular metabolites on LOC system. The volatile carbonyl metabolites (VCMs) generated by cells exposure to various types of NPs with different concentrations were captured and detected by high-resolution mass spectrometry (MS). Compared with conventional cell viability and reactive oxygen species (ROS) analysis, our method discerns the toxicological impact of NPs at low concentrations by analyzed VCM at levels as low as ppb level. The LOC system based metabolic gas detection confirmed that low concentrations of NPs have a toxic effect on the cell model, which was not reflected in the fluorescence detection, and the effect of NP material is more significant than the size effect. Furthermore, this method can distinguish different NPs acting on cell models through cluster analysis of multiple VCMs.
    MeSH term(s) Humans ; Lab-On-A-Chip Devices ; Lung/cytology ; Lung/metabolism ; Lung/drug effects ; Volatile Organic Compounds/analysis ; Volatile Organic Compounds/metabolism ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Cell Survival/drug effects ; A549 Cells ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/analysis ; Microphysiological Systems
    Chemical Substances Volatile Organic Compounds ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.126066
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Estimation for Entropy and Parameters of Generalized Bilal Distribution under Adaptive Type II Progressive Hybrid Censoring Scheme.

    Shi, Xiaolin / Shi, Yimin / Zhou, Kuang

    Entropy (Basel, Switzerland)

    2021  Volume 23, Issue 2

    Abstract: Entropy measures the uncertainty associated with a random variable. It has important applications in cybernetics, probability theory, astrophysics, life sciences and other fields. Recently, many authors focused on the estimation of entropy with different ...

    Abstract Entropy measures the uncertainty associated with a random variable. It has important applications in cybernetics, probability theory, astrophysics, life sciences and other fields. Recently, many authors focused on the estimation of entropy with different life distributions. However, the estimation of entropy for the generalized Bilal (GB) distribution has not yet been involved. In this paper, we consider the estimation of the entropy and the parameters with GB distribution based on adaptive Type-II progressive hybrid censored data. Maximum likelihood estimation of the entropy and the parameters are obtained using the Newton-Raphson iteration method. Bayesian estimations under different loss functions are provided with the help of Lindley's approximation. The approximate confidence interval and the Bayesian credible interval of the parameters and entropy are obtained by using the delta and Markov chain Monte Carlo (MCMC) methods, respectively. Monte Carlo simulation studies are carried out to observe the performances of the different point and interval estimations. Finally, a real data set has been analyzed for illustrative purposes.
    Language English
    Publishing date 2021-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e23020206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Magnetic Resonance Thermometry-Guided Laser Interstitial Thermal Therapy in Neurosurgery, a Promising Tool for Dural-Based Lesions?

    Shi, Yimin / Mao, Ying

    World neurosurgery

    2017  Volume 98, Page(s) 836–838

    MeSH term(s) Humans ; Hyperthermia, Induced ; Laser Therapy ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Neurosurgery ; Neurosurgical Procedures
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.11.063
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-

    He, Jiaxin / Cui, Jialin / Shi, Yimin / Wang, Tao / Xin, Junyan / Li, Yimeng / Shan, Xiaomeng / Zhu, Zhiyao / Gao, Yanbin

    Journal of diabetes research

    2023  Volume 2023, Page(s) 7423661

    Abstract: Objective: Deficiencies in klotho are implicated in various kidney dysfunctions including diabetic nephropathy (DN) related to inflammatory responses. Klotho is closely related to inflammatory responses and is a potential target for ameliorating kidney ... ...

    Abstract Objective: Deficiencies in klotho are implicated in various kidney dysfunctions including diabetic nephropathy (DN) related to inflammatory responses. Klotho is closely related to inflammatory responses and is a potential target for ameliorating kidney failure. Pyroptosis, an inflammatory form of programmed cell death, is reported to take part in DN pathogenesis recently. This study is aimed at exploring whether and how klotho inhibited podocyte pyroptosis and whether astragaloside IV (AS-IV) protect podocyte through the regulation of klotho.
    Materials and methods: SD rat model of DN and conditionally immortalized mouse podocytes exposed to high glucose were treated with AS-IV. Biochemical assays and morphological examination, cell viability assay, cell transfection, phalloidin staining, ELISA, LDH release assay, SOD and MDA detection, MMP assay, ROS level detection, flow cytometry analysis, TUNEL staining assay, PI/Hoechst 33342 staining, immunofluorescence assay, and western blot were performed to elucidate podocyte pyroptosis and to observe the renal morphology.
    Results: The treatment of AS-IV can improve renal function and protect podocytes exposed to high glucose. Klotho was decreased, and AS-IV increased klotho levels in serum and kidney tissue of DN rats as well as podocytes exposed to high glucose. AS-IV can inhibit DN glomeruli pyroptosis
    Conclusion: Altogether, our results demonstrate that the protective effect of AS-IV in upregulating klotho expression in diabetes-induced podocyte injury is associated with the inhibition of NLRP3-mediated pyroptosis via the NF-
    MeSH term(s) Rats ; Mice ; Animals ; NF-kappa B/metabolism ; Diabetic Nephropathies/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism ; Rats, Sprague-Dawley ; Glucose/pharmacology ; Glucose/metabolism ; Podocytes/metabolism ; Inflammasomes/metabolism ; Diabetes Mellitus/metabolism
    Chemical Substances NF-kappa B ; astragaloside A (3A592W8XKE) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; Glucose (IY9XDZ35W2) ; Inflammasomes ; Nlrp3 protein, mouse ; Nlrp3 protein, rat
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2023/7423661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Volatile compounds in perianth and corona of Narcissus Pseudonarcissus cultivars

    Li, Xi / Tang, Dongqin / Shi, Yimin

    Natural product research. 2019 Aug. 3, v. 33, no. 15

    2019  

    Abstract: Narcissus pseudonarcissus (daffodil) is a valuable plant for the cosmetic, pharmaceutical and therapeutical traits. The flower volatile compounds (FVCs) of ten Narcissus pseudonarcissus cultivars were analyzed by Headspace/Solid Phase Micro Extraction- ... ...

    Abstract Narcissus pseudonarcissus (daffodil) is a valuable plant for the cosmetic, pharmaceutical and therapeutical traits. The flower volatile compounds (FVCs) of ten Narcissus pseudonarcissus cultivars were analyzed by Headspace/Solid Phase Micro Extraction-Gas Chromatography Mass Spectrometry (HS/SPME- GC/MS). 69 and 73 FVCs were detected in perianth and corona of the ten cultivars. The compounds are largely comprised of monoterpenes, sesquiterpene, benzenoid compounds and other minor compounds classes. Monoterpenes were major component among the FVCs, with beta-ocimene and beta-myrcene as the two major compounds in most perianths and coronas. The composition and content of the FVCs of different cultivars are quite different from each other.
    Keywords Narcissus pseudonarcissus ; beta-ocimene ; cultivars ; gas chromatography-mass spectrometry ; headspace analysis ; myrcene ; perianth ; sesquiterpenoids ; solid phase microextraction ; volatile compounds
    Language English
    Dates of publication 2019-0803
    Size p. 2281-2284.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2018.1499632
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  10. Article: Permissible noninformative priors for the accelerated life test model with censored data.

    Zhang, Fode / Shi, Yimin

    SpringerPlus

    2016  Volume 5, Page(s) 366

    Abstract: In this paper, the Jeffreys priors for the step-stress partially accelerated life test with Type-II adaptive progressive hybrid censoring scheme data are considered. Given a density function family satisfied certain regularity conditions, the Fisher ... ...

    Abstract In this paper, the Jeffreys priors for the step-stress partially accelerated life test with Type-II adaptive progressive hybrid censoring scheme data are considered. Given a density function family satisfied certain regularity conditions, the Fisher information matrix and Jeffreys priors are obtained. Taking the Weibull distribution as an example, the Jeffreys priors, posterior analysis and its permissibility are discussed. The results, which present that how the accelerated stress levels, censored size, hybrid censoring time and stress change time etc. affect the Jeffreys priors, are obtained. In addition, a theorem which shows there exists a relationship between single observation and multi observations for permissible priors is proved. Finally, using Metroplis with in Gibbs sampling algorithm, these factors are confirmed by computing the frequentist coverage probabilities.
    Language English
    Publishing date 2016-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661116-8
    ISSN 2193-1801
    ISSN 2193-1801
    DOI 10.1186/s40064-016-2004-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top