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  1. Article ; Online: Use of serum KL-6 and chest radiographic severity grade to predict 28-day mortality in COVID-19 patients with pneumonia: a retrospective cohort study.

    Zou, Jing / Shi, Yiping / Xue, Shan / Jiang, Handong

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 187

    Abstract: Background: Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. Therefore, the aim of this study was ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. Therefore, the aim of this study was to develop a simple nomogram model to categorize patients who might have a poor short-term outcome.
    Methods: A retrospective cohort study of 189 COVID-19 patients was performed at Shanghai Ren Ji Hospital from December 12, 2022 to February 28, 2023. Chest radiography and biomarkers, including KL-6 were assessed. Risk factors of 28-day mortality were selected by a Cox regression model. A nomogram was developed based on selected variables by SMOTE strategy. The predictive performance of the derived nomogram was evaluated by calibration curve.
    Results: In total, 173 patients were enrolled in this study. The 28-day mortality event occurred in 41 inpatients (23.7%). Serum KL-6 and radiological severity grade (RSG) were selected as the final risk factors. A nomogram model was developed based on KL-6 and RSG. The calibration curve suggested that the nomogram model might have potential clinical value. The AUCs for serum KL-6, RSG, and the combined score in the development group and validation group were 0.885 (95% CI: 0.804-0.952), 0.818 (95% CI: 0.711-0.899), 0.868 (95% CI: 0.776-0.942) and 0.932 (95% CI: 0.862-0.997), respectively.
    Conclusions: Our results suggested that the nomogram based on KL-6 and RSG might be a potential method for evaluating 28-day mortality in COVID-19 patients. A high combined score might indicate a poor outcome in COVID-19 patients with pneumonia.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; China/epidemiology ; Radiography
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-024-02992-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension.

    Shan, Ruohan / Zhang, Yuxiang / Shi, Yiping / Wang, Xiaowen / Wang, Xueke / Ma, Guanying / Li, Qian

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Background: Studies have shown that the chronic use of cannabis is associated with a decrease in blood pressure. Our previous studies prove that activating the cannabinoid type 2 (CB2) receptor in the brain can effectively reduce blood pressure in ... ...

    Abstract Background: Studies have shown that the chronic use of cannabis is associated with a decrease in blood pressure. Our previous studies prove that activating the cannabinoid type 2 (CB2) receptor in the brain can effectively reduce blood pressure in spontaneously hypertensive rats; however, the exact mechanism has not been clarified. The objective of this study is to demonstrate that activation of microglial CB2 receptors can effectively reduce the levels of TNF-α, IL-1β, and IL-6 in the paraventricular nucleus (PVN) through inhibiting aerobic glycolysis, thereby relieving hypertension.
    Methods: AngiotensinII (AngII) was administered to BV2 cells and C57 mice to induce hypertension and the release of proinflammatory cytokines. The mRNA and protein expression of the CB2 receptor, TNF-α, IL-1β, IL-6, and the PFK and LDHa enzymes were detected using RT-qPCR and Western blotting. The Seahorse XF Energy Metabolism Analyzer was used to measure the oxidative phosphorylation and aerobic glycolysis metabolic pathways in BV2 cells. The long-term effects of injecting JWH133, a selective CB2 receptor agonist, intraperitoneally on blood pressure were ascertained. ELISA was used to measure norepinephrine and lactic acid levels while immunofluorescence labeling was used to locate the CB2 receptor and c-Fos. By injecting pAAV-F4/80-GFP-mir30shRNA (AAV2-r-CB2shRNA) into the lateral cerebral ventricle, the CB2 receptor in microglia was specifically knocked down.
    Results: Activation of CB2 receptors by the agonist JWH133 suppressed TNF-α, IL-1β, and IL-6 by inhibiting PFK and LDHa enzymes involved in glycolysis, as well as lactic acid accumulation, along with a reduction in glycoPER levels (marks of aerobic glycolysis) in AngII-treated BV2 cells. In AngII-treated mice, the administration of JWH133 specifically activated CB2 receptors on microglia, resulting in decreased expression levels of PFK, LDHa, TNF-α, IL-1β, and IL-6, subsequently leading to a decrease in c-Fos protein expression within PVN neurons as well as reduced norepinephrine levels in plasma, ultimately contributing to blood pressure reduction.
    Conclusion: The results suggest that activation of the microglia CB2 receptor decreases the neuroinflammation to relieve hypertension; the underlying mechanism is related to inhibiting aerobic glycolysis of microglia.
    MeSH term(s) Rats ; Mice ; Animals ; Neuroinflammatory Diseases ; Tumor Necrosis Factor-alpha/metabolism ; Microglia/metabolism ; Interleukin-6/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Cannabinoids/pharmacology ; Cannabinoid Receptor Agonists/pharmacology ; Rats, Inbred SHR ; Hypertension/drug therapy ; Hypertension/metabolism ; Glycolysis ; Lactic Acid/metabolism ; Norepinephrine/metabolism
    Chemical Substances 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC (TDG8048RDA) ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Receptor, Cannabinoid, CB2 ; Cannabinoids ; Cannabinoid Receptor Agonists ; Lactic Acid (33X04XA5AT) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis.

    Yang, Zhenke / Wang, Jinghui / Qi, Yiming / Shi, Yiping / Li, Fakun / Wang, Weijuan / Tian, Xiaowei / Mei, Xuefang / Zhang, Zhenchao / Wang, Shuai

    Parasites & vectors

    2024  Volume 17, Issue 1, Page(s) 14

    Abstract: Background: Trichomonas vaginalis is a protozoan parasite, widely recognized as the most prevalent non-viral sexually transmitted infection (STI) globally. This infection is linked to various complications, including pelvic inflammatory disease, adverse ...

    Abstract Background: Trichomonas vaginalis is a protozoan parasite, widely recognized as the most prevalent non-viral sexually transmitted infection (STI) globally. This infection is linked to various complications, including pelvic inflammatory disease, adverse pregnancy outcomes, and an increased risk of acquiring HIV. Current molecular detection methods for T. vaginalis are often costly and technically challenging.
    Methods: We developed a novel detection method for T. vaginalis using a multi-enzyme isothermal rapid amplification-clustered regularly interspaced short palindromic repeats (MIRA-CRISPR)/Cas13a-lateral flow device (LFD). This assay targets the repeated DNA sequence (GenBank: L23861.1) of T. vaginalis and is performed at a constant temperature of 37 °C for approximately 1 hour.
    Results: The detection limit of genomic DNA (gDNA) using our protocol was 1 × 10
    Conclusions: The MIRA-CRISPR/Cas13a-LFD method is a convenient, rapid, stable, and accurate diagnostic tool for detecting T. vaginalis. This method has the potential to enhance the diagnosis and management of vaginitis, offering a significant improvement over existing diagnostic techniques.
    MeSH term(s) Animals ; Female ; Pregnancy ; Base Sequence ; Trichomonas vaginalis/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; DNA ; Trichomonas Infections ; Escherichia coli
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-023-06106-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Photosynthetic characteristics of

    Shi, Yi-Ping / Song, Yan-Tao / Namuhan / Peng, Qing-Tian / Lyu, Lin-You / Shen, Yue / Qian, Na / Wu, Yun-Na

    Ying yong sheng tai xue bao = The journal of applied ecology

    2023  Volume 34, Issue 10, Page(s) 2655–2662

    Abstract: To explore the effect of monoculture and mixture sowing artificial grassland on the photosynthetic characteristics ... ...

    Title translation 羊草和紫花苜蓿人工草地光合特性.
    Abstract To explore the effect of monoculture and mixture sowing artificial grassland on the photosynthetic characteristics of
    MeSH term(s) Medicago sativa ; Carbon Dioxide ; Grassland ; Photosynthesis/physiology ; Poaceae ; Plant Leaves/physiology ; Water ; Nitrogen
    Chemical Substances Carbon Dioxide (142M471B3J) ; Water (059QF0KO0R) ; Nitrogen (N762921K75)
    Language Chinese
    Publishing date 2023-10-28
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202310.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Use of

    Shi, Yiping / Xu, Lian / Zhu, Yinjie / Wang, Yining / Chen, Ruohua / Liu, Jianjun

    Frontiers in oncology

    2021  Volume 11, Page(s) 646110

    Abstract: Purpose: Differentiating lymph node metastases (LNM) from peripheral ganglia by physiological prostate-specific membrane antigen (PSMA) uptake is challenging. Two tracers (: Methods: Dual : Results: PSMA-11-positive ganglia (n = 381) and LNM (n = ... ...

    Abstract Purpose: Differentiating lymph node metastases (LNM) from peripheral ganglia by physiological prostate-specific membrane antigen (PSMA) uptake is challenging. Two tracers (
    Methods: Dual
    Results: PSMA-11-positive ganglia (n = 381) and LNM (n = 83) were identified in 138 and 58 patients, respectively. The LNM SUVmax of PSMA-11-PET (16.4 ± 14.8 vs 2.3 ± 0.7,
    Conclusion: The FDG-PET and PSMA-11-PET SUVmax, especially when combined, could well differentiate LNM from ganglia. The tracers uptake differed between cervical/coeliac and sacral ganglia, so the lesion location should be considered during image assessment.
    Language English
    Publishing date 2021-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.646110
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  6. Article ; Online: Diagnostic value of

    Chen, Ruohua / Wang, Yining / Shi, Yiping / Zhu, Yinjie / Xu, Lian / Huang, Gang / Liu, Jianjun

    European journal of nuclear medicine and molecular imaging

    2021  Volume 48, Issue 9, Page(s) 2970–2977

    Abstract: Purpose: 68: Methods: Seventy-two BCR patients with negative : Results: The detection rate of : Conclusion: PSA level and Gleason score are independent predictors ... ...

    Abstract Purpose: 68
    Methods: Seventy-two BCR patients with negative
    Results: The detection rate of
    Conclusion: PSA level and Gleason score are independent predictors of
    MeSH term(s) Edetic Acid ; Fluorodeoxyglucose F18 ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Male ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Retrospective Studies
    Chemical Substances Gallium Isotopes ; Gallium Radioisotopes ; gallium 68 PSMA-11 ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Edetic Acid (9G34HU7RV0) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-02-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-021-05221-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
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  7. Article ; Online: The added value of

    Chen, Ruohua / Wang, Yining / Zhu, Yinjie / Shi, Yiping / Xu, Lian / Huang, Gang / Liu, Jianjun

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.262250
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  8. Article ; Online: The Added Value of

    Chen, Ruohua / Wang, Yining / Zhu, Yinjie / Shi, Yiping / Xu, Lian / Huang, Gang / Liu, Jianjun

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 63, Issue 1, Page(s) 69–75

    Abstract: ... ...

    Abstract 68
    MeSH term(s) Gallium Isotopes ; Gallium Radioisotopes
    Chemical Substances Gallium Isotopes ; Gallium Radioisotopes ; gallium 68 PSMA-11
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.262250
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    Zs.MO 328: Show issues

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  9. Article: Experience of Dr. Ding Guangdi in treating chronic enteritis.

    Shi, Yiping

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2007  Volume 27, Issue 2, Page(s) 128–130

    MeSH term(s) Adult ; China ; Chronic Disease/therapy ; Drugs, Chinese Herbal/therapeutic use ; Enteritis/drug therapy ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Medicine, Chinese Traditional/history
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2007-06
    Publishing country China
    Document type Case Reports ; Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603186-9
    ISSN 0254-6272 ; 0255-2922
    ISSN (online) 0254-6272
    ISSN 0255-2922
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  10. Article: Delayed post-diuretic

    Shi, Yiping / Chen, Ruohua / Wang, Yining / Huang, Gan / Xia, Qian / Liu, Jianjun

    Journal of Cancer

    2020  Volume 11, Issue 13, Page(s) 3745–3750

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2020-04-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.44512
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