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  1. Book: Animal metamorphosis

    Shi, Yun-Bo

    (Current topics in developmental biology ; 103)

    2013  

    Author's details ed. by Yun-Bo Shi
    Series title Current topics in developmental biology ; 103
    Collection
    Language English
    Size XVI, 440, [14] S. : Ill.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017588369
    ISBN 978-0-12-385979-2 ; 0-12-385979-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 175 -103- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Life Without Thyroid Hormone Receptor.

    Shi, Yun-Bo

    Endocrinology

    2021  Volume 162, Issue 4

    Abstract: Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but also for animal development. This is particularly true during the neonatal period when T3 levels are high in mammals. Many processes during this postembryonic ... ...

    Abstract Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but also for animal development. This is particularly true during the neonatal period when T3 levels are high in mammals. Many processes during this postembryonic developmental period resemble those during amphibian metamorphosis. Anuran metamorphosis is perhaps the most dramatic developmental process controlled by T3 and affects essentially all organs/tissues, often in an organ autonomous manner. This offers a unique opportunity to study how T3 regulates vertebrate development. Earlier transgenic studies in the pseudo-tetraploid anuran Xenopus laevis revealed that T3 receptors (TRs) are necessary and sufficient for mediating the effects of T3 during metamorphosis. Recent gene knockout studies with gene-editing technologies in the highly related diploid anuran Xenopus tropicalis showed, surprisingly, that TRs are not required for most metamorphic transformations, although tadpoles lacking TRs are stalled at the climax of metamorphosis and eventually die. Analyses of the changes in different organs suggest that removal of TRs enables premature development of many adult tissues, likely due to de-repression of T3-inducible genes, while preventing the degeneration of tadpole-specific tissues, which is possibly responsible for the eventual lethality. Comparison with findings in TR knockout mice suggests both conservation and divergence in TR functions, with the latter likely due to the greatly reduced need, if any, to remove embryo/prenatal-specific tissues during mammalian postembryonic development.
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; Humans ; Mammals/genetics ; Mammals/growth & development ; Mammals/metabolism ; Metamorphosis, Biological ; Receptors, Thyroid Hormone/genetics ; Receptors, Thyroid Hormone/metabolism ; Triiodothyronine/metabolism
    Chemical Substances Receptors, Thyroid Hormone ; Triiodothyronine (06LU7C9H1V)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqab028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis.

    Shi, Yun-Bo / Fu, Liezhen / Tanizaki, Yuta

    Molecular and cellular endocrinology

    2024  Volume 586, Page(s) 112193

    Abstract: Intestinal development takes places in two phases, the initial formation of neonatal (mammals)/larval (anurans) intestine and its subsequent maturation into the adult form. This maturation occurs during postembryonic development when plasma thyroid ... ...

    Abstract Intestinal development takes places in two phases, the initial formation of neonatal (mammals)/larval (anurans) intestine and its subsequent maturation into the adult form. This maturation occurs during postembryonic development when plasma thyroid hormone (T3) level peaks. In anurans such as the highly related Xenopus laevis and Xenopus tropicalis, the larval/tadpole intestine is drastically remodeled from a simple tubular structure to a complex, multi-folded adult organ during T3-dependent metamorphosis. This involved complete degeneration of larval epithelium via programmed cell death and de novo formation of adult epithelium, with concurrent maturation of the muscles and connective tissue. Here, we will summarize our current understanding of the underlying molecular mechanisms, with a focus on more recent genetic and genome-wide studies.
    MeSH term(s) Animals ; Xenopus laevis ; Xenopus/genetics ; Xenopus/metabolism ; Triiodothyronine/metabolism ; Adult Stem Cells ; Gene Expression Regulation, Developmental ; Intestines ; Thyroid Hormones/metabolism ; Metamorphosis, Biological/genetics ; Organogenesis/genetics ; Mammals/metabolism
    Chemical Substances Triiodothyronine (06LU7C9H1V) ; Thyroid Hormones
    Language English
    Publishing date 2024-02-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2024.112193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The 2018 Ming K. Jeang award for excellence in

    Shi, Yun-Bo

    Cell & bioscience

    2019  Volume 9, Page(s) 42

    Abstract: Two research papers, one from a group led by Dr. Haifan Lin of Yale University School of Medicine, New Haven, USA and another from two laboratories led by Drs. Yihong Ye of National Institute of Diabetes and Digestive and Kidney Diseases, National ... ...

    Abstract Two research papers, one from a group led by Dr. Haifan Lin of Yale University School of Medicine, New Haven, USA and another from two laboratories led by Drs. Yihong Ye of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA, and Ting Zhang of Southern University of Science and Technology, Shenzhen, China, respectively, won the 2017 Ming K. Jeang Award for Excellence in
    Language English
    Publishing date 2019-05-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-019-0305-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protein arginine methyltransferase 1 is required for the maintenance of adult small intestinal and colonic epithelial cell homeostasis.

    Peng, Zhaoyi / Bao, Lingyu / Shi, Bingyin / Shi, Yun-Bo

    International journal of biological sciences

    2024  Volume 20, Issue 2, Page(s) 554–568

    Abstract: The vertebrate adult intestinal epithelium has a high self-renewal rate driven by intestinal stem cells (ISCs) in the crypts, which play central roles in maintaining intestinal integrity and homeostasis. However, the underlying mechanisms remain elusive. ...

    Abstract The vertebrate adult intestinal epithelium has a high self-renewal rate driven by intestinal stem cells (ISCs) in the crypts, which play central roles in maintaining intestinal integrity and homeostasis. However, the underlying mechanisms remain elusive. Here we showed that protein arginine methyltransferase 1 (PRMT1), a major arginine methyltransferase that can also function as a transcription co-activator, was highly expressed in the proliferating cells of adult mouse intestinal crypts. Intestinal epithelium-specific knockout of PRMT1, which ablates PRMT1 gene starting during embryogenesis, caused distinct, region-specific effects on small intestine and colon: increasing and decreasing the goblet cell number in the small intestinal and colonic crypts, respectively, leading to elongation of the crypts in small intestine but not colon, while increasing crypt cell proliferation in both regions. We further generated a tamoxifen-inducible intestinal epithelium-specific PRMT1 knockout mouse model and found that tamoxifen-induced knockout of PRMT1 in the adult mice resulted in the same region-specific intestinal phenotypes. Thus, our studies have for the first time revealed that the epigenetic enzyme PRMT1 has distinct, region-specific roles in the maintenance of intestinal epithelial architecture and homeostasis, although PRMT1 may influence intestinal development.
    MeSH term(s) Animals ; Mice ; Arginine ; Cell Proliferation/genetics ; Epithelial Cells/metabolism ; Homeostasis/genetics ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Mice, Knockout ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Tamoxifen
    Chemical Substances Arginine (94ZLA3W45F) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Tamoxifen (094ZI81Y45) ; Prmt1 protein, mouse (EC 2.1.1.319)
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.89958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: Programmed cell death

    Shi, Yun-Bo

    [proceedings of the International Symposium on Programmed Cell Death, held September 8 - 12, 1996 in Shanghai, China]

    1997  

    Event/congress International Symposium on Programmed Cell Death (1996, Schanghai)
    Author's details ed. by Yun-Bo Shi
    Keywords Zelltod
    Language English
    Size VIII, 171 S. : Ill., graph. Darst.
    Publisher Plenum Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    Note Includes bibliographical references and index
    HBZ-ID HT009980426
    ISBN 0-306-45680-x ; 978-0-306-45680-x0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 1819 order for loan Magazin

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  7. Article: Steroid-receptor coactivator complexes in thyroid hormone-regulation of Xenopus metamorphosis.

    Tanizaki, Yuta / Bao, Lingyu / Shi, Yun-Bo

    Vitamins and hormones

    2023  Volume 123, Page(s) 483–502

    Abstract: Anuran metamorphosis is perhaps the most drastic developmental change regulated by thyroid hormone (T3) in vertebrate. It mimics the postembryonic development in mammals when many organs/tissues mature into adult forms and plasma T3 level peaks. T3 ... ...

    Abstract Anuran metamorphosis is perhaps the most drastic developmental change regulated by thyroid hormone (T3) in vertebrate. It mimics the postembryonic development in mammals when many organs/tissues mature into adult forms and plasma T3 level peaks. T3 functions by regulating target gene transcription through T3 receptors (TRs), which can recruit corepressor or coactivator complexes to target genes in the absence or presence of T3, respectively. By using molecular and genetic approaches, we and others have investigated the role of corepressor or coactivator complexes in TR function during the development of two highly related anuran species, the pseudo-tetraploid Xenopus laevis and diploid Xenopus tropicalis. Here we will review some of these studies that demonstrate a critical role of coactivator complexes, particularly those containing steroid receptor coactivator (SRC) 3, in regulating metamorphic rate and ensuring the completion of metamorphosis.
    MeSH term(s) Humans ; Adult ; Animals ; Xenopus laevis ; Xenopus ; Thyroid Hormones ; Co-Repressor Proteins ; Receptors, Steroid ; Steroids ; Mammals
    Chemical Substances Thyroid Hormones ; Co-Repressor Proteins ; Receptors, Steroid ; Steroids
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The 2017 Ming K. Jeang award for excellence in

    Shi, Yun-Bo

    Cell & bioscience

    2018  Volume 8, Page(s) 44

    Abstract: Two research groups led by Dr. Shui Qing Ye of University of Missouri Kansas City School of Medicine, Kansas City, USA and Dr. Dihua Yu of University of Texas MD Anderson Cancer Center, Houston, USA, respectively, won the 2017 Ming K Jeang Award for ... ...

    Abstract Two research groups led by Dr. Shui Qing Ye of University of Missouri Kansas City School of Medicine, Kansas City, USA and Dr. Dihua Yu of University of Texas MD Anderson Cancer Center, Houston, USA, respectively, won the 2017 Ming K Jeang Award for Excellence in
    Language English
    Publishing date 2018-07-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-018-0241-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Thyroid hormone and intestinal tumor: a Wnt connection.

    Shi, Yun-Bo

    Oncotarget

    2018  Volume 9, Issue 62, Page(s) 31941

    Language English
    Publishing date 2018-08-10
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.25822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis.

    Wang, Shouhong / Shi, Yun-Bo

    Cell & bioscience

    2021  Volume 11, Issue 1, Page(s) 71

    Abstract: Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate. Anuran Xenopus laevis has been used as a model to study regeneration as ... ...

    Abstract Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate. Anuran Xenopus laevis has been used as a model to study regeneration as many tadpole organs can regenerate. In particular, the tail, which consists of many axial and paraxial tissues, such as spinal cord, dorsal aorta and muscle, commonly present in vertebrates, can fully regenerate when amputated at late embryonic stages and most of the tadpole stages. Interestingly, between stage 45 when feeding begins to stage 47, the Xenopus laevis tail cannot regenerate after amputation. This period, termed "refractory period", has been known for about 20 years. The underlying molecular and genetic basis is unclear in part due to the difficult to carry out genetic studies in this pseudo-tetraploid species. Here we compared tail regeneration between Xenopus laevis and the highly related diploid anuran Xenopus tropicalis and found surprisingly that Xenopus tropicalis lacks the refractory period. Further molecular and genetic studies, more feasible in this diploid species, should reveal the basis for this evolutionary divergence in tail regeneration between two related species and facilitate the understanding how tissue regenerative capacity is controlled, thus with important implications for human regenerative medicine.
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Letter
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-021-00582-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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