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Article ; Online: Clinical features and biomarker differences of severe intrinsic and extrinsic atopic dermatitis.

Liu, Zhong / Shi, Zeqi / Deng, Yunhua

2024 Volume 43, Issue 1, Page(s) 97–103

Abstract: Objectives: Atopic dermatitis (AD) can be classified into intrinsic AD(IAD) and extrinsic AD(EAD). However, the differences in clinical features and pathogenesis between these two subtypes of AD are currently unclear. This study aimed to analyse the ... ...

Abstract	Objectives: Atopic dermatitis (AD) can be classified into intrinsic AD(IAD) and extrinsic AD(EAD). However, the differences in clinical features and pathogenesis between these two subtypes of AD are currently unclear. This study aimed to analyse the differences in clinical features and peripheral blood biomarkers between Chinese patients with severe IAD and EAD in order to elucidate the physiopathogenesis of AD. Materials and methods: A total of 316 hospitalised patients definitively diagnosed with severe AD were included in this study. There were 72 cases of severe IAD and 244 cases of severe EAD. The clinical features of the patients were recorded in details. Serum total IgE, IgA, IgG, IgM, complementC3/C4, peripheral blood cell counts, lactate dehydrogenase (LDH), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IL-2R, IL-6, IL-8, and TNF-α in AD patients and 60 age-matched healthy controls were analysed. IAD and EAD had similar severity/Scoring Atopic Dermatitis (SCORAD) scores. Results: Compared with healthy controls, IAD patients had significantly higher total IgE, eosinophils, monocytes, LDH, CRP, IL-2R, IL-6, IL-8 and TNF-α, and lower IgM and C4. EAD patients had significantly higher total IgE, IgA, eosinophils, white blood cell (WBC) counts, neutrophils, monocytes, basophils, LDH, CRP, IL-2R, IL-6, IL-8, TNF-α and lower IgM than healthy controls. IAD patients had a higher percentage of rural/urban living and female/male, a shorter course of disease and lower total IgE, eosinophils, WBC counts, neutrophils, monocytes, basophils, LDH, IgG and C4 than EAD patients. SCORAD scores, eosinophils, LDH expression levels increased with total IgE uniquely in patients with EAD. Conclusions: IAD and EAD exhibit specific clinical features and molecular changes. IAD has a more complex physiopathogenesis, and deserves further investigation.
MeSH term(s)	Humans ; Male ; Female ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Interleukin-8 ; Immunoglobulin E ; Biomarkers ; C-Reactive Protein ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-6 ; Interleukin-8 ; Immunoglobulin E (37341-29-0) ; Biomarkers ; C-Reactive Protein (9007-41-4) ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.1080/15569527.2023.2300782
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Zs.A 1782: Show issues

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Article ; Online: The role of dermal fibroblasts in autoimmune skin diseases.

Shi, Zeqi / Liu, Zhong / Wei, Yujia / Zhang, Ri / Deng, Yunhua / Li, Dong

Frontiers in immunology

2024 Volume 15, Page(s) 1379490

Abstract: Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various ... ...

Abstract	Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various dermatological conditions such as psoriasis, vitiligo, and atopic dermatitis. Recently, variations in the subtypes of fibroblasts and their expression profiles have been identified in these prevalent autoimmune skin diseases, implying that fibroblasts may exhibit distinct functionalities across different diseases. In this review, from the perspective of their fundamental functions and remarkable heterogeneity, we have comprehensively collected evidence on the role of fibroblasts and their distinct subpopulations in psoriasis, vitiligo, atopic dermatitis, and scleroderma. Importantly, these findings hold promise for guiding future research directions and identifying novel therapeutic targets for treating these diseases.
MeSH term(s)	Humans ; Dermatitis, Atopic ; Vitiligo ; Skin ; Psoriasis ; Autoimmune Diseases ; Fibroblasts
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1379490
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Article ; Online: CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators.

Shi, Zeqi / He, Zuowen / Wang, Dao Wen

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 12

Abstract: Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed ... ...

Abstract	Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs), which are merely biologically active. EETs possess a wide range of established protective effects on many systems of which anti-inflammatory actions have gained great interest. EETs attenuate vascular inflammation and remodeling by inhibiting activation of endothelial cells and reducing cross-talk between inflammatory cells and blood vessels. EETs also process direct and indirect anti-inflammatory properties in the myocardium and therefore alleviate inflammatory cardiomyopathy and cardiac remodeling. Moreover, emerging studies show the substantial roles of EETs in relieving inflammation under other pathophysiological environments, such as diabetes, sepsis, lung injuries, neurodegenerative disease, hepatic diseases, kidney injury, and arthritis. Furthermore, pharmacological manipulations of the AA-CYP450-EETs-sEH pathway have demonstrated a contribution to the alleviation of numerous inflammatory diseases, which highlight a therapeutic potential of drugs targeting this pathway. This review summarizes the progress of AA-CYP450-EETs-sEH pathway in regulation of inflammation under different pathological conditions and discusses the existing challenges and future direction of this research field.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Arachidonic Acid/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Eicosanoids/metabolism ; Endothelial Cells/metabolism ; Epoxide Hydrolases/metabolism ; Humans ; Inflammation/drug therapy ; Neurodegenerative Diseases
Chemical Substances	Anti-Inflammatory Agents ; Eicosanoids ; Arachidonic Acid (27YG812J1I) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Epoxide Hydrolases (EC 3.3.2.-)
Language	English
Publishing date	2022-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27123873
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Article ; Online: Exosomal miRNAs in autoimmune skin diseases.

Zhang, Ri / Wei, Yujia / Wang, Tingmei / Nie, Xiaoqi / Shi, Zeqi / Deng, Yunhua / Li, Dong

Frontiers in immunology

2023 Volume 14, Page(s) 1307455

Abstract: Exosomes, bilaterally phospholipid-coated small vesicles, are produced and released by nearly all cells, which comprise diverse biological macromolecules, including proteins, DNA, RNA, and others, that participate in the regulation of their biological ... ...

Abstract	Exosomes, bilaterally phospholipid-coated small vesicles, are produced and released by nearly all cells, which comprise diverse biological macromolecules, including proteins, DNA, RNA, and others, that participate in the regulation of their biological functions. An increasing number of studies have revealed that the contents of exosomes, particularly microRNA(miRNA), play a significant role in the pathogenesis of various diseases, including autoimmune skin diseases. MiRNA is a class of single-stranded non-coding RNA molecules that possess approximately 22 nucleotides in length with the capability of binding to the untranslated as well as coding regions of target mRNA to regulate gene expression precisely at the post-transcriptional level. Various exosomal miRNAs have been found to be significantly expressed in some autoimmune skin diseases and involved in the pathogenesis of conditions via regulating the secretion of crucial pathogenic cytokines and the direction of immune cell differentiation. Thus, exosomal miRNAs might be promising biomarkers for monitoring disease progression, relapse and reflection to treatment based on their functions and changes. This review summarized the current studies on exosomal miRNAs in several common autoimmune skin diseases, aiming to dissect the underlying mechanism from a new perspective, seek novel biomarkers for disease monitoring and lay the foundation for developing innovative target therapy in the future.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Biomarkers/metabolism ; Autoimmune Diseases/genetics ; Autoimmune Diseases/metabolism
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Comment
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1307455
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Article ; Online: 1,25-Dihydroxyvitamin D

Wei, Yujia / Wang, Tingmei / Nie, Xiaoqi / Shi, Zeqi / Liu, Zhong / Zeng, Ying / Pan, Ronghua / Zhang, Ri / Deng, Yunhua / Li, Dong

Nutrients

2023 Volume 15, Issue 21

Abstract: Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic ... ...

Abstract	Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study aimed to elucidate the immunomodulatory effects of 1,25(OH)₂D₃ in vitiligo. Cross-sectional relationships between serum 1,25(OH)₂D₃ levels and disease characteristics were investigated in 327 patients with vitiligo. The immunomodulatory and therapeutic effects of 1,25(OH)₂D₃ were then investigated in vivo and in vitro, respectively. We found that 1,25(OH)₂D₃ deficiency was associated with hyperactivity of CD8+ T cells in the vitiligo cohort. In addition, 1,25(OH)₂D₃ suppressed glycolysis by activating the AMP-activated protein kinase (AMPK) signaling pathway, thereby inhibiting the proliferation, cytotoxicity and aberrant activation of CD8+ T cells. Finally, the in vivo administration of 1,25(OH)₂D₃ to melanocyte-associated vitiligo (MAV) mice reduced the infiltration and function of CD8+ T cells and promoted repigmentation. In conclusion, 1,25(OH)₂D₃ may serve as an essential biomarker of the progression and severity of vitiligo. The modulation of autoreactive CD8+ T cell function and glycolysis by 1,25(OH)₂D₃ may be a novel approach for treating vitiligo.
MeSH term(s)	Humans ; Mice ; Animals ; Vitiligo/drug therapy ; Vitiligo/complications ; Calcitriol/metabolism ; CD8-Positive T-Lymphocytes
Chemical Substances	1,25-dihydroxyvitamin D (66772-14-3) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214697
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Article ; Online: Exosomes containing miR-1469 regulate natural killer cells by targeting CD122 in non-segmental vitiligo.

Wei, Yujia / Zhou, Ting / Pan, Ronghua / Nie, Xiaoqi / Liu, Zhong / Shi, Zeqi / Zeng, Ying / Zhang, Ri / Deng, Yunhua / Li, Dong

Journal of dermatological science

2023 Volume 113, Issue 2, Page(s) 42–50

Abstract: Background: Plasma exosomal microRNAs (miRNAs) have been used as potential biomarkers for various diseases and have been investigated for their possible involvement in the pathogenesis of vitiligo. However, the miRNA expression profile of plasma ... ...

Abstract	Background: Plasma exosomal microRNAs (miRNAs) have been used as potential biomarkers for various diseases and have been investigated for their possible involvement in the pathogenesis of vitiligo. However, the miRNA expression profile of plasma exosomes in patients with non-segmental vitiligo (NSV) has not been determined yet. Objective: To screen differentially expressed microRNAs in plasma exosomes derived from patients with NSV and explore their roles in the pathogenesis of NSV. Methods: High-throughput sequencing was performed to determine the expression profiles of exosomal miRNAs in NSV. The effect of upregulated miR-1469 in NSV circulating exosomes on natural killer (NK) cells was further investigated using various molecular biological techniques. Results: MiR-1469 was identified as a candidate biomarker whose expression was significantly increased in circulating exosomes of NSV patients. Circulating exosomes were internalized by NK cells and increased NK cell proliferation viability and IFN-γ secretion capacity delivering miR-1469. Further studies revealed that the upregulation of CD122, the predicted target of miR-1469, could partially reverse the effect of miR-1469 on natural killer cells. Conclusion: Alterations in plasma exosomal cargo occur in NSV and appear to contribute to NK cell dysfunction. Exosomal miR-1469 may be a biomarker of disease activity and could be used as a therapeutic drug target against innate immunity in NSV patients. The present study provides new insights into the role of exosomal miRNAs in NSV and suggests a novel miR-1469-CD122-IFN-γ pathway of NK cell underlying pathogenesis of NSV.
MeSH term(s)	Humans ; Exosomes/genetics ; Exosomes/metabolism ; Vitiligo/genetics ; Vitiligo/metabolism ; MicroRNAs/metabolism ; Biomarkers/metabolism ; Killer Cells, Natural
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-12-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2023.12.006
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Zs.A 2870: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: [Endogenous protective effects of arachidonic acid epoxygenase metabolites, epoxyeicosatrienoic acids, in cardiovascular system].

He, Zuo-Wen / Wang, Bei / Chen, Chen / Shi, Ze-Qi / Wang, Dao-Wen

Sheng li xue bao : [Acta physiologica Sinica

2021 Volume 73, Issue 4, Page(s) 617–630

Abstract: The morbidity and mortality of cardiovascular diseases are increasing annually, which is one of the primary causes of human death. Recent studies have shown that epoxyeicosatrienoic acids (EETs), endogenous metabolites of arachidonic acid (AA) via CYP450 ...

Abstract	The morbidity and mortality of cardiovascular diseases are increasing annually, which is one of the primary causes of human death. Recent studies have shown that epoxyeicosatrienoic acids (EETs), endogenous metabolites of arachidonic acid (AA) via CYP450 epoxygenase, possess a spectrum of protective properties in cardiovascular system. EETs not only alleviate cardiac remodeling and injury in different pathological models, but also improve subsequent hemodynamic disturbances and cardiac dysfunction. Meanwhile, various studies have demonstrated that EETs, as endothelial-derived hyperpolarizing factors, regulate vascular tone by activating various ion channels on endothelium and smooth muscle, which in turn can lower blood pressure, improve coronary blood flow and regulate pulmonary artery pressure. In addition, EETs are protective in endothelium, including inhibiting inflammation and adhesion of endothelial cells, attenuating platelet aggregation, promoting fibrinolysis and revascularization. EETs can also prevent aortic remodeling, including attenuating atherosclerosis, adventitial remodeling, and aortic calcification. Therefore, it is clinically important to study the physiological and pathophysiological effects of EETs in the cardiovascular system to further elucidate the mechanisms, as well as provide new strategy for the prevention and treatment of cardiovascular diseases. This review summarizes the endogenous cardioprotective effects and mechanisms of EETs in order to provide a new insight for research in this field.
MeSH term(s)	8,11,14-Eicosatrienoic Acid/pharmacology ; Cardiovascular System ; Cytochrome P-450 Enzyme System ; Eicosanoids ; Endothelial Cells ; Humans
Chemical Substances	Eicosanoids ; Cytochrome P-450 Enzyme System (9035-51-2) ; arachidonate epoxygenase (EC 1.14.14.1) ; 8,11,14-Eicosatrienoic Acid (FC398RK06S)
Language	Chinese
Publishing date	2021-08-13
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 386: Show issues

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Article: Hierarchically urchin-like hollow NiCo2S4 prepared by a facile template-free method for high-performance supercapacitors

Shi, Zeqi / Shen, Xuetao / Zhang, Zhe / Wang, Xi / Gao, Ning / Xu, Zhanwei / Chen, Xueying / Liu, Xinyue

Journal of colloid and interface science. 2021 Dec. 15, v. 604

2021

Abstract: Hollow structures draw much attention for high energy density supercapacitors due to their large hollow cavities, high specific surface area, and low interfacial contact resistance. However, constructing hierarchical hollow structures remains a challenge. ...

Abstract	Hollow structures draw much attention for high energy density supercapacitors due to their large hollow cavities, high specific surface area, and low interfacial contact resistance. However, constructing hierarchical hollow structures remains a challenge. Herein, we reported a facile template-free method for a novel urchin-like hollow nickel cobalt sulfide (NiCo₂S₄). The hollow interior and urchin exterior remarkably improved the specific capacitance and accommodated structural collapse caused by electrochemical reactions. Owing to these features, the urchin-like hollow NiCo₂S₄ spheres exhibited an impressive capacitance of 1398F g⁻¹ at 1 A g⁻¹ and maintained 1110F g⁻¹ with a large current density of 10 A g⁻¹. The hybrid supercapacitor fabricated by NiCo₂S₄ and active carbon possesses an energy density of 39.3 Wh kg⁻¹ at a power density of 749.6 W kg⁻¹ and an outstanding cycling stability of 74.4% retention after 5000 cycles. Our work presents a facile method of constructing a hollow structure of binary sulfide materials and also makes progress on highly efficient supercapacitors.
Keywords	capacitance ; carbon ; cobalt sulfide ; electrochemical capacitors ; electrochemistry ; energy density ; nickel ; surface area
Language	English
Dates of publication	2021-1215
Size	p. 292-300.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.06.144
Database	NAL-Catalogue (AGRICOLA)

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Z 71/707: Show issues

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Article: N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function.

Hang, Weijian / Shu, Hongyang / Wen, Zheng / Liu, Jinyan / Jin, Zhiyuan / Shi, Zeqi / Chen, Chen / Wang, Dao Wen

Frontiers in pharmacology

2021 Volume 12, Page(s) 636204

Abstract: Rationale: ...

Abstract	Rationale:
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.636204
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Article ; Online: Hierarchically urchin-like hollow NiCo

Shi, Zeqi / Shen, Xuetao / Zhang, Zhe / Wang, Xi / Gao, Ning / Xu, Zhanwei / Chen, Xueying / Liu, Xinyue

Journal of colloid and interface science

2021 Volume 604, Page(s) 292–300

Abstract	Hollow structures draw much attention for high energy density supercapacitors due to their large hollow cavities, high specific surface area, and low interfacial contact resistance. However, constructing hierarchical hollow structures remains a challenge. Herein, we reported a facile template-free method for a novel urchin-like hollow nickel cobalt sulfide (NiCo
Language	English
Publishing date	2021-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.06.144
Database	MEDical Literature Analysis and Retrieval System OnLINE

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