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Article ; Online: Geocenter Motions Derived from BDS Observations

Xingxing Li / Shi Huang / Yongqiang Yuan / Keke Zhang / Jiaqing Lou

Remote Sensing, Vol 15, Iss 1243, p

Effects of the Solar Radiation Pressure Model and Constellation Configuration

2023 Volume 1243

Abstract: As the first hybrid-constellation global navigation system, China’s BeiDou navigation satellite system (BDS) has been fully constructed since July 2020 and provides open services for worldwide users. Due to the natural sensitivity of satellite tracking ... ...

Abstract	As the first hybrid-constellation global navigation system, China’s BeiDou navigation satellite system (BDS) has been fully constructed since July 2020 and provides open services for worldwide users. Due to the natural sensitivity of satellite tracking techniques to geocenter motion, BDS has the capability to determine the geocenter coordinates (GCC). This study aims to improve the precision of geocenter coordinates derived from BDS. To that end, 3-year sets of daily geocenter coordinates have been determined with BDS observations. Different solar radiation pressure (SRP) models, including the empirical CODE orbit model (ECOM), the extended ECOM model (ECOM2), and the a priori box-wing along with the ECOM model (BW + ECOM), have been applied for the BDS geocenter estimation. We show that the BW + ECOM model is beneficial in recovering the geocenter motion. Compared to the ECOM, the BW + ECOM model appears to mitigate the draconitic signal of BDS, which reduces the annual amplitude of the GCC-Z by a factor of 2.9. On the other hand, the amplitude of the 3 cpy signal is also reduced by a factor of 2.9. Furthermore, we studied the impact of BDS constellation configuration on the geocenter estimation. The results indicate that the inclusion of IGSO satellites significantly mitigates the spurious signals in the spectra of the GCC-Z. The amplitudes of the annual signal and 3 cpy signal are reduced by (28%, 14%), (33%, 61%), and (31%, 9%) for ECOM, ECOM2, and BW + ECOM cases, respectively. Meanwhile, the amplitude of the 7-day signal related to the orbital period of MEO satellites is also reduced by 32–45%. Thus, the BW + ECOM model and the MEO+IGSO hybrid configuration are recommended for BDS to determine the geocenter coordinates. However, despite these improvements, a significant annual signal with an amplitude of 20.2 mm and a visible 3 cpy signal with an amplitude of 6.1 mm still exist when compared to the Satellite Laser Ranging (SLR) solution.
Keywords	geocenter motion ; BDS ; hybrid-constellation ; solar pressure radiation ; Science ; Q
Subject code	551
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison Between Subsidy Policies on Photovoltaic Industry of China and the U.S.

Shi HUANG

International Business and Management, Vol 11, Iss 1, Pp 32-

Based on Three-Stage Sequential Game Models

2015 Volume 40

Abstract: This paper firstly analyzes the effects of China’s and the U.S. subsidy policies through comparing the developing strategies, specific subsidies and industrial conditions. Then by establishing two three-stage sequential game models, the inherent defects ... ...

Abstract	This paper firstly analyzes the effects of China’s and the U.S. subsidy policies through comparing the developing strategies, specific subsidies and industrial conditions. Then by establishing two three-stage sequential game models, the inherent defects of China’s subsidy are studied. Finally the advantages of the U.S. industrial and trade policy portfolio are analyzed to give policy enlightenment. The result shows: China’s export oriented production subsidies could not maximize social welfare in the short term. It was not conductive to the development of core industrial competitiveness because of the extrusion effect of R&D. What’s more, it tended to provoke quick and excess production capacity which led to a large number of low-priced exports, causing trade conflicts and loss of oversea markets. While the U.S. combined regulatory compliant subsidy and trade remedy. Market subsidy increased the demand and helped industry to expand production scale and lower the cost. R&D subsidy encouraged R&D investment and improved industrial competitiveness. Trade remedy was used to prevent foreign low-priced import shocks and guarantee the effectiveness of the two subsidies. To sum up, China shall change the export-oriented development strategy, develop core competitiveness on technology, eliminate unreasonable subsidies, make good use of market subsidy, R&D subsidy and trade remedy measures.
Keywords	Industrial policy ; Subsidy ; Trade remedy ; Photovoltaic ; Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H
Subject code	650
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	Canadian Research & Development Center of Sciences and Cultures
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Comparative Empirical Study on the Macroeconomic Objectives and Effectiveness of Interest Rate Policies of China and U.S.

Shi HUANG

Canadian Social Science, Vol 11, Iss 8, Pp 53-

2015 Volume 58

Abstract: This paper summarizes the relevant literatures about the economic effects of interest rate policy and Taylor rules, on the basis of which macroeconomic objectives indicators of China’s and U.S.’s interest rate policies are come up with. Then the macro- ... ...

Abstract	This paper summarizes the relevant literatures about the economic effects of interest rate policy and Taylor rules, on the basis of which macroeconomic objectives indicators of China’s and U.S.’s interest rate policies are come up with. Then the macro-economic objectives and effectiveness of their interest rate adjustment policies are studied through Granger causality test and multivariate co-integration regression model. The result shows: Firstly, both of China and U.S. take economic growth, price level and employment level into consideration when adjust the benchmark interest rates. China’s adjustment pays more attention to stable price level and promoting employment level, while U.S.’s adjustment focuses more on stimulating economic growth and promoting employment level. Secondly, compared with China, U.S.’s market-oriented interest rate adjustment mechanism is more effective to reflect and respond to changes in the macroeconomic situations. Thirdly, the effectiveness of U.S.’s adjustment is obviously superior to China’s. U.S.’s benchmark interest rate adjustment can significantly affect the economic growth and employment level, and price level to some extent as well; while China’s effectiveness is confined to price level. Therefore, China should accelerate the interest rate liberalization and learn from U.S. to reform the function mechanism of interest rate policy, so as to enhance the interest rate policy on the sensitivity and effectiveness of macro-economy.
Keywords	Interest rate adjustment policy ; Macro-economy ; Economic growth ; Price level ; Employment Level ; Social Sciences ; H ; Social sciences (General) ; H1-99
Subject code	339
Publishing date	2015-08-01T00:00:00Z
Publisher	Canadian Academy of Oriental and Occidental Culture
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Analysis of Key Technologies for Sustainable Machine Tools Design

Chunhua Feng / Shi Huang

Applied Sciences, Vol 10, Iss 3, p

2020 Volume 731

Abstract: Machine tools as indispensable tools for manufacturing products are typical high-energy, high-carbon manufacturing systems due to their larger mass, longer life cycles and huge resources and energy consumption. The current research trend of sustainable ... ...

Abstract	Machine tools as indispensable tools for manufacturing products are typical high-energy, high-carbon manufacturing systems due to their larger mass, longer life cycles and huge resources and energy consumption. The current research trend of sustainable machine tools aims to reduce cost, energy consumption and increase sustainability without compromising their functionality, usability, productivity, accuracy, etc. However, there is a lack of systematic reviews about what are the key technologies for sustainable machine tools design. Thus, a comprehensive literature review of machine tool design for sustainability is needed in order to make clear how to design and evaluate sustainable machine tools from the viewpoint of life cycle sustainability analysis. The aim of this paper is to review the sustainable design and assessment aspects of machine tool design from partial goals to integrated aims according to whole sustainability dimensions such as the environment, economy and society, as well as involving key techniques in different life cycle stages. Recent research and study on improving directly or indirectly sustainability performance of machine tools according to focus points could be summarized as: design optimization of components such as lightweight using topology and bionic methods; structure design with modular design and layout; reducing cutting fluids and lubricant oil by employing minimum quantity lubrication, dry and cryogenic machining; reducing energy consumption; waste reduction by reusing, remanufacturing and recycling; sustainability assessment i.e., energy model, life cycle cost and life cycle social benefit. This paper assists designers and manufacturers to improve sustainability of machine tools by specific optimization measures in their activities.
Keywords	machine tools ; sustainable design ; life cycle ; sustainable manufacturing ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670 ; 690
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolitesResearch in context

Guangqi Gao / Siyuan Shen / Tao Zhang / Jiachao Zhang / Shi Huang / Zhihong Sun / Heping Zhang

EBioMedicine, Vol 91, Iss , Pp 104533- (2023)

2023

Abstract: Summary: Background: Probiotics have been increasingly proposed for enhancing immune checkpoint blockade (ICB) treatments against cancer. However, its causal relationship with immunotherapeutic efficacy remains unclear, which promoted us to explore if ... ...

Abstract	Summary: Background: Probiotics have been increasingly proposed for enhancing immune checkpoint blockade (ICB) treatments against cancer. However, its causal relationship with immunotherapeutic efficacy remains unclear, which promoted us to explore if and how probiotic Lacticaseibacillus rhamnosus Probio-M9 manipulates gut microbiome for expected outcomes. Methods: We evaluated the effects of Probio-M9 on the anti-PD-1 treatment against colorectal cancer in mice via a multi-omics approach. We defined the mechanisms of Probio-M9-mediated antitumor immunity by comprehensive analyses of metagenome and metabolites of commensal gut microbes as well as the immunologic factors and serum metabolome of the host. Findings: The results indicated that Probio-M9 intervention strengthened the anti-PD-1-based tumor inhibition. Both prophylactic and therapeutic administration of Probio-M9 showed conspicuous performance in controlling tumor growth with ICB treatment. The supplement of Probio-M9 modulated enhanced immunotherapy response through promoting beneficial microbes (e.g., Lactobacillus and Bifidobacterium animalis), producing beneficial metabolites including butyric acids in the gut, and accumulating blood-derived α-ketoglutaric acid, N-acetyl-l-glutamic acid and pyridoxine in particular, which promoted the infiltration and activation of cytotoxic T lymphocytes (CTLs) and suppressing the function of regulatory T cells (Tregs) in the tumor microenvironment (TME). Subsequently, we found that enhanced immunotherapeutic response was transmissible by transplanting either post-probiotic-treatment gut microbes or intestinal metabolites to new tumor-bearing mice. Interpretation: This study offered valuable insight into the causal role of Probio-M9 in correcting the defects in gut microbiota that compromised anti-PD-1 therapeutic efficacy, which can be used as an alternative synergetic agent with ICB for clinical cancer treatment. Funding: This research was supported by Research Fund for the National Key R&D Program of China ...
Keywords	Gut microbiota ; Anti-PD-1 ; Probiotics ; Lacticaseibacillus rhamnosus Probio-M9 ; α-ketoglutaric acid ; Synergistic anti-tumor therapeutics ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Xiaoyun Lei / Shi Huang

PLoS ONE, Vol 13, Iss 1, p e

Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population.

2018 Volume 0191210

Abstract: This corrects the article DOI:10.1371/journal.pone.0187644.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pone.0187644.].
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sativene Sesquiterpenoids from the Plant Endophytic Fungus

Wang, Xin-Jia / Wang, Zhe / Han, Jing / Su, Shi-Huang / Gong, Yuan-Xiang / Zhang, Yu / Tan, Ning-Hua / Wang, Jia / Feng, Li

Journal of agricultural and food chemistry

2024 Volume 72, Issue 5, Page(s) 2598–2611

Abstract: Thirteen new sativene sesquiterpenoids ( ...

Abstract	Thirteen new sativene sesquiterpenoids (
MeSH term(s)	Molecular Structure ; Plant Growth Regulators ; Sesquiterpenes/chemistry ; Fungi ; Bipolaris
Chemical Substances	sativene ; Plant Growth Regulators ; Sesquiterpenes
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c05815
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Article ; Online: Enrichment in conservative amino acid changes among fixed and standing missense variations in slowly evolving proteins

Mingrui Wang / Dapeng Wang / Jun Yu / Shi Huang

PeerJ, Vol 8, p e

2020 Volume 9983

Abstract: The process of molecular evolution has many elements that are not yet fully understood. Evolutionary rates are known to vary among protein coding and noncoding DNAs, and most of the observed changes in amino acid or nucleotide sequences are assumed to be ...

Abstract	The process of molecular evolution has many elements that are not yet fully understood. Evolutionary rates are known to vary among protein coding and noncoding DNAs, and most of the observed changes in amino acid or nucleotide sequences are assumed to be non-adaptive by the neutral theory of molecular evolution. However, it remains unclear whether fixed and standing missense changes in slowly evolving proteins are more or less neutral compared to those in fast evolving genes. Here, based on the evolutionary rates as inferred from identity scores between orthologs in human and Rhesus Macaques (Macaca mulatta), we found that the fraction of conservative substitutions between species was significantly higher in their slowly evolving proteins. Similar results were obtained by using four different methods of scoring conservative substitutions, including three that remove the impact of substitution probability, where conservative changes require fewer mutations. We also examined the single nucleotide polymorphisms (SNPs) by using the 1000 Genomes Project data and found that missense SNPs in slowly evolving proteins also had a higher fraction of conservative changes, especially for common SNPs, consistent with more non-conservative substitutions and hence stronger natural selection for SNPs, particularly rare ones, in fast evolving proteins. These results suggest that fixed and standing missense variants in slowly evolving proteins are more likely to be neutral.
Keywords	Evolution ; Neutral ; Evolutionary rates ; Mutation saturation ; Conservative amino acid substitution ; Medicine ; R
Subject code	612
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute Effects of Soleus Stretching on Ankle Flexibility, Dynamic Balance and Speed Performances in Soccer Players

Shi Huang / Hong-Jia Zhang / Xin Wang / Winson Chiu-Chun Lee / Wing-Kai Lam

Biology, Vol 11, Iss 374, p

2022 Volume 374

Abstract: Most dynamic stretching protocols include the gastrocnemius muscle, but soleus stretches are often neglected, which is the key powerful muscle for the push-off (concentric) of all speed movements. The purpose of this study was to examine whether the ... ...

Abstract	Most dynamic stretching protocols include the gastrocnemius muscle, but soleus stretches are often neglected, which is the key powerful muscle for the push-off (concentric) of all speed movements. The purpose of this study was to examine whether the added soleus stretch in a regular stretching protocol would have greater benefits for ankle flexibility, dynamic balance and functional performance. Fourteen healthy male soccer players received each of the stretching conditions (regular stretching only (Regular), regular stretching with soleus stretching (Soleus) and no stretching (Control)) randomly on different training days, with two-day separation. The ankle flexibility, standing heel-lift balance and speed performances were assessed following each stretching intervention. The active dynamic stretches were performed for 30 s with three repetitions on each of the three (Regular) and four (Soleus) muscles. One-way ANOVA with repeated measures (or the Friedman non-parametric test) was performed to determine any significant effect with alpha = 0.05. Our findings revealed that both the Regular and Soleus stretching groups showed an increased active range of ankle motion compared to the no-stretching control ( Ps < 0.05). In the heel raise balance test, both stretching groups experienced a significant increase in maximum plantarflexion strength as well as resultant anterior–posterior and medial–lateral CoP excursions compared to the no-stretching control ( Ps < 0.05). In the sprinting tasks, both the Soleus and Regular stretching groups induced faster linear and curved running times ( Ps < 0.05). When comparing the two stretching groups, Soleus stretching led to better ankle flexibility, maximum plantarflexion strength and curved running time ( Ps < 0.05). Thus, added stretches on the soleus muscles can provide further benefits to speed performances in soccer.
Keywords	stretching ; football ; agility ; dynamic stretch ; leg strength ; dynamic balance ; Biology (General) ; QH301-705.5
Subject code	796
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population.

Xiaoyun Lei / Shi Huang

PLoS ONE, Vol 12, Iss 11, p e

2017 Volume 0187644

Abstract: Type 2 diabetes (T2D) is a complex disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have ... ...

Abstract	Type 2 diabetes (T2D) is a complex disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked with quantitative variations of complex traits and diseases. Here we studied MAC in T2D using previously published SNP datasets and found higher MAC in cases relative to matched controls. A set of 357 SNPs was found to have the best predictive accuracy in a British population. A weighted risk score calculated by using this set produced an area under the curve (AUC) score of 0.86, which is comparable to risk models built by phenotypic markers. These results identify a novel genetic risk element in T2D susceptibility and provide a potentially useful genetic method to identify individuals with high risk of T2D.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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