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  1. Book ; Conference proceedings: Molecular mechanisms of metal toxicity and carcinogenesis

    Shi, Xianglin

    [Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held at ... Morgantown, West Virginia, from September 10 - 12, 2000]

    (Molecular and cellular biochemistry ; 222,1/2 = Focussed issue)

    2001  

    Institution Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis
    Author's details (guest eds.: Xianglin Shi ...)
    Series title Molecular and cellular biochemistry ; 222,1/2 = Focussed issue
    Collection
    Keywords Metall ; Carcinogenität ; Cytotoxizität
    Subject Zytotoxizität ; Metalle ; Karzinogenität ; Cancerogenität ; Kanzerogenität
    Language English
    Size 229 S. : Ill., graph. Darst.
    Publisher Kluwer
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT013510253
    ISBN 0-7923-7498-3 ; 978-0-7923-7498-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 892 -222- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Simplified Oligonucleotide Phosphorus Deprotection Process with Reduced 3-(2-Cyanoethyl) Thymidine Impurities.

    Zhou, Xuan / Shi, Xianglin / Fillon, Yannick / Antia, Firoz / Pickel, Thomas / Yang, Jing / Zhang, William / Delavari, Armin / Zhang, Jiabao

    Nucleic acid therapeutics

    2024  Volume 34, Issue 2, Page(s) 83–89

    Abstract: Oligonucleotides have emerged as valuable new therapeutics. Presently, oligonucleotide manufacturing consists in a series of stepwise additions until the full-length product is obtained. Deprotection of the phosphorus backbone before cleavage and ... ...

    Abstract Oligonucleotides have emerged as valuable new therapeutics. Presently, oligonucleotide manufacturing consists in a series of stepwise additions until the full-length product is obtained. Deprotection of the phosphorus backbone before cleavage and deprotection (C&D) by ammonolysis is necessary to control the 3-(2-cyanoethyl) thymidine (CNET) impurity. In this study, we demonstrate that the use of piperazine as a scavenger of acrylonitrile allows phosphorus deprotection and C&D to be combined in a single step. This reduces solvent consumption, processing time, and CNET levels. Additionally, we showed that substitution of piperazine for triethylamine in the phosphorus deprotection step of supported-synthesis leads to reduced reaction times and lower levels of CNET impurities.
    MeSH term(s) Oligonucleotides ; Phosphorus ; Piperazines
    Chemical Substances Oligonucleotides ; Phosphorus (27YLU75U4W) ; Piperazines
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2639888-6
    ISSN 2159-3345 ; 2159-3337
    ISSN (online) 2159-3345
    ISSN 2159-3337
    DOI 10.1089/nat.2023.0060
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  3. Article ; Online: The Chelate Effect Rationalizes Observed Rate Acceleration and Enantioselectivity in BINOL-Catalyzed Petasis Reactions.

    Haeffner, Fredrik / Pickel, Thomas C / Hou, April / Walker, Donald G / Kiesman, William F / Shi, Xianglin

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 13, Page(s) e202203331

    Abstract: Density functional theory (DFT) calculations afforded insight into the origin of the experimentally observed reaction rate acceleration (≥500 fold) and enantioselectivity (≥99 % ee) of 1,1'-bi-2-naphthol- (BINOL-) catalyzed three-component Petasis ... ...

    Abstract Density functional theory (DFT) calculations afforded insight into the origin of the experimentally observed reaction rate acceleration (≥500 fold) and enantioselectivity (≥99 % ee) of 1,1'-bi-2-naphthol- (BINOL-) catalyzed three-component Petasis reactions . BINOL accelerates the rate determining step by forming a B
    Language English
    Publishing date 2023-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202203331
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  4. Article: A Simple, Readily Accessible, and Effective Apparatus for the ­Photoisomerization of cis-Cyclooctenes to trans-Cyclooctenes

    Pickel, Thomas C. / Genung, Nathan E. / Guckian, Kevin M. / Shi, Xianglin

    Synlett

    2021  Volume 32, Issue 17, Page(s) 1711–1713

    Abstract: A simple, cost effective, and readily accessible apparatus for the photoisomerization of cis -cyclooctenes to trans -cyclooctenes is described. Utilizing only FEP tubing, aluminum vent pipe, a household germicidal lamp, and a flash chromatography ... ...

    Abstract A simple, cost effective, and readily accessible apparatus for the photoisomerization of cis -cyclooctenes to trans -cyclooctenes is described. Utilizing only FEP tubing, aluminum vent pipe, a household germicidal lamp, and a flash chromatography system, trans -cyclooctenes can be prepared in good yield.
    Keywords -cyclooctene ; photochemistry ; bioconjugation ; click chemistry ; flow chemistry
    Language English
    Publishing date 2021-07-30
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0040-1720385
    Database Thieme publisher's database

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  5. Article ; Online: Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line".

    Son, Young-Ok / Lee, Jeong-Chae / Hitron, J Andrew / Pan, Jingju / Zhang, Zhuo / Shi, Xianglin

    Toxicological sciences : an official journal of the Society of Toxicology

    2020  Volume 175, Issue 1, Page(s) 144

    Language English
    Publishing date 2020-02-16
    Publishing country United States
    Document type Journal Article ; Expression of Concern
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfaa011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1709: Show issues Location:
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  6. Article: Oxidative Stress and Metabolic Reprogramming in Cr(VI) Carcinogenesis.

    Clementino, Marco / Shi, Xianglin / Zhang, Zhuo

    Current opinion in toxicology

    2017  Volume 8, Page(s) 20–27

    Abstract: Cr(VI)-containing compounds are well-established lung carcinogens. Chronic exposure of the normal human epithelial cells is able to induce malignant cell transformation, the first stage of metal carcinogenesis. These Cr(VI)-transformed cells exhibit ... ...

    Abstract Cr(VI)-containing compounds are well-established lung carcinogens. Chronic exposure of the normal human epithelial cells is able to induce malignant cell transformation, the first stage of metal carcinogenesis. These Cr(VI)-transformed cells exhibit increased level of antioxidants, reduced capacity of generating reactive oxygen species (ROS), and development of apoptosis resistance, promoting tumorigenesis of Cr(VI)-transformed cells, the second stage of metal carcinogenesis. The mechanism of Cr(VI) induced carcinogenesis is still under investigation. Recent studies indicate that ROS play a positive role in the first stage while a negative role in the second stage. Transformed cells adapt metabolism to support tumor initiation and progression. Altered metabolic activities directly participate in the process of cell transformation or support a large requirement for nucleotides, amino acids, and lipids for tumor growth. In malignantly Cr(VI)-transformed cells, mitochondrial oxidative phosphorylation is defective, and pentose phosphate pathway, glycolysis, and glutaminolysis are upregulated. These metabolic reprogramming supports rapid cell proliferation and contributes to tumorigenesis of Cr(VI)-transformed cells. This article summarizes the current progress in the studies of metabolic reprogramming and Cr(VI) carcinogenesis with emphasis on the metabolic enzymes and oxidative stress related major oncogenic pathways.
    Language English
    Publishing date 2017-12-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-2934
    ISSN 2468-2934
    DOI 10.1016/j.cotox.2017.11.015
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  7. Article ; Online: Prevention of Polyphenols Against Carcinogenesis Induced by Environmental Carcinogens.

    Clementino, Marco / Shi, Xianglin / Zhang, Zhuo

    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

    2017  Volume 36, Issue 1, Page(s) 87–98

    Abstract: Cancer is one of the major causes of death in humans. Of all cancers, 19% are attributed to exposure to environmental chemical carcinogens. Dietary polyphenols from teas, vegetables, fruits, and many others exhibit multiple activities against cancers. ... ...

    Abstract Cancer is one of the major causes of death in humans. Of all cancers, 19% are attributed to exposure to environmental chemical carcinogens. Dietary polyphenols from teas, vegetables, fruits, and many others exhibit multiple activities against cancers. Exposure to environmental carcinogens such as ultraviolet B (UVB), polycyclic aromatic hydrocarbons (PAHs), and heavy metals has been demonstrated to cause cancer in humans. In this article, we specifically select UVB, PAHs, and metals as representative of three types of environmental carcinogens: physical, organic, and inorganic, respectively. We provide a comprehensive review on the role of various dietary polyphenols against carcinogenesis induced by those three types of carcinogens. We summarize the current knowledge of and prospects for prevention of those three groups of carcinogens induced by dietary polyphenols in vitro and in vivo.
    MeSH term(s) Carcinogenesis/chemically induced ; Carcinogenesis/drug effects ; Carcinogens, Environmental/toxicity ; Diet ; Environmental Pollutants/toxicity ; Humans ; Metals, Heavy/toxicity ; Neoplasms/prevention & control ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polyphenols/pharmacology ; Protective Agents/pharmacology
    Chemical Substances Carcinogens, Environmental ; Environmental Pollutants ; Metals, Heavy ; Polycyclic Aromatic Hydrocarbons ; Polyphenols ; Protective Agents
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441790-2
    ISSN 2162-6537 ; 0731-8898 ; 0146-4779
    ISSN (online) 2162-6537
    ISSN 0731-8898 ; 0146-4779
    DOI 10.1615/JEnvironPatholToxicolOncol.2017019057
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    Zs.A 1472: Show issues Location:
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  8. Article ; Online: Development of Kilogram-Scale Convergent Liquid-Phase Synthesis of Oligonucleotides.

    Zhou, Xuan / Kiesman, William F / Yan, Wuming / Jiang, Hong / Antia, Firoz D / Yang, Jing / Fillon, Yannick A / Xiao, Li / Shi, Xianglin

    The Journal of organic chemistry

    2021  Volume 87, Issue 4, Page(s) 2087–2110

    Abstract: Oligonucleotide drugs show promise to treat diseases afflicting millions of people. To address the need to manufacture large quantities of oligonucleotide therapeutics, the novel convergent liquid-phase synthesis has been developed for an 18-mer ... ...

    Abstract Oligonucleotide drugs show promise to treat diseases afflicting millions of people. To address the need to manufacture large quantities of oligonucleotide therapeutics, the novel convergent liquid-phase synthesis has been developed for an 18-mer oligonucleotide drug candidate. Fragments containing tetra- and pentamers were synthesized and assembled into the 18-mer without column chromatography, which had a similar impurity profile to material made by standard solid-phase oligonucleotide synthesis. Two of the fragments have been synthesized at ∼3 kg/batch sizes and four additional tetra- and pentamer fragments were synthesized at >300-g scale, and a 34-mer was assembled from the fragments. Critical impurities are controlled in the fragment syntheses to provide oligonucleotides of purities suitable for clinical use after applying standard full-length product purification process. Impurity control in the assembly steps demonstrated the potential to eliminate chromatography of full-length oligonucleotides, which should enhance scalability and reduce the environmental impact of the process. The convergent assembly and telescoping of reactions made the long synthesis (>60 reactions) practical by reducing production time, material loss, and chances for impurity generation.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Oligonucleotides/chemistry ; Solid-Phase Synthesis Techniques
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c01756
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    Zs.A 4473: Show issues Location:
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  9. Article ; Online: Retraction Note: Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism.

    Pratheeshkumar, Poyil / Son, Young-Ok / Divya, Sasidharan Padmaja / Wang, Lei / Zhang, Zhuo / Shi, Xianglin

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 17001

    Abstract: This article has been retracted. ...

    Abstract This article has been retracted.
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-53858-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Verteporfin inhibits lipopolysaccharide-induced inflammation by multiple functions in RAW 264.7 cells.

    Wang, Yuting / Wang, Lei / Wise, James T F / Shi, Xianglin / Chen, Zhimin

    Toxicology and applied pharmacology

    2019  Volume 387, Page(s) 114852

    Abstract: Inflammation is a physiologic response to damage triggered by infection, injury or chemical irritation. Chronic inflammation produces repeated damage to cells and tissues, which can induce a variety of human diseases including cancer. Verteporfin, an FDA ...

    Abstract Inflammation is a physiologic response to damage triggered by infection, injury or chemical irritation. Chronic inflammation produces repeated damage to cells and tissues, which can induce a variety of human diseases including cancer. Verteporfin, an FDA approved drug, is used for the treatment of age-related macular degeneration. The anti-tumor effects of verteporfin have been demonstrated by a number of studies. However, fewer studies focus on the anti-inflammatory functions of this drug. In this study, we investigated the anti-inflammatory effects and potential mechanisms of verteporfin. The classic lipopolysaccharide (LPS)-induced inflammation cell model was used. RAW 264.7 cells were pre-treated with verteporfin or vehicle control, followed by LPS stimulation. Verteporfin inhibited IL-6 and TNF-α at mRNA and protein expression levels. This effect was mediated through inhibition of the NF-κB and JAK/STAT pathways. Finally, verteporfin exhibited an anti-inflammation effect by crosslinking of protein such as NF-κB p65, JAK1, JAK2, STAT1, or STAT3 leading to inflammation. Taken together, these results indicate that verteporfin has the potential to be an effective therapeutic agent against inflammatory diseases.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Lipopolysaccharides/immunology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; RAW 264.7 Cells ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Verteporfin/pharmacology ; Verteporfin/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Inflammation Mediators ; Lipopolysaccharides ; Verteporfin (0X9PA28K43)
    Language English
    Publishing date 2019-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2019.114852
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