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Article: A Rare Case of Laryngeal Non-IgM Lymphoplasmacytic Lymphoma.

Hong, Michelle K / Han, Albert Y / Shiba, Travis L

2022 Volume 14, Issue 9, Page(s) e29136

Abstract: Laryngeal lymphoplasmacytic lymphoma has been previously reported only a handful of times in the literature. It can be difficult to diagnose without significant histologic workup and proper methodology. Here, we demonstrate the first known case of ... ...

Abstract	Laryngeal lymphoplasmacytic lymphoma has been previously reported only a handful of times in the literature. It can be difficult to diagnose without significant histologic workup and proper methodology. Here, we demonstrate the first known case of laryngeal lymphoplasmacytic lymphoma with non-immunoglobulin M (IgM) features. In this case report, a 79-year-old female with seropositive rheumatoid arthritis presented with five months of dysphonia and dyspnea on exertion. Lab studies revealed high levels of serum IgA and IgG. Flexible laryngoscopy and computed tomography of the neck showed a left supraglottic submucosal mass, which was surgically excised with a carbon dioxide laser. The histology of the mass confirmed the diagnosis of lymphoplasmacytic lymphoma. The patient was treated with 30.6 Gy of radiation therapy and eight cycles of rituximab with successful remission of her lymphoma and no evidence of disease recurrence six months after treatment completion. Lymphoplasmacytic lymphoma without corresponding IgM gammopathy is unusual and has been shown to have a higher frequency of extramedullary involvement. This is the first known manifestation of non-IgM lymphoplasmacytic lymphoma in the larynx.
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.29136
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Article ; Online: Secondary syphilis of the oropharynx and cervical lymph nodes: a case report.

Han, Albert Y / Wang, Jennifer N / Yu, Alice C / Shiba, Travis L

Ear, nose, & throat journal

2022 , Page(s) 1455613221095605

Abstract: Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be ... ...

Abstract	Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be mistaken for head and neck cancer. We report a case of an enlarging throat and painless cystic neck mass in a transgender woman in her forties who was initially suspected to have oropharyngeal squamous cell carcinoma. A subsequent workup revealed the presence of spirochetes without cellular atypia consistent with secondary syphilis. We include the ultrasonography images as well as an endoscopic photograph of the oropharyngeal manifestation in this report.
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221095605
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Article ; Online: Dynamics of phonatory posturing at phonation onset.

Shiba, Travis L / Chhetri, Dinesh K

The Laryngoscope

2016 Volume 126, Issue 8, Page(s) 1837–1843

Abstract: Introduction: In speech and singing, the intrinsic laryngeal muscles set the prephonatory posture prior to the onset of phonation. The timing and shape of the prephonatory glottal posture can directly affect the resulting phonation type. We investigated ...

Abstract	Introduction: In speech and singing, the intrinsic laryngeal muscles set the prephonatory posture prior to the onset of phonation. The timing and shape of the prephonatory glottal posture can directly affect the resulting phonation type. We investigated the dynamics of human laryngeal phonatory posturing. Methods: Onset of vocal fold adduction to phonation was observed in 27 normal subjects using high-speed video recording. Subjects were asked to utter a variety of phonation types (modal, breathy, pressed, /i/ following sniff). Digital videokymography with concurrent acoustic signal was analyzed to assess the timing of the following: onset of adduction to final phonatory posture (FPT), phonation onset time (POT), and phonatory posture time (PPT). Final phonatory posture time was determined as the moment at which the laryngeal configuration used in phonation was first achieved. Results: Thirty-three audiovisual recordings met inclusion criteria. Average FPT, PPT, and POT were as follows: 303, 106, and 409 ms for modal; 430, 104, and 534 ms for breathy; 483, 213, and 696 ms for pressed; and 278, 98, and 376 ms for sniff-/i/. The following posturing features were observed: 1) pressed phonation: increased speed of closure just prior to final posture, complete glottal closure, and increased supraglottic hyperactivity; and 2) breathy phonation: decreased speed of closure prior to final posture, increased posterior glottal gap, and increased midmembranous gap. Conclusions: Phonation onset latency was shortest for modal and longest for pressed voice. These findings are likely explained by glottal resistance and subglottal pressure requirements. Level of evidence: NA. Laryngoscope, 126:1837-1843, 2016.
MeSH term(s)	Glottis/physiology ; Humans ; Phonation/physiology
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.25816
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Article ; Online: Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits.

Goel, Alexander N / Gowda, Bhavani S / Veena, Mysore S / Shiba, Travis L / Long, Jennifer L

The Annals of otology, rhinology, and laryngology

2018 Volume 127, Issue 12, Page(s) 962–968

Abstract: Objectives:: Cell therapies using mesenchymal stromal cells (MSCs) have been proposed as a promising new tool for the treatment of vocal fold scarring. However, the mechanisms by which MSCs promote healing as well as their duration of survival within ... ...

Abstract	Objectives:: Cell therapies using mesenchymal stromal cells (MSCs) have been proposed as a promising new tool for the treatment of vocal fold scarring. However, the mechanisms by which MSCs promote healing as well as their duration of survival within the host vocal fold have yet to be defined. The aim of this work was to assess the persistence of embedded MSCs within a tissue-engineered vocal fold mucosal replacement in a rabbit model of vocal fold injury. Methods:: Male rabbit adipose-derived MSCs were embedded within a 3-dimensional fibrin gel, forming the cell-based outer vocal fold replacement. Four female rabbits underwent unilateral resection of vocal fold epithelium and lamina propria and reconstruction with cell-based outer vocal fold replacement implantation. Polymerase chain reaction and fluorescent in situ hybridization for the sex-determining region of the Y chromosome (SRY-II) in the sex-mismatched donor-recipient pairs sought persistent cells after 4 weeks. Results:: A subset of implanted male cells was detected in the implant site at 4 weeks. Many SRY-II-negative cells were also detected at the implant site, presumably representing native female cells that migrated to the area. No SRY-II signal was detected in contralateral control vocal folds. Conclusions:: The emergent tissue after implantation of a tissue-engineered outer vocal fold replacement is derived both from initially embedded adipose-derived stromal cells and infiltrating native cells. Our results suggest this tissue-engineering approach can provide a well-integrated tissue graft with prolonged cell activity for repair of severe vocal fold scars.
MeSH term(s)	Animals ; Cicatrix/pathology ; Cicatrix/physiopathology ; Cicatrix/therapy ; Mesenchymal Stem Cells/physiology ; Rabbits ; Regeneration/physiology ; Tissue Engineering/methods ; Tissue Transplantation/methods ; Treatment Outcome ; Vocal Cord Dysfunction/etiology ; Vocal Cord Dysfunction/physiopathology ; Vocal Cord Dysfunction/therapy ; Vocal Cords/pathology ; Vocal Cords/physiology ; Vocal Cords/transplantation
Language	English
Publishing date	2018-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/0003489418806008
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Article: Photodocumentation of the development of type I posterior glottic stenosis after intubation injury.

Howard, Nelson Scott / Shiba, Travis L / Pesce, Julianna E / Chhetri, Dinesh K

Case reports in surgery

2015 Volume 2015, Page(s) 504791

Abstract: Bilateral vocal fold immobility may result from bilateral recurrent laryngeal nerve paralysis or physiologic insults to the airway such as glottic scars. The progression of mucosal injury to granulation tissue, and then posterior glottis stenosis, is an ... ...

Abstract	Bilateral vocal fold immobility may result from bilateral recurrent laryngeal nerve paralysis or physiologic insults to the airway such as glottic scars. The progression of mucosal injury to granulation tissue, and then posterior glottis stenosis, is an accepted theory but has not been photodocumented. This paper presents serial images from common postintubation injury to less common posterior glottic stenosis with interarytenoid synechia.
Language	English
Publishing date	2015-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2015/504791
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Article ; Online: Tissue-Engineered Vocal Fold Mucosa Implantation in Rabbits.

Shiba, Travis L / Hardy, Jordan / Luegmair, Georg / Zhang, Zhaoyan / Long, Jennifer L

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2016 Volume 154, Issue 4, Page(s) 679–688

Abstract: Objective: To assess phonatory function and wound healing of a tissue-engineered vocal fold mucosa (TE-VFM) in rabbits. An "artificial" vocal fold would be valuable for reconstructing refractory scars and resection defects, particularly one that uses ... ...

Abstract	Objective: To assess phonatory function and wound healing of a tissue-engineered vocal fold mucosa (TE-VFM) in rabbits. An "artificial" vocal fold would be valuable for reconstructing refractory scars and resection defects, particularly one that uses readily available autologous cells and scaffold. This work implants a candidate TE-VFM after resecting native epithelium and lamina propria in rabbits. Study design: Prospective animal study. Setting: Research laboratory. Subjects and methods: Rabbit adipose-derived stem cells were isolated and cultured in three-dimensional fibrin scaffolds to form TE-VFM. Eight rabbits underwent laryngofissure, unilateral European Laryngologic Society type 2 cordectomy, and immediate reconstruction with TE-VFM. After 4 weeks, larynges were excised, phonated, and examined by histology. Results: Uniform TE-VFM implants were created, with rabbit mesenchymal cells populated throughout fibrin hydrogels. Rabbits recovered uneventfully after implantation. Phonation was achieved in all, with mucosal waves evident at the implant site. Histology after 4 weeks showed resorbed fibrin matrix, continuous epithelium, and mildly increased collagen relative to contralateral unoperated vocal folds. Elastic fiber appearance was highly variable. Inflammatory cell infiltrate was limited to animals receiving sex-mismatched implants. Conclusion: TE-VFMs were successfully implanted into 8 rabbits, with minor evidence of scar formation and immune reaction. Vibration was preserved 4 weeks after resecting and reconstructing the complete vocal fold cover layer. Further studies will investigate the mechanism and durability of improvement. TE-VFM with autologous cells is a promising new approach for vocal fold reconstruction.
MeSH term(s)	Adipose Tissue/cytology ; Animals ; Cells, Cultured ; Disease Models, Animal ; Laryngoscopy ; Phonation ; Prospective Studies ; Rabbits ; Regeneration ; Stem Cell Transplantation ; Tissue Engineering/methods ; Tissue Scaffolds ; Vocal Cords/surgery ; Wound Healing
Language	English
Publishing date	2016-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599816628501
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Article ; Online: Lentiviral transduction of face and limb flaps: implications for immunomodulation of vascularized composite allografts.

Leto Barone, Angelo A / Zhou, Zhao Y / Hughes, Michael W / Park, Ryan / Schulman, Ruth M / Lee, Steven / Vidar, Evan N / Shiba, Travis L / Weber, Erin L / Cetrulo, Curtis L

Plastic and reconstructive surgery

2011 Volume 129, Issue 2, Page(s) 391–400

Abstract: Background: Ex vivo introduction of an immunomodulatory transgene into a face or hand allograft may improve the risk-to-benefit ratio of vascularized composite allografts. Abrogation of the immunogenicity of the skin component of a face or hand ... ...

Abstract	Background: Ex vivo introduction of an immunomodulatory transgene into a face or hand allograft may improve the risk-to-benefit ratio of vascularized composite allografts. Abrogation of the immunogenicity of the skin component of a face or hand allograft may decrease alloreactivity and permit the induction of immunologic tolerance. Proof-of-principle demonstrations of transduction of composite tissue have been established using adenoviral vectors, producing transient gene expression. The authors hypothesized that transduction, integration, and long-term expression of transgenes in a vascularized composite allograft could be achieved using lentiviral vectors. Methods: Ex vivo transduction of heterogeneous primary rat cell lines representative of a composite tissue flap's cellular architecture was performed using a luc-enhanced green fluorescent protein (eGFP) human immunodeficiency virus-1-based lentiviral vector. Ex vivo injections of rat superficial inferior epigastric artery flaps with the viral vector were performed intraarterially, intramuscularly, and intradermally. Results: Quantifiable reporter expression by flow cytometry (fluorescence-activated cell sorting) analysis and in vitro bioluminescence was observed. The luc-eGFP vector exhibited broad tropism and allowed transgene expression in relevant cell lines and throughout the flaps. Ex vivo intradermal transfection resulted in genomic integration and long-term constitutive gene expression (>150 days). Similarly, efficient intradermal transfection of face and hand flaps in a rat model corroborated this approach. Ex vivo intravascular perfusion of the vector proved inferior to intradermal injection. Conclusions: Intradermal delivery of the transgenes proved superior to intravascular perfusion. Optimization of this gene-delivery approach may allow long-term, constitutive expression of immunomodulatory proteins in face and hand allografts. Future goals include replacement of the luciferase and eGFP reporter genes with key immunomodulatory proteins.
MeSH term(s)	Animals ; Extremities/surgery ; Face/surgery ; Gene Transfer Techniques ; Humans ; Immunomodulation ; Lentivirus/genetics ; Rats ; Surgical Flaps/blood supply ; Surgical Flaps/immunology ; Transduction, Genetic
Language	English
Publishing date	2011-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0b013e31823aeaeb
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Article: Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.

Saha, Supriya K / Pietras, Eric M / He, Jeannie Q / Kang, Jason R / Liu, Su-Yang / Oganesyan, Gagik / Shahangian, Arash / Zarnegar, Brian / Shiba, Travis L / Wang, Yao / Cheng, Genhong

The EMBO journal

2006 Volume 25, Issue 14, Page(s) 3257–3263

Abstract: Upon recognition of viral infection, RIG-I and Helicard recruit a newly identified adapter termed Cardif, which induces type I interferon (IFN)-mediated antiviral responses through an unknown mechanism. Here, we demonstrate that TRAF3, like Cardif, is ... ...

Abstract	Upon recognition of viral infection, RIG-I and Helicard recruit a newly identified adapter termed Cardif, which induces type I interferon (IFN)-mediated antiviral responses through an unknown mechanism. Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA. Cardif-mediated IFNalpha induction occurs through a direct interaction between the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) within Cardif. Interestingly, while the entire N-terminus of TRAF3 was functionally interchangeable with that of TRAF5, the TRAF domain of TRAF3 was not. Our data suggest that this distinction is due to an inability of the TRAF domain of TRAF5 to bind the TIM of Cardif. Finally, we show that preventing association of TRAF3 with this TIM by mutating two critical amino acids in the TRAF domain also abolishes TRAF3-dependent IFN production following viral infection. Thus, our findings suggest that the direct and specific interaction between the TRAF domain of TRAF3 and the TIM of Cardif is required for optimal Cardif-mediated antiviral responses.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/physiology ; Animals ; Cell Line ; Cells, Cultured ; Humans ; Interferon-alpha/antagonists & inhibitors ; Interferon-alpha/biosynthesis ; Intracellular Fluid/physiology ; Mice ; RNA, Double-Stranded/antagonists & inhibitors ; RNA, Double-Stranded/physiology ; RNA, Viral/antagonists & inhibitors ; RNA, Viral/genetics ; RNA, Viral/physiology ; Sendai virus/genetics ; Sendai virus/physiology ; TNF Receptor-Associated Factor 3 ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/physiology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Interferon-alpha ; MAVS protein, human ; RNA, Double-Stranded ; RNA, Viral ; TNF Receptor-Associated Factor 3 ; TRAF3 protein, human ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Language	English
Publishing date	2006-07-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/sj.emboj.7601220
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