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  1. Article ; Online: Hypertension paradox in Japan: the road ahead.

    Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 11, Page(s) 2497–2499

    MeSH term(s) Humans ; Cross-Sectional Studies ; Japan/epidemiology ; Hypertension/physiopathology ; Blood Pressure ; Clinical Medicine
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01414-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Thermoreceptor TRPV1 regulates body weight and blood pressure in the absence of thermogenin.

    Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 5, Page(s) 917–919

    MeSH term(s) Blood Pressure ; Body Weight ; Humans ; Mitochondrial Proteins ; TRPV Cation Channels ; Thermoreceptors ; Uncoupling Protein 1
    Chemical Substances Mitochondrial Proteins ; TRPV Cation Channels ; TRPV1 protein, human ; Uncoupling Protein 1
    Language English
    Publishing date 2022-03-02
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00867-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Another evidence that supports the continued use of RAS inhibitors in end-stage kidney diseases.

    Yamazaki, Osamu / Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01695-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Mitochondrial fission: a new mechanism of hypertension and cardiovascular remodeling induced by Angiotensin II.

    Ueda, Kohei / Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01670-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Mineralocorticoid Receptor Antagonists for Preventing Chronic Kidney Disease Progression: Current Evidence and Future Challenges.

    Fujii, Wataru / Shibata, Shigeru

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Regulation and action of the mineralocorticoid receptor (MR) have been the focus of intensive research over the past 80 years. Genetic and physiological/biochemical analysis revealed how MR and the steroid hormone aldosterone integrate the responses of ... ...

    Abstract Regulation and action of the mineralocorticoid receptor (MR) have been the focus of intensive research over the past 80 years. Genetic and physiological/biochemical analysis revealed how MR and the steroid hormone aldosterone integrate the responses of distinct tubular cells in the face of environmental perturbations and how their dysregulation compromises fluid homeostasis. In addition to these roles, the accumulation of data also provided unequivocal evidence that MR is involved in the pathophysiology of kidney diseases. Experimental studies delineated the diverse pathological consequences of MR overactivity and uncovered the multiple mechanisms that result in enhanced MR signaling. In parallel, clinical studies consistently demonstrated that MR blockade reduces albuminuria in patients with chronic kidney disease. Moreover, recent large-scale clinical studies using finerenone have provided evidence that the non-steroidal MR antagonist can retard the kidney disease progression in diabetic patients. In this article, we review experimental data demonstrating the critical importance of MR in mediating renal injury as well as clinical studies providing evidence on the renoprotective effects of MR blockade. We also discuss areas of future investigation, which include the benefit of non-steroidal MR antagonists in non-diabetic kidney disease patients, the identification of surrogate markers for MR signaling in the kidney, and the search for key downstream mediators whereby MR blockade confers renoprotection. Insights into these questions would help maximize the benefit of MR blockade in subjects with kidney diseases.
    MeSH term(s) Humans ; Albuminuria ; Aldosterone ; Kidney ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Receptors, Mineralocorticoid/genetics ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/prevention & control
    Chemical Substances Aldosterone (4964P6T9RB) ; Mineralocorticoid Receptor Antagonists ; Receptors, Mineralocorticoid ; NR3C2 protein, human
    Language English
    Publishing date 2023-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anti-adrenergic agents and the risk of postoperative acute kidney injury.

    Asakawa, Shinichiro / Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 3, Page(s) 796–798

    MeSH term(s) Humans ; Cohort Studies ; Retrospective Studies ; Risk Factors ; Acute Kidney Injury/chemically induced ; Adrenergic Antagonists ; Kidney
    Chemical Substances Adrenergic Antagonists
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01546-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Reply to: Hypertension and severe COVID-19.

    Shibata, Shigeru / Asayama, Kei

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1355

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Hypertension
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01223-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Don't miss the isolated diastolic hypertension.

    Yamazaki, Osamu / Shibata, Shigeru

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 10, Page(s) 2421–2424

    MeSH term(s) Humans ; Blood Pressure ; Hypertension ; Renal Insufficiency, Chronic ; Proteinuria ; Kidney
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01386-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Current situation of telemedicine research for cardiovascular risk in Japan.

    Shibata, Shigeru / Hoshide, Satoshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1171–1180

    Abstract: Hypertension continues to be a principal risk factor for the occurrence of cardiovascular disorders, stroke, and kidney diseases. Although more than 40 million subjects suffer from hypertension in Japan, its optimal control is achieved only a ... ...

    Abstract Hypertension continues to be a principal risk factor for the occurrence of cardiovascular disorders, stroke, and kidney diseases. Although more than 40 million subjects suffer from hypertension in Japan, its optimal control is achieved only a subpopulation of patients, highlighting the need for novel approaches to manage this disorder. Toward the better control of blood pressure, the Japanese Society of Hypertension has developed the Future Plan, in which the application of the state-of-art information and communication technology, including web-based resources, artificial intelligence, and big data analysis, is considered as one of the promising solutions. In fact, the rapid advance of digital health technologies, as well as ongoing coronavirus disease 2019 pandemic, has triggered the structural changes in the healthcare system globally, increasing demand for the remote delivery of the medical services. Nonetheless, it is not entirely clear what evidence exists that support the widespread use of telemedicine in Japan. Here, we summarize the current status of telemedicine research, particularly in the field of hypertension and other cardiovascular risk factors. We note that there have been very few interventional studies in Japan that clearly showed the superiority or noninferiority of telemedicine over standard care, and that the methods of online consultation considerably varied among studies. Clearly, more evidence is necessary for wide implementation of telemedicine in hypertensive patients in Japan, and also those with other cardiovascular risk factors.
    MeSH term(s) Humans ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Japan/epidemiology ; Artificial Intelligence ; Risk Factors ; Telemedicine ; Hypertension/epidemiology ; Heart Disease Risk Factors
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01224-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Role of Pendrin in the Pathophysiology of Aldosterone-Induced Hypertension.

    Shibata, Shigeru

    American journal of hypertension

    2019  Volume 32, Issue 7, Page(s) 607–613

    Abstract: The recent advances in genetics and molecular biology have resulted in the characterization of key components that critically regulate renal NaCl transport and blood pressure. Pendrin is a Cl-/HCO3- exchanger that is highly expressed in thyroid, inner ... ...

    Abstract The recent advances in genetics and molecular biology have resulted in the characterization of key components that critically regulate renal NaCl transport and blood pressure. Pendrin is a Cl-/HCO3- exchanger that is highly expressed in thyroid, inner ear, and kidney. In the kidney, it is selectively present at the apical membrane in non-α intercalated cells of the connecting tubules and cortical collecting duct. Besides its role in acid/base homeostasis, accumulating studies using various genetically modified animals have provided compelling evidence that pendrin regulates extracellular fluid volume and electrolyte balance at the downstream of aldosterone signaling. We have shown that angiotensin II and aldosterone cooperatively control pendrin abundance partly through mammalian target of rapamycin signaling and mineralocorticoid receptor dephosphorylation, which is necessary for the kidney to prevent extracellular fluid loss and electrolyte disturbances under physiologic perturbations. In line with the experimental observations, several clinical data indicated that the impaired pendrin function can cause fluid and electrolyte abnormalities in humans. The purpose of this review is to provide an update on the recent progress regarding the role of pendrin in fluid and electrolyte homeostasis, as well as in the pathophysiology of hypertension associated with mineralocorticoid receptor signaling.
    MeSH term(s) Acid-Base Equilibrium ; Aldosterone/metabolism ; Animals ; Blood Pressure ; Humans ; Hyperaldosteronism/metabolism ; Hyperaldosteronism/physiopathology ; Hypertension/metabolism ; Hypertension/physiopathology ; Hypokalemia/metabolism ; Hypokalemia/physiopathology ; Kidney/metabolism ; Kidney/physiopathology ; Receptors, Mineralocorticoid/metabolism ; Signal Transduction ; Sulfate Transporters/metabolism ; Water-Electrolyte Balance
    Chemical Substances NR3C2 protein, human ; Receptors, Mineralocorticoid ; SLC26A4 protein, human ; Sulfate Transporters ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpz054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2329: Show issues Location:
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