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  1. Article ; Online: Osteoblastgenic and Osteogenic Effects of KY-273 with CDK8/19 Inhibitory Activity in Bone Marrow Mesenchymal Stem Cells and Female Rats.

    Yamamoto, Megumi / Shibata, Yui / Ito, Yuma / Fukui, Masaki / Kioka, Hikaru / Shoji, Yoshimichi / Kitao, Tatsuya / Shirahase, Hiroaki / Hinoi, Eiichi

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 3, Page(s) 669–679

    Abstract: Osteoporosis is caused by imbalance between osteogenesis and bone resorption, thus, osteogenic drugs and resorption inhibitors are used for treatment of osteoporosis. The present study examined the effects of (R)-4-(1-hydroxyethyl)-3-{4-[2-( ... ...

    Abstract Osteoporosis is caused by imbalance between osteogenesis and bone resorption, thus, osteogenic drugs and resorption inhibitors are used for treatment of osteoporosis. The present study examined the effects of (R)-4-(1-hydroxyethyl)-3-{4-[2-(tetrahydropyran-4-yloxy)ethoxy]phenoxy}benzamide (KY-273), a diphenyl ether derivative, on CDK8/19 activity, osteoblast differentiation and femoral bone using micro-computed tomography in female rats. KY-273 potently inhibited CDK8/19 activity, promoted osteoblast differentiation with an increase in alkaline phosphatase (ALP) activity, and gene expression of type I collagen, ALP and BMP-4 in mesenchymal stem cells (ST2 cells). In female rat femur, ovariectomy decreased metaphyseal trabecular bone volume (Tb.BV), mineral content (Tb.BMC), yet had no effect on metaphyseal and diaphyseal cortical bone volume (Ct.BV), mineral content (Ct.BMC) and strength parameters (BSPs). In ovaries-intact and ovariectomized rats, oral administration of KY-273 (10 mg/kg/d) for 6 weeks increased metaphyseal and diaphyseal Ct.BV, Ct.BMC, and BSPs without affecting medullary volume (Med.V), but did not affect Tb.BV and Tb.BMC. In ovariectomized rats, alendronate (3 mg/kg/d) caused marked restoration of Tb.BV, Tb.BMC and structural parameters after ovariectomy, and increased metaphyseal but not diaphyseal Ct.BV, Ct.BMC, and BSPs. In ovaries-intact and ovariectomized rats, by the last week, KY-273 increased bone formation rate/bone surface at the periosteal but not the endocortical side. These findings indicate that KY-273 causes osteogenesis in cortical bone at the periosteal side without reducing Med.V. In conclusion, KY-273 has cortical-bone-selective osteogenic effects by osteoblastogenesis via CDK8/19 inhibition in ovaries-intact and ovariectomized rats, and is an orally active drug candidate for bone diseases such as osteoporosis in monotherapy and combination therapy.
    MeSH term(s) Humans ; Rats ; Female ; Animals ; Osteogenesis ; Bone Density ; Rats, Sprague-Dawley ; X-Ray Microtomography ; Osteoporosis/drug therapy ; Ovariectomy ; Mesenchymal Stem Cells ; Minerals/pharmacology ; Cyclin-Dependent Kinase 8
    Chemical Substances Minerals ; CDK8 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 8 (EC 2.7.11.22)
    Language English
    Publishing date 2024-03-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transient Pseudohypoaldosteronism Secondary to Group B Streptococcus Pyelonephritis.

    Morisaki, Atsuo / Naruse, Yuki / Shibata, Yui / Mori, Masato / Hiramoto, Ryugo

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15071

    Abstract: Secondary pseudohypoaldosteronism is a condition characterized by aldosterone resistance in renal tubules. It is highly associated with urinary tract infection and urinary tract malformations. Only a few cases of pseudohypoaldosteronism secondary to ... ...

    Abstract Secondary pseudohypoaldosteronism is a condition characterized by aldosterone resistance in renal tubules. It is highly associated with urinary tract infection and urinary tract malformations. Only a few cases of pseudohypoaldosteronism secondary to group B
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nest and maternal origin can influence morphology and locomotor performance of hatchling green turtles (Chelonia mydas) incubated in field nests

    Booth, David T / Feeney, Róisín / Shibata, Yui

    Marine biology. 2013 Jan., v. 160, no. 1

    2013  

    Abstract: In numerous laboratory experiments involving the incubation of reptile eggs, both the maternal origin of eggs and the incubating environment (nest effect) have been demonstrated to influence hatchling phenotype. Although different hatchling phenotypes ... ...

    Abstract In numerous laboratory experiments involving the incubation of reptile eggs, both the maternal origin of eggs and the incubating environment (nest effect) have been demonstrated to influence hatchling phenotype. Although different hatchling phenotypes have been reported from natural nests, the separate effects of maternal origin and nest on hatchling phenotype in natural nests have not been demonstrated because in natural nests the two effects are confounded with each other. Here, we use a split clutch design to experimentally separate nest effects from maternal origin effects in field nests of green turtles (Chelonia mydas). We found both maternal origin and nest to influence hatchling morphology and locomotor performance in some but not all field nests. By using egg mass (maternal origin effect) and nest temperature (nest effect) in multiple regression analysis, we found maternal origin had a greater influence than nest temperature on the morphological attributes of hatchling mass and carapace size, but nest temperature had a greater influence than maternal origin on the performance attributes of self-righting time, self-righting propensity, swim thrust during the first 30 min of swimming, and power stroke rate during the first 30 min of swimming.
    Keywords Chelonia mydas ; egg incubation ; egg masses ; eggs ; experimental design ; maternal effect ; nests ; phenotype ; regression analysis ; stroke ; swimming ; temperature
    Language English
    Dates of publication 2013-01
    Size p. 127-137.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1117-4
    ISSN 1432-1793 ; 0025-3162
    ISSN (online) 1432-1793
    ISSN 0025-3162
    DOI 10.1007/s00227-012-2070-y
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Search for a Novel Allergen in Hen's Egg Allergy Using an IgE Immunoblotting Assay.

    Sogawa, Kazuyuki / Takahashi, Yuria / Shibata, Yui / Satoh, Mamoru / Kodera, Yoshio / Nomura, Fumio / Tanaka, Toshio / Sato, Hironori / Yamaide, Fumiya / Nakano, Taiji / Iwahashi, Kazuhiko / Sugita-Konishi, Yoshiko / Shimada, Akinori / Shimojo, Naoki

    International archives of allergy and immunology

    2018  Volume 176, Issue 3-4, Page(s) 189–197

    Abstract: Background: Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Chicken egg allergy is frequently observed in infants. Therefore, some of them have to exclude hen's eggs from their daily ...

    Abstract Background: Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Chicken egg allergy is frequently observed in infants. Therefore, some of them have to exclude hen's eggs from their daily diet to avoid allergenic symptoms. Hen's egg is composed of 2 soluble parts; one is egg white, which has been characterized as the major source of allergenicity, while the other is egg yolk, which is estimated as a miner source. Only 2 allergens from egg yolk, α-livetin (Gal d 5) and YGP42 (Gal d 6), have been described to date.
    Methods: Sera from 53 patients allergic to hen's eggs and 2 patients allergic to sesame were obtained from the Department of Pediatrics, Chiba University Hospital. The study was performed using SDS-PAGE, IgE immunoblotting, and dot blotting.
    Results: Seven bands of egg yolk were detected by IgE immunoblotting. Out of these bands, a possible new allergen was further characterized by LC-MS/MS. The 33-kDa band was identified as yolk glycoprotein (YGP40) by LC-MS/MS. A total of 21 of the 53 patients (47%) had YGP40 detected by dot blotting.
    Conclusions: We identified YGP40 as a new hen's egg yolk allergen and detected 4 sites of YGP40 as linear epitopes.
    MeSH term(s) Allergens/analysis ; Child ; Child, Preschool ; Egg Hypersensitivity/etiology ; Egg Yolk/immunology ; Female ; Humans ; Immunoblotting/methods ; Immunoglobulin E/analysis ; Infant ; Male
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000488144
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  5. Article: Search for a Novel Allergen in Hen’s Egg Allergy Using an IgE Immunoblotting Assay

    Sogawa, Kazuyuki / Takahashi, Yuria / Shibata, Yui / Satoh, Mamoru / Kodera, Yoshio / Nomura, Fumio / Tanaka, Toshio / Sato, Hironori / Yamaide, Fumiya / Nakano, Taiji / Iwahashi, Kazuhiko / Sugita-Konishi, Yoshiko / Shimada, Akinori / Shimojo, Naoki

    International Archives of Allergy and Immunology

    2018  Volume 176, Issue 3-4, Page(s) 189–197

    Abstract: Background: Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Chicken egg allergy is frequently observed in infants. Therefore, some of them have to exclude hen’s eggs from their daily ... ...

    Institution Department of Biochemistry, School of Life and Environmental Science, Azabu University, Sagamihara, Japan
    Divisions of Clinical Mass Spectrometry and Clinical Genetics, Chiba University Hospital, Chiba, Japan
    Center for Disease Proteomics, Kitasato University School of Science, Sagamihara, Japan
    Department of Animal Behavior and Management, School of Veterinary Medicine, Azabu University, Sagamihara, Japan
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Department of Physiology, School of Life and Environmental Science, Azabu University, Sagamihara, Japan
    Department of Food and Life Sciences, School of Life and Environmental Science, Azabu University, Sagamihara, Japan
    Laboratory of Pathology, School of Life and Environmental Science, Azabu University, Sagamihara, Japan
    Abstract Background: Food allergy is a serious health issue affecting roughly 4% of children, with a substantial effect on quality of life. Chicken egg allergy is frequently observed in infants. Therefore, some of them have to exclude hen’s eggs from their daily diet to avoid allergenic symptoms. Hen’s egg is composed of 2 soluble parts; one is egg white, which has been characterized as the major source of allergenicity, while the other is egg yolk, which is estimated as a miner source. Only 2 allergens from egg yolk, α-livetin (Gal d 5) and YGP42 (Gal d 6), have been described to date. Methods: Sera from 53 patients allergic to hen’s eggs and 2 patients allergic to sesame were obtained from the Department of Pediatrics, Chiba University Hospital. The study was performed using SDS-PAGE, IgE immunoblotting, and dot blotting. Results: Seven bands of egg yolk were detected by IgE immunoblotting. Out of these bands, a possible new allergen was further characterized by LC-MS/MS. The 33-kDa band was identified as yolk glycoprotein (YGP40) by LC-MS/MS. A total of 21 of the 53 patients (47%) had YGP40 detected by dot blotting. Conclusions: We identified YGP40 as a new hen’s egg yolk allergen and detected 4 sites of YGP40 as linear epitopes.
    Keywords Egg yolk allergy ; Hen’s eggs ; YGP40 ; Vitellogenin-2 ; IgE ; Serum testing
    Language English
    Publishing date 2018-04-18
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Molecules and Cells in Allergy - Original Paper
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000488144
    Database Karger publisher's database

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  6. Article ; Online: Urinary albumin and transferrin as early diagnostic markers of chronic kidney disease.

    Maeda, Hiroto / Sogawa, Kazuyuki / Sakaguchi, Kazuko / Abe, Saori / Sagizaka, Wataru / Mochizuki, Shunsuke / Horie, Waka / Watanabe, Toshifumi / Shibata, Yui / Satoh, Mamoru / Sanda, Akihiro / Nomura, Fumio / Suzuki, Jun

    The Journal of veterinary medical science

    2015  Volume 77, Issue 8, Page(s) 937–943

    Abstract: Feline renal diseases are increasingly noted in veterinary practice. It is important to diagnose and identify the pathological basis of renal dysfunction accurately at an early stage, but there are only a few reports on this area in clinical veterinary ... ...

    Abstract Feline renal diseases are increasingly noted in veterinary practice. It is important to diagnose and identify the pathological basis of renal dysfunction accurately at an early stage, but there are only a few reports on this area in clinical veterinary medicine. We investigated the efficacy of measurement of urinary albumin (u-Alb) and urinary transferrin (u-Tf) for early diagnosis using 5-µl urine samples collected noninvasively by catheterization from normal (IRIS stage I) cats and cats with stage I chronic kidney disease (CKD). The u-Alb levels in normal and stage I CKD cats were 6.0 ± 4.5 and 11.2 ± 8.4 mg/dl, respectively, and the u-Tf levels were 0.09 ± 0.42 and 0.52 ± 0.79 mg/dl, respectively. Based on ROC curve analysis, the sensitivity and specificity of u-Alb and u-Tf were higher than those of the currently used biomarker, the plasma creatinine level. The sensitivity of u-Alb was higher than that of u-Tf, whereas the specificity of u-Tf was higher than that of u-Alb. The validity of the threshold albumin level (20 mg/dl) was confirmed by measurements using SDS-PAGE. Since leakage of u-Tf in urine precedes leakage of u-Alb, inclusion of u-Tf in biochemistry tests may be appropriate for IRIS staging as a diagnostic marker of early diagnosis of renal disorder in cats.
    MeSH term(s) Albuminuria/veterinary ; Animals ; Cat Diseases/diagnosis ; Cat Diseases/urine ; Cats/urine ; Electrophoresis, Polyacrylamide Gel/veterinary ; Female ; Male ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/urine ; Renal Insufficiency, Chronic/veterinary ; Transferrin/urine
    Chemical Substances Transferrin
    Language English
    Publishing date 2015-08
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.14-0427
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