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  1. Article ; Online: Prenatal diagnosis of familial porencephaly associated with fetal stroke.

    Shields, A D / Knutzen, D / Khan, M / Sobh, O / Jacobs, K

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2023  Volume 62, Issue 1, Page(s) 153–154

    MeSH term(s) Female ; Humans ; Pregnancy ; Porencephaly/diagnosis ; Prenatal Diagnosis/methods ; Stroke/diagnostic imaging ; Stroke/etiology
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Letter
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.26168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis.

    Shields, A D / Wang, Q / Winder, D G

    Neuroscience

    2009  Volume 163, Issue 1, Page(s) 339–351

    Abstract: Stress is a major driving force in reinstatement of drug-seeking behavior. The bed nucleus of the stria terminalis (BNST) has been identified as a key brain region in this behavior, and receives a dense input of the stress-neurotransmitter norepinephrine ...

    Abstract Stress is a major driving force in reinstatement of drug-seeking behavior. The bed nucleus of the stria terminalis (BNST) has been identified as a key brain region in this behavior, and receives a dense input of the stress-neurotransmitter norepinephrine through the ventral noradrenergic bundle. Activation of alpha(2)-adrenergic receptors (alpha(2)-ARs) in the BNST blocks stress-induced reinstatement of drug-seeking, indicating a potentially important role for these receptors. Currently, it is unclear how alpha(2)-AR agonists elicit this behavioral action, or through which alpha(2)-AR subtype. Activation of alpha(2)-ARs decreases glutamatergic transmission in the BNST, an effect which is nearly absent in the alpha(2A)-AR knockout mouse. Here, we take advantage of a knock-in mouse in which a hemagglutinin-tagged alpha(2A)-AR was inserted into the endogenous locus, along with the alpha(2A)-AR selective agonist guanfacine, to further study the role of the alpha(2A)-AR subtype in modulation of neurotransmission in the BNST. Using immunohistochemistry, we find that alpha(2A)-ARs are highly expressed in the BNST, and that this expression is more similar in distribution to the vesicular glutamate transporters than to either norepinephrine transporter or tyrosine hydroxylase positive terminals. Using whole cell patch-clamp recordings, we show that guanfacine causes a depression of evoked excitatory and, to a more limited extent, inhibitory fast synaptic transmission. In total, these data support a prominent heterosynaptic role for alpha(2A)-ARs in modulating fast synaptic transmission in the BNST.
    MeSH term(s) Adrenergic alpha-Agonists/pharmacology ; Animals ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Gene Knock-In Techniques ; Glutamic Acid/metabolism ; Guanfacine/pharmacology ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Norepinephrine/metabolism ; Organ Culture Techniques ; Patch-Clamp Techniques ; Receptors, Adrenergic, alpha-2/drug effects ; Receptors, Adrenergic, alpha-2/genetics ; Receptors, Adrenergic, alpha-2/metabolism ; Septal Nuclei/cytology ; Septal Nuclei/drug effects ; Septal Nuclei/metabolism ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology ; Substance-Related Disorders/metabolism ; Substance-Related Disorders/physiopathology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Time Factors
    Chemical Substances Adra2a protein, mouse ; Adrenergic alpha-Agonists ; Receptors, Adrenergic, alpha-2 ; Guanfacine (30OMY4G3MK) ; Glutamic Acid (3KX376GY7L) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2009-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2009.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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