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Article: Aesthetic Female-to-Male Chest Transformation: Power of Combining Modified Mastectomy with a Pectoral Implant.

Abbed, Turkia / Shifrin, David A

Plastic and reconstructive surgery. Global open

2017 Volume 5, Issue 8, Page(s) e1445

Abstract: Gender reassignment surgery has gained in popularity with increased media exposure and society's recognition of gender dysphoria. Female-to-male gender reassignment often begins with the "top" or chest surgery. Mastectomy with free nipple grafting is the ...

Abstract	Gender reassignment surgery has gained in popularity with increased media exposure and society's recognition of gender dysphoria. Female-to-male gender reassignment often begins with the "top" or chest surgery. Mastectomy with free nipple grafting is the most frequently described technique in the literature. This technique is reliable yet lacks the ability to provide a true male chest shape. We discuss our technique for female-to-male "top" surgery combining traditional mastectomy techniques with a lower pole pedicle vascularized areola and a pectoral implant. A 32-year-old African American female with bilateral C cup breast with grade 2/3 ptosis presented for "top" surgery. Intraoperatively, the nipple areola complex was maintained on a lower pole pedicle at a thickness of 1.5 cm to maintain neurovascularity. A superior mastectomy flap was raised at the level of the breast capsule and remaining breast tissue excised. A lateral subpectoral pocket was created for insertion of a silicone pectoral implant. The new nipple position matured in the infero-lateral quadrant of greatest projecting portion of the chest. Lower pole pedicle provided vascularity to the areola, which avoids the need for a free nipple graft and potential hypopigmentation. Pectoral silicone implant provided upper pole fullness to mimic the male chest muscular distribution. Modification of mastectomy-based female-to-male gender reassignment surgery with a lower pole pedicle-based areola and pectoral implant provides an aesthetic improvement over the classic mastectomy with free nipple graft technique.
Language	English
Publishing date	2017-08-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000001445
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Zs.A 7091: Show issues

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Article ; Online: An Analysis of Independent Variables Affecting Surgical Outcomes in Patients Undergoing Repair of Maxillofacial Trauma: An American College of Surgeons National Surgical Quality Improvement Program Study.

Cohen, Stephanie M / Rosett, Brian E / Shifrin, David A

The Journal of craniofacial surgery

2017 Volume 28, Issue 3, Page(s) 596–599

Abstract: Introduction: Facial fractures, from straightforward closed nasal reductions to complex pan facial fractures, are commonly encountered in the Plastic Surgical community. However, very little has been discussed in the literature regarding the outcomes of ...

Abstract	Introduction: Facial fractures, from straightforward closed nasal reductions to complex pan facial fractures, are commonly encountered in the Plastic Surgical community. However, very little has been discussed in the literature regarding the outcomes of facial fractures relating to contributing factors. Our aim was to evaluate a battery of independent variables in order to identify, which, if any, factors correlate with suboptimal outcomes in patients who have undergone facial fracture surgery. Methods: Under the data use agreement of the American College of Surgeons public use files of the NSQIP, patients involving repair of facial fractures, Current Procedural Terminology codes 21310 to 21470 inclusive, were queried. The outcomes examined included: wound dehiscence, superficial surgical site infection, deep surgical site infection, readmission, open wound/wound infection and return to the operating room. Results: There were 2069 facial fracture patients in the National Surgical Quality Improvement Program datasets (2005-2013). Thirteen perioperative risk factors and patient comorbidities were evaluated for correlation with the 6 outcomes. Of the 6 outcomes evaluated, open wound/wound infection was the most prevalent outcome (6%). Factors statistically significant for presence of open wound/wound infection were American Society of Anesthesiology classification (P = 0.002), presence of bleeding disorder (P = 0.008), emergency patient (P = 0.001), chronic alcohol use (P = 0.002), and chronic steroid use (P = 0.034). Discussion: Several factors correlated with presence of an open wound/wound infection; however, variables such as diabetes and active tobacco use, which are often thought to contribute to wound infections, were shown to be statistically nonsignificant. Although this study was limited by its observational nature, these data may indicate a change in perception of the factors correlated with wound infections.
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000003545
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.

Shifrin, David A / Tyska, Matthew J

Gut microbes

2012 Volume 3, Issue 5, Page(s) 460–462

Abstract: Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal ...

Abstract	Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.
MeSH term(s)	Animals ; Enterocytes/immunology ; Gastrointestinal Tract/immunology ; Humans ; Immunity, Innate ; Microvilli/immunology ; Models, Biological ; Secretory Vesicles/immunology
Language	English
Publishing date	2012-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1949-0984
ISSN (online)	1949-0984
DOI	10.4161/gmic.21247
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Article ; Online: ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.

Crawley, Scott W / Weck, Meredith L / Grega-Larson, Nathan E / Shifrin, David A / Tyska, Matthew J

Developmental cell

2016 Volume 36, Issue 2, Page(s) 190–200

Abstract: Transporting and sensory epithelial cells shape apical specializations using protocadherin-based adhesion. In the enterocyte brush border, protocadherin function requires a complex of cytoplasmic binding partners, although the composition of this complex ...

Abstract	Transporting and sensory epithelial cells shape apical specializations using protocadherin-based adhesion. In the enterocyte brush border, protocadherin function requires a complex of cytoplasmic binding partners, although the composition of this complex and logic governing its assembly remain poorly understood. We found that ankyrin repeat and sterile α motif domain containing 4B (ANKS4B) localizes to the tips of adherent brush border microvilli and is essential for intermicrovillar adhesion. ANKS4B interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton. ANKS4B and USH1C also bind to the MYO7B cargo-binding tail at distinct sites. However, a tripartite complex only forms if ANKS4B and MYO7B are first activated by USH1C. This study uncovers an essential role for ANKS4B in brush border assembly, reveals a hierarchy in the molecular interactions that drive intermicrovillar adhesion, and informs our understanding of diseases caused by mutations in USH1C and ankyrin repeat proteins, such as Usher syndrome.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Carrier Proteins/metabolism ; Cell Adhesion ; Cell Membrane/metabolism ; Cytoskeleton/metabolism ; Enterocytes/metabolism ; Epithelial Cells/metabolism ; Humans ; Microvilli/metabolism
Chemical Substances	ANKS4B protein, human ; Adaptor Proteins, Signal Transducing ; Carrier Proteins ; USH1C protein, human
Language	English
Publishing date	2016-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2015.12.022
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Successful treatment of Parry-Romberg syndrome with autologous fat grafting: 14-year follow-up and review.

Hunstad, Joseph P / Shifrin, David A / Kortesis, Bill G

Annals of plastic surgery

2011 Volume 67, Issue 4, Page(s) 423–425

Abstract: Parry first described the syndrome of progressive facial atrophy in 1825, followed by Romberg in 1846. The clinical hallmark of the syndrome is atrophy of the facial soft tissues, including fat and muscle as well as underlying bone. Clinicians have ... ...

Abstract	Parry first described the syndrome of progressive facial atrophy in 1825, followed by Romberg in 1846. The clinical hallmark of the syndrome is atrophy of the facial soft tissues, including fat and muscle as well as underlying bone. Clinicians have classically reserved treatment until the end of the disease process, after the "burn out" stage. Various treatment modalities have been attempted with differing results. In this study, we present a case of Parry-Romberg syndrome treated with autologous fat grafting. This case report reviews the history of the disease, examines the safety and clinical outcomes of fat grafting as a treatment modality, and challenges the classic timing of that treatment. Additionally, long-term follow-up with photos and histological analysis of specimens are included.
MeSH term(s)	Adipose Tissue/transplantation ; Child ; Facial Hemiatrophy/surgery ; Follow-Up Studies ; Humans ; Male ; Transplantation, Autologous/methods
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0b013e31820b3aa8
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Zs.A 1419: Show issues

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Article: Lymphoma of the breast capsule in a silicone implant-reconstructed patient.

Do, Viet / Shifrin, David A / Oostendorp, Leon

The American surgeon

2010 Volume 76, Issue 9, Page(s) 1030–1031

MeSH term(s)	Adenocarcinoma/surgery ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; Breast Implantation ; Breast Implants ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Cyclophosphamide ; Doxorubicin ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/drug therapy ; Lymphoma, Large-Cell, Anaplastic/pathology ; Lymphoma, Large-Cell, Anaplastic/surgery ; Mastectomy, Modified Radical ; Mastectomy, Simple ; Neoplasms, Second Primary/pathology ; Neoplasms, Second Primary/surgery ; Prednisone ; Vincristine
Chemical Substances	Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2010-09
Publishing country	United States
Document type	Letter
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Article ; Online: Dynamics of brush border remodeling induced by enteropathogenic E. coli.

Shifrin, David A / Crawley, Scott W / Grega-Larson, Nathan E / Tyska, Matthew J

Gut microbes

2014 Volume 5, Issue 4, Page(s) 504–516

Abstract: Enteropathogenic Escherichia coli (EPEC) induces dramatic remodeling of enterocyte brush borders, a process that includes microvillar effacement and actin pedestal formation. Although the Arp2/3 complex is involved in formation of a branched actin ... ...

Abstract	Enteropathogenic Escherichia coli (EPEC) induces dramatic remodeling of enterocyte brush borders, a process that includes microvillar effacement and actin pedestal formation. Although the Arp2/3 complex is involved in formation of a branched actin network within pedestals, the fate of parallel actin bundles in microvilli during infection remains unclear. Here, we find that in polarized intestinal epithelial cells, EPEC stimulates long-range microvillar dynamics, pulling protrusions toward sites of bacterial attachment in a process mediated by the adhesion molecule protocadherin-24. Additionally, retraction of the EPEC bundle forming pilus stimulates directed elongation of nearby microvilli. These processes lead to coalescence of microvilli and incorporation of the underlying parallel actin bundles into pedestals. Furthermore, stabilization of microvillar actin bundles delays pedestal formation. Together, these results suggest a model where EPEC takes advantage of pre-existing actin filaments in microvillar core bundles to facilitate pedestal formation.
MeSH term(s)	Actins/metabolism ; Bacterial Adhesion ; Caco-2 Cells ; Enterocytes/microbiology ; Enterocytes/physiology ; Enterocytes/ultrastructure ; Enteropathogenic Escherichia coli/physiology ; Host-Pathogen Interactions ; Humans ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Microvilli/physiology
Chemical Substances	Actins
Language	English
Publishing date	2014-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1949-0984
ISSN (online)	1949-0984
DOI	10.4161/gmic.32084
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Article ; Online: An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.

McCulloch, Kathryn M / Yamakawa, Izumi / Shifrin, David A / McConnell, Russell E / Foegeding, Nora J / Singh, Prashant K / Mao, Suli / Tyska, Matthew J / Iverson, T M

The Journal of biological chemistry

2019 Volume 294, Issue 10, Page(s) 3454–3463

Abstract: Annexin proteins function as ... ...

Abstract	Annexin proteins function as Ca
MeSH term(s)	Animals ; Annexins/chemistry ; Annexins/metabolism ; Cell Membrane/metabolism ; Epithelial Cells/cytology ; Humans ; Hydrogen-Ion Concentration ; Intestinal Mucosa/metabolism ; Intestines ; Liposomes/metabolism ; Mice ; Models, Molecular ; Organ Specificity ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Multimerization ; Protein Structure, Quaternary ; Protein Transport
Chemical Substances	ANXA13 protein, human ; Annexins ; Anxa13 protein, mouse ; Liposomes
Language	English
Publishing date	2019-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.004571
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Article ; Online: Extracellular vesicles: communication, coercion, and conditioning.

Shifrin, David A / Demory Beckler, Michelle / Coffey, Robert J / Tyska, Matthew J

Molecular biology of the cell

2013 Volume 24, Issue 9, Page(s) 1253–1259

Abstract: Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological ... ...

Abstract	Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular space by virtue of their association with small vesicles, which are released by a variety of cell types. Although the biological significance of such vesicles was initially debated, purification and subsequent functional studies have shown that these extracellular vesicles are bioactive organelles carrying a wide range of protein and nucleic acid cargoes. In many cases these vesicles are laden with molecules that are involved in cell signaling, although other diverse functions are being revealed at a rapid pace. In this Perspective, we discuss recent developments in the understanding of the major pathways of extracellular vesicle biogenesis and how these vesicles contribute to the maintenance of physiological homeostasis.
MeSH term(s)	Animals ; Cell Communication ; Cell-Derived Microparticles/physiology ; Exosomes/physiology ; Extracellular Space ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Transport
Language	English
Publishing date	2013-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E12-08-0572
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Zs.A 2853: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 410: Show issues

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Article: Squamous cell carcinoma of the scrotum in a radiation technologist and the use of sentinel lymph node biopsy in recurrent disease.

Shifrin, David A / Lange, Marianne K / Kahnoski, Richard J / Avallone, Anthony N

The American surgeon

2007 Volume 73, Issue 3, Page(s) 302–303

Abstract: Squamous cell carcinoma (SCC) of the scrotum is an uncommon neoplasm. It has been described in many different occupations and is associated with a myriad of carcinogens, yet the etiology still remains a mystery. This is the first report of its occurrence ...

Abstract	Squamous cell carcinoma (SCC) of the scrotum is an uncommon neoplasm. It has been described in many different occupations and is associated with a myriad of carcinogens, yet the etiology still remains a mystery. This is the first report of its occurrence in a radiation technologist. Additionally, the use of sentinel lymph node biopsy in SCC has been advocated as a safe method of limiting the morbidity associated with bilateral ilioinguinal dissections. This is the first report of its use in recurrent metastatic SCC of the scrotum.
MeSH term(s)	Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Diagnosis, Differential ; Follow-Up Studies ; Genital Neoplasms, Male/etiology ; Genital Neoplasms, Male/pathology ; Genital Neoplasms, Male/surgery ; Humans ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Radiation-Induced/pathology ; Neoplasms, Radiation-Induced/surgery ; Occupational Diseases/etiology ; Occupational Diseases/pathology ; Occupational Diseases/surgery ; Pelvis ; Radiation, Ionizing ; Radiology Department, Hospital ; Scrotum ; Sentinel Lymph Node Biopsy/methods
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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