Article ; Online: Inhibition of degranulation in mast cells attached to a hydrogel through defective microtubule tracts.
2019 Volume 381, Issue 2, Page(s) 248–255
Abstract: Mast cells (MCs) are important effectors of the immediate allergic response. MCs are distributed throughout various tissues and organs, and adhere to extracellular matrix (ECM) with broad stiffness in the body. Here we compared cellular responses ... ...
Abstract | Mast cells (MCs) are important effectors of the immediate allergic response. MCs are distributed throughout various tissues and organs, and adhere to extracellular matrix (ECM) with broad stiffness in the body. Here we compared cellular responses following antigen stimulation in MCs on glass-base dishes with and without a hydrogel. We found that an antigen-induced increase in intracellular Ca |
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MeSH term(s) | Animals ; Calcium/metabolism ; Cell Adhesion/drug effects ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Cell Degranulation/drug effects ; Cell Degranulation/physiology ; Cell Line ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Focal Adhesions/drug effects ; Focal Adhesions/metabolism ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Mast Cells/cytology ; Mast Cells/drug effects ; Mast Cells/physiology ; Microtubules/drug effects ; Microtubules/metabolism ; Microtubules/pathology ; Rats ; Signal Transduction/drug effects ; Surface Properties ; Tissue Scaffolds/chemistry |
Chemical Substances | Hydrogels ; Calcium (SY7Q814VUP) |
Language | English |
Publishing date | 2019-05-18 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1493-x |
ISSN | 1090-2422 ; 0014-4827 |
ISSN (online) | 1090-2422 |
ISSN | 0014-4827 |
DOI | 10.1016/j.yexcr.2019.05.019 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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