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  1. Article ; Online: Southeast Asia's environmental challenges: emergence of new contaminants and advancements in testing methods.

    Bhagat, Jacky / Singh, Nisha / Shimada, Yasuhito

    Frontiers in toxicology

    2024  Volume 6, Page(s) 1322386

    Abstract: Emerging contaminants, including pharmaceuticals, personal care products, microplastics, and per- and poly-fluoroalkyl substances, pose a major threat to both ecosystems and human health in Southeast Asia. As this region undergoes rapid industrialization ...

    Abstract Emerging contaminants, including pharmaceuticals, personal care products, microplastics, and per- and poly-fluoroalkyl substances, pose a major threat to both ecosystems and human health in Southeast Asia. As this region undergoes rapid industrialization and urbanization, the increasing presence of unconventional pollutants in water bodies, soil, and various organisms has become an alarming concern. This review comprehensively examines the environmental challenges posed by emerging contaminants in Southeast Asia and recent progress in toxicity testing methods. We discuss the diverse range of emerging contaminants found in Southeast Asia, shedding light on their causes and effects on ecosystems, and emphasize the need for robust toxicological testing methods. This review is a valuable resource for researchers, policymakers, and environmental practitioners working to mitigate the impacts of emerging contaminants and secure a sustainable future for Southeast Asia.
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2024.1322386
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  2. Article ; Online: Development of a novel zebrafish model of diabetic nephropathy.

    Zang, Liqing / Saitoh, Sei / Katayama, Kan / Zhou, Weibin / Nishimura, Norihiro / Shimada, Yasuhito

    Disease models & mechanisms

    2024  

    Abstract: Diabetic nephropathy (DN) is a substantial healthcare challenge as a complication of diabetes, owing to the high risk of morbidity and mortality involved. Although significant progress has been made in understanding the pathogenesis of DN, more efficient ...

    Abstract Diabetic nephropathy (DN) is a substantial healthcare challenge as a complication of diabetes, owing to the high risk of morbidity and mortality involved. Although significant progress has been made in understanding the pathogenesis of DN, more efficient models are required to develop new therapeutics. Here, we created a DN model in zebrafish by crossing diabetic Tg(acta1:dnIGF1R-EGFP) and proteinuria-tracing Tg(l-fabp::VDBP-GFP) lines, named zMIR/VDBP. Overfed adult zMIR/VDBP fish developed severe hyperglycemia and proteinuria, which were not observed in wild-type zebrafish. Renal histopathology revealed human DN-like characteristics, such as glomerular basement membrane thickening, foot process effacement, and glomerular sclerosis. Glomerular dysfunction is restored upon calorie restriction. RNA sequencing (RNA-seq) analysis demonstrated that zebrafish DN kidneys exhibited transcriptional patterns similar to human DN pathogenesis. Notably, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway was activated, a phenomenon observed in the early phase of human DN. In addition, metformin improved hyperglycemia and proteinuria in DN zebrafish by modulating AKT phosphorylation. Our results indicated that zMIR/VDBP fish are suitable for elucidating the mechanisms underlying human DN and could be a powerful tool for therapeutic discovery.
    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050438
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  3. Article: Application of omics approaches for assessing microplastic and nanoplastic toxicity in fish and seafood species

    Bhagat, Jacky / Zang, Liqing / Nishimura, Norihiro / Shimada, Yasuhito

    Trends in analytical chemistry. 2022 Sept., v. 154

    2022  

    Abstract: Numerous reports on the occurrence of microplastics/nanoplastics (MP/NP) in aquatic environments have triggered severe concerns about the adverse impact of these particles on aquatic organisms and their transfer through food webs. The past few years have ...

    Abstract Numerous reports on the occurrence of microplastics/nanoplastics (MP/NP) in aquatic environments have triggered severe concerns about the adverse impact of these particles on aquatic organisms and their transfer through food webs. The past few years have seen an emerging interest among toxicologists in the use of omics technologies to elucidate the response of fish and other aquatic organisms to environmental contaminants. Omics approaches, such as transcriptomics, proteomics, microbiomics, and metabolomics, have advanced our knowledge of MP/NP-related toxicity. The integration of multi-omics provides a deeper understanding of the toxicity mechanisms and pathways involved. This review provides comprehensive updates and status on applying omics technologies to study the MP/NP-related toxicity in fish and seafood species. Compared with other toxicants, the signature profile or fingerprint of MP/NP still requires further development. Further, a robust regulatory oversight is required to monitor and minimise MP/NP contamination in commercially-important aquatic species.
    Keywords analytical chemistry ; fish ; metabolomics ; multiomics ; nanoplastics ; pollution ; proteomics ; seafoods ; toxic substances ; toxicity ; transcriptomics
    Language English
    Dates of publication 2022-09
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2022.116674
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  4. Article: Beneficial effects of seaweed-derived components on metabolic syndrome via gut microbiota modulation.

    Zang, Liqing / Baharlooeian, Maedeh / Terasawa, Masahiro / Shimada, Yasuhito / Nishimura, Norihiro

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1173225

    Abstract: Metabolic syndrome comprises a group of conditions that collectively increase the risk of abdominal obesity, diabetes, atherosclerosis, cardiovascular diseases, and cancer. Gut microbiota is involved in the pathogenesis of metabolic syndrome, and ... ...

    Abstract Metabolic syndrome comprises a group of conditions that collectively increase the risk of abdominal obesity, diabetes, atherosclerosis, cardiovascular diseases, and cancer. Gut microbiota is involved in the pathogenesis of metabolic syndrome, and microbial diversity and function are strongly affected by diet. In recent years, epidemiological evidence has shown that the dietary intake of seaweed can prevent metabolic syndrome via gut microbiota modulation. In this review, we summarize the current
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1173225
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  5. Article ; Online: Zebrafish Models for Skeletal Muscle Senescence: Lessons from Cell Cultures and Rodent Models.

    Ichii, Shogo / Matsuoka, Izumi / Okazaki, Fumiyoshi / Shimada, Yasuhito

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Human life expectancy has markedly increased over the past hundred years. Consequently, the percentage of elderly people is increasing. Aging and sarcopenic changes in skeletal muscles not only reduce locomotor activities in elderly people but also ... ...

    Abstract Human life expectancy has markedly increased over the past hundred years. Consequently, the percentage of elderly people is increasing. Aging and sarcopenic changes in skeletal muscles not only reduce locomotor activities in elderly people but also increase the chance of trauma, such as bone fractures, and the incidence of other diseases, such as metabolic syndrome, due to reduced physical activity. Exercise therapy is currently the only treatment and prevention approach for skeletal muscle aging. In this review, we aimed to summarize the strategies for modeling skeletal muscle senescence in cell cultures and rodents and provide future perspectives based on zebrafish models. In cell cultures, in addition to myoblast proliferation and myotube differentiation, senescence induction into differentiated myotubes is also promising. In rodents, several models have been reported that reflect the skeletal muscle aging phenotype or parts of it, including the accelerated aging models. Although there are fewer models of skeletal muscle aging in zebrafish than in mice, various models have been reported in recent years with the development of CRISPR/Cas9 technology, and further advancements in the field using zebrafish models are expected in the future.
    Language English
    Publishing date 2022-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238625
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    Zs.MO 81: Show issues

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  6. Article: Editorial: Zebrafish Models for Human Disease Studies.

    Zang, Liqing / Torraca, Vincenzo / Shimada, Yasuhito / Nishimura, Norihiro

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 861941

    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.861941
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  7. Article ; Online: Transcriptome analysis of molecular response to UVC irradiation in zebrafish embryos.

    Zang, Liqing / Shimada, Yasuhito / Miyake, Hideto / Nishimura, Norihiro

    Ecotoxicology and environmental safety

    2022  Volume 231, Page(s) 113211

    Abstract: Ultraviolet (UV) rays can be both harmful and beneficial to humans. This study aimed to investigate the toxicity and safety of ultraviolet C (UVC) exposure in living organisms and the corresponding biodefense molecular mechanisms. Zebrafish embryos, at ... ...

    Abstract Ultraviolet (UV) rays can be both harmful and beneficial to humans. This study aimed to investigate the toxicity and safety of ultraviolet C (UVC) exposure in living organisms and the corresponding biodefense molecular mechanisms. Zebrafish embryos, at an early developmental stage (5-6 h post-fertilization), were irradiated with increasing UVC dosages using high-efficiency deep-ultraviolet light-emitting diodes (278 nm). Morphological phenotypes including survival rate, hatching rate, heart rate, and malformation rate were evaluated. Compared to un-irradiated controls, all zebrafish embryos exposed to 4.5 mJ/cm
    MeSH term(s) Animals ; Embryo, Nonmammalian/radiation effects ; Gene Expression Profiling ; Transcriptome ; Ultraviolet Rays ; Zebrafish/genetics
    Language English
    Publishing date 2022-01-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2022.113211
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Developing a Model for a siRNA Delivery System by Cancer Implantation into Zebrafish Circulation.

    Shimada, Yasuhito / Hazekawa, Mai

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2174, Page(s) 263–275

    Abstract: In recent decades, zebrafish (Danio rerio) has become a major in vivo model for the evaluation of drug efficacies and toxicities. In the field of drug delivery research, zebrafish larvae are a suitable model for the use of fluorescent-labeled chemicals, ... ...

    Abstract In recent decades, zebrafish (Danio rerio) has become a major in vivo model for the evaluation of drug efficacies and toxicities. In the field of drug delivery research, zebrafish larvae are a suitable model for the use of fluorescent-labeled chemicals, nanoparticle, liposome, or micelle-mediated delivery systems because of their transparent body wall. In the current chapter, we describe the method to perform micelle-based siRNA delivery using cancer cells implanted into the circulation of zebrafish.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Carbocyanines/chemistry ; Cell Line, Tumor ; Cell Transplantation ; Drug Delivery Systems/methods ; Fluorescent Dyes/chemistry ; Gene Transfer Techniques ; Humans ; Larva/genetics ; Luminescent Proteins/genetics ; Melanoma/pathology ; Micelles ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Transplants ; Zebrafish/genetics ; Red Fluorescent Protein
    Chemical Substances Carbocyanines ; Fluorescent Dyes ; Luminescent Proteins ; Micelles ; RNA, Small Interfering ; cyanine dye 5 ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0759-6_17
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  9. Article: Worming into a robust model to unravel the micro/nanoplastic toxicity in soil: A review on Caenorhabditis elegans

    Bhagat, Jacky / Nishimura, Norihiro / Shimada, Yasuhito

    Trends in analytical chemistry. 2021 May, v. 138

    2021  

    Abstract: In recent years, Caenorhabditis elegans have emerged as a powerful toxicity model, thanks to the numerous promising features (small size, short life cycle, well-characterized genome, ease of culture, and genetic manipulation), it possesses along with ... ...

    Abstract In recent years, Caenorhabditis elegans have emerged as a powerful toxicity model, thanks to the numerous promising features (small size, short life cycle, well-characterized genome, ease of culture, and genetic manipulation), it possesses along with relieving ethical constraints. The wide availability of mutants, transgenic lines, and the diversity of fluorescent proteins makes C. elegans a worthy candidate to assess the effects of micro/nanoplastics (M/NPs). In this review, we summarize the recent finding on M/NPs toxicity using C. elegans and suggest future directions. As there are considerable concerns about M/NPs toxicity in soil environment, and knowledge gaps on the toxicological pathway involved in M/NPs toxicity, we believe that C. elegans assay provide a promising and powerful tool that has the potential to quicken up this research. Nevertheless, more studies are still needed to get a comprehensive understanding of the mechanisms involved in M/NPs toxicity.
    Keywords Caenorhabditis elegans ; analytical chemistry ; edaphic factors ; ethics ; fluorescence ; genetic engineering ; genetically modified organisms ; genome ; models ; nanoplastics ; soil ; toxicity ; toxicology
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2021.116235
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  10. Article: Ecotoxicological effects of TiO2 nanoparticulates and bulk Ti on microalgae Chaetoceros muelleri

    Baharlooeian, Maedeh / Kerdgari, Mahnaz / Shimada, Yasuhito

    Environmental technology & innovation. 2021 Aug., v. 23

    2021  

    Abstract: The substantial use of titanium compounds in different industries has raised concerns about the negative effects on aquatic environments. Therefore it is important to assess their fate in aquatic environments and their uptake by organisms. This study ... ...

    Abstract The substantial use of titanium compounds in different industries has raised concerns about the negative effects on aquatic environments. Therefore it is important to assess their fate in aquatic environments and their uptake by organisms. This study aimed to assess the toxicological effects of nanoparticle TiO₂ and bulk Ti on Chaetoceros muelleri, the microalgae used as a bioindicator of water pollution, in different periods. The compositions of fatty acids, proteins, and carotenoids were selected as ecotoxicological markers in microalgae. The interaction of algal cells with nano-TiO₂ (nTiO₂) and bulk Ti was evaluated using Fourier transform infrared (FT-IR) spectroscopy. Physiological and biological results of ecological responses of algae showed that the fatty acid profile, protein, and carotenoid contents decreased in comparison with control samples at different times. Although it was observed that carotenoid and protein contents were significantly different (P < 0.05) at different times, the samples demonstrated no significant difference on days 3 and 6 for bulk Ti and day 3 for nTiO₂, respectively. The FT-IR measurements indicated a chemical interaction between the nano and bulk compounds with algal cells on their cell surfaces. However, relative to control samples, nTiO₂ and bulk Ti increased polyunsaturated and monounsaturated fatty acids and decreased saturated fatty acids Further studies are required to elucidate the acute effects of nTiO₂and bulk Ti and their ecotoxicological feedback on the marine environment.
    Keywords Chaetoceros muelleri ; Fourier transform infrared spectroscopy ; carotenoids ; ecotoxicology ; environmental technology ; fatty acid composition ; marine environment ; microalgae ; titanium ; titanium dioxide ; water pollution
    Language English
    Dates of publication 2021-08
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2352-1864
    DOI 10.1016/j.eti.2021.101720
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