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Article: [Benign thyroid nodule].

Shimizu, Kazuo

Nihon rinsho. Japanese journal of clinical medicine

2011 Volume 69 Suppl 2, Page(s) 368–375

MeSH term(s)	Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy
Language	Japanese
Publishing date	2011-03
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: [Therapeutic guidelines--the current status and problems. 3. Management of thyroid cancer].

Shimizu, Kazuo

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2010 Volume 99, Issue 4, Page(s) 747–754

MeSH term(s)	Female ; Humans ; Male ; Thyroid Neoplasms/surgery
Language	Japanese
Publishing date	2010-04-12
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
DOI	10.2169/naika.99.747
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Article ; Online: Direct and Indirect Bactericidal Effects of Cold Atmospheric-Pressure Microplasma and Plasma Jet.

Yahaya, Ahmad Guji / Okuyama, Tomohiro / Kristof, Jaroslav / Blajan, Marius Gabriel / Shimizu, Kazuo

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 9

Abstract: The direct and indirect bactericidal effects of dielectric barrier discharge (DBD) cold atmospheric-pressure microplasma in an air and plasma jet generated in an argon-oxygen gas mixture was investigated ... ...

Abstract	The direct and indirect bactericidal effects of dielectric barrier discharge (DBD) cold atmospheric-pressure microplasma in an air and plasma jet generated in an argon-oxygen gas mixture was investigated on
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Atmospheric Pressure ; Microbial Sensitivity Tests ; Ozone/analysis ; Ozone/chemistry ; Plasma Gases/chemistry ; Plasma Gases/pharmacology ; Reactive Nitrogen Species/chemistry ; Reactive Oxygen Species/chemistry ; Staphylococcus aureus/drug effects ; Sterilization/methods ; Water/chemistry
Chemical Substances	Anti-Bacterial Agents ; Plasma Gases ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Water (059QF0KO0R) ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26092523
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Article: [Toxic multinodular goiter (TMNG)].

Shimizu, Kazuo

Nihon rinsho. Japanese journal of clinical medicine

2006 Volume Suppl 1, Page(s) 298–302

MeSH term(s)	Antithyroid Agents/therapeutic use ; Diagnosis, Differential ; Diagnostic Imaging ; Ethanol/administration & dosage ; Goiter, Nodular/diagnosis ; Goiter, Nodular/etiology ; Goiter, Nodular/physiopathology ; Goiter, Nodular/therapy ; Humans ; Injections, Intralesional ; Thyroid Function Tests ; Thyroidectomy/methods
Chemical Substances	Antithyroid Agents ; Ethanol (3K9958V90M)
Language	Japanese
Publishing date	2006-05-28
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: [Oncogenic emergency and treatment in thyroid disease].

Shimizu, Kazuo

Nihon Geka Gakkai zasshi

2004 Volume 105, Issue 4, Page(s) 266–270

Abstract: The urgent treatment of thyroid disease is mainly considered to be that of thyroid neoplasia, especially malignant thyroid tumors. The clinical symptoms produced by malignant neoplasia are acute respiratory failure caused by tumor compression and/or ... ...

Abstract	The urgent treatment of thyroid disease is mainly considered to be that of thyroid neoplasia, especially malignant thyroid tumors. The clinical symptoms produced by malignant neoplasia are acute respiratory failure caused by tumor compression and/or invasion of the trachea. Massive bleeding caused by tumor invasion of the major vessels also requires emergency therapy. In general, thyroid cancer has a favorable prognosis in patients with well-differentiated papillary carcinoma, which makes up more than 90% of thyroid malignancies. However, anaplastic carcinoma, undifferentiated papillary carcinoma, and malignant lymphoma originating from the thyroid sometimes require urgent therapy to save lives. Anaplastic carcinoma that is basically transformed from well-differentiated papillary carcinoma shows rapid growth and invades the surrounding tissue to produce tracheal obstruction. Repeated postoperative recurrences in patient with papillary carcinoma suggest undifferentiated carcinoma that eventually becomes the same endostage as anaplastic carcinoma. Radical surgery is needed in such cases initially, although making a differential diagnosis between well- and undifferentiated carcinoma is extremely difficult. Urgent treatment of these diseases consists of ensuring that the airway remains open to improve quality of life, but does not include radical treatment. Stent insertion is one adequate method for the urgent treatment of respiratory disturbance caused by tumor compression. Malignant lymphoma frequently develops from Hashimoto's thyroiditis. Immediately after making an accurate pathologic diagnosis, chemotherapy and/or radiation therapy are effective in reducing enlarged goiters rather than surgical management.
MeSH term(s)	Emergencies ; Hemorrhage/therapy ; Humans ; Respiratory Insufficiency/therapy ; Thyroid Neoplasms/complications
Language	Japanese
Publishing date	2004-04
Publishing country	Japan
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	412544-7
ISSN	1880-1129 ; 0301-4894
ISSN (online)	1880-1129
ISSN	0301-4894
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Article: Case Report: A Case of Moyamoya Syndrome Associated With Multiple Endocrine Neoplasia Type 2A.

Matano, Fumihiro / Murai, Yasuo / Watanabe, Atsushi / Shirokane, Kazutaka / Igarashi, Takehito / Shimizu, Kazuo / Shimada, Takashi / Morita, Akio

Frontiers in endocrinology

2021 Volume 12, Page(s) 703410

Abstract: To the best of our knowledge, we report a case of MEN2A complicated by moyamoya syndrome. A 52-year-old woman presented with vertigo. Magnetic resonance angiography (MRA) revealed bilateral supraclinoid stenosis of the internal carotid artery and ... ...

Abstract	To the best of our knowledge, we report a case of MEN2A complicated by moyamoya syndrome. A 52-year-old woman presented with vertigo. Magnetic resonance angiography (MRA) revealed bilateral supraclinoid stenosis of the internal carotid artery and abnormal moyamoya-like vessels around the basal ganglia. She had a heterozygous variant of
MeSH term(s)	Adenosine Triphosphatases/genetics ; Adrenal Gland Neoplasms/physiopathology ; Carcinoma, Neuroendocrine/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Moyamoya Disease/etiology ; Moyamoya Disease/metabolism ; Moyamoya Disease/pathology ; Multiple Endocrine Neoplasia Type 2a/complications ; Mutation ; Pedigree ; Pheochromocytoma/physiopathology ; Thyroid Neoplasms/physiopathology ; Ubiquitin-Protein Ligases/genetics
Chemical Substances	RNF213 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2021-11-11
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.703410
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Article ; Online: Learning Curve for Endoscopic Thyroidectomy Using Video-Assisted Neck Surgery: Retrospective Analysis of a Surgeon's Experience with 100 Patients.

Nagaoka, Ryuta / Sugitani, Iwao / Kazusaka, Hiroko / Matsui, Mami / Sen, Masaomi / Saitou, Marie / Jikuzono, Tomoo / Okamura, Ritsuko / Igarashi, Takehito / Shimizu, Kazuo

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2021 Volume 89, Issue 3, Page(s) 277–286

Abstract: Background: Endoscopic thyroidectomy offers excellent cosmetic outcomes but requires some time for surgeons to become proficient. We examined the learning curve for the first 100 patients treated by a single surgeon using a subclavian approach for video- ...

Abstract	Background: Endoscopic thyroidectomy offers excellent cosmetic outcomes but requires some time for surgeons to become proficient. We examined the learning curve for the first 100 patients treated by a single surgeon using a subclavian approach for video-assisted neck surgery (VANS). Methods: We retrospectively studied the records of 100 patients (99 women, 1 man; mean age, 36.2 years) with either benign or malignant thyroid disease treated between 2016 and 2020. Results: Preoperative diagnosis was papillary thyroid carcinoma (PTC) in 36 cases and other (non-PTC) in 64 cases. All patients underwent lobectomy, with additional unilateral central node dissection for patients with PTC. Mean operative time was 125 min for non-PTC cases and 129 min for PTC cases (p = 0.43); blood loss was 33.8 mL and 7.6 mL, respectively (p = 0.01). Recurrent laryngeal nerve paralysis (RNP) was observed in 12 patients (12%) and hemorrhage in 2 patients (2%). In a comparison of the first 30 cases and subsequent 70 cases, no significant differences in operative time or blood loss were evident, although tumor size was significantly greater among later non-PTC cases (32.4 mm vs. 39.5 mm, p = 0.039). RNP was significantly lower in later cases (26.7% vs. 5.7%, p = 0.003). Multivariate analysis revealed that tumor size was a significant risk factor for increased blood loss, and increased experience significantly correlated with a decrease in RNP. Conclusions: In VANS, satisfactory surgical proficiency was reached after treating 30 patients.
MeSH term(s)	Adult ; Female ; Humans ; Learning Curve ; Male ; Neck Dissection ; Retrospective Studies ; Surgeons ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Video-Assisted Surgery ; Vocal Cord Paralysis
Language	English
Publishing date	2021-09-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2022_89-302
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Article ; Online: Novel method to improve transdermal drug delivery by atmospheric microplasma irradiation.

Shimizu, Kazuo / Hayashida, Kentaro / Blajan, Marius

Biointerphases

2015 Volume 10, Issue 2, Page(s) 29517

Abstract: Application of atmospheric plasma could be used for wound healing, skin rejuvenation, and wrinkle treatment. The authors explored the feasibility of atmospheric microplasma irradiation (AMI) for enhancement of percutaneous absorption of drugs as an ... ...

Abstract	Application of atmospheric plasma could be used for wound healing, skin rejuvenation, and wrinkle treatment. The authors explored the feasibility of atmospheric microplasma irradiation (AMI) for enhancement of percutaneous absorption of drugs as an alternative to hypodermic needles. Pig skin was used as a biological sample exposed to AMI and analyzed by attenuated total reflection-Fourier transform infrared spectroscopy. A tape-stripping test (an evaluation method for skin-barrier performance) was also conducted to compare with AMI. Transepidermal water loss was also measured and compared with and without AMI. Results showed that surface modification of the stratum corneum (outermost skin layer) was observed upon AMI. Small pores on sample skin were observed with plasma jet irradiation due to the collision of charged particles. Percutaneous absorption was confirmed without damage upon microplasma irradiation. Our data suggested that dye pathways through skin samples could be related to the dynamic behavior of intercellular lipid bilayers, suggesting that AMI could enhance percutaneous absorption.
MeSH term(s)	Administration, Cutaneous ; Animals ; Atmosphere ; Dehydration ; Drug Delivery Systems/methods ; Female ; Permeability/radiation effects ; Pharmaceutical Preparations/administration & dosage ; Plasma Gases ; Skin/chemistry ; Skin/radiation effects ; Spectroscopy, Fourier Transform Infrared ; Sus scrofa
Chemical Substances	Pharmaceutical Preparations ; Plasma Gases
Language	English
Publishing date	2015-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234510-3
ISSN	1559-4106 ; 1934-8630
ISSN (online)	1559-4106
ISSN	1934-8630
DOI	10.1116/1.4919708
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Article ; Online: Effects of microplasma irradiation on human gingival fibroblasts.

Takahashi, Ryoichi / Shimizu, Kazuo / Numabe, Yukihiro

Odontology

2014 Volume 103, Issue 2, Page(s) 194–202

Abstract: The purpose of this research was to clarify the effects of microplasma irradiation on human gingival fibroblasts (HGF). Microplasma irradiation exposure for all HGF samples was limited to 30 s at an irradiation distance of 10 mm with a gas flow of 10 L/ ... ...

Abstract	The purpose of this research was to clarify the effects of microplasma irradiation on human gingival fibroblasts (HGF). Microplasma irradiation exposure for all HGF samples was limited to 30 s at an irradiation distance of 10 mm with a gas flow of 10 L/min. Three experimental groups were used: a 0 V control group (Control); a 650 V (low) microplasma irradiation group (LV); and a 975 V (high) irradiation group (HV). The following cellular characteristics were evaluated in order to analyze the effects of microplasma treatment; morphology, cell count, DNA content, metabolic activity, cell migration, fibroblast growth factor β (FGF-2) production, type I collagen secretion, and cytotoxic analysis. Cell count, DNA content and FGF-2 production have all been linked to wound healing and, interestingly, both the LV and HV groups showed significant (P < 0.05) increases in these categories at 72 h after irradiation when compared to the control group. Cytotoxic effects were measured by determining the levels of lactate dehydrogenase, cell death, and DNA damage in HGF cells. In these analyses, the HV and LV groups were not statistically different when compared with the control group at 72 h post-irradiation. These findings suggest that microplasma irradiation activated HGF with no clear cell-damaging effects.
MeSH term(s)	Cell Movement/radiation effects ; Cell Proliferation/radiation effects ; Cells, Cultured ; Enzyme-Linked Immunosorbent Assay ; Fibroblast Growth Factors/metabolism ; Fibroblasts/radiation effects ; Gingiva/cytology ; Humans ; Plasma Gases/pharmacology ; Wound Healing/radiation effects
Chemical Substances	Plasma Gases ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2014-06-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2092085-4
ISSN	1618-1255 ; 1618-1247
ISSN (online)	1618-1255
ISSN	1618-1247
DOI	10.1007/s10266-014-0157-2
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Article ; Online: Paclitaxel enhances antibody-dependent cell-mediated cytotoxicity of trastuzumab by rapid recruitment of natural killer cells in HER2-positive breast cancer.

Miura, Daishu / Yoneyama, Kimiyasu / Furuhata, Yoshiaki / Shimizu, Kazuo

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2014 Volume 81, Issue 4, Page(s) 211–220

Abstract: Introduction: An important mechanism by which trastuzumab inhibits the growth of human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells is the activation of a host tumor response via antibody-dependent cell-mediated cytotoxicity ( ... ...

Abstract	Introduction: An important mechanism by which trastuzumab inhibits the growth of human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells is the activation of a host tumor response via antibody-dependent cell-mediated cytotoxicity (ADCC). Although paclitaxel has a synergistic effect in combination with trastuzumab, whether ADCC is enhanced by paclitaxel is not known. In the present study we examined whether adding paclitaxel to trastuzumab enhances ADCC and also investigated the kinetics of effector cells in ADCC. Materials and methods: The subjects were 20 patients with HER2-positive breast cancer: 9 received the combination of trastuzumab (4 mg/kg as a loading dose and 2 mg/kg weekly) and paclitaxel (80 mg/m(2) weekly) and 19 received monotherapy with trastuzumab. In blood samples (mononuclear cells) obtained before and 10 minutes after administration of chemotherapy, ADCC and the number of effector cells, including natural killer (NK) cells, monocytes, and CD64+ cells, were compared in each case. The ADCC was analyzed with a (51)Cr releasing assay using the SK-BR-3 cell line, and the fractions of NK cells (both CD16+ [FcγRIII] and CD56+) and CD64+ (FcγRI) cells were analyzed with flow cytometry. Results: The mean ADCC level increased 20% after trastuzumab monotherapy and 126% (p<0.05) after combination therapy with trastuzumab and paclitaxel. All 9 patients receiving combination therapy had increased ADCC levels. The number of NK cells increased 51% after trastuzumab monotherapy and 112% (p<0.05) after combination therapy. No significant changes were found in monocytes (39% increase) or CD64+ cells (53% increase) after trastuzumab monotherapy, but monocytes decreased 40% (p<0.05) and CD64+ cells decreased 24% after combination therapy. Conclusions: Adding paclitaxel to trastuzumab significantly enhances ADCC, with levels twice as great as with trastuzumab monotherapy, through a rapid recruitment of NK cells. This finding suggests that the combination of trastuzumab and paclitaxel has a stronger-than-expected synergistic effect in HER2-positive breast cancer.
MeSH term(s)	Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibody-Dependent Cell Cytotoxicity/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocyte Count ; Monocytes/drug effects ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Receptor, ErbB-2/metabolism ; Trastuzumab
Chemical Substances	Antibodies, Monoclonal, Humanized ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2014-08-29
Publishing country	Japan
Document type	Journal Article ; Observational Study
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.81.211
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