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  1. Article ; Online: Letter to the Editor Regarding "Medical Malpractice Litigation after Spine Surgery in Beijing Between 2013 and 2018".

    Shimizu, Satoru

    World neurosurgery

    2024  Volume 183, Page(s) 260–261

    MeSH term(s) Humans ; Beijing ; Malpractice ; Databases, Factual
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.11.131
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    Zs.A 1159: Show issues Location:
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  2. Article ; Online: Insights into the associative role of hypertension and angiotensin II receptor in lower urinary tract dysfunction.

    Shimizu, Shogo

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  Volume 47, Issue 4, Page(s) 987–997

    Abstract: In men, the lower urinary tract comprises the urinary bladder, urethra, and prostate, and its primary functions include urine storage and voiding. Hypertension is a condition that causes multi-organ damage and an age-dependent condition. Hypertension and ...

    Abstract In men, the lower urinary tract comprises the urinary bladder, urethra, and prostate, and its primary functions include urine storage and voiding. Hypertension is a condition that causes multi-organ damage and an age-dependent condition. Hypertension and the renin-angiotensin system activation are associated with the development of lower urinary tract dysfunction. Hypertensive animal models show bladder dysfunction, urethral dysfunction, and prostatic hyperplasia. In the renin-angiotensin system, angiotensin II and the angiotensin II type 1 receptor, which are expressed in the lower urinary tract, have been implicated in the pathogenesis of lower urinary tract dysfunction. Moreover, among the several antihypertensives, renin-angiotensin system inhibitors have proven effective in human and animal models of lower urinary tract dysfunction. This review aimed to elucidate the hitherto known mechanisms underlying the development of lower urinary tract dysfunction in relation to hypertension and the angiotensin II/angiotensin II type 1 receptor axis and the effect of renin-angiotensin system inhibitors on lower urinary tract dysfunction. Possible mechanisms through which hypertension or activation of Ang II/AT1 receptor axis causes LUTD such as bladder dysfunction, urethral dysfunction, and prostatic hyperplasia. LUT: lower urinary tract, LUTD: lower urinary tract dysfunction, AT1: angiotensin II type 1, ACE: angiotensin-converting enzyme.
    MeSH term(s) Male ; Animals ; Humans ; Urinary Bladder/metabolism ; Angiotensin II/pharmacology ; Receptor, Angiotensin, Type 1/metabolism ; Prostatic Hyperplasia ; Hypertension ; Renin-Angiotensin System ; Antihypertensive Agents/pharmacology ; Enzyme Inhibitors/pharmacology
    Chemical Substances Angiotensin II (11128-99-7) ; Receptor, Angiotensin, Type 1 ; Antihypertensive Agents ; Enzyme Inhibitors
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01597-8
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    Zs.A 3898: Show issues Location:
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  3. Article: [Roles for mechanosensor in bladder urothelium].

    Shimizu, Shogo

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 2, Page(s) 212

    MeSH term(s) Urinary Bladder ; Urothelium ; Muscle, Smooth
    Language Japanese
    Publishing date 2023-02-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22158
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    Zs.A 439: Show issues Location:
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  4. Article: [Benign prostatic hyperplasia and autoimmune disease].

    Shimizu, Shogo

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 3, Page(s) 290

    MeSH term(s) Male ; Humans ; Prostatic Hyperplasia/therapy ; Prostate ; Disease Progression ; Autoimmune Diseases
    Language Japanese
    Publishing date 2023-04-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23001
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    Zs.A 439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: [Drug therapy targeting angiotensin II type 1 receptors in brain against frequent urination].

    Shimizu, Shogo

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 5, Page(s) 379–383

    Abstract: The production of angiotensin II (Ang II) in the brain plays important roles as neurotransmitter and neuropeptide. Central Ang II is involved in regulating various physiological processes, such as blood pressure and water homeostasis, via Ang II type 1 ( ... ...

    Abstract The production of angiotensin II (Ang II) in the brain plays important roles as neurotransmitter and neuropeptide. Central Ang II is involved in regulating various physiological processes, such as blood pressure and water homeostasis, via Ang II type 1 (AT1) receptors. We have demonstrated that Ang II induces frequent urination via AT1 receptors in the brain even at doses that does not seem to affect the blood pressure in animal experiment. Intracerebroventricular administration of Ang II was also found to reduce the bladder capacity without affecting the maximum voiding pressure, post voiding residual urine volume or voiding efficiency. Additionally, the activation of AT1 receptor downstream signal pathway (phospholipase C/protein kinase C/NADPH oxidase/superoxide anion) and suppression of GABAergic nervous system in the brain are involved in the mechanism underlying the central Ang II-inducted frequent urination. AT1 receptor blockers (ARBs) have been widely used to treat hypertension. We demonstrated that peripherally administered ARBs telmisartan, which can penetrate blood-brain barrier, exerted an inhibitory effect on central Ang II-inducted frequent urination. We present the possible drug therapy targeting AT1 receptors in the brain against frequent urination on the results obtained from our recent research work.
    MeSH term(s) Animals ; Angiotensin II/physiology ; Angiotensin Receptor Antagonists/therapeutic use ; Brain/metabolism ; Receptor, Angiotensin, Type 1/drug effects ; Urination/physiology ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/physiopathology
    Chemical Substances Angiotensin II (11128-99-7) ; Angiotensin Receptor Antagonists ; Receptor, Angiotensin, Type 1
    Language Japanese
    Publishing date 2023-09-06
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Therapeutic targets in the brain for overactive bladder: A focus on angiotensin II type 1 receptor.

    Shimizu, Shogo

    Journal of pharmacological sciences

    2023  Volume 153, Issue 2, Page(s) 69–72

    Abstract: Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, ... ...

    Abstract Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, β
    MeSH term(s) Male ; Humans ; Female ; Urinary Bladder, Overactive/drug therapy ; Receptor, Angiotensin, Type 1 ; Quality of Life ; Solitary Nucleus ; Reflex ; Angiotensin II
    Chemical Substances Receptor, Angiotensin, Type 1 ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-07-22
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2023.07.005
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    Zs.A 237: Show issues Location:
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  7. Article ; Online: Letter to the Editor Regarding "Improving Surgeon Well-being: Ergonomics in Neurosurgery".

    Shimizu, Satoru

    World neurosurgery

    2023  Volume 179, Page(s) 252

    MeSH term(s) Humans ; Neurosurgery ; Neurosurgical Procedures ; Ergonomics ; Surgeons
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.08.061
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    Zs.A 1159: Show issues Location:
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  8. Article ; Online: The First Synthesis of Subporphyrins.

    Shimizu, Soji

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 10, Page(s) e202217099

    Abstract: Because of the rich coordination chemistry and unique optical and electrochemical properties, porphyrin analogues have been intensively investigated. Among them, subporphyrins have been long-awaited molecules, with only their boron complexes known to ... ...

    Abstract Because of the rich coordination chemistry and unique optical and electrochemical properties, porphyrin analogues have been intensively investigated. Among them, subporphyrins have been long-awaited molecules, with only their boron complexes known to date because of the crucial role of the central boron atom as a template in synthesis. The challenges related to the synthesis of a genuine subporphyrin (boron-free) have finally been met and reported in a recent article from Kim, Osuka, and Song. A key strategy of their synthesis lies in the introduction of an exocyclic double bond at the meso-position and subsequent reduction to obtain macrocyclic conjugation. Considering the fact that the development of porphyrin chemistry is ultimately linked to the availability of free base porphyrins, this seminal work will facilitate studies on coordination chemistry and applications in materials science.
    Language English
    Publishing date 2023-01-12
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202217099
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  9. Article ; Online: Unilateral radiculopathy away from the puncture site due to adhesive arachnoiditis after spinal anesthesia for an emergent cesarean delivery: a case report.

    Shimizu, Satoshi

    JA clinical reports

    2022  Volume 8, Issue 1, Page(s) 28

    Abstract: Background: Adhesive arachnoiditis has been described as a deteriorating neurological complication after neuraxial blockade; however, few pieces of literatures have reported minor cases that resemble peripheral neuropathy.: Case presentation: A 29- ... ...

    Abstract Background: Adhesive arachnoiditis has been described as a deteriorating neurological complication after neuraxial blockade; however, few pieces of literatures have reported minor cases that resemble peripheral neuropathy.
    Case presentation: A 29-year-old nulliparous woman underwent an emergent cesarean delivery under spinal anesthesia at the second and third lumbar interspace (L2/3) without any specific concerns. Subsequently, she developed left L5 and sacral first (S1) radiculopathy that persisted for 2 months. Although the neurological findings more likely indicated peripheral neuropathy, magnetic resonance imaging revealed localized adhesive arachnoiditis at the left L5/S1 level. Her symptoms gradually improved and entirely disappeared within 2 months without any particular treatment.
    Conclusion: The neurological symptoms that show a clear tendency to improve spontaneously do not always undergo a detailed workup. Therefore, such minor adhesive arachnoiditis might have occurred more than expected. Imaging such cases might cumulatively further the understanding of its etiology.
    Language English
    Publishing date 2022-04-12
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-022-00518-3
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  10. Article ; Online: Actual Amount Adsorbed as Estimated from the Surface Excess Isotherm.

    Shimizu, Seishi / Matubayasi, Nobuyuki

    Langmuir : the ACS journal of surfaces and colloids

    2024  Volume 40, Issue 3, Page(s) 1666–1673

    Abstract: The amount of adsorption at equilibrium is commonly used for reporting solid/solution isotherms, despite the admonishment by the International Union of Pure and Applied Chemistry (IUPAC) against equating the surface excess (i.e., the measurable quantity ... ...

    Abstract The amount of adsorption at equilibrium is commonly used for reporting solid/solution isotherms, despite the admonishment by the International Union of Pure and Applied Chemistry (IUPAC) against equating the surface excess (i.e., the measurable quantity for sorption, signifying the competitive sorption of adsorbate and solvent) with the actual amount adsorbed. The consensus, more generally stated, is that the surface excess cannot be divided into individual isotherms for sorbate and solvent unless simplifying model assumptions are introduced. Here we show, contrary to the IUPAC report, that there exists a simple method for assigning the total isotherm to the sorbate's actual amount adsorbed and to the individual solute isotherm. This requires a combination of isotherm and volumetric measurements. For dilute sorbates, we establish criteria to show if the total isotherm is dominated by the amount of sorption at the interface, in agreement with the common assumption in the practical literature. In the absence of the volume data, we propose an approximate yet more versatile method based on the specific surface area to carry out order-of-magnitude analysis to examine whether the actual amount adsorbed dominates surface excess. Application of our methods to the adsorption of sodium decyl sulfate on polystyrene latex, malachite green on activated carbons, and thiophenes on a metal-organic framework all demonstrated the dominance of the actual amount adsorbed, significantly simplifying isotherm analysis in terms of the underlying interactions (i.e., surface-sorbate and net self-interactions at the interface), eliminating the need for excess surface quantities. Analysis of fully miscible solvent-sorbate isotherms (e.g., the mixtures of organic solvents adsorbed on mesoporous silica and carbonaceous adsorbents) indicates the contributions from both sorbate and solvent isotherms.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c02597
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