LIVIVO - Search results -

Search results

Result 1 - 10 of total 91

Search options

Article ; Online: Deep Brain Stimulation Using Animal Models of Parkinson's Disease.

Nakajima, Asuka / Shimo, Yasushi

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2322, Page(s) 151–160

Abstract: The use of deep brain stimulation (DBS) as a therapy for neurological disorders, especially Parkinson's disease (PD), is widely applied in the field of functional neurosurgery. Both the subthalamic nucleus and the globus pallidus interna are major ... ...

Abstract	The use of deep brain stimulation (DBS) as a therapy for neurological disorders, especially Parkinson's disease (PD), is widely applied in the field of functional neurosurgery. Both the subthalamic nucleus and the globus pallidus interna are major targets for PD. Experimental DBS is performed using animal models to evaluate new indications and promote advancements in technology. In this chapter, we reviewed our experience with the concept of experimental DBS, including its development and validation. The following work aimed to establish that experimental DBS in animals is an adequate tool for exploring new indications for DBS and to further refine DBS technology.
MeSH term(s)	Animals ; Deep Brain Stimulation/methods ; Disease Models, Animal ; Globus Pallidus/physiopathology ; Humans ; Macaca fuscata ; Neurosurgical Procedures/methods ; Parkinson Disease/physiopathology ; Subthalamic Nucleus/physiopathology
Language	English
Publishing date	2021-05-27
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1495-2_15
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: [Parkinson's disease and it's look-alike].

Shimo, Yasushi / Hattori, Nobutaka

Rinsho shinkeigaku = Clinical neurology

2020 Volume 60, Issue 12, Page(s) 815–821

Abstract: The diagnosis of Parkinson's disease (PD) requires the exclusion of other diseases using various methods. However, it is difficult to differentiate these diseases based only on clinical symptoms, and information regarding responses to drugs and several ... ...

Abstract	The diagnosis of Parkinson's disease (PD) requires the exclusion of other diseases using various methods. However, it is difficult to differentiate these diseases based only on clinical symptoms, and information regarding responses to drugs and several imaging examinations are often needed for a diagnosis. In recent years, various neurological signs and symptoms have been reported that are particularly useful in neurological examinations for differentiating PD, progressive supranuclear palsy, and multiple system atrophy. Currently, diagnosis using imaging techniques and artificial intelligence are being developed, but systematic neurological examinations will continue to be important in diagnosing these diseases.
MeSH term(s)	Artificial Intelligence ; Diagnosis, Differential ; Diagnostic Imaging/methods ; Diagnostic Techniques, Neurological/trends ; Humans ; Multiple System Atrophy ; Neurologic Examination/methods ; Neurologic Examination/trends ; Parkinson Disease/diagnosis ; Parkinson Disease/diagnostic imaging ; Supranuclear Palsy, Progressive ; Syndrome
Language	Japanese
Publishing date	2020-11-20
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001459
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Propofol Withdrawal Dyskinesia in a Parkinson's Disease Patient with Levodopa-Induced Dyskinesia.

Nakajima, Asuka / Iwamuro, Hirokazu / Tokugawa, Joji / Odo, Masahiko / Shimo, Yasushi

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2022 Volume 50, Issue 2, Page(s) 322–323

MeSH term(s)	Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Propofol/adverse effects ; Antiparkinson Agents/adverse effects ; Dyskinesias/drug therapy ; Dyskinesias/etiology
Chemical Substances	Levodopa (46627O600J) ; Propofol (YI7VU623SF) ; Antiparkinson Agents
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2022.4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1203: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Antagonism of metabotropic glutamate receptor type 5 prevents levodopa-induced dyskinesia development in a male rat model of Parkinson's disease: Electrophysiological evidence.

Kamo, Hikaru / Iwamuro, Hirokazu / Nakamura, Ryota / Nojiri, Shuko / Okuzumi, Ayami / Ogawa, Takashi / Nakajima, Asuka / Hattori, Nobutaka / Shimo, Yasushi

Journal of neuroscience research

2024 Volume 102, Issue 3, Page(s) e25302

Abstract: Levodopa-induced dyskinesia (LID) is a common complication in patients with advanced Parkinson's disease (PD) undergoing treatment with levodopa. Glutamate receptor antagonists can suppress LID; however, the underlying mechanisms remain unclear. Here, we ...

Abstract	Levodopa-induced dyskinesia (LID) is a common complication in patients with advanced Parkinson's disease (PD) undergoing treatment with levodopa. Glutamate receptor antagonists can suppress LID; however, the underlying mechanisms remain unclear. Here, we aimed to evaluate the effect of 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP), a metabotropic glutamate receptor 5 (mGluR5) antagonist, on dyskinesia. We recorded the neuronal activity of the entopeduncular nucleus and examined responses to cortical electric stimulation in the control group (n = 6) and three groups of rats (male PD model). Saline was intraperitoneally administered to dopamine lesioned (DL) rats (n = 6), levodopa/benserazide (L/B) was administered to LID rats (n = 8), and L/B combined with MTEP was administered to MTEP rats (n = 6) twice daily for 14 days. We administered L/B to LID and MTEP rats 48 h after the final administration of MTEP to examine the chronic effect of MTEP. The control and DL groups did not have LID. The MTEP group had less LID than the LID group (p < .01) on day 1 and day 18. The control group had a typical triphasic pattern consisting of early excitation (early-Ex), inhibition, and late excitation (late-Ex). However, the inhibition phase disappeared, was partially observed, and was fully suppressed in the DL, LID, and MTEP groups, respectively. The cortico-striato-entopeduncular pathway is important in the pathophysiology of LID. mGluR5 antagonism suppresses LID progression by preventing physiological changes in the cortico-striato-entopeduncular pathway. Future studies are required to validate these results.
MeSH term(s)	Humans ; Rats ; Male ; Animals ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Receptor, Metabotropic Glutamate 5 ; Antiparkinson Agents/adverse effects ; Dyskinesia, Drug-Induced/drug therapy ; Dyskinesia, Drug-Induced/prevention & control ; Dyskinesia, Drug-Induced/metabolism ; Oxidopamine
Chemical Substances	Levodopa (46627O600J) ; Receptor, Metabotropic Glutamate 5 ; Antiparkinson Agents ; Oxidopamine (8HW4YBZ748)
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.25302
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1232: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: [The role of neurologists in DBS treatment on Parkinson's disease].

Shimo, Yasushi

Rinsho shinkeigaku = Clinical neurology

2012 Volume 52, Issue 11, Page(s) 1103–1105

Abstract: Deep brain simulation (DBS) is a widely accepted surgical therapy for Parkinson's disease, dystonia and tremor in Japan. In other countries, DBS has been applied to neuropsychiatric or neurodegenerative diseases, such as Tourette syndrome, depression, ... ...

Abstract	Deep brain simulation (DBS) is a widely accepted surgical therapy for Parkinson's disease, dystonia and tremor in Japan. In other countries, DBS has been applied to neuropsychiatric or neurodegenerative diseases, such as Tourette syndrome, depression, obsessive compulsive disorder, Alzheimer disease, etc. So far, these diseases have been treated mainly by neurologists or psychiatrists, however after the invention of DBS, neurosurgeons now play an important role in the treatment of these diseases, especially in Parkinson's disease. Several reports showed that better postoperative outcomes can be obtained when patient is managed by a neurologist who is responsible for stimulation programming and drug adjustments. The therapy should be done while adjusting both the drugs and the stimulation (DBS) simultaneously. Hence, neurologists should be familiar with programming of DBS, as well as the medical therapy.
MeSH term(s)	Deep Brain Stimulation ; Humans ; Interprofessional Relations ; Neurology ; Parkinson Disease/therapy ; Physician's Role
Language	Japanese
Publishing date	2012-11-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.52.1103
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1455: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 223: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Future of Tanscranial Magnetic Stimulation in Movement Disorders: Introduction of Novel Methods.

Ugawa, Yoshikazu / Shimo, Yasushi / Terao, Yasuo

Journal of movement disorders

2020 Volume 13, Issue 2, Page(s) 115–117

Language	English
Publishing date	2020-04-06
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3021788-X
ISSN	2093-4939 ; 2005-940X
ISSN (online)	2093-4939
ISSN	2005-940X
DOI	10.14802/jmd.19083
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Motor/Nonmotor Symptoms and Progression in Patients with Parkinson's Disease: Prevalence and Risks in a Longitudinal Study.

Yoritaka, Asako / Shimo, Yasushi / Hatano, Taku / Hattori, Nobutaka

Parkinson's disease

2020 Volume 2020, Page(s) 2735361

Abstract: We previously assessed the prevalence and risks of motor/nonmotor symptoms in a large sample of Japanese patients with Parkinson's disease. In the present study, we longitudinally assessed the prevalence and risk of motor/nonmotor symptoms, changes in ... ...

Abstract	We previously assessed the prevalence and risks of motor/nonmotor symptoms in a large sample of Japanese patients with Parkinson's disease. In the present study, we longitudinally assessed the prevalence and risk of motor/nonmotor symptoms, changes in treatment, disease progression, and death in patients with Parkinson's disease. We enrolled 1,227 patients diagnosed and treated at our hospital in Tokyo at first evaluation. We were able to follow-up 445 patients until the second evaluation, 7.4 years later. Using Kaplan-Meier survival curves and the Cox proportional-hazards model in 1,227 patients, motor/nonmotor symptoms were analyzed in association with the following events: pain, wearing-off, camptocormia, psychosis, orthostatic hypotension, pneumonia, tube feeding, modified Hoehn and Yahr stages (H-Y) 3 and 4 of the on state, and death. The mean age (standard deviation) at the first evaluation was 67.2 (9.9) years, while the mean ages at onset and disease duration were 57.8 (11.7) years and 9.3 (6.6) years, respectively. The mean H-Y of the on state was 2.7 (1.1) at the first evaluation. Age at onset and duration of levodopa use decreased the hazard ratios (HRs) (0.968 and 0.910, respectively) for wearing-off. Female sex increased the HRs (1.414) for wearing-off and decreased the HRs for orthostatic hypotension (0.540) and pneumonia (0.510). Older age at onset increased the HR for psychosis (1.035), orthostatic hypotension (1.033), H-Y 3 (1.048) and 4 (1.071), pneumonia (1.123), tube feeding (1.140), and death (1.095). Early onset of orthostatic hypotension itself increased the HR for numerous events, especially for death (0.893). Our results indicated that age, sex, and some nonmotor symptoms may predict many Parkinson's disease-related events. In addition, these data may provide a useful reference for the clinical course of Parkinson's disease.
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573854-9
ISSN	2042-0080 ; 2090-8083
ISSN (online)	2042-0080
ISSN	2090-8083
DOI	10.1155/2020/2735361
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on

Fukae, Jiro / Eguchi, Hiroto / Wada, Yoichi / Fuse, Atsuhito / Chishima, Rika / Nakatani, Mitsuyoshi / Nakajima, Asuka / Hattori, Nobutaka / Shimo, Yasushi

Frontiers in neurology

2023 Volume 14, Page(s) 1183306

Abstract: Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ...

Abstract	Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging demonstrated that he had hyperhomocysteinemia induced by multiple factors including the C677T polymorphism on 5.10-methylenetetrahydrofolate reductase (
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1183306
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Indication for Deep Brain Stimulation].

Shimo, Yasushi / Umemura, Atsushi / Hattori, Nobutaka

Brain and nerve = Shinkei kenkyu no shinpo

2019 Volume 71, Issue 8, Page(s) 885–892

Abstract: Various methods for the management of motor fluctuation in Parkinson's disease have been developed. Among them, deep brain stimulation (DBS) is an important therapeutic option that has been proved to be effective. However, the indications and timing of ... ...

Abstract	Various methods for the management of motor fluctuation in Parkinson's disease have been developed. Among them, deep brain stimulation (DBS) is an important therapeutic option that has been proved to be effective. However, the indications and timing of induction therapy are controversial. When contemplating therapy, it is important to consider not only the motor function but also the specific disease course and psychiatric aspects, of each patient.
MeSH term(s)	Deep Brain Stimulation ; Humans ; Parkinson Disease/therapy
Language	Japanese
Publishing date	2019-07-25
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416201369
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 398: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.

Tsunemi, Taiji / Oyama, Genko / Saiki, Shinji / Hatano, Taku / Fukae, Jiro / Shimo, Yasushi / Hattori, Nobutaka

Movement disorders : official journal of the Movement Disorder Society

2021 Volume 36, Issue 8, Page(s) 1759–1771

Abstract: Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device-aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG), we performed a literature search for relevant ... ...

Abstract	Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device-aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG), we performed a literature search for relevant articles (to November 3, 2020) using PubMed supplemented by hand searching. Retrieved articles were categorized by relevance to identified research questions, including motor complications and symptoms; nonmotor symptoms; functioning, quality of life, and caregiver burden; optimal timing of treatment initiation and administration duration; discontinuation; and complications. Most eligible studies (n = 56) were open-label, observational studies including relatively small patient numbers. LCIG consistently reduces OFF time and increased ON time without troublesome dyskinesia with varying effects regarding ON time with troublesome dyskinesia and the possibility of diphasic dyskinesia. More recent evidence provides some increased support for the benefits of LCIG in relation to nonmotor symptoms, quality of life, activities of daily living, and reduced caregiver burden. Patient age does not appear to significantly impact the effectiveness of LCIG. Discontinuation rates with LCIG (~17%-26%) commonly relate to device-related issues, although the ability to easily discontinue LCIG may represent a potential benefit. LCIG may be a favorable option for patients with advanced Parkinson's disease who show predominant nonmotor symptoms and vulnerability to complications of other advanced therapy modalities. Larger, well-controlled studies, including precise investigation of cost effectiveness, would further assist treatment selection. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
MeSH term(s)	Activities of Daily Living ; Antiparkinson Agents ; Carbidopa ; Drug Combinations ; Gels ; Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Quality of Life
Chemical Substances	Antiparkinson Agents ; Drug Combinations ; Gels ; Levodopa (46627O600J) ; Carbidopa (MNX7R8C5VO)
Language	English
Publishing date	2021-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.28595
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 238: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito