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  1. Book ; Online ; E-Book: Coronary vasomotion abnormalities

    Shimokawa, Hiroaki

    2021  

    Abstract: This book reviews the latest findings on epicardial coronary spasm and coronary microvascular dysfunction (CMD), important diseases for understanding coronary artery vasomotion abnormalities. The book chiefly consists of two major parts, each of which ... ...

    Author's details Hiroaki Shimokawa, editor
    Abstract This book reviews the latest findings on epicardial coronary spasm and coronary microvascular dysfunction (CMD), important diseases for understanding coronary artery vasomotion abnormalities. The book chiefly consists of two major parts, each of which explores the epidemiology, pathophysiology, diagnosis and treatment of the diseases. The chapters present a range of experimental and clinical studies, including the editor’s life’s work on coronary spasm; how Rho-kinase activation plays an important role in connection with the disease; how chronic adventitial inflammation is a central pathophysiology of the spasm; the importance of Rho-kinase activation in the pathogenesis of CMD; how epicardial spasm and CMD frequently co-exist; and much more. Coronary Vasomotion Abnormalities will help practicing cardiologists, cardiac surgeons, vascular biologists and radiologists understand the latest issues concerning the clinical, interventional, and surgical management of these conditions, and offer these readers valuable insights into the effective treatment of microvascular angina. .
    Keywords Coronary vasospasm
    Subject code 616.123
    Language English
    Size 1 online resource (VII, 155 p. 43 illus., 42 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-7594-0 ; 981-15-7593-2 ; 978-981-15-7594-5 ; 978-981-15-7593-8
    DOI 10.1007/978-981-15-7594-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Roles of endothelial and smooth muscle cell dysfunction and vasa vasorum in vasomotor disorders in ischemia with no obstructive coronary artery disease.

    Shimokawa, Hiroaki

    Vascular pharmacology

    2023  Volume 153, Page(s) 107234

    Abstract: Recently, the importance has emerged of ischemia with no obstructive coronary artery disease (INOCA), for which endothelial and vascular smooth muscle cell (VSMC) dysfunctions and alterations in coronary vasa vasorum are involved. Regarding endothelial ... ...

    Abstract Recently, the importance has emerged of ischemia with no obstructive coronary artery disease (INOCA), for which endothelial and vascular smooth muscle cell (VSMC) dysfunctions and alterations in coronary vasa vasorum are involved. Regarding endothelial vasodilator functions, both endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor play important roles in modulating vascular tone, especially in the microcirculation. Recent studies have suggested systemic endothelial dysfunction in INOCA. Regarding VSMC dysfunction, Rho-kinase has been identified as a key molecular mechanism of VSMC hyperconstriction in INOCA. Finally, recent advances of coronary imaging have demonstrated the important role of altered adventitial vasa vasorum functions in INOCA.
    MeSH term(s) Humans ; Coronary Artery Disease ; Vasa Vasorum ; Endothelium ; Ischemia ; Coronary Vessels
    Chemical Substances endothelium-dependent hyperpolarization factor
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2023.107234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The 2020 Olympic/Paralympic Games and Covid-19 in Japan.

    Shimokawa, Hiroaki

    European heart journal

    2021  Volume 42, Issue 38, Page(s) 3895–3896

    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab543
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  4. Article: Reactive oxygen species in cardiovascular health and disease: special references to nitric oxide, hydrogen peroxide, and Rho-kinase.

    Shimokawa, Hiroaki

    Journal of clinical biochemistry and nutrition

    2020  Volume 66, Issue 2, Page(s) 83–91

    Abstract: The interaction between endothelial cells and vascular smooth muscle cells (VSMC) plays an important role in regulating cardiovascular homeostasis. Endothelial cells synthesize and release endothelium-derived relaxing factors (EDRFs), including ... ...

    Abstract The interaction between endothelial cells and vascular smooth muscle cells (VSMC) plays an important role in regulating cardiovascular homeostasis. Endothelial cells synthesize and release endothelium-derived relaxing factors (EDRFs), including vasodilator prostaglandins, nitric oxide (NO), and endothelium-dependent hyperpolarization (EDH) factors. Importantly, the contribution of EDRFs to endothelium-dependent vasodilatation markedly varies in a vessel size-dependent manner; NO mainly mediates vasodilatation of relatively large vessels, while EDH factors in small resistance vessels. We have previously identified that endothelium-derived hydrogen peroxide (H
    Language English
    Publishing date 2020-02-14
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 632945-7
    ISSN 1880-5086 ; 0912-0009
    ISSN (online) 1880-5086
    ISSN 0912-0009
    DOI 10.3164/jcbn.19-119
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  5. Article ; Online: Management of Coronary Artery Spasm.

    Lanza, Gaetano Antonio / Shimokawa, Hiroaki

    European cardiology

    2023  Volume 18, Page(s) e38

    Abstract: Calcium channel blockers (CCBs) are the first-line treatment for coronary artery spasm (CAS). When CAS-related angina symptoms are not well controlled by CCB therapy, long-acting nitrates or (where available) nicorandil can be added as second-line ... ...

    Abstract Calcium channel blockers (CCBs) are the first-line treatment for coronary artery spasm (CAS). When CAS-related angina symptoms are not well controlled by CCB therapy, long-acting nitrates or (where available) nicorandil can be added as second-line medications. In the case of CAS refractory to standard treatments, several other alternative drugs and interventions have been proposed, including the Rho-kinase inhibitor fasudil, anti-adrenergic drugs, neural therapies and percutaneous coronary interventions. In patients with syncope or cardiac arrest caused by CAS-related tachyarrhythmias, or even bradyarrhythmias, implantation of an ICD or pacemaker, respectively, should be considered according to the risk of recurrence and efficacy of vasodilator therapy.
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1758-3764
    ISSN (online) 1758-3764
    DOI 10.15420/ecr.2022.47
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Localized dissection of the sinus of Valsalva mimicking spontaneous coronary artery dissection.

    Yuge, Norihisa / Manabe, Susumu / Sugimura, Koichiro / Shimokawa, Hiroaki

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 36, Issue 6

    Abstract: A 56-year-old man, suspected of having ST-segment elevation myocardial infarction due to spontaneous coronary artery dissection, underwent emergency percutaneous coronary intervention. Although he had moderate aortic regurgitation with aortic root ... ...

    Abstract A 56-year-old man, suspected of having ST-segment elevation myocardial infarction due to spontaneous coronary artery dissection, underwent emergency percutaneous coronary intervention. Although he had moderate aortic regurgitation with aortic root dilation and mild heart failure, it was controlled with medications. Two weeks after discharge, he was readmitted with severe heart failure due to severe aortic regurgitation and underwent an aortic root replacement. Intraoperative findings revealed that localized dissection of the sinus of Valsalva involved the right coronary artery, resulting in coronary artery dissection. In cases of spontaneous coronary artery dissection, attention should be paid to coronary artery dissection caused by localized aortic root dissection.
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad091
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  7. Article ; Online: Circulation Journal Awards for the Year 2015.

    Shimokawa, Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society

    2016  Volume 80, Issue 3, Page(s) 545–554

    MeSH term(s) Awards and Prizes ; Biomedical Research ; Humans ; Portraits as Topic
    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-66-0115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial Statistics and Best Reviewers Award for 2015.

    Shimokawa, Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society

    2016  Volume 80, Issue 2, Page(s) 285–288

    MeSH term(s) Awards and Prizes ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-66-0114
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  9. Article ; Online: The Circulation Journal in the World.

    Shimokawa, Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society

    2016  Volume 80, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Blood Circulation ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-66-0113
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  10. Article ; Online: The 8-Year Journey With the Circulation Journal　- 2008~2016.

    Shimokawa, Hiroaki

    Circulation journal : official journal of the Japanese Circulation Society

    2016  Volume 80, Issue 8, Page(s) 1661–1664

    MeSH term(s) Blood Circulation ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2016-07-25
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-66-0124
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