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  1. AU="Shimomura, Taizou"
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  1. Artikel ; Online: Rapid amelioration of hyperglycemia facilitated by dasatinib in a chronic myeloid leukemia patient with type 2 diabetes mellitus.

    Ono, Keiko / Suzushima, Hitoshi / Watanabe, Yuko / Kikukawa, Yoshitaka / Shimomura, Taizou / Furukawa, Noboru / Kawaguchi, Tatsuya / Araki, Eiichi

    Internal medicine (Tokyo, Japan)

    2012  Band 51, Heft 19, Seite(n) 2763–2766

    Abstract: Tyrosine kinase inhibitors (TKIs) have been shown to affect glucose metabolism in patients with chronic myeloid leukemia (CML); however, their precise mechanism of action remains unknown. We herein report the case of a 57-year-old diabetic CML patient ... ...

    Abstract Tyrosine kinase inhibitors (TKIs) have been shown to affect glucose metabolism in patients with chronic myeloid leukemia (CML); however, their precise mechanism of action remains unknown. We herein report the case of a 57-year-old diabetic CML patient who was resistant to imatinib and initially required 20 units of insulin daily to control his blood glucose levels. After the initiation of dasatinib, the patient's insulin requirements declined rapidly and insulin treatment was discontinued within two weeks. Meanwhile, the fasting C-peptide immunoreactivity increased two-fold, suggesting that dasatinib facilitated the recovery of insulin production. Dasatinib may therefore be beneficial for diabetic CML patients, especially those who require insulin treatment.
    Mesh-Begriff(e) Antineoplastic Agents/therapeutic use ; Benzamides ; Blood Glucose/metabolism ; Dasatinib ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Drug Resistance, Neoplasm ; Humans ; Hyperglycemia/blood ; Hyperglycemia/drug therapy ; Hyperglycemia/etiology ; Hypoglycemic Agents/administration & dosage ; Imatinib Mesylate ; Insulin/administration & dosage ; Insulin/blood ; Leukemia, Myeloid, Accelerated Phase/complications ; Leukemia, Myeloid, Accelerated Phase/drug therapy ; Male ; Middle Aged ; Piperazines/therapeutic use ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/therapeutic use ; Thiazoles/therapeutic use
    Chemische Substanzen Antineoplastic Agents ; Benzamides ; Blood Glucose ; Hypoglycemic Agents ; Insulin ; Piperazines ; Protein Kinase Inhibitors ; Pyrimidines ; Thiazoles ; Imatinib Mesylate (8A1O1M485B) ; Dasatinib (RBZ1571X5H)
    Sprache Englisch
    Erscheinungsdatum 2012-10-01
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.51.8314
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood.

    Yuasa, Hiromi / Takakura, Nobuyuki / Shimomura, Taizou / Suenobu, Souichi / Yamada, Taketo / Nagayama, Hitomi / Oike, Yuichi / Suda, Toshio

    Biochemical and biophysical research communications

    2002  Band 298, Heft 5, Seite(n) 731–737

    Abstract: To investigate the behavior of hematopoietic stem cells (HSCs) in cord blood (CB), we analyzed the expression and function of TIE2, a tyrosine kinase receptor. A subpopulation of Lineage (Lin)(-/low)CD34(+) cells in CB expressed TIE2 (18.8%). Assays for ... ...

    Abstract To investigate the behavior of hematopoietic stem cells (HSCs) in cord blood (CB), we analyzed the expression and function of TIE2, a tyrosine kinase receptor. A subpopulation of Lineage (Lin)(-/low)CD34(+) cells in CB expressed TIE2 (18.8%). Assays for long-term culture-initiating cells (LTC-IC) and cobble-stone formation revealed that Lin(-/low)CD34(+)TIE2(+) cells showed to have a capacity of primitive hematopoietic precursor cells in vitro. When Lin(-/low)CD34(+)TIE2(+) cells were cultured on the stromal cells, they transmigrated under the stromal layers and kept an immature character for a few weeks. By contrast, Lin(-/low)CD34(+)TIE2(-) cells differentiated immediately within a few weeks. Finally, we confirmed that 1x10(4)Lin(-/low)CD34(+)TIE2(+) cells were engrafted in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice, while 1x10(4)Lin(-/low)CD34(+)TIE2(-) cells were not. Taken together, we conclude that TIE2 is a marker of HSCs in CB. A ligand for TIE2, Ang-1 promoted the adhesion of sorted primary Lin(-/low)CD34(+)TIE2(+) cells to fibronectin (FN), and this adhesion may play a critical role in keeping HSCs in an immature status under the stromal cells.
    Mesh-Begriff(e) Angiogenesis Inducing Agents/metabolism ; Angiopoietin-1 ; Animals ; Antigens, CD34/blood ; Biomarkers ; Cell Adhesion ; Cells, Cultured ; Female ; Fetal Blood/cytology ; Fetal Blood/enzymology ; Fetal Blood/immunology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/classification ; Hematopoietic Stem Cells/enzymology ; Hematopoietic Stem Cells/immunology ; Humans ; In Vitro Techniques ; Infant, Newborn ; Ligands ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Pregnancy ; Receptor Protein-Tyrosine Kinases/blood ; Receptor, TIE-2 ; Transplantation, Heterologous
    Chemische Substanzen ANGPT1 protein, human ; Angiogenesis Inducing Agents ; Angiopoietin-1 ; Angpt1 protein, mouse ; Antigens, CD34 ; Biomarkers ; Ligands ; Membrane Glycoproteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Receptor, TIE-2 (EC 2.7.10.1)
    Sprache Englisch
    Erscheinungsdatum 2002-11-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/s0006-291x(02)02524-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 116: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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