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  1. Article ; Online: Wilbrand Knee Revisited.

    Shin, Robert K / Kachhela, Jaydeep / Tang, Cha-Min

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  

    Abstract: Background: Over a century ago, German ophthalmologist Hermann Wilbrand reported inferonasal crossing fibers within the chiasm curve anteriorly into the contralateral optic nerve. This anatomic bend, "Wilbrand knee," is classically cited as the ... ...

    Abstract Background: Over a century ago, German ophthalmologist Hermann Wilbrand reported inferonasal crossing fibers within the chiasm curve anteriorly into the contralateral optic nerve. This anatomic bend, "Wilbrand knee," is classically cited as the explanation for the "junctional scotoma," a contralateral superotemporal visual field defect associated with lesions affecting the optic nerve at its junction with the chiasm. More recent reports have called into question the existence of Wilbrand knee or suggested that it may simply be an artifact.
    Methods: Four human optic chiasms (obtained from cadaver donors with no reported premortem visual pathology) and 2 monkey chiasms were fixed and thin sectioned (40 µm), then examined using anisotropic scattering imaging, a novel technique that takes advantage of the fact that light reflects off well-defined linear structures (i.e., axonal tracts) in a predictable manner based on their orientation. Using this technique, tissue structures oriented in different directions can be distinguished at high resolution without the need for tissue staining.
    Results: In all 4 human optic chiasms, thin fiber tracts consistent with, but less prominent than, those Wilbrand had described were observed. No such tracts were found in the monkey chiasms.
    Conclusions: Wilbrand knee exists in humans but is modest in its anterior projection. Wilbrand knee does not seem to be present in monkeys, however, which may explain conflicting reports in the literature regarding its existence.
    Language English
    Publishing date 2023-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000002044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Does Wilbrand's Knee Exist?

    Shin, Robert K / Sadun, Alfredo A / Lee, Andrew G / Van Stavern, Gregory P

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2024  Volume 44, Issue 1, Page(s) 125–128

    MeSH term(s) Humans ; Optic Nerve ; Optic Chiasm
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000002071
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  3. Article: Podcast on B Cell-Targeting Therapies and Other Multiple Sclerosis Concerns During COVID-19.

    Shin, Robert K / Repovic, Pavle / Berger, Joseph R

    Neurology and therapy

    2022  Volume 11, Issue 2, Page(s) 515–524

    Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to raise questions for people living with multiple sclerosis (MS) and their healthcare providers. Common questions have included whether people living with MS are at higher risk of COVID- ... ...

    Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to raise questions for people living with multiple sclerosis (MS) and their healthcare providers. Common questions have included whether people living with MS are at higher risk of COVID-19 or of severe disease, whether certain disease-modifying therapies (DMTs) for MS heighten COVID-19 risk, and if/how COVID-19 vaccinations should be administered in relation to MS treatments. Anti-CD20 therapies, which target B cells, have been of particular interest given the role B cells play in the response to both the virus that causes COVID-19 (SARS-CoV-2) and vaccines. As more data surfaces and the pandemic evolves, additional questions have emerged regarding the administration of booster shots and differences between B cell-targeting therapies and other DMTs in terms of their immunomodulatory effects. In this podcast article, MS specialists discuss these challenges to MS care during the COVID-19 pandemic and the recent data which are currently informing their clinical decision-making. As the pandemic evolves, providers should continually partner with people living with MS to achieve MS treatment goals informed by the latest developments in COVID-19. Video: Podcast Video (MP4 388175 KB).
    Language English
    Publishing date 2022-01-23
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-021-00321-9
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  4. Article: Expert Perspectives on COVID-19 Vaccination for People Living with Multiple Sclerosis.

    Shin, Robert K / Rammohan, Kottil W / Williams, Mitzi J

    Neurology and therapy

    2021  Volume 10, Issue 2, Page(s) 415–425

    Language English
    Publishing date 2021-08-04
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-021-00266-z
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  5. Article ; Online: A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings.

    Safadi, Amy L / Osborne, Benjamin / Chitnis, Tanuja / Graves, Jennifer S / Newsome, Scott D / Zamvil, Scott S / Solomon, Isaac H / Shin, Robert K

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 6

    Abstract: A 28-year-old woman presented with subacute relapsing left-sided weakness. MRI demonstrated both enhancing C3-C6 and nonenhancing T2-T4 lesions. Initial provisional diagnosis was inflammatory/autoimmune. Her left-sided weakness progressed despite ... ...

    Abstract A 28-year-old woman presented with subacute relapsing left-sided weakness. MRI demonstrated both enhancing C3-C6 and nonenhancing T2-T4 lesions. Initial provisional diagnosis was inflammatory/autoimmune. Her left-sided weakness progressed despite immunosuppressive therapies. We reassessed our original suspected diagnosis because of an atypical clinicoradiologic course, leading to biopsy and a definitive diagnosis.
    MeSH term(s) Humans ; Female ; Adult ; Multiple Sclerosis/diagnostic imaging ; Biopsy ; Immunosuppression Therapy ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pandemic forward: Lessons learned and expert perspectives on multiple sclerosis care in the COVID-19 era.

    Nicholas, Jacqueline A / Shin, Robert K / Alvarez, Enrique / Hendin, Barry / Nair, Kavita V / Lublin, Fred D

    Multiple sclerosis and related disorders

    2020  Volume 49, Page(s) 102715

    MeSH term(s) COVID-19 ; Humans ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/therapy ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2020-12-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2020.102715
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  7. Article ; Online: Author response.

    Gold, Daniel R / Shin, Robert

    Neurology

    2013  Volume 81, Issue 6, Page(s) 603

    MeSH term(s) Female ; Humans ; Male ; Paralysis/diagnosis ; Trochlear Nerve Diseases/diagnosis
    Language English
    Publishing date 2013-08-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
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  8. Article ; Online: Re: Oculomotor nerve tumors masquerading as recurrent painful ophthalmoplegic neuropathy.

    Shin, Robert K / Mejico, Luis J / Boghen, Dan

    Cephalalgia : an international journal of headache

    2016  Volume 36, Issue 8, Page(s) 814

    Language English
    Publishing date 2016
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102415607071
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    Zs.A 1645: Show issues Location:
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  9. Article ; Online: ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses.

    Watford, Sean / Ly Pham, Ly / Wignall, Jessica / Shin, Robert / Martin, Matthew T / Friedman, Katie Paul

    Reproductive toxicology (Elmsford, N.Y.)

    2019  Volume 89, Page(s) 145–158

    Abstract: The Toxicity Reference Database (ToxRefDB) structures information from over 5000 in vivo toxicity studies, conducted largely to guidelines or specifications from the US Environmental Protection Agency and the National Toxicology Program, into a public ... ...

    Abstract The Toxicity Reference Database (ToxRefDB) structures information from over 5000 in vivo toxicity studies, conducted largely to guidelines or specifications from the US Environmental Protection Agency and the National Toxicology Program, into a public resource for training and validation of predictive models. Herein, ToxRefDB version 2.0 (ToxRefDBv2) development is described. Endpoints were annotated (e.g. required, not required) according to guidelines for subacute, subchronic, chronic, developmental, and multigenerational reproductive designs, distinguishing negative responses from untested. Quantitative data were extracted, and dose-response modeling for nearly 28,000 datasets from nearly 400 endpoints using Benchmark Dose (BMD) Modeling Software were generated and stored. Implementation of controlled vocabulary improved data quality; standardization to guideline requirements and cross-referencing with United Medical Language System (UMLS) connects ToxRefDBv2 observations to vocabularies linked to UMLS, including PubMed medical subject headings. ToxRefDBv2 allows for increased connections to other resources and has greatly enhanced quantitative and qualitative utility for predictive toxicology.
    MeSH term(s) Animals ; Computational Biology/methods ; Computational Biology/trends ; Databases, Factual/trends ; Dose-Response Relationship, Drug ; Hazardous Substances/chemistry ; Hazardous Substances/classification ; Hazardous Substances/toxicity ; Models, Biological ; Software ; Toxicology/methods ; Toxicology/trends ; United States ; United States Environmental Protection Agency
    Chemical Substances Hazardous Substances
    Language English
    Publishing date 2019-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2019.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2316: Show issues Location:
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  10. Article: Evaluation of the learning curve for laparoscopic Roux-en-Y gastric bypass surgery.

    Shin, Robert B

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2005  Volume 1, Issue 2, Page(s) 91–94

    Abstract: Background: The literature reports that the learning curve for laparoscopic Roux-en-Y gastric bypass (LRYGBP) is approximately 75-100 cases. This aim of the present study was to evaluate the safety and feasibility of shortening the learning curve for ... ...

    Abstract Background: The literature reports that the learning curve for laparoscopic Roux-en-Y gastric bypass (LRYGBP) is approximately 75-100 cases. This aim of the present study was to evaluate the safety and feasibility of shortening the learning curve for performing LRYGBP by an experienced laparoscopic surgeon.
    Methods: This study analyzed retrospectively the first 100 consecutive LRYGBP cases performed by an experienced laparoscopic surgeon between April 2003 and September 2003. The surgeon performed these cases after first assisting in 30 cases, and the first 4 cases were proctored by an experienced laparoscopic bariatric surgeon. Two cases done after previous gastric stapling and Nissen fundoplication were excluded from the study. Outcome variables included operative time, complications, conversion, and mortality.
    Results: For the first 100 LRYGBP patients, the mean age was 42.6 years (range, 22-62 years) and mean body mass index (BMI) was 47.6 kg/m2 (range, 36-71.8). The complications included 1 case of intestinal leak, 1 case of small bowel obstruction, 6 cases of gastrojejunal stenosis, 8 cases of wound infection, 1 case of wound seroma, and 2 cases of pulmonary embolism, resulting in 1 mortality. One case was converted to an open technique. Over the second 50 cases, there was a significant reduction in mean operative time, to 73 minutes (range, 39-145 minutes) from 113 minutes (range, 54-238 minutes) (P < .0001). However, despite the reduction in complication frequency (no gastrointestinal leak or obstruction, 2 cases of gastrojejunal stenosis, 2 cases of wound infection, no pulmonary embolism/deep venous thrombosis, and no mortality), there was no significant correlation between the mortality, conversion, and complication rates and the surgeon's experience.
    Conclusion: A bariatric surgical practice incorporating LRYGBP can be safely done by an experienced laparoscopic surgeon. With appropriate advanced laparoscopic skills, preparatory steps, proctorship, and adequate volume of cases, the learning curve for performing LRYGBP can be reduced to 50 cases. Further experience is associated with a significant reduction in operative time with acceptable mortality, complication, and conversion rates.
    MeSH term(s) Adult ; Anastomosis, Roux-en-Y/education ; Clinical Competence ; Education, Medical, Continuing ; Female ; Gastric Bypass/education ; Humans ; Laparoscopy ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Time Factors
    Language English
    Publishing date 2005-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2005.01.003
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    Zs.A 6572: Show issues Location:
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