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  1. Article: Deformation Behavior and Microstructure of 6061 Aluminum Alloy Processed by Severe Plastic Deformation Using Biaxial Alternate Forging.

    Ha, Seong-Ho / Shin, Young-Chul

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 5

    Abstract: The deformation behavior and microstructure of 6061 aluminum alloy processed by severe plastic deformation (SPD) using biaxial alternate forging that can evaluate the forming limit and mechanical properties of alloys, simultaneously, were investigated in ...

    Abstract The deformation behavior and microstructure of 6061 aluminum alloy processed by severe plastic deformation (SPD) using biaxial alternate forging that can evaluate the forming limit and mechanical properties of alloys, simultaneously, were investigated in this study. A finite element (FE) analysis on the biaxial alternating forging process, considering the strain-hardening coefficient and forging pass of the material, was conducted. When the strain-hardening coefficient is 0, an average effective strain of 440% was found within a diameter of 4 mm in the core of the workpiece after eight passes, while it was 300% at the same pass number when the strain-hardening coefficient was 0.2. The average effective strain estimated from the FE analysis was about 264% after eight passes of forging, which is considered to be a level of SPD that significantly exceeds the elongation of the raw material. As a result of the tensile test according to the forging pass, after two passes, the strength of the material could be gradually improved without significant degradation of elongation. Even though a large strain of 264% was found after eight passes were applied, deformed grains and twins with no recrystallized structure in optical microstructures with different forging passes were found.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17050968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Low molecular weight chitooligosaccharide inhibits infection of SARS‐CoV‐2 in vitro

    Jang, Donghwan / Lee, Dagyum / Shin, Young Chul / Lee, Joong Su / Jung, Jihee / Ryoo, Sungweon

    Journal of applied microbiology. 2022 Aug., v. 133, no. 2

    2022  

    Abstract: AIMS: The discovery of antiviral substances to respond to COVID‐19 is a global issue, including the field of drug development based on natural materials. Here, we showed that chitosan‐based substances have natural antiviral properties against SARS‐CoV‐2 ... ...

    Abstract AIMS: The discovery of antiviral substances to respond to COVID‐19 is a global issue, including the field of drug development based on natural materials. Here, we showed that chitosan‐based substances have natural antiviral properties against SARS‐CoV‐2 in vitro. METHODS AND RESULTS: The molecular weight of chitosan‐based substances was measured by the gel permeation chromatography analysis. In MTT assay, the chitosan‐based substances have low cytotoxicity to Vero cells. The antiviral effect of these substances was confirmed by quantitative viral RNA targeting the RdRp and E genes and plaque assay. Among the substances tested, low molecular weight chitooligosaccharide decreased the fluorescence intensity of SARS‐CoV‐2 nucleocapsid protein of the virus‐infected cells in a dose‐dependent manner. CONCLUSIONS: In conclusion, the chitooligosaccharide, a candidate for natural treatment, has antiviral effects against the SARS‐CoV‐2 virus in vitro. SIGNIFICANCE AND IMPACT OF STUDY: In this study, it was suggested for the first time that chitosan‐based substances such as chitooligosaccharide can have an antiviral effect on SARS‐CoV‐2 in vitro.
    Keywords COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; antiviral properties ; chitooligosaccharides ; cytotoxicity ; dose response ; drug development ; fluorescence ; gel chromatography ; molecular weight ; nucleocapsid proteins ; toxicity testing ; viruses
    Language English
    Dates of publication 2022-08
    Size p. 1089-1098.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15618
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
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  3. Article ; Online: Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro.

    Jang, Donghwan / Lee, Dagyum / Shin, Young Chul / Lee, Joong Su / Jung, Jihee / Ryoo, Sungweon

    Journal of applied microbiology

    2022  Volume 133, Issue 2, Page(s) 1089–1098

    Abstract: Aims: The discovery of antiviral substances to respond to COVID-19 is a global issue, including the field of drug development based on natural materials. Here, we showed that chitosan-based substances have natural antiviral properties against SARS-CoV-2 ...

    Abstract Aims: The discovery of antiviral substances to respond to COVID-19 is a global issue, including the field of drug development based on natural materials. Here, we showed that chitosan-based substances have natural antiviral properties against SARS-CoV-2 in vitro.
    Methods and results: The molecular weight of chitosan-based substances was measured by the gel permeation chromatography analysis. In MTT assay, the chitosan-based substances have low cytotoxicity to Vero cells. The antiviral effect of these substances was confirmed by quantitative viral RNA targeting the RdRp and E genes and plaque assay. Among the substances tested, low molecular weight chitooligosaccharide decreased the fluorescence intensity of SARS-CoV-2 nucleocapsid protein of the virus-infected cells in a dose-dependent manner.
    Conclusions: In conclusion, the chitooligosaccharide, a candidate for natural treatment, has antiviral effects against the SARS-CoV-2 virus in vitro.
    Significance and impact of study: In this study, it was suggested for the first time that chitosan-based substances such as chitooligosaccharide can have an antiviral effect on SARS-CoV-2 in vitro.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Chitosan/pharmacology ; Chlorocebus aethiops ; Molecular Weight ; Oligosaccharides ; SARS-CoV-2 ; Vero Cells
    Chemical Substances Antiviral Agents ; Oligosaccharides ; oligochitosan ; Chitosan (9012-76-4)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.15618
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  4. Article ; Online: Examining the links between burnout and suicidal ideation in diverse occupations.

    Oh, Dae Jong / Shin, Young Chul / Oh, Kang-Seob / Shin, Dong-Won / Jeon, Sang-Won / Cho, Sung Joon

    Frontiers in public health

    2023  Volume 11, Page(s) 1243920

    Abstract: Introduction: It is uncertain whether burnout is associated with suicidal ideation among workers not in health care services. The aim of this study was to identify how burnout and suicidal ideation are linked among employees in various occupations and ... ...

    Abstract Introduction: It is uncertain whether burnout is associated with suicidal ideation among workers not in health care services. The aim of this study was to identify how burnout and suicidal ideation are linked among employees in various occupations and whether depression affects this link.
    Methods: This cross-sectional study collected data from 12,083 participants aged 19-65 years from 25 companies and public institutions who underwent workplace mental health screening. Burnout and depression were assessed using both the Oldenburg Burnout Inventory and the Center for Epidemiologic Studies Depression Scale. Suicidal ideation was assessed by a self-rated questionnaire from the Korea National Health and Nutrition Examination Survey.
    Results: Exhaustion but not the cynicism dimension of burnout was associated with increased odds of suicidal ideation after adjustment for depression and other covariates (odds ratio [OR] = 1.47, 95% CI = 1.26-1.72). The association of exhaustion with suicidal ideation was significant in both depressed (OR = 1.36, 95% CI = 1.14-1.61) and not depressed (OR = 1.77, 95% CI = 1.13-2.76) participants. In exhausted participants, insufficient job control, an unfavorable occupational climate, low educational level, and depression were associated with increased odds of suicidal ideation.
    Conclusion: Exhaustion is linked with risk of suicidal ideation in employees not in health care service, regardless of depression status. Exhausted employees, particularly those having poor job resources, should be recognized as an at-risk group.
    MeSH term(s) Humans ; Suicidal Ideation ; Cross-Sectional Studies ; Nutrition Surveys ; Burnout, Psychological ; Occupations
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1243920
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  5. Article ; Online: N

    Choi, Sung-In / Shin, Young Chul / Lee, Joong Su / Yoon, Yeo Cho / Kim, Ju Myung / Sung, Mi-Kyung

    Food & function

    2023  Volume 14, Issue 18, Page(s) 8533–8544

    Abstract: Ulcerative colitis (UC) is a chronic gastrointestinal disease whose incidence is increasing rapidly worldwide. Anti-inflammatory medications, including 5-aminosalicylic acid (5-ASA), corticosteroids, and immunosuppressants, are used for its treatment; ... ...

    Abstract Ulcerative colitis (UC) is a chronic gastrointestinal disease whose incidence is increasing rapidly worldwide. Anti-inflammatory medications, including 5-aminosalicylic acid (5-ASA), corticosteroids, and immunosuppressants, are used for its treatment; however, new alternatives would be required due to the serious side effects of some of these medications.
    MeSH term(s) Animals ; Mice ; Acetylglucosamine ; Colitis/chemically induced ; Colitis/drug therapy ; Inflammation/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy
    Chemical Substances Acetylglucosamine (V956696549)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo00282a
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  6. Article: Characteristics of Korean Employees Without Depression but Having Suicidal Ideation.

    Jeon, Hye Jeong / Oh, Kang Seob / Shin, Young Chul / Shin, Dong Won / Cho, Sung Joon / Jeon, Sang Won

    Psychiatry investigation

    2023  Volume 20, Issue 7, Page(s) 644–654

    Abstract: Objective: The aim of this study was to identify the factors related to suicidal ideation targeting the risk group showing suicidal ideation despite the absence of depression in Korean workers.: Methods: The data of 14,425 participants who were ... ...

    Abstract Objective: The aim of this study was to identify the factors related to suicidal ideation targeting the risk group showing suicidal ideation despite the absence of depression in Korean workers.
    Methods: The data of 14,425 participants who were employees aged of 18 to 75 years who attended a mental health checkup program at the Workplace Mental Health Institute, Kangbuk Samsung Hospital from June 2015 to October 2019 were analyzed. A self-report questionnaire consisting of sociodemographic factors, suicidal ideation, job stress, levels of depression and anxiety, and resilience was administered. A Hierarchical logistic regression model was used with suicidal ideation as dependent variable. Separate analyses were conducted according to depressive symptoms using the 20-item Center for Epidemiological Studies Depression (CES-D) scale.
    Results: Being women, older, and having low resilience, more perceived stress, more severe anxiety and less sleeping hours were associated with suicidal ideation in no-depression group (CES-D <16). In the subcategories of job stress, lack of reward was significantly associated with suicidal ideation in no-depression group.
    Conclusion: This study identified the characteristics of a group that has no depression but has suicidal ideation in Korean workers. Among job stress items, lack of reward is a clear characteristic to be considered with caution in this group.
    Language English
    Publishing date 2023-07-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.30773/pi.2023.0035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6598: Show issues Location:
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  7. Article: Evaluation of the Dose-Dependent Effects of Fermented Mixed Grain Enzyme Food on Adiposity and Its Metabolic Disorders in High-Fat Diet-Induced Obese Mice

    Han, Youngji / Shin, Young Chul / Kim, Ae-Hyang / Kwon, Eun-Young / Choi, Myung-Sook

    Journal of medicinal food. 2021 Aug. 01, v. 24, no. 8

    2021  

    Abstract: Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet ... ...

    Abstract Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet supplementation with fermented enzyme foods can have a beneficial functional impact on the body. We examined the antiobesity properties of fermented mixed grain (FMG) with digestive enzymes (FMG) in diet-induced obese mice. Sixty C57BL/6J mice were randomly assigned to six dietary groups: (1) normal diet (ND), (2) high-fat diet (HFD), (3) Bacilus Coagulans, (4) steamed grain, (5) low-dose FMG (L-FMG), and (6) high-dose FMG (H-FMG) supplement for 12 weeks. The results showed that H-FMG supplement dramatically decreased body weight and fat mass with simultaneous decreases in plasma lipid contents. Furthermore, H-FMG significantly lowered fasting blood glucose concentrations and improved glucose tolerance compared with the HFD group. Also, the concentrations of inflammatory cytokines secreted from adipocytes in H-FMG–supplemented mice decreased dramatically. Taken together, our findings indicated that H-FMG can ameliorate HFD-induced obesity and its associated complications and could be used as a potential preventive intervention for obesity.
    Keywords adipocytes ; adiposity ; blood glucose ; blood lipids ; cytokines ; dose response ; fermentation ; functional foods ; glucose tolerance ; high fat diet ; metabolic syndrome ; obesity ; weight loss
    Language English
    Dates of publication 2021-0801
    Size p. 873-882.
    Publishing place Mary Ann Liebert, Inc.
    Document type Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2021.K.0070
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
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  8. Article ; Online: Comparison of the factors for suicidal ideation and suicide attempt: a comprehensive examination of stress, view of life, mental health, and alcohol use.

    Kim, Agnus M / Jeon, Sang-Won / Cho, Sung Joon / Shin, Young Chul / Park, Jae-Hyun

    Asian journal of psychiatry

    2021  Volume 65, Page(s) 102844

    Abstract: This study was performed to examine the elements that cause suicidal ideation to develop into a suicide attempt by comparing the factors related to suicidal ideation and attempt. The subjects in the study were 5982 employees, who received mental health ... ...

    Abstract This study was performed to examine the elements that cause suicidal ideation to develop into a suicide attempt by comparing the factors related to suicidal ideation and attempt. The subjects in the study were 5982 employees, who received mental health screening from January 2016 to December 2019 in Korea. Multivariate binary logistic regression analysis was performed with suicidal ideation and suicide attempt as dependent variables respectively. While suicidal ideation was associated with both moderate and severe grades of depression and alcohol consumption, only severe grades of depression and alcohol consumption were associated with suicide attempts. Among family, interpersonal, work-related, and financial stress, which were significant predictors of suicidal ideation, only family stress predicted suicide attempts. Whereas dissatisfaction with the present, regret for the past, and hopelessness for the future were all predictors for suicidal ideation, only regret for the past was a significant predictor of suicide attempts. The distinctive impact of family stress on suicide attempts suggests that family support can play a pivotal role in suicide prevention, and the significant impact of regret for the past on suicide attempts indicates the need for a cognitive approach in a high-risk population. Finally, the substantial impact of alcohol on suicide attempts compared to suicidal ideation suggests the importance of alcohol regulation in suicide prevention.
    MeSH term(s) Alcohol Drinking/epidemiology ; Humans ; Mental Health ; Risk Factors ; Suicidal Ideation ; Suicide, Attempted
    Language English
    Publishing date 2021-09-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2021.102844
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  9. Article ; Online: Evaluation of the Dose-Dependent Effects of Fermented Mixed Grain Enzyme Food on Adiposity and Its Metabolic Disorders in High-Fat Diet-Induced Obese Mice.

    Han, Youngji / Shin, Young Chul / Kim, Ae-Hyang / Kwon, Eun-Young / Choi, Myung-Sook

    Journal of medicinal food

    2021  Volume 24, Issue 8, Page(s) 873–882

    Abstract: Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet ... ...

    Abstract Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet supplementation with fermented enzyme foods can have a beneficial functional impact on the body. We examined the antiobesity properties of fermented mixed grain (FMG) with digestive enzymes (FMG) in diet-induced obese mice. Sixty C57BL/6J mice were randomly assigned to six dietary groups: (1) normal diet (ND), (2) high-fat diet (HFD), (3)
    MeSH term(s) Adiposity ; Animals ; Body Weight ; Diet, High-Fat/adverse effects ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2021.K.0070
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5916: Show issues Location:
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  10. Article: Perceived Control and Work-Related Stress Mediate the Effects of Grit on Depression among Employees.

    Jung, Sra / Shin, Young Chul / Oh, Kang-Seob / Shin, Dong-Won / Kim, Eun Soo / Lee, Mi Yeon / Cho, Sung Joon / Jeon, Sang-Won

    Brain sciences

    2022  Volume 13, Issue 1

    Abstract: We developed and evaluated an interpersonal model of depression in employees, where passion and perseverance affect occupational stress and perceived control, which in turn affect risk of depression. The participants were employees of 18 private ... ...

    Abstract We developed and evaluated an interpersonal model of depression in employees, where passion and perseverance affect occupational stress and perceived control, which in turn affect risk of depression. The participants were employees of 18 private companies and local government organizations in Korea aged 19 to 65 years. A total of 11,422 participants completed questionnaires including the Korean version of the Grit scale, the occupational stress scale, the perceived control subscale in the perceived stress scale, and the Center for Epidemiologic Studies Depression Scale. Mediation analysis was performed to determine relationships among trait-level passion and perseverance, work-related stress, perceived control, and depression. Passion and perseverance preceded depression in employees. Higher occupational stress and lower perceived control mediated the association between passion and depression, and between perseverance and depression. Passion and perseverance exert preventive effects on depression by decreasing workplace stress and elevating perceived control. Future studies should investigate the effects of psychological characteristics on the development of depression in employees.
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13010009
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