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  1. AU="Shin Ohta"
  2. AU="Herrera, José M."
  3. AU="Bolanle, Ogunyemi Folasade"
  4. AU="Spezialetti, Matteo"
  5. AU=Rosas Lucia E
  6. AU="Spadotto, Valeria"
  7. AU="Jimenez-Macias, Jorge L"

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  1. Article ; Online: Evaluating the effect of aromatherapy on a stress marker in healthy subjects

    Chiaki Takagi / Saori Nakagawa / Naoto Hirata / Shin Ohta / Sadahiko Shimoeda

    Journal of Pharmaceutical Health Care and Sciences, Vol 5, Iss 1, Pp 1-

    2019  Volume 7

    Abstract: Abstract Background/purpose Chemotherapy is important for cancer treatment, but patients’ physical and mental stress may lead to unfavorable pain control, an increase in the risk of relapse, and a reduction in the quality of life (QOL). Recently, ... ...

    Abstract Abstract Background/purpose Chemotherapy is important for cancer treatment, but patients’ physical and mental stress may lead to unfavorable pain control, an increase in the risk of relapse, and a reduction in the quality of life (QOL). Recently, aromatherapy has been performed in addition to palliative care in many countries, such as Japan and the United States, but scientific evidence remains insufficient. To investigate the usefulness of aromatherapy as complementary and alternative medicine, we evaluated its influence on the immune and autonomic nervous systems. Methods We instructed healthy volunteers to inhale aroma oil at bedtime for 6 weeks, and measured changes in the salivary level of secretory immunoglobulin A (s-IgA). Furthermore, blood was collected in addition to saliva in some healthy volunteers, and the blood level of noradrenaline (NA) was measured to examine its relationship to changes in the salivary s-IgA level. Results Aromatherapy with lavender and grapefruit oils significantly increased the salivary s-IgA level: lavender oil increased 3.5-fold (p = 0.03), and grapefruit oil increased 2.55-fold (p = 0.04). On lavender oil inhalation, there was a weak, positive correlation between changes in the salivary s-IgA level and those in the blood NA level (R2 = 0.24). Conclusion The results showed that aromatherapy with lavender and grapefruit oils reduced stress by acting on the immune and autonomic nervous systems in healthy volunteers. In the future, its clinical usefulness must be investigated through similar examination in patients in whom the stress level may be high.
    Keywords Aromatherapy ; Stress ; Complementary and alternative medicine ; Secretory immunoglobulin A ; Noradrenaline ; Therapeutics. Pharmacology ; RM1-950 ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Roles of Early Mobilization Program in Preventing Muscle Weakness and Decreasing Psychiatric Disorders in Patients with Coronavirus Disease 2019 Pneumonia

    Toru Kotani / Mizuki Sugiyama / Fumika Matsuzaki / Kota Kubodera / Jin Saito / Mika Kaneki / Atsuko Shono / Hiroko Maruo / Maiko Mori / Shin Ohta / Fumihito Kasai

    Journal of Clinical Medicine, Vol 10, Iss 2941, p

    A Retrospective Observational Cohort Study

    2021  Volume 2941

    Abstract: Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a ... ...

    Abstract Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a single-center, retrospective observational study to investigate the prevalence of persistent symptoms three months after discharge from the intensive care unit by checking the medical records. All patients received an early mobilization program. Four out of 13 patients (31%) had postintensive care syndrome. No patients had muscle weakness, and 11 patients (85%) returned to their previous work. However, psychiatric disorder, such as anxiety (23%) and posttraumatic stress disorder (15%), were observed. Eleven patients claimed persistent symptoms, including fatigue and numbness in the extremities. Our results suggest that the implementation of an early rehabilitation program plays some role in preventing muscle weakness and that decreasing psychiatric disorders should be a next target of patient care in the intensive care unit.
    Keywords postintensive care syndrome ; coronavirus disease 2019 ; acute respiratory failure ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Combination treatment of short-course systemic corticosteroid and favipiravir in a successfully treated case of critically ill COVID-19 pneumonia with COPD

    Hideki Inoue / Megumi Jinno / Shin Ohta / Yasunari Kishino / Tomoko Kawahara / Hatsuko Mikuni / Haruna Sato / Mayumi Yamamoto / Yoko Sato / Chisato Onitsuka / Yuiko Goto / Hitoshi Ikeda / Hiroki Sato / Tomoki Uno / Yoshitaka Uchida / Tomoyuki Kimura / Yoshito Miyata / Kuniaki Hirai / Tetsuya Homma /
    Yoshio Watanabe / Sojiro Kusumoto / Shintaro Suzuki / Issei Tokimatsu / Akihiko Tanaka / Hironori Sagara

    Respiratory Medicine Case Reports, Vol 31, Iss , Pp 101200- (2020)

    2020  

    Abstract: Use of systemic corticosteroids for the treatment for coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary disease (COPD) patients is not well described. A 58-year-old man with fever and progressive dyspnea was admitted to the Showa ... ...

    Abstract Use of systemic corticosteroids for the treatment for coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary disease (COPD) patients is not well described. A 58-year-old man with fever and progressive dyspnea was admitted to the Showa University Hospital, and showed severe respiratory failure which needed mechanical ventilation. His chest computed tomography scanning showed emphysema and bilateral ground-glass opacity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. He received 30 mg prednisolone for five days with antiviral drug of favipiravir, and was successfully extubated on day five. A SARS-CoV-2 polymerase chain reaction (PCR) test became negative on day 15. He was discharged on day 21. Serum IgM and IgG antibodies against SARS-CoV-2 converted to positive on day 7 and they kept positive on day 54 for both IgM and IgG. Combination treatment of short-course systemic corticosteroid and favipiravir might improve the prognosis for critically ill COVID-19 pneumonia with COPD without negative influence on viral clearance or antibody production.
    Keywords COVID-19 ; SARS-CoV-2 ; COPD ; Favipiravir ; Systemic corticosteroid ; Pneumonia ; Diseases of the respiratory system ; RC705-779 ; covid19
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Inhibition of Virus-Induced Cytokine Production from Airway Epithelial Cells by the Late Addition of Budesonide

    Tetsuya Homma / Yosuke Fukuda / Yoshitaka Uchida / Tomoki Uno / Megumi Jinno / Yasunari Kishino / Mayumi Yamamoto / Hiroki Sato / Kaho Akimoto / Keisuke Kaneko / Akiko Fujiwara / Haruna Sato / Kuniaki Hirai / Yoshito Miyata / Hideki Inoue / Shin Ohta / Yoshio Watanabe / Sojiro Kusumoto / Koichi Ando /
    Shintaro Suzuki / Toshimitsu Yamaoka / Akihiko Tanaka / Tohru Ohmori / Hironori Sagara

    Medicina, Vol 56, Iss 3, p

    2020  Volume 98

    Abstract: Background: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue. We have reported poly I:C, a mimic product of the virus and ligand of toll-like ... ...

    Abstract Background: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue. We have reported poly I:C, a mimic product of the virus and ligand of toll-like receptor 3 (TLR3), induced inflammatory chemokines from airway epithelial cells and found prior incubation with corticosteroids diminishes the effect of TLR3 activation. In clinical practice, mild asthma is recommended as-needed budesonide (BUD) when symptoms occur following a viral infection, etc. However, many questions still surround BUD’s usefulness if taken after a virus has already infected airway tissue. Objective: The aim of this study was to investigate the inhibitory effects of BUD on inflammatory cytokines induced by viral infection. Methods : Normal human bronchial epithelial (NHBE) cells were stimulated with poly I:C or infected with human rhinovirus-16 (HRV16) and BUD was added after the initial stimulation. Expression of both thymic stromal lymphopoietin (TSLP) and CCL26/eotaxin-3 was quantified by real-time RT-PCR and enzyme-linked immunosorbent assay (ELISA), respectively. Knockdown study was performed. Results : Pre-or post-incubation with BUD inhibited both poly I:C- and HRV16-induced mRNAs and proteins of both thymic stromal lymphopoietin (TSLP) and CCL26 with significance. Knockdown of the glucocorticoid receptor diminished these effects of BUD. Under the same conditions of BUD’s experiment, post-incubation with neither fluticasone propionate nor dexamethasone suppressed expression of both TSLP and CCL26, which induced by poly I:C. Conclusion: Post-addition of BUD inhibited the virus-induced TSLP and CCL26 from the airway epithelial cells. These results suggest that inhalation of BUD after viral infection has beneficial effects on asthma. Conclusion: Late addition of BUD may benefit among patient with viral infection and type 2 allergic airway disease such as asthma.
    Keywords budesonide ; thymic stromal lymphopoietin (tslp) ; rhinovirus ; epithelial cells ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report.

    Kuniaki, Hirai / Akihiko, Tanaka / Tetsuya, Homma / Hatsuko, Mikuni / Tomoko, Kawahara / Shin, Ohta / Sojiro, Kusumoto / Mayumi, Yamamoto / Fumihiro, Yamaguchi / Shintaro, Suzuki / Tsukasa, Ohnishi / Hironori, Sagara

    Frontiers in nutrition

    2018  Volume 5, Page(s) 71

    Abstract: Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment with bronchodilators, nutritional support, and pulmonary rehabilitation for ... ...

    Abstract Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment with bronchodilators, nutritional support, and pulmonary rehabilitation for frailty in patients with COPD, none have addressed the effects of traditional Japanese medicine (Kampo medicine). Herein, we report the successful management of frailty using Ninjin'yoeito therapy in a 76-year-old patient with COPD. Despite being prescribed multiple bronchodilators, nutritional supplement therapy, patient education, and pulmonary rehabilitation, the patient exhibited unintentional weight loss, low energy, and low physical activity. Ninjin'yoeito was prescribed and these subjective symptoms began to improve 1 month after treatment initiation. In 6 months, the patient reported no frailty, had increased muscle mass, and had achieved an almost normal healthy state. Ninjin'yoeito has been associated with both physical effects, such as improvement in overall physical strength and appetite, and reduction in fatigue, and psychological effects, such as greater motivation and reduction of depression and anxiety symptoms. Physicians have usually treated COPD primarily with organ-specific treatments, such as bronchodilators; however, addressing both the physiological and psychological vulnerability has been difficult. This case report illustrates the potential usefulness of Ninjin'yoeito treatment for frailty in patients with COPD.
    Language English
    Publishing date 2018-09-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2018.00071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice

    Naoto Hirata / Ken-ichi Ishibashi / Tatsuya Usui / Jiro Yoshioka / Satoru Hata / Yoshiyuki Adachi / Noriko Nagi-Miura / Shin Ohta / Naohito Ohno

    International Journal of Vascular Medicine , Vol

    2012  Volume 2012

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correlation of Arterial CO 2 and Respiratory Impedance Values among Subjects with COPD

    Tomoki Uno / Tetsuya Homma / Masahiko Shigemura / Yosuke Fukuda / Tomoyuki Kimura / Chihiro Onitsuka / Tomoko Kawahara / Hiroki Sato / Kaho Akimoto / Hiromitsu Suganuma / Ayaka Kashima / Shigenori Yamamoto / Takaya Ebato / Tomohiro Matsunaga / Keisuke Kaneko / Hatsuko Mikuni / Haruna Sato / Yoshitaka Uchida / Akiko Fujiwara /
    Naota Kuwahara / Ryo Manabe / Hitomi Ida / Kuniaki Hirai / Yoshito Miyata / Megumi Jinno / Shin Ohta / Yasunari Kishino / Hideki Inoue / Mayumi Yamamoto / Yoshio Watanabe / Sojiro Kusumoto / Koichi Ando / Shintaro Suzuki / Akihiko Tanaka / Tohru Ohmori / Hironori Sagara

    Journal of Clinical Medicine, Vol 9, Iss 2819, p

    2020  Volume 2819

    Abstract: Chronic obstructive pulmonary disease (COPD) is a respiratory illness characterized by airflow limitation and chronic respiratory symptoms with a global prevalence estimated to be more than 10% in 2010 and still on the rise. Furthermore, hypercapnic ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory illness characterized by airflow limitation and chronic respiratory symptoms with a global prevalence estimated to be more than 10% in 2010 and still on the rise. Furthermore, hypercapnic subject COPD leads to an increased risk of mortality, morbidity, and poor QoL (quality of life) than normocapnic subjects. Series of studies showed the usefulness of the forced oscillation technique (FOT) to measure small airway closure. Traditional findings suggested that hypercapnia may not be the main treating targets, but recent findings suggested that blood stream CO 2 may lead to a worse outcome. This study aimed to seek the relationship between CO 2 and small airway closure by using FOT. Subjects with COPD ( n = 124; hypercapnia 22 and normocapnia 102) were analyzed for all pulmonary function values, FOT values, and arterial blood gas analysis. Student’s t -test, Spearman rank correlation, and multi linear regression analysis were used to analyze the data. COPD subjects with hypercapnia showed a significant increase in R5, R20, Fres, and ALX values, and a greater decrease in X5 value than normocapnic patients. Also, multiple linear regression analysis showed R5 was associated with hypercapnia. Hypercapnia may account for airway closure among subjects with COPD and this result suggests treating hypercapnia may lead to better outcomes for such a subject group.
    Keywords CO 2 ; hypercapnia ; FOT ; Medicine ; R
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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