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  1. Article ; Online: Dental Caries Status among Yi Preschool Children in Yunnan Province, China

    Ni Zhou / Hui Ding / Juan Liu / Jieyi Chen / Shinan Zhang / Chun-Hung Chu

    International Journal of Environmental Research and Public Health, Vol 18, Iss 8393, p

    A Cross-Sectional Study

    2021  Volume 8393

    Abstract: Background: The Yi ethnic group is the sixth largest minority in China. The aim of this study was to investigate dental caries status among Yi preschool children in the Yunnan province, China. Method: This cross-sectional study invited 5-year-old Yi ... ...

    Abstract Background: The Yi ethnic group is the sixth largest minority in China. The aim of this study was to investigate dental caries status among Yi preschool children in the Yunnan province, China. Method: This cross-sectional study invited 5-year-old Yi children using multistage cluster sampling. Two trained and calibrated dentists examined the children in kindergartens. The children’s dental caries experience was assessed using the decayed, missing, and filled teeth (dmft) index. Visual plaque on an indexed tooth of each six sextants was recorded and the oral hygiene status was assessed using the Visible Plaque Index. Parents completed questionnaires that surveyed their educational attainment. The questionnaires also collected information about the children’s demographics, snacking habits, oral-health-related behaviors and dental visit experiences. The associations between caries experiences and potential factors were analyzed using zero-inflated negative binomial regression. Results: All 452 invited children (249 boys, 55%) participated in this study with a response rate of 100%. Dental caries prevalence rate was 83%. The mean dmft score and decayed teeth score were 5.2 ± 4.4 and 5.1 ± 4.4, respectively. Almost half of the children (n = 211, 47%) had visible plaque on four or more of the six sextants. Most (n = 366, 81%) of the children had not visited a dentist in the prior 12 months. Regression analysis found the children’s caries experience was associated with their dental visit experience. Conclusion: The great majority of the Yi preschool children experienced dental caries and almost all of the cavities were not restored. Their oral hygiene was poor and visible plaque was commonly found on their teeth.
    Keywords child ; cross-sectional study ; dental caries ; oral health ; ethnic group ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Oral Health Status of 12-Year-Old Hani Children in the Yunnan Province of China

    Jieyi Chen / Ni Zhou / Biao Xu / Yuexiao Li / Shinan Zhang / Chunhung Chu

    International Journal of Environmental Research and Public Health, Vol 18, Iss 5294, p

    A Cross-Sectional Study

    2021  Volume 5294

    Abstract: Background: The aim of this cross-sectional study was to investigate the oral health status of Hani 12-year-old children in Yunnan, a province in Southwest China. Method: This study employed a multistage sampling method to recruit children from local ... ...

    Abstract Background: The aim of this cross-sectional study was to investigate the oral health status of Hani 12-year-old children in Yunnan, a province in Southwest China. Method: This study employed a multistage sampling method to recruit children from local primary schools. Two calibrated dentists examined the status of dental caries, gingival bleeding and dental fluorosis by adopting the diagnosis criteria recommended by the World Health Organization. A self-administrated questionnaire was distributed. The chi-square test and multivariate logistic regression were conducted. Results: This study invited 480 Hani children, and recruited 413 children (52% boys) (response rate: 86%). The dental caries prevalence was 52%, and the caries experience associated with the mean (standard deviation) decayed, missing and filled teeth (DMFT) score was 1.10 (1.46). Gingival bleeding was diagnosed in 252 children (61%), and dental fluorosis was found in two children (0.5%). The results of the regression model indicated the prevalence of dental caries were associated with sugary snacking habits ( p = 0.002). The prevalence of gingival bleeding was related to the mother’s education level as well as the child’s monthly pocket money ( p < 0.05). Conclusion: Dental caries and gingival bleeding were prevalent among 12-year-old Hani children in the Yunnan province in China. Dental fluorosis was uncommon.
    Keywords dental caries ; ethnic group ; minority group ; child ; China ; Medicine ; R
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Dental Caries and the Erosive Tooth Wear Status of 12-Year-Old Children in Jakarta, Indonesia

    Diah Ayu Maharani / Shinan Zhang / Shiqian Sherry Gao / Chun-Hung Chu / Anton Rahardjo

    International Journal of Environmental Research and Public Health, Vol 16, Iss 16, p

    2019  Volume 2994

    Abstract: Background: Indonesia has the largest population of all countries in southeast Asia. However, little information is available on the oral health status of Indonesian children. The aims of this study were to assess dental caries and erosive tooth wear in ... ...

    Abstract Background: Indonesia has the largest population of all countries in southeast Asia. However, little information is available on the oral health status of Indonesian children. The aims of this study were to assess dental caries and erosive tooth wear in 12-year-old children in Jakarta, Indonesia and to investigate the associated risk factors. Methods: Samples were selected using cluster sampling. Parents were asked to complete a self-administered questionnaire regarding their oral health knowledge, demographic information, their child’s dietary habits, and oral health-related behaviors. Experience of caries and erosive tooth wear were recorded using the Decayed, Missing (due to caries), and Filled Teeth (DMFT) index and the Basic Erosive Wear Examination (BEWE) index, respectively. Results: Of 779 children invited, 696 participated in the survey. Of these, 61% had experienced caries, and the mean DMFT score was 1.58. Almost all decay was untreated. Children who were female, who had a high frequency of soft drink intake, and whose father’s educational level was low were more likely to have dental caries. Most children had at least one lesion of erosive tooth wear. Children whose mother’s educational level was low were more likely to have erosive tooth wear. Conclusions: The prevalence of dental caries and erosive tooth wear was high in 12-year-old children in Jakarta. Their dietary habits and parental level of education were associated with the presence of these dental conditions.
    Keywords dental caries ; erosive tooth wear ; oral health behaviors ; epidemiology ; children ; Medicine ; R
    Subject code 670
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Dual Regulation Effects of ESR1/NEDD4L on SLC7A11 in Breast Cancer Under Ionizing Radiation

    Rui Liu / Lin Liu / Yan Bian / Shinan Zhang / Yue Wang / Huajian Chen / Xinyue Jiang / Guanghui Li / Qing Chen / Chang Xue / Mengke Li / Lianchang Liu / Xiaodong Liu / Shumei Ma

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 9

    Abstract: Radiotherapy is one of the most important treatments for breast cancer. Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, whether ionizing radiation (IR) could induce ferroptosis in ... ...

    Abstract Radiotherapy is one of the most important treatments for breast cancer. Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, whether ionizing radiation (IR) could induce ferroptosis in breast cancer and how it works remain unknown. Bioinformatics analysis were performed to screen ferroptosis-related genes differentially expressed in breast tumor tissue and normal tissue. Then, breast cancer cell lines with different estrogen receptor (ER) phenotypes were used for studies in vitro, including ER-positive (MCF-7 and ZR-75-1) and ER-negative (MDA-MB-231) cells. The dynamic changes of mRNA and protein levels were examined after x-ray of 8 Gy by qRT-PCR and Western blotting, respectively. Immunoprecipitation (IP) was used to explore the interaction between proteins. Luciferase assay was used to analyze the transcriptional regulation effect of ESR1 on SLC7A11. BODIPY C11 and trypan blue dyes were used to determine lipid peroxidation and cell death, respectively. The result showed that the ferroptosis-related gene SLC7A11 was higher in breast cancer tissues compared with normal tissues and associated with poor survival. A positive correlation exists between ESR1 and SLC7A11 expression. ESR1 promoted SLC7A11 expression at the early stage after IR. ESR1/SLC7A11 knockdown significantly enhanced IR-induced ferroptosis in ER-positive cells. At 12 h after IR, the IP data showed the interaction between E3 ubiquitin ligase NEDD4L and SLC7A11 increased, followed by the ubiquitylation and degradation of SLC7A11. Thus, SLC7A11 expression was regulated by both ESR1 and NEDD4L, in opposite ways. For the first time, we elucidated that ESR1 and NEDD4L functioned together after radiation treatment and finally induced ferroptosis in breast cancer cells, which provides novel insight into the guidance of clinical treatment of breast cancer.
    Keywords ESR1 ; SLC7A11 ; ionizing radiation ; NEDD4L ; ferroptosis ; breast cancer ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dental and Periodontal Status of 5 and 12 year old Children in Jakarta and it’s Satellite Cities

    Melissa Adiatman / Afida Luthfi Yuvana / Avina Anin Nasia / Anton Rahardjo / Diah Ayu Maharani / Shinan Zhang

    Journal of Dentistry Indonesia, Vol 23, Iss 1, Pp 5-

    2016  Volume 9

    Abstract: Jakarta is the capital city of Indonesia which is surrounded by its satellite cities Bogor, Depok, Tangerang, Bekasi, which can be shortened by Jabodetabek. Objective: The study aims to describe oral health among 5 and 12 years-old children in ... ...

    Abstract Jakarta is the capital city of Indonesia which is surrounded by its satellite cities Bogor, Depok, Tangerang, Bekasi, which can be shortened by Jabodetabek. Objective: The study aims to describe oral health among 5 and 12 years-old children in Jabodetabek. Methods: This cross-sectional oral-health survey was conducted from 2014 with ethics approval. Sample of 5-year-old and 12-year-old Indonesian children living in Jabodetabek were selected using cluster sampling method. One trained examiner performed the clinical examination. Caries experience was measured using DMFT index, severity of decayed teeth was assessed using PUFA index, gingival status and oral hygiene were measured by Loe and Sillness modified index. Results: A total of 390 5-year-old and 458 12-year-old children with balanced proportion between girls and boys participated the survey. The prevalence of caries experience among the 5-year-old children and 12-year-old children were 90% and 84% respectively. The mean DMFT and DT scores among the 5-year-old children and 12-year-old children were 7.5±5.5 and 6.8±4.8; 3.2±2.2 and 2.9±2.1 respectively. Pulp involvement were apparent in 45% and 23% of caries in 5 and 12-year-old children respectively. Most children, 45% 5-year-old children and 92% 12-year-old children had substantial amount of plaque. Moreover, 68% 12-year-old children had gingivitis. Conclusion: Dental caries were prevalent among 5 and 12-year-old Indonesian children in Jakarta its satellite cities. The oral health condition of most of the children were poor. DOI: 10.14693/jdi.v23i1.982
    Keywords oral health ; dental caries ; periodontal ; children ; Indonesia ; Medicine ; R ; Dentistry ; RK1-715
    Subject code 380 ; 360
    Language English
    Publishing date 2016-04-01T00:00:00Z
    Publisher University of Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Mechanism of red mud combined with Fenton's reagent in sewage sludge conditioning

    Zhang, Hao / Changzhu Yang / Jiakuan Yang / Jian Song / Li Peng / Nan Ye / Sen Luo / Sha Liang / Shinan Zhang / Wenbo Yu / Xingxing Shen / Yafei Shi / Ye Li

    Water research. 2014 Aug. 01, v. 59

    2014  

    Abstract: Red mud was evaluated as an alternative skeleton builder combined with Fenton's reagent in sewage sludge conditioning. The results show that red mud combined with Fenton's reagent showed good conditioning capability with the pH of the filtrate close to ... ...

    Abstract Red mud was evaluated as an alternative skeleton builder combined with Fenton's reagent in sewage sludge conditioning. The results show that red mud combined with Fenton's reagent showed good conditioning capability with the pH of the filtrate close to neutrality, indicating that red mud acted as a neutralizer as well as a skeleton builder when jointly used with Fenton's reagent. Through response surface methodology (RSM), the optimal dosages of Fe2+, H2O2 and red mud were proposed as 31.9, 33.7 and 275.1 mg/g DS (dry solids), respectively. The mechanism of the composite conditioner could be illuminated as follows: (1) extracellular polymeric substances (EPS), including loosely bound EPS and tightly bound EPS, were degraded into dissolved organics, e.g., proteins and polysaccharides; (2) bound water was released and converted into free water due to the degradation of EPS; and (3) morphology of the conditioned sludge exhibited a porous structure in contrast with the compact structure of raw sludge, and the addition of red mud formed new mineral phases and a rigid lattice structure in sludge, allowing the outflow of free water. Thus, sludge dewatering performance was effectively improved. The economic assessment for a wastewater treatment plant of 370,000 equivalent inhabitants confirms that using red mud conditioning, combined with Fenton's reagent, leads to a saving of approximately 411,000 USD/y or 50.8 USD/t DS comparing with using lime and ordinary Portland cement combined with Fenton's reagent, and approximately 612,000 USD/y or 75.5 USD/t DS comparing with the traditional treatment.
    Keywords bound water ; cement ; dewatering ; economic analysis ; filtrates ; hydrogen peroxide ; iron ; pH ; polysaccharides ; proteins ; response surface methodology ; sewage sludge ; wastewater treatment
    Language English
    Dates of publication 2014-0801
    Size p. 239-247.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2014.04.026
    Database NAL-Catalogue (AGRICOLA)

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