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  1. Article ; Online: Primary Mediastinal B-Cell Lymphoma: The Role of Consolidative Radiation for a "Terrible" Lymphoma.

    Anderson, Garrett / Shinde, Ashwin

    International journal of radiation oncology, biology, physics

    2021  Volume 111, Issue 3, Page(s) 592–593

    MeSH term(s) Humans ; Lymphoma ; Lymphoma, B-Cell/radiotherapy ; Lymphoma, Large B-Cell, Diffuse ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/radiotherapy
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.02.641
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    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Neoadjuvant therapy in localized non-small cell lung cancer: can we do better than chemotherapy?

    Chau, Brittney / Shinde, Ashwin / Amini, Arya

    Translational cancer research

    2022  Volume 8, Issue Suppl 6, Page(s) S633–S635

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.08.43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Challenging Current Conventions: Up-Front Stereotactic Radiosurgery Alone for Limited Brain Metastases in Small Cell Lung Cancer.

    Shinde, Ashwin / Amini, Arya

    International journal of radiation oncology, biology, physics

    2019  Volume 103, Issue 5, Page(s) 1031–1032

    MeSH term(s) Aged ; Asymptomatic Diseases ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/prevention & control ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Cranial Irradiation/adverse effects ; Cranial Irradiation/methods ; Female ; Humans ; Liver Neoplasms/secondary ; Lung Neoplasms/pathology ; Magnetic Resonance Imaging ; Radiosurgery ; Randomized Controlled Trials as Topic ; Small Cell Lung Carcinoma/diagnostic imaging ; Small Cell Lung Carcinoma/radiotherapy ; Small Cell Lung Carcinoma/secondary ; Time Factors ; Watchful Waiting
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Case Reports ; Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.03.024
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    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Palliative Radiation for Cancer Pain Management.

    Amini, Arya / Shinde, Ashwin / Wong, Jeffrey

    Cancer treatment and research

    2021  Volume 182, Page(s) 145–156

    Abstract: Bone metastases are the most common cause of cancer-related pain. Radiation therapy (RT) is a very common and effective treatment to relieve pain. Conventionally fractionated RT typically consists of the following regimens: 8 Gy in a single treatment, 20  ...

    Abstract Bone metastases are the most common cause of cancer-related pain. Radiation therapy (RT) is a very common and effective treatment to relieve pain. Conventionally fractionated RT typically consists of the following regimens: 8 Gy in a single treatment, 20 Gy in five fractions, 24 Gy in six fractions, or 30 Gy in ten fractions. All treatment regimens have similar rates of pain relief (range 50-80%), with single-fraction treatment often requiring retreatment. While many painful bony metastases can be managed with RT alone, some may be more complex, often requiring multidisciplinary management, including the need for surgical stabilization or augmentation prior to RT. There are multiple assessment tools including the neurologic, oncologic, mechanical, and systemic (NOMS) decision framework, which allows clinicians to assess the proper course of treatment for these patients. For patients with good prognosis, oligometastatic disease, or those presenting with more radioresistant tumors, stereotactic body radiotherapy (SBRT) may be another option, which offers ablative doses of radiation delivered over several treatments. This chapter reviews the fundamentals of RT for palliation.
    MeSH term(s) Bone Neoplasms/complications ; Bone Neoplasms/radiotherapy ; Dose Fractionation, Radiation ; Humans ; Pain ; Pain Management ; Palliative Care ; Radiosurgery
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 0927-3042
    ISSN 0927-3042
    DOI 10.1007/978-3-030-81526-4_10
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  5. Article ; Online: Triggering daily online adaptive radiotherapy in the pelvis: Dosimetric effects and procedural implications of trigger parameter-value selection.

    Yock, Adam D / Ahmed, Mahmoud / Masick, Sarah / Morales-Paliza, Manuel / Kluwe, Christien / Shinde, Ashwin / Kirschner, Austin / Shinohara, Eric

    Journal of applied clinical medical physics

    2023  Volume 24, Issue 10, Page(s) e14060

    Abstract: Background: Online adaptive radiotherapy (ART) can address dosimetric consequences of variations in anatomy by creating a new plan during treatment. However, ART is time- and labor-intensive and should be implemented in a resource-conscious way. ... ...

    Abstract Background: Online adaptive radiotherapy (ART) can address dosimetric consequences of variations in anatomy by creating a new plan during treatment. However, ART is time- and labor-intensive and should be implemented in a resource-conscious way. Adaptive triggers composed of parameter-value pairs may direct the judicious use of online ART.
    Purpose: This work analyzed our clinical experience using CBCT-based daily online ART to demonstrate how a conceptual framework based on adaptive triggers affects the dosimetric and procedural impact of ART.
    Methods: Sixteen patients across several pelvic sites were treated with CBCT-based daily online ART. Differences in standardized dose metrics were compared between the original plan, the original plan recalculated on the daily anatomy, and an adaptive plan. For each metric, trigger values were analyzed in terms of the proportion of treatments adapted and the distribution of metric values.
    Results: Target coverage metrics were compromised due to anatomic variation with the average change per treatment ranging from -0.90 to -0.05 Gy, -0.47 to -0.02 Gy, -0.31 to -0.01 Gy, and -12.45% to -2.65% for PTV D99%, PTV D95%, CTV D99%, and CTV V100%, respectively. These were improved using the adaptive plan (-0.03 to 0.01 Gy, -0.02 to 0.00 Gy, -0.03 to 0.00 Gy, and -4.70% to 0.00%, respectively). Increasingly strict triggers resulted in a non-linear increase in the proportion of treatments adapted and improved the distribution of metric values with diminishing returns. Some organ-at-risk (OAR) metrics were compromised by anatomic variation and improved using the adaptive plan, but changes in most OAR metrics were randomly distributed.
    Conclusions: Daily online ART improved target coverage across multiple pelvic treatment sites and techniques. These effects were larger than those for OAR metrics, suggesting that maintaining target coverage was our primary benefit of CBCT-based daily online ART. Analyses like these can determine online ART triggers from a cost-benefit perspective.
    MeSH term(s) Humans ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Image-Guided/methods ; Organs at Risk ; Radiotherapy Dosage ; Pelvis ; Radiotherapy, Intensity-Modulated/methods
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.14060
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  6. Article ; Online: Can Immunotherapy Replace Radiotherapy in Melanoma Brain Metastases?

    Shinde, Ashwin / Li, Richard / Amini, Arya / Glaser, Scott

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 12, Page(s) 1030–1031

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Brain Neoplasms ; Humans ; Immunotherapy ; Melanoma
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.18.01982
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    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 650: Show issues

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  7. Article ; Online: Dosimetric Predictors of Genitourinary Toxicity From a Phase I Trial of Prostate Bed Stereotactic Body Radiation Therapy.

    Shinde, Ashwin / Li, Richard / Han, Chunhui / Frankel, Paul / Sampath, Sagus

    Practical radiation oncology

    2020  Volume 11, Issue 1, Page(s) e90–e97

    Abstract: Purpose: Our purpose was to analyze dose-volume parameters associated with genitourinary (GU) toxicity from a phase I clinical trial of prostate bed stereotactic body radiation therapy.: Methods and materials: Patients were treated in escalating dose ...

    Abstract Purpose: Our purpose was to analyze dose-volume parameters associated with genitourinary (GU) toxicity from a phase I clinical trial of prostate bed stereotactic body radiation therapy.
    Methods and materials: Patients were treated in escalating dose levels of 35, 40, and 45 Gy, over 5 fractions. Data from all 26 patients enrolled in the protocol were analyzed using multiple dose-volume cut points for multiple GU organs at risk. Univariate logistical regression and Fisher exact test were used to assess statistical significance associated with incidence of toxicity.
    Results: The median follow-up was 36 months for all patients. Acute GU toxicity was mild and resolved spontaneously. Eight out of 26 patients (30.7%) developed late GU toxicity of grade 2 or higher. Two patients developed grade 3 ureteral stenosis, 1 in the 35 Gy arm and the other in the 45 Gy arm. Three patients developed grade 2 or higher hematuria/cystitis, and 3 developed grade 2 or higher incontinence. Incidence of grade 3 ureteral stenosis was related to the absolute volume of bladder wall receiving greater than 20, 25, and 30 Gy (P < .01). Grade 2 cystitis and hematuria were related to the volume of bladder wall receiving 20 Gy less than 34% and 35 Gy less than 25% (18.8% vs 60% and 23.8% vs 80%, respectively, P < .05). Incontinence was related to mean urethral dose less than 35 Gy and 25 Gy (4.3% vs 66.7% and 0% vs 37.5%, respectively, P < .05) and volume of urethra receiving 35 Gy less than 24% (8.3% vs 50%, P < .05).
    Conclusions: This is the first analysis to report dose-volume thresholds associated with late GU toxicity in patients receiving prostate bed stereotactic body radiation therapy. We recommend limiting the bladder wall receiving 25 Gy to less than 18 cubic centimeters to reduce the risk for late grade 3 ureteral stenosis.
    MeSH term(s) Dose Fractionation, Radiation ; Humans ; Male ; Prostatic Neoplasms/radiotherapy ; Radiosurgery/adverse effects ; Radiotherapy Dosage ; Urogenital System
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2020.06.004
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  8. Article ; Online: Re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol 2019;75:410-8: Future Steps for Definitive Therapy in Metastatic Prostate Cancer: Lessons from the HORRAD Trial.

    Shinde, Ashwin / Li, Richard / Amini, Arya / Glaser, Scott

    European urology

    2018  Volume 75, Issue 3, Page(s) e69–e70

    MeSH term(s) Androgen Antagonists ; Humans ; Male ; Prospective Studies ; Prostate-Specific Antigen ; Prostatic Neoplasms
    Chemical Substances Androgen Antagonists ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2018-11-18
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.11.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 294: Show issues

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  9. Article ; Online: Node-positive Nonmetastatic Prostate Cancer: Time to Reconsider Prognostic Staging?

    Shinde, Ashwin / Li, Richard / Glaser, Scott / Amini, Arya

    European urology

    2018  Volume 75, Issue 3, Page(s) 355–357

    Abstract: Node-positive nonmetastatic prostate cancer is currently prognosticated as stage IV, despite evidence that a proportion of this patient population can be cured. We provide evidence and request reconsideration of prognostic staging in the next edition of ... ...

    Abstract Node-positive nonmetastatic prostate cancer is currently prognosticated as stage IV, despite evidence that a proportion of this patient population can be cured. We provide evidence and request reconsideration of prognostic staging in the next edition of the American Joint Committee on Cancer staging manual.
    MeSH term(s) Chemotherapy, Adjuvant ; Clinical Decision-Making ; Databases, Factual ; Humans ; Lymph Nodes/pathology ; Male ; Neoplasm Staging/methods ; Predictive Value of Tests ; Prostatectomy ; Prostatic Neoplasms/classification ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Radiotherapy, Adjuvant ; Risk Factors ; Time Factors ; Treatment Outcome ; United States
    Language English
    Publishing date 2018-09-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.09.017
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  10. Article ; Online: The evolving role of radiation therapy for resectable and unresectable gastric cancer.

    Shinde, Ashwin / Novak, Jennifer / Amini, Arya / Chen, Yi-Jen

    Translational gastroenterology and hepatology

    2019  Volume 4, Page(s) 64

    Abstract: Gastric cancer is a common malignancy worldwide, and treatment of localized disease has shifted from surgery alone to the addition of chemotherapy at various stages in treatment. The role of radiation in the management of gastric cancer has evolved ... ...

    Abstract Gastric cancer is a common malignancy worldwide, and treatment of localized disease has shifted from surgery alone to the addition of chemotherapy at various stages in treatment. The role of radiation in the management of gastric cancer has evolved significantly since the seminal publication of INT 0116 demonstrated a survival advantage to adjuvant chemoradiation. In this review, we summarize multiple landmark studies discussing the role of radiation in non-metastatic gastric cancer, both in resectable and unresectable patients. This review will additionally discuss the evidence for pre-operative chemoradiation, as the benefit has already been demonstrated in esophageal and rectal cancer.
    Language English
    Publishing date 2019-08-30
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh.2019.08.06
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