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  1. Article ; Online: Electrochemical low valent cobalt-catalyzed addition of aryl and vinyl chlorides to α-ketoamides

    Shinde, Prashant S / Shinde, Valmik S / Rueping, Magnus

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 28, Page(s) 3826–3829

    Abstract: The development of an electrochemical cobalt catalyzed C-Cl bond activation at room temperature for the nucleophilic addition of aryl and vinyl chlorides to α-ketoamides is described. The overall method operates through an electrochemically induced low ... ...

    Abstract The development of an electrochemical cobalt catalyzed C-Cl bond activation at room temperature for the nucleophilic addition of aryl and vinyl chlorides to α-ketoamides is described. The overall method operates through an electrochemically induced low valent cobalt catalyst that oxidatively adds to aryl or vinyl chlorides affording medicinally important 3-hydroxy oxindole and 3-hydroxypyrrolidinone scaffolds. The development of an enantioselective version using a chiral pyrox ligand is also demonstrated.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00309h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Paired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source

    Kumar, Gadde Sathish / Shinde, Prashant S. / Chen, Haifeng / Muralirajan, Krishnamoorthy / Kancherla, Rajesh / Rueping, Magnus

    Organic letters. 2022 Aug. 29, v. 24, no. 35

    2022  

    Abstract: A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic ...

    Abstract A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including N,N-dialkyl aniline and indole derivatives.
    Keywords Lewis bases ; aniline ; electrochemistry ; electrolysis ; indoles
    Language English
    Dates of publication 2022-0829
    Size p. 6357-6363.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c01897
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Paired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source.

    Kumar, Gadde Sathish / Shinde, Prashant S / Chen, Haifeng / Muralirajan, Krishnamoorthy / Kancherla, Rajesh / Rueping, Magnus

    Organic letters

    2022  Volume 24, Issue 35, Page(s) 6357–6363

    Abstract: A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic ...

    Abstract A decarboxylative cyanation of amino acids under paired electrochemical reaction conditions has been developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including
    MeSH term(s) Catalysis ; Electrolysis ; Molecular Structure ; Nitriles/chemistry ; Pyridines
    Chemical Substances Nitriles ; Pyridines
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy.

    Tiwari, Rajeshwari / Shinde, Prashant S / Sreedharan, Sreejesh / Dey, Anik Kumar / Vallis, Katherine A / Mhaske, Santosh B / Pramanik, Sumit Kumar / Das, Amitava

    Chemical science

    2020  Volume 12, Issue 7, Page(s) 2667–2673

    Abstract: Controlled and efficient activation is the crucial aspect of designing an effective prodrug. Herein we demonstrate a proof of concept for a light activatable prodrug with desired organelle specificity. Mertansine, a benzoansamacrolide, is an efficient ... ...

    Abstract Controlled and efficient activation is the crucial aspect of designing an effective prodrug. Herein we demonstrate a proof of concept for a light activatable prodrug with desired organelle specificity. Mertansine, a benzoansamacrolide, is an efficient microtubule-targeting compound that binds at or near the vinblastine-binding site in the mitochondrial region to induce mitotic arrest and cell death through apoptosis. Despite its efficacy even in the nanomolar level, this has failed in stage 2 of human clinical trials owing to the lack of drug specificity and the deleterious systemic toxicity. To get around this problem, a recent trend is to develop an antibody-conjugatable maytansinoid with improved tumor/organelle-specificity and lesser systematic toxicity. Endogenous CO is recognized as a regulator of cellular function and for its obligatory role in cell apoptosis. CO blocks the proliferation of cancer cells and effector T cells, and the primary target is reported to be the mitochondria. We report herein a new mitochondria-specific prodrug conjugate (
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d0sc06270g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Single Center 7 Year Experience of Coronary Artery Perforation: Angiographic and Procedural Characteristics, Management and Outcome.

    Nawale, Jaywant M / Chaurasia, Ajay S / Borikar, Nikhil Anand / Nalawade, Digvijay Deelip / Shah, Meghav M / Shinde, Prashant S

    Heart views : the official journal of the Gulf Heart Association

    2019  Volume 20, Issue 3, Page(s) 93–100

    Abstract: Context: Coronary artery perforation is a rare but potentially catastrophic complication of percutaneous coronary intervention (PCI). It is infrequent complication of PCI.: Aims: The objective of the study is to report the 7-year experience of ... ...

    Abstract Context: Coronary artery perforation is a rare but potentially catastrophic complication of percutaneous coronary intervention (PCI). It is infrequent complication of PCI.
    Aims: The objective of the study is to report the 7-year experience of coronary artery perforation with respect to incidence, clinical and angiographic characteristics, management and outcomes.
    Settings and design: The study involved retrospective analysis of single centre 7 years of percutaneous coronary intervention data. Patients who had complication of coronary artery perforation during PCI were identified and included in the study.
    Subjects and methods: Retrospective analysis of clinical, angiographic and procedural characteristics as well as management and outcome of coronary artery perforation was done.
    Statistical analysis used: The whole data were tabulated, variables were presented as mean and percentages and comparison was done within them.
    Results: A total of 37 cases of coronary artery perforation were identified from 4532 PCI performed. Most of the coronary artery perforation belonged to Ellis Type II and Type III (both
    Conclusions: Coronary artery perforation is rare but potentially fatal complication of percutaneous coronary intervention. Complication of coronary artery perforation can be managed effectively in the catheterization laboratory without the need of emergency of bailout surgery and in-hospital outcomes remain good in the majority of cases.
    Language English
    Publishing date 2019-10-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 2575257-1
    ISSN 0976-5123 ; 1995-705X
    ISSN (online) 0976-5123
    ISSN 1995-705X
    DOI 10.4103/HEARTVIEWS.HEARTVIEWS_84_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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