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  1. Article ; Online: "Happy to close?" The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery.

    Smith, Laurie / Coxon-Meggy, Alexandra / Shinkwin, Michael / Cornish, Julie / Watkins, Alan / Fegan, Greg / Torkington, Jared

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2023  Volume 25, Issue 6, Page(s) 1222–1227

    Abstract: Aim: Incisional hernia (IH) is a common complication of colorectal surgery, affecting up to 30% of patients at 2 years. Given the associated morbidity and high recurrence rates after attempted repair of IH, emphasis should be placed on prevention. There ...

    Abstract Aim: Incisional hernia (IH) is a common complication of colorectal surgery, affecting up to 30% of patients at 2 years. Given the associated morbidity and high recurrence rates after attempted repair of IH, emphasis should be placed on prevention. There is an association between surgeon volume and outcomes in hernia surgery, yet there is little evidence regarding impact of the seniority of the surgeon performing abdominal wall closure on IH rate. The aim of our study was to assess the rates of IH at 1 year following abdominal wall closure between junior and senior surgeons in patients undergoing elective colorectal surgery.
    Methods: This was an exploratory analysis of patients who underwent elective surgery for colorectal cancer between 2014-2018 as part of the Hughes Abdominal Repair Trial (HART), a prospective, multicentre randomised control trial comparing abdominal wall closure methods. Grade of surgeon performing abdominal closure was categorised into "trainee" and "consultant" and compared to IH rate at one year.
    Results: A total of 663 patients were included in this retrospective analysis of patients in the HART trial. The rate of IH in patients closed by trainees was 20%, compared to 12% in those closed by consultants (p = <0.001). When comparing closure methods, IH rates were significantly higher in the Hughes closure arm between trainees and consultants (20% vs. 12%, p = 0.032), but not high enough in the mass closure arm to reach statistical significance (21% vs. 13%, p = 0.058). On multivariate analysis, age (p = 0.036, OR: 1.02, 95% CI: 1.00-1.04), Male sex (p = 0.049, OR: 1.61, 95% CI: 1.00-2.59) and closure by a trainee (p = 0.006, OR: 1.85, 95% CI: 1.20-2.85) were identified as risk factors for developing IH.
    Conclusion: Patients who undergo abdominal wall closure by a surgeon in training have an increased risk of developing IH when compared to those closed by a consultant. Further work is needed to determine the impact of supervised and unsupervised trainees on IH rates, but abdominal wall closure should be regarded as a training opportunity in its own right.
    MeSH term(s) Humans ; Male ; Incisional Hernia/epidemiology ; Incisional Hernia/etiology ; Incisional Hernia/prevention & control ; Abdominal Wall/surgery ; Retrospective Studies ; Prospective Studies ; Colorectal Surgery ; Surgical Mesh/adverse effects ; Abdominal Wound Closure Techniques/adverse effects
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Overall readmissions and readmissions related to dehydration after creation of an ileostomy: a systematic review and meta-analysis.

    Vogel, I / Shinkwin, M / van der Storm, S L / Torkington, J / A Cornish, J / Tanis, P J / Hompes, R / Bemelman, W A

    Techniques in coloproctology

    2022  Volume 26, Issue 5, Page(s) 333–349

    Abstract: Background: Hospital readmissions after creation of an ileostomy are common and come with a high clinical and financial burden. The aim of this review with pooled analysis was to determine the incidence of dehydration-related and all-cause readmissions ... ...

    Abstract Background: Hospital readmissions after creation of an ileostomy are common and come with a high clinical and financial burden. The aim of this review with pooled analysis was to determine the incidence of dehydration-related and all-cause readmissions after formation of an ileostomy, and the associated costs.
    Methods: A systematic literature search was conducted for studies reporting on dehydration-related and overall readmission rates after formation of a loop or end ileostomy between January 1990 and April 2021. Analyses were performed using R Statistical Software Version 3.6.1.
    Results: The search yielded 71 studies (n = 82,451 patients). The pooled incidence of readmissions due to dehydration was 6% (95% CI 0.04-0.09) within 30 days, with an all-cause readmission rate of 20% (CI 95% 0.18-0.23). Duration of readmissions for dehydration ranged from 2.5 to 9 days. Average costs of dehydration-related readmission were between $2750 and $5924 per patient. Other indications for readmission within 30 days were specified in 15 studies, with a pooled incidence of 5% (95% CI 0.02-0.14) for dehydration, 4% (95% CI 0.02-0.08) for stoma outlet problems, and 4% (95% CI 0.02-0.09) for infections.
    Conclusions: One in five patients are readmitted with a stoma-related complication within 30 days of creation of an ileostomy. Dehydration is the leading cause for these readmissions, occurring in 6% of all patients within 30 days. This comes with high health care cost for a potentially avoidable cause. Better monitoring, patient awareness and preventive measures are required.
    MeSH term(s) Dehydration/epidemiology ; Dehydration/etiology ; Dehydration/prevention & control ; Humans ; Ileostomy/adverse effects ; Patient Readmission ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-02-22
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-022-02580-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Warmed and humidified insufflation to prevent perioperative hypothermia and improve the quality of recovery in elective laparoscopic colorectal resection patients: a feasibility study for a triple-blind randomized controlled trial.

    Reeves, Nicola / White, Judith / Bird, Samuel / Shinkwin, Michael / Cornish, Julie / Torkington, Jared

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 23, Issue 12, Page(s) 3262–3271

    Abstract: Aim: The use of standard CO: Method: A single-centre, triple-blind, feasibility, randomized controlled trial (RCT) of adults scheduled for planned laparoscopic colorectal surgery. The primary outcome was recruitment. Secondary outcomes included ... ...

    Abstract Aim: The use of standard CO
    Method: A single-centre, triple-blind, feasibility, randomized controlled trial (RCT) of adults scheduled for planned laparoscopic colorectal surgery. The primary outcome was recruitment. Secondary outcomes included feasibility of blinding, acceptability to patients and suitability of objective measures: patient-reported quality of recovery using a validated questionnaire (QoR-40), patient pain scores and semi-continuous core temperature measurements.
    Results: Thirty-nine participants were randomized to either the WHCO2 group (n = 19) or standard care alone (n = 20). Recruitment to the study was successful and acceptable to patients. Blinding of the surgeons, patients and assessors was effective. Response rates to QoR-40 were high but ceiling effects were observed, indicating that the tool was unsuitable in this population. Fewer patients in the WHCO2 group reported postoperative nausea and vomiting (PONV) at days 1 (53% vs. 65%) and 3 (37% vs. 60%). The median hospital length of stay was 5.5 days in the standard care group and 4 days in the WHCO2 group.
    Conclusion: A study of WHCO2 for insufflation in laparoscopic colorectal surgery would be highly acceptable to both patients and researchers. Potential reductions in PONV and hospital length of stay in patients treated with WHCO2 merit further investigation. The design of the full-scale RCT will benefit from this feasibility study.
    MeSH term(s) Adult ; Carbon Dioxide ; Colorectal Neoplasms ; Feasibility Studies ; Humans ; Humidity ; Hypothermia/etiology ; Hypothermia/prevention & control ; Insufflation ; Laparoscopy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and the emergency presentation of colorectal cancer.

    Shinkwin, Michael / Silva, Louise / Vogel, Irene / Reeves, Nicola / Cornish, Julie / Horwood, James / Davies, Michael M / Torkington, Jared / Ansell, James

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 23, Issue 8, Page(s) 2014–2019

    Abstract: Aim: The COVID-19 pandemic led to widespread disruption of colorectal cancer services during 2020. Established cancer referral pathways were modified in response to reduced diagnostic availability. The aim of this paper is to assess the impact of COVID- ... ...

    Abstract Aim: The COVID-19 pandemic led to widespread disruption of colorectal cancer services during 2020. Established cancer referral pathways were modified in response to reduced diagnostic availability. The aim of this paper is to assess the impact of COVID-19 on colorectal cancer referral, presentation and stage.
    Methods: This was a single centre, retrospective cohort study performed at a tertiary referral centre. Patients diagnosed and managed with colorectal adenocarcinoma between January and December 2020 were compared with patients from 2018 and 2019 in terms of demographics, mode of presentation and pathological cancer staging.
    Results: In all, 272 patients were diagnosed with colorectal adenocarcinoma during 2020 compared with 282 in 2019 and 257 in 2018. Patients in all years were comparable for age, gender and tumour location (P > 0.05). There was a significant decrease in urgent suspected cancer referrals, diagnostic colonoscopy and radiological imaging performed between March and June 2020 compared with previous years. More patients presented as emergencies (P = 0.03) with increased rates of large bowel obstruction in 2020 compared with 2018-2019 (P = 0.01). The distribution of TNM grade was similar across the 3 years but more T4 cancers were diagnosed in 2020 versus 2018-2019 (P = 0.03).
    Conclusion: This study demonstrates that a relatively short-term impact on the colorectal cancer referral pathway can have significant consequences on patient presentation leading to higher risk emergency presentation and surgery at a more advanced stage. It is therefore critical that efforts are made to make this pathway more robust to minimize the impact of other future adverse events and to consolidate the benefits of earlier diagnosis and treatment.
    MeSH term(s) COVID-19 ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Emergencies ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Combined MR imaging and spectroscopy of bone and soft tissue tumors.

    Zlatkin, M B / Lenkinski, R E / Shinkwin, M / Schmidt, R G / Daly, J M / Holland, G A / Frank, T / Kressel, H Y

    Journal of computer assisted tomography

    1990  Volume 14, Issue 1, Page(s) 1–10

    Abstract: Twenty-three patients with bone and soft tissue tumors were studied with combined magnetic resonance (MR) imaging and spectroscopy. The MR examinations were utilized to determine the size, internal characteristics, and relationships of the tumor to the ... ...

    Abstract Twenty-three patients with bone and soft tissue tumors were studied with combined magnetic resonance (MR) imaging and spectroscopy. The MR examinations were utilized to determine the size, internal characteristics, and relationships of the tumor to the surrounding tissues. They also determined the optimal placement of the surface coil. The surface coil profile was the localization technique utilized. Four patients were also studied with one-dimensional chemical shift localization. Tumors were grouped according to histologic type, degree of muscle contamination, size, and extent of necrosis. Quantitative comparison among the groups was carried out by comparing the mean ratios of the low-energy phosphate portion of the spectra [phosphomonoester (PME), Pi, phosphodiester (PDE)] to beta-nucleotide triphosphate (NTP). Tumor spectra typically showed a relative elevation in PME, Pi, and PDE and a relative decrease in phosphocreatinine. No characteristic spectra were observed for individual tumor types. Contamination of the tumor spectra from surrounding muscle impaired interpretation of the spectral data. Tumor size and extent of necrosis were important determinants of the relative degree of abnormally elevated metabolite peaks (PME, Pi, PDE). A trend toward a higher mean PME/beta-NTP ratio was observed among high-grade lesions. Combined MR imaging and spectroscopy is a useful way to study tumor metabolism. Muscle contamination is a significant problem in analysis of the spectra. Better localization techniques are required.
    MeSH term(s) Bone Neoplasms/diagnosis ; Female ; Histiocytoma, Benign Fibrous/diagnosis ; Humans ; Liposarcoma/diagnosis ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Male ; Middle Aged ; Muscular Diseases/diagnosis ; Soft Tissue Neoplasms/diagnosis
    Language English
    Publishing date 1990-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80392-3
    ISSN 1532-3145 ; 0363-8715
    ISSN (online) 1532-3145
    ISSN 0363-8715
    DOI 10.1097/00004728-199001000-00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Components of energy expenditure in tumor-bearing animals.

    Luketich, J D / Rigberg, D / Banchs, R / Shinkwin, M / Sigal, R / Daly, J / Mullen, J L

    The Journal of surgical research

    1990  Volume 48, Issue 6, Page(s) 573–578

    Abstract: Single snapshot measurements of resting energy expenditure (REE) suggest that hypermetabolism contributes to cancer cachexia, but tumor impact on total 24-hr energy expenditure (TEE) is unknown. Automated multicage indirect calorimetry was employed to ... ...

    Abstract Single snapshot measurements of resting energy expenditure (REE) suggest that hypermetabolism contributes to cancer cachexia, but tumor impact on total 24-hr energy expenditure (TEE) is unknown. Automated multicage indirect calorimetry was employed to measure daily energy expenditure in adult Buffalo rats (n = 16) randomized to tumor inoculation or controls. Measurements included baseline REE, activity EE (AEE), thermic response to food (TEF), and TEE. Rats (n = 16) were randomized. Metabolic measurements, tumor size, and body weight were recorded weekly. Animals were sacrificed at Week 5 for analysis of host and tumor composition. Significant depletion of total lean body mass occurred in TB rats (greater than 15% wt loss, ANOVA P less than 0.001) which inversely correlated with tumor growth (r = -0.81, P less than 0.001). REE, TEF, AEE, and TEE did not change in controls (ANOVA P = n.s.). In TB rats, a 19.5% increase in REE occurred (119.4 +/- 3.3 to 138.7 +/- 1.8 kcal/kg LBM/day, P less than 0.01). TEE remained unchanged (157.3 +/- 5.6 vs 152.9 +/- 3.6 kcal/kg LBM/day, P = n.s.) due to a 66% decrease in AEE (32.9 +/- 3.1 to 10.5 +/- 1.7 kcal/kg LBM/day, P = 0.01). TEF did not change (4.7 +/- 0.8 vs 5.0 +/- 0.3 kcal/kg LBM/day, P = n.s.). Both TB and controls demonstrated a decreased REE in response to a 24-hr fast (7.9% vs 4.8%, P = n.s.). Respiratory quotient decreased in both groups when comparing fed to fasted values: TB (0.86 to 0.76) and controls (0.86 to 0.71), but the decline was greater in controls (P = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Animals ; Body Composition ; Body Weight ; Calorimetry, Indirect ; Eating ; Energy Metabolism ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Liver Neoplasms, Experimental/physiopathology ; Rats ; Rats, Inbred BUF ; Respiration
    Language English
    Publishing date 1990-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/0022-4804(90)90233-r
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  7. Article: Optical and nuclear magnetic resonance studies of hypoxia in human tissue and tumors.

    Chance, B / Borer, E / Evans, A / Holtom, G / Kent, J / Maris, M / McCully, K / Northrop, J / Shinkwin, M

    Annals of the New York Academy of Sciences

    1988  Volume 551, Page(s) 1–16

    Abstract: Correlations of energy state with response to therapy are more difficult to analyze because of the large effect of tumor clearing and oxygenation upon the tumor energy state as detected by PMRS alone. The combination of time-resolved hemoglobinometry ... ...

    Abstract Correlations of energy state with response to therapy are more difficult to analyze because of the large effect of tumor clearing and oxygenation upon the tumor energy state as detected by PMRS alone. The combination of time-resolved hemoglobinometry using picosecond laser technology and localized PMRS seems appropriate to unravel the complexities of therapeutic intervention, tumor energetics, and oxygenation.
    MeSH term(s) Energy Metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Neoplasms/metabolism ; Oxygen/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 1988
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.1988.tb22316.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Digital subtraction cholangiography: a new technique for visualising the common bile duct during cholecystectomy.

    Motson, R W / Shinkwin, M A / May, A R / Akhtar, N

    Annals of the Royal College of Surgeons of England

    1988  Volume 70, Issue 3, Page(s) 135–138

    Abstract: Operative cholangiography is for most surgeons a routine part of every cholecystectomy. Computerised digital subtraction angiography was adapted for operative cholangiography using a portable machine. After cannulation of the cystic duct the background ... ...

    Abstract Operative cholangiography is for most surgeons a routine part of every cholecystectomy. Computerised digital subtraction angiography was adapted for operative cholangiography using a portable machine. After cannulation of the cystic duct the background image was subtracted before injecting contrast. Only the contrast within the bile duct appears on the monitor and resolution is high. A permanent record was made on 10 X 10 cm spot films. Eighteen pre-exploratory cholangiograms were performed using this method. In 12 no stones were demonstrated on digital subtraction cholangiography (DSC), nor were there clinical indications of common bile duct stones. These patients underwent cholecystectomy only. Stones were demonstrated on DSC in 3 patients and all had stones at exploration of the common bile duct (CBD). Three patients had no stones demonstrated on DSC but were explored on clinical grounds. No stones were found. Postoperative T-tube cholangiograms confirmed the absence of stones in 5 patients. A retained stone was present in one patient who had not had a postexploratory examination at operation and was not related to the use of this cholangiographic technique. DSC combines the benefits of image intensification and still radiography and has been accurate in both predicting and excluding common bile duct stones.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cholangiography/methods ; Cholecystectomy ; Common Bile Duct/diagnostic imaging ; Female ; Gallstones/diagnostic imaging ; Humans ; Male ; Middle Aged ; Subtraction Technique
    Language English
    Publishing date 1988-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
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  9. Article: The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism.

    Davis, L E / Lenkinski, R E / Shinkwin, M A / Kressel, H Y / Daly, J M

    Cancer

    1993  Volume 72, Issue 12, Page(s) 3715–3722

    Abstract: Background: Protein calorie malnutrition, which is highly prevalent in tumor-bearing hosts, increases toxicity to 5-fluorouracil (5-FU), but the mechanisms are unclear. This study investigated the effects of protein depletion on 5-FU in vivo hepatic ... ...

    Abstract Background: Protein calorie malnutrition, which is highly prevalent in tumor-bearing hosts, increases toxicity to 5-fluorouracil (5-FU), but the mechanisms are unclear. This study investigated the effects of protein depletion on 5-FU in vivo hepatic metabolism using F19-nuclear magnetic resonance spectroscopy (19F-NMRS).
    Methods: Rats received normal (21.5%) or low (2.5%) protein diet for 25 days. 5-FU was injected intraperitoneally, and hepatic fluorine spectra were obtained. Parallel experiments were conducted to determine serum 5-FU pharmacokinetics using high-performance liquid chromatography (HPLC) and to measure hepatic dihydropyrimidine dehydrogenase (DPD) activity.
    Results: The mean time of initial detection of fluoro-beta-alanine and the mean duration of the 5-FU signal in the liver were significantly prolonged in the low-protein group. 5-FU clearance and hepatic DPD activity were significantly lower in the low-protein group. Low-protein animals demonstrated increased toxicity, with diarrhea, weight loss, leukopenia (P < 0.001), and an 85% mortality, compared with regular diet animals, who had mild diarrhea and weight loss but no leukopenia and a 12% mortality.
    Conclusion: Protein depletion results in increased toxicity to 5-FU, which is associated with a significantly decreased rate of hepatic metabolism and clearance of 5-FU and a significant decrease in hepatic DPD activity. 19F-NMRS can noninvasively identify these alterations of 5-FU metabolism in vivo and may serve as a useful guide to determining chemotherapy dosage adjustments to reduce toxicity.
    MeSH term(s) Animals ; Dietary Proteins/administration & dosage ; Dihydrouracil Dehydrogenase (NADP) ; Fluorouracil/metabolism ; Fluorouracil/pharmacokinetics ; Fluorouracil/toxicity ; Liver/metabolism ; Magnetic Resonance Spectroscopy ; Male ; Oxidoreductases/metabolism ; Protein-Energy Malnutrition/metabolism ; Rats ; Rats, Inbred BUF
    Chemical Substances Dietary Proteins ; Oxidoreductases (EC 1.-) ; Dihydrouracil Dehydrogenase (NADP) (EC 1.3.1.2) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 1993-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(19931215)72:12<3715::aid-cncr2820721225>3.0.co;2-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors.

    Shinkwin, M A / Lenkinski, R E / Daly, J M / Zlatkin, M B / Frank, T S / Holland, G A / Kressel, H Y

    Cancer

    1991  Volume 67, Issue 7, Page(s) 1849–1858

    Abstract: Eighteen patients with soft tissue masses underwent integrated magnetic resonance imaging (MRI) and phosphorus spectroscopy (31P-MRS) to evaluate benign and malignant tumor morphology and metabolism. Spectra from soft tissue tumors had a significantly ... ...

    Abstract Eighteen patients with soft tissue masses underwent integrated magnetic resonance imaging (MRI) and phosphorus spectroscopy (31P-MRS) to evaluate benign and malignant tumor morphology and metabolism. Spectra from soft tissue tumors had a significantly higher proportion of phosphate in the low-energy portion of the 31P spectrum (P less than 0.001) with a concomitant decrease in phosphocreatine (P less than 0.01) compared with 31P spectra from normal muscle. Malignant tumors had a mean pH of 7.35 +/- 0.13 which was greater than that of muscle tissue with a mean pH of 7.08 +/- 0.07 (P less than 0.001). All tumors had greater relative levels of phosphomonoesters, inorganic phosphate, and phosphodiesters compared with those in muscle tissue but considerable variability among tumors was noted due to tumor size, extent of tumor necrosis, and muscle contamination. Integrated MRI/MRS studies are necessary to provide exact localization of the tumor and a more correct interpretation of the 31P-MRS data.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Leiomyosarcoma/diagnosis ; Lipoma/diagnosis ; Liposarcoma/diagnosis ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Muscles/pathology ; Necrosis/pathology ; Phosphorus ; Retroperitoneal Neoplasms/diagnosis ; Soft Tissue Neoplasms/diagnosis
    Chemical Substances Phosphorus (27YLU75U4W)
    Language English
    Publishing date 1991-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(19910401)67:7<1849::aid-cncr2820670706>3.0.co;2-e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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