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Article ; Online: True significance of the number of retrieved lymph nodes in stage II colon cancer resected by minimally invasive surgery: Influence of tumor sidedness.

Iguchi, Kenta / Sugiyama, Atsuhiko / Mushiake, Hiroyuki / Hasegawa, Seiji / Rino, Yasushi / Saito, Aya / Shiozawa, Manabu

Asian journal of endoscopic surgery

2024 Volume 17, Issue 3, Page(s) e13312

Abstract: Background: In patients with stage II colon cancer (CC) undergoing minimally invasive surgery, the association between the clinical significance of lymph node yield and tumor localization remains unknown. We aimed to determine the optimal number of ... ...

Abstract	Background: In patients with stage II colon cancer (CC) undergoing minimally invasive surgery, the association between the clinical significance of lymph node yield and tumor localization remains unknown. We aimed to determine the optimal number of lymph nodes to be retrieved based on tumor localization in patients with stage II CC undergoing minimally invasive surgery. Methods: This was a multicenter retrospective study. Overall, 263 patients with stage II CC who underwent laparoscopic surgery between January 1, 2008 and December 31 were enrolled. The primary outcome was the optimal number of lymph nodes retrieved based on tumor localization. Results: The median number of retrieved lymph nodes was 30 and 26 in the right-(n = 125) and left-sided (n = 138) CC groups, respectively (p = .0007). Inadequate dissection (<12 nodes) occurred in 4.2% of patients: 1.6% in the right-sided CC group and 6.5% in the left-sided CC group. Multivariate Cox regression analysis showed a decreasing trend in adjusted hazard ratios with increasing nodes, with an optimal cutoff of 15 lymph nodes in the left-sided CC group (adjusted hazard ratio, 5.868; 95% confidence interval, 1.247-27.62; p = .02). Lymph node yield was not independently associated with survival in the right-sided CC group. Conclusions: For patients with left-sided stage II CC undergoing laparoscopic surgery, aiming for at least 15 retrieved lymph nodes may be optimal for accurate staging and prognostic assessment. The optimal lymph node yield likely varies based on tumor location, requiring further investigation in right-sided CC.
MeSH term(s)	Humans ; Retrospective Studies ; Neoplasm Staging ; Colonic Neoplasms/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Lymph Node Excision ; Prognosis ; Minimally Invasive Surgical Procedures
Language	English
Publishing date	2024-04-17
Publishing country	Japan
Document type	Multicenter Study ; Journal Article
ZDB-ID	2503256-2
ISSN	1758-5910 ; 1758-5902
ISSN (online)	1758-5910
ISSN	1758-5902
DOI	10.1111/ases.13312
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Book ; Online: An Analytical Formula for Determining the Electrical Impedance between a Single Adherent Cell and Sensor Substrate

Shiozawa, Masataka / Uno, Shigeyasu

2022

Abstract: An analytical formula for electrical impedance between an adherent living cell and sensor substrate measured using a microelectrode is presented for the first time. Previously-reported formula has been applicable only for the case where many cells are on ...

Abstract	An analytical formula for electrical impedance between an adherent living cell and sensor substrate measured using a microelectrode is presented for the first time. Previously-reported formula has been applicable only for the case where many cells are on a large electrode. In contrast, our formula is valid even when a microelectrode smaller than the cell size is underneath the cell, which is often the case for the state-of-the-art single-cell analysis. Numerical simulations for verifying the accuracy of our formula reveals that the discrepancies between the theoretical impedances calculated by our formula and numerical simulation results are negligibly small. Our formula will be useful for describing cell-substrate impedance properties in equivalent circuit model analysis or sensor design optimizations. Comment: 29 pages, 7 figures, journal manuscript
Keywords	Physics - Biological Physics ; Quantitative Biology - Quantitative Methods
Subject code	612
Publishing date	2022-05-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Efficacy and Safety of Somatostatin Analog after Axillary Node Dissection in Breast Cancer: A Systematic Review and Meta-analysis.

Hirono, Satsuki / Watanabe, Jun / Miki, Atsushi / Shiozawa, Mikio / Sata, Naohiro

JMA journal

2023 Volume 6, Issue 3, Page(s) 274–281

Abstract: Background: Somatostatin analogs are expected to reduce lymphatic leakage. However, whether they can be used after axillary lymphadenectomy is unclear. This study aimed to assess the efficacy and safety of somatostatin analogs in axillary ... ...

Abstract	Background: Somatostatin analogs are expected to reduce lymphatic leakage. However, whether they can be used after axillary lymphadenectomy is unclear. This study aimed to assess the efficacy and safety of somatostatin analogs in axillary lymphadenectomy for breast cancer patients. Methods: We performed a random-effects meta-analysis by searching electronic databases for randomized trials and trial registries until June 2022. The primary outcomes were the volume of drained fluid, the duration of drainage, and seroma incidence. Bias was assessed using the Cochrane Collaboration's tool and the Grading of Recommendations, Assessment, Development, and Evaluations approach. Results: Six trials (738 participants) and one protocol without results were included. Somatostatin analogs may reduce the volume of drained fluid (mean difference = -22.07 mL, 95% confidence interval [CI] = -42.09 to -2.05; I Conclusions: There was limited evidence supporting somatostatin analogs for lymphorrhea after axillary lymphadenectomy. Multicenter randomized controlled trials are needed to confirm the efficacy and safety of somatostatin analogs after axillary lymphadenectomy.
Language	English
Publishing date	2023-05-22
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2022-0219
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Article ; Online: Discoloration of fiber-reinforced composite resin disc for computer-aided design/computer-aided manufacturing after immersion in coffee and curry solutions.

Shiozawa, Maho / Tsuchida, Yumi / Suzuki, Tetsuya / Takahashi, Hidekazu

Dental materials journal

2022 Volume 42, Issue 1, Page(s) 64–71

Abstract: The purpose of this study was to clarify the discoloration of fiber-reinforced composite resin (FRC) disc materials. The color differences (ΔEs) of three CAD/CAM disc materials, FRC with different fiber orientations, composite resin, and polyether-ether- ... ...

Abstract	The purpose of this study was to clarify the discoloration of fiber-reinforced composite resin (FRC) disc materials. The color differences (ΔEs) of three CAD/CAM disc materials, FRC with different fiber orientations, composite resin, and polyether-ether-ketones were evaluated after month-long immersion in water, coffee, and curry. The ΔEs of all materials after coffee and curry immersion increased with increasing immersion periods, while those after water immersion barely increased. FRC exhibited a smaller color difference and water sorption value than composite resin and a greater color difference and water sorption value than polyether-ether-ketones. The ΔEs after coffee immersion were significantly correlated with the water sorption value. The ΔE of FRC with fiber orientations perpendicular to the surface was greater than that of FRC with fiber orientations parallel to the surface, likely due to greater exposure of the matrix-fiber interface. This result suggested that the fiber orientations of FRC affected the discoloration.
MeSH term(s)	Composite Resins ; Coffee ; Immersion ; Ketones ; Computer-Aided Design ; Water ; Materials Testing ; Surface Properties ; Color
Chemical Substances	Composite Resins ; Coffee ; Ketones ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	605650-7
ISSN	1881-1361 ; 0287-4547
ISSN (online)	1881-1361
ISSN	0287-4547
DOI	10.4012/dmj.2022-121
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Article ; Online: Effect of thickness on color appearance of multilayer CAD/CAM composite resin blocks.

Ha, Roubing / Tsuchida, Yumi / Shiozawa, Maho / Takahashi, Hidekazu

Odontology

2022 Volume 110, Issue 4, Page(s) 664–672

Abstract: The aim of this study was to evaluate the effect of thickness on the color appearance and translucency parameter (TP) of multilayer CAD/CAM composite resin blocks. Four brands of A3-shade multilayer CAD/CAM composite resin blocks were examined (Katana ... ...

Abstract	The aim of this study was to evaluate the effect of thickness on the color appearance and translucency parameter (TP) of multilayer CAD/CAM composite resin blocks. Four brands of A3-shade multilayer CAD/CAM composite resin blocks were examined (Katana Avencia, CERASMART Multi, KZR-CAD HR Block 4 E-va, and Block HC Hard AN). Six specimens of five thicknesses were prepared for each brand, yielding 120 specimens in total. CIELab* values were determined using a spectrophotometer against black and white backgrounds, and the TP was calculated. The color differences (ΔE
MeSH term(s)	Ceramics ; Color ; Composite Resins ; Computer-Aided Design ; Dental Porcelain ; Materials Testing ; Surface Properties
Chemical Substances	Composite Resins ; Dental Porcelain (12001-21-7)
Language	English
Publishing date	2022-03-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2092085-4
ISSN	1618-1255 ; 1618-1247
ISSN (online)	1618-1255
ISSN	1618-1247
DOI	10.1007/s10266-022-00701-z
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Article: A Low Mean Closing Load and a Decrease in Load Change at the Tip Increase the Comfort of Scissors.

Ota, Gaku / Kaneda, Yuji / Maeda, Yoshitaka / Oiwa, Kosuke / Ae, Ryusuke / Shiozawa, Mikio / Horie, Hisanaga / Sata, Naohiro / Kawahira, Hiroshi

Cureus

2024 Volume 16, Issue 1, Page(s) e51900

Abstract: Introduction During surgery, surgeons intuitively recognize when they are using dull scissors and find them difficult to use. The purpose of this study was to objectively evaluate the physical characteristics of scissors and the comfort reported by ... ...

Abstract	Introduction During surgery, surgeons intuitively recognize when they are using dull scissors and find them difficult to use. The purpose of this study was to objectively evaluate the physical characteristics of scissors and the comfort reported by surgeons to develop objective quality control standards for scissors used in surgery. Methods Sensory and measurement tests were conducted to evaluate the comfort and physical characteristics of ten pairs of Cooper scissors. As a sensory test, thirty-one volunteer surgeons opened and closed the scissors and selected three that felt comfortable and three that were uncomfortable. The results were scored. For measurement, a load was applied to the handle of the scissors. The load pressure and displacement of the width between each handle when the scissors were closed were measured. Results A strong negative correlation was found between the total comfort score and the mean load value between sensory and measurement tests (r=-0.717, p=0.0195). The correlation between the total score and the change in load at the tip showed a moderate negative correlation (r=-0.687, p=0.0282). Multiple regression analysis showed that the change in load at the tip was an independent factor affecting the total score. Conclusions Surgeons consider scissors with a low mean load required to close the scissors and a small change in load at the tip to be comfortable. The mean load on scissors and the change in load at the tip should be considered in the development of quality control standards for scissors used in surgery.
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51900
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Article: Trends in Anti-Influenza Drug Prescription and Adverse Drug Reaction Reporting After the Lifting of Oseltamivir Prescribing Restrictions in Pediatric Outpatients: An Ecological Study Using the MDV Analyzer

Tokunaga, Misaki / Kikuchi, Daisuke / Noda, Aoi / Oikawa, Sachiko / Shiozawa, Makoto / Hino, Hiroaki / Miura, Ryosuke / Usui, Kensuke / Obara, Taku / Okada, Kouji

Drugs - real world outcomes

2024

Abstract: Background: Abnormal behavior after oseltamivir administration has been reported in the media; in 2007, the package insert for oseltamivir phosphate was revised to restrict its administration to individuals aged over 10 years. However, in 2018, the age ... ...

Abstract	Background: Abnormal behavior after oseltamivir administration has been reported in the media; in 2007, the package insert for oseltamivir phosphate was revised to restrict its administration to individuals aged over 10 years. However, in 2018, the age limitation specified in the package insert was removed. Here, we evaluated the trends in anti-influenza drug prescription and adverse drug reactions (ADRs) reported in pediatric outpatients after revising the oseltamivir package insert as an ecological study. Methods: Anti-influenza drug prescriptions for pediatric outpatients with influenza aged 0-19 years were downloaded from the acute Diagnosis Procedure Combination hospital databases using the MDV analyzer Results: During the influenza epidemic season (January-March), the percentage of oseltamivir prescriptions for patients with influenza aged 10-19 years tripled after the revision of the oseltamivir package insert (9.3% during the 2016/2017 season and 29.2% during the 2019/2020 season); however, reports of abnormal behavior did not increase (two during the 2016/2017 season and none during the 2019/2020 season). Conclusions: The number of oseltamivir-related ADR reports among minors over 10 years of age did not increase although the proportion of oseltamivir prescriptions increased after the revision of the oseltamivir package insert.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806600-5
ISSN	2198-9788 ; 2199-1154
ISSN (online)	2198-9788
ISSN	2199-1154
DOI	10.1007/s40801-023-00414-x
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Article: Acute Stroke Care in the With-COVID-19 Era: Experience at a Comprehensive Stroke Center in Japan.

Koge, Junpei / Shiozawa, Masayuki / Toyoda, Kazunori

Frontiers in neurology

2021 Volume 11, Page(s) 611504

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2020.611504
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Article: Evaluation of Scissor Glide Characteristics Through Surgeons' Subjective Assessment: The Application of Nitriding in Scissor Hardening Tests.

Ota, Gaku / Shiozawa, Mikio / Watanabe, Jun / Maeda, Yoshitaka / Oiwa, Kosuke / Mizuno, Jun / Sata, Naohiro / Kawahira, Hiroshi

Cureus

2024 Volume 16, Issue 1, Page(s) e52402

Abstract: Introduction: In robotic surgery, studies on providing tactile feedback to users are ongoing. However, the accuracy of the subjective sensations of surgeons, as users, has been largely unassessed. This study aimed to assess the validity of surgeons' ... ...

Abstract	Introduction: In robotic surgery, studies on providing tactile feedback to users are ongoing. However, the accuracy of the subjective sensations of surgeons, as users, has been largely unassessed. This study aimed to assess the validity of surgeons' subjective evaluations of scissors resistance through interindividual, inter-surgeon, and objective evaluations. Furthermore, in this study, we explored the possibility of using nitriding to increase the hardness of the scissors and assessed changes in subjective resistance values before and after nitriding using this approach. Method: Five surgeons conducted validation of five curved surgical scissors (145 mm; Arakawa Seisakujyo Co., Ltd., Tokyo, Japan) and assessed their subjective resistance using a scale from 0 to 10, where a rating of 10 signified significant resistance impeding the scissors' closure. The temporal changes in subjective resistance values, from maximum open to close, were graphically recorded. To demonstrate the reproducibility of subjective resistance values, the subjective resistance values of the same control scissors were measured at intervals of at least two weeks, and the correlation coefficient was calculated. To analyze the closing characteristics of subjective resistance values between different pairs of scissors, the effect of scissor type and scissor closure position was compared as two independent variables using a two-factor analysis of variance. A comparative evaluation was conducted to assess the frictional properties of scissors after nitriding, comparing the subjective assessment by surgeons with the objective assessment using a digital force gauge. Results: The correlation coefficient of subjective resistance values measured by surgeons demonstrated a high reproducibility of 0.746. A two-factor analysis of variance conducted on subjective resistance values demonstrated the presence of a primary effect for the sample factor (scissors), as well as for the position factor (closing process), with the additional observation of the interaction between these two factors. The results from the two-factor analysis of variance above provide evidence supporting the validity of the subjective resistance measurements. There was a significant increase in subjective resistance after the nitriding process. The graph of subjective resistance values and objective resistance values showed similarity. Conclusions: The surgeons' subjective assessment of scissors resistance showed high reproducibility and validity, as evidenced by distinguishable differences in scissor movement interactions and pre- and post-nitriding resistance. Further studies are warranted to expand on these findings.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52402
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Article ; Online: A Case of Colon Cancer with Extramural Tumor Deposits in the Main Lymph Node Area: A Case Report.

Ono, Yukari / Ida, Arika / Ogimi, Takashi / Asari, Masahiro / Numata, Koji / Mikayama, Yo / Shiozawa, Manabu

Journal of the anus, rectum and colon

2023 Volume 7, Issue 4, Page(s) 307–310

Abstract: A 72-year-old man with type 2 sub-circumferential tumors in the descending colon and two nodules around the pedicle of the inferior mesenteric artery (main lymph node area) underwent laparoscopic left hemicolectomy with D3 lymphadenectomy. Two lymph ... ...

Abstract	A 72-year-old man with type 2 sub-circumferential tumors in the descending colon and two nodules around the pedicle of the inferior mesenteric artery (main lymph node area) underwent laparoscopic left hemicolectomy with D3 lymphadenectomy. Two lymph nodes around the inferior mesenteric artery pedicle were completely excised. Pathological examination revealed a moderately differentiated tubular adenocarcinoma. Nodules were only found in the main lymph node area, and no lymph node structures were observed in these nodules. These tumor deposits (TDs) may be extramural TDs without lymph node structure or lymph node skip metastasis. The presence of TDs in colorectal cancer is associated with an adverse prognosis, and the requirement of chemotherapy in such cases should be examined. Therefore, it is important to correctly recognize TDs and categorize the disease into a high- or low-risk group within stage III. We report this case because it is necessary to review the definition of TDs, and the assessment of extramural TDs remains controversial.
Language	English
Publishing date	2023-10-25
Publishing country	Japan
Document type	Case Reports
ISSN	2432-3853
ISSN (online)	2432-3853
DOI	10.23922/jarc.2023-014
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