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  1. Article ; Online: Targeting interleukin (IL)-4/IL-13 in immune checkpoint inhibitor-induced bullous pemphigoid: a cautionary note on the beneficial effect of T helper 2 immunity in melanoma and immunotherapy: reply from the authors.

    Shipman, William D / Singh, Katelyn / Cohen, Jeffery M / Leventhal, Jonathan / Damsky, William / Tomayko, Mary M

    The British journal of dermatology

    2023  Volume 190, Issue 1, Page(s) 138

    MeSH term(s) Humans ; Pemphigoid, Bullous/chemically induced ; Pemphigoid, Bullous/drug therapy ; Pemphigoid, Bullous/immunology ; Melanoma/drug therapy ; Interleukin-13 ; Immune Checkpoint Inhibitors/therapeutic use ; Interleukins ; Immunotherapy/adverse effects
    Chemical Substances Interleukin-13 ; Immune Checkpoint Inhibitors ; Interleukins
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immune checkpoint inhibitor-induced bullous pemphigoid is characterized by interleukin (IL)-4 and IL-13 expression and responds to dupilumab treatment.

    Shipman, William D / Singh, Katelyn / Cohen, Jeffrey M / Leventhal, Jonathan / Damsky, William / Tomayko, Mary M

    The British journal of dermatology

    2023  Volume 189, Issue 3, Page(s) 339–341

    MeSH term(s) Humans ; Pemphigoid, Bullous/chemically induced ; Pemphigoid, Bullous/drug therapy ; Interleukin-13 ; Immune Checkpoint Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized/adverse effects
    Chemical Substances dupilumab (420K487FSG) ; Interleukin-13 ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad149
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  3. Article ; Online: An update on the use of hydroxychloroquine in cutaneous lupus erythematosus: A systematic review.

    Shipman, William D / Vernice, Nicholas A / Demetres, Michelle / Jorizzo, Joseph L

    Journal of the American Academy of Dermatology

    2019  Volume 82, Issue 3, Page(s) 709–722

    Abstract: Background: Hydroxychloroquine is widely used for the treatment of cutaneous lupus erythematosus (CLE). Although new recommendations exist for hydroxychloroquine dosing, there is still uncertainty about the dosage that will elicit a satisfactory ... ...

    Abstract Background: Hydroxychloroquine is widely used for the treatment of cutaneous lupus erythematosus (CLE). Although new recommendations exist for hydroxychloroquine dosing, there is still uncertainty about the dosage that will elicit a satisfactory response in CLE while limiting adverse effects, specifically retinopathy.
    Objective: To summarize hydroxychloroquine dosages, outcomes, and adverse effects in the treatment of CLE, focusing on retinopathy.
    Methods: A comprehensive literature search from inception to December 2018 was performed in Ovid MEDLINE, Ovid Embase, and The Cochrane Library (Wiley). Studies were screened against predefined inclusion and exclusion criteria.
    Results: Twelve studies were selected and included 5 retrospective studies, 3 prospective studies, 2 case series, and 2 randomized controlled trials. These studies show that a hydroxychloroquine dosage up to 400 mg/d is effective for most CLE patients (range of effectiveness, 50%-97%), with few adverse effects. One incidence of retinopathy, after a very high cumulative dose, was reported across all 12 studies (852 total patients).
    Limitations: Because retinopathy and other serious adverse effects may not appear until much later, many of these studies are limited by short follow-up time.
    Conclusions: This evidence suggests that hydroxychloroquine for CLE is effective at 400 mg/d, with an exceedingly low incidence of retinopathy and other adverse effects.
    MeSH term(s) Humans ; Hydroxychloroquine/therapeutic use ; Lupus Erythematosus, Cutaneous/drug therapy
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2019-07-13
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2019.07.027
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  4. Article ; Online: Fibroblast subtypes in tissues affected by autoimmunity: with lessons from lymph node fibroblasts.

    Shipman, William D / Sandoval, Marvin J / Veiga, Keila / Donlin, Laura T / Lu, Theresa T

    Current opinion in immunology

    2020  Volume 64, Page(s) 63–70

    Abstract: The recent advent of single-cell technologies has fast-tracked the discovery of multiple fibroblast subsets in tissues affected by autoimmune disease. In recent years, interest in lymph node fibroblasts that support and regulate immune cells has also ... ...

    Abstract The recent advent of single-cell technologies has fast-tracked the discovery of multiple fibroblast subsets in tissues affected by autoimmune disease. In recent years, interest in lymph node fibroblasts that support and regulate immune cells has also grown, leading to an expanding framework of stromal cell subsets with distinct spatial, transcriptional, and functional characteristics. Inflammation can drive tissue fibroblasts to adopt a lymphoid tissue stromal cell phenotype, suggesting that fibroblasts in diseased tissues can have counterparts in lymphoid tissues. Here, we examine fibroblast subsets in tissues affected by autoimmunity in the context of knowledge gained from studies on lymph node fibroblasts, with the ultimate aim to better understand stromal cell heterogeneity in these immunologically reactive tissues.
    MeSH term(s) Autoimmunity ; Fibroblasts ; Humans ; Lymph Nodes ; Lymphoid Tissue ; Stromal Cells
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.03.002
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  5. Article: Tertiary lymphoid organs in systemic autoimmune diseases:  pathogenic or protective?

    Shipman, William D / Dasoveanu, Dragos C / Lu, Theresa T

    F1000Research

    2017  Volume 6, Page(s) 196

    Abstract: Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate ... ...

    Abstract Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear. Here, we discuss how tertiary lymphoid organs can generate potentially pathogenic cells but may also limit the extent of the response and damage in autoimmune disease.
    Language English
    Publishing date 2017-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.10595.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Mammalian Target of Rapamycin Pathway Assessment in Antiphospholipid Antibody-Positive Patients with Livedo.

    Sevim, Ecem / Siddique, Salma / Chalasani, Madhavi Latha S / Chyou, Susan / Shipman, William D / O'Shea, Orla / Harp, Joanna / Alpan, Oral / Zuily, Stéphane / Lu, Theresa T / Erkan, Doruk

    The Journal of rheumatology

    2022  Volume 49, Issue 9, Page(s) 1026–1030

    Abstract: Objective: In antiphospholipid antibody (aPL) nephropathy, activation of the mammalian target of rapamycin (mTOR) contributes to endothelial cell proliferation, a key finding of aPL microvascular disease. Here, we examined mTOR activation in the skin of ...

    Abstract Objective: In antiphospholipid antibody (aPL) nephropathy, activation of the mammalian target of rapamycin (mTOR) contributes to endothelial cell proliferation, a key finding of aPL microvascular disease. Here, we examined mTOR activation in the skin of aPL-positive patients with livedo.
    Methods: Three patient groups with livedo were studied: (1) persistently aPL-positive with systemic lupus erythematosus (SLE); (2) persistently aPL-positive without SLE; and (3) aPL-negative SLE (control). After collecting aPL-related medical history, two 5-mm skin biopsies of livedo were performed on each patient: (1) peripheral (erythematous-violaceous lesion); and (2) central (nonviolaceous area). We stained specimens for phosphorylated protein kinase B (p-AKT) and phosphorylated S6 ribosomal protein (p-S6RP) as mTOR activity markers, CD31 to identify endothelial cells, and Ki-67 to show cellular proliferation. We counted cells in the epidermis and compared mTOR-positive cell counts between peripheral and central samples, and between patient groups, using Freidman test and Wilcoxon signed-rank test.
    Results: Ten patients with livedo reticularis were enrolled: 4 aPL-positive without SLE (antiphospholipid syndrome [APS] classification met, n = 3), 4 aPL-positive SLE (APS classification met, n = 3), and 2 aPL-negative SLE (control). In all aPL-positive patients, epidermal p-AKT and p-S6RP staining were significantly increased in both peripheral and central skin samples when compared to aPL-negative SLE controls; both were more pronounced in the lower basal layers of epidermis.
    Conclusion: Our study demonstrates increased mTOR activity in livedoid lesions of aPL-positive patients with or without SLE compared to aPL-negative patients with SLE, with more prominent activity in the lower basal layers of the epidermis. These findings may serve as a basis for further investigating the mTOR pathway in aPL-positive patients.
    MeSH term(s) Humans ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome ; Endothelial Cells ; Ki-67 Antigen ; Lupus Erythematosus, Systemic ; Proto-Oncogene Proteins c-akt ; Ribosomal Proteins ; Sirolimus ; TOR Serine-Threonine Kinases ; Livedo Reticularis
    Chemical Substances Antibodies, Antiphospholipid ; Ki-67 Antigen ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ribosomal Proteins ; Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-06-01
    Publishing country Canada
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.220049
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    Zs.MO 135: Show issues

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  7. Article ; Online: Treating hidradenitis suppurativa during the COVID-19 pandemic: teledermatology exams of sensitive body areas.

    Okeke, Chidubem A V / Shipman, William D / Perry, Jessica D / Kerns, Michelle L / Okoye, Ginette A / Byrd, Angel S

    The Journal of dermatological treatment

    2020  Volume 33, Issue 2, Page(s) 1163–1164

    MeSH term(s) COVID-19 ; Hidradenitis Suppurativa/diagnosis ; Humans ; Pandemics
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Letter
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2020.1781042
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  8. Article ; Online: Exploring the risk of severe COVID-19 infection in patients with hidradenitis suppurativa.

    Seltzer, Janyla A / Okeke, Chidubem A V / Perry, Jessica D / Shipman, William D / Okoye, Ginette A / Byrd, Angel S

    Journal of the American Academy of Dermatology

    2020  Volume 83, Issue 2, Page(s) e153–e154

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hidradenitis Suppurativa ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.05.012
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  9. Article ; Online: Lymphatic Function in Autoimmune Diseases.

    Schwartz, Noa / Chalasani, Madhavi Latha S / Li, Thomas M / Feng, Zhonghui / Shipman, William D / Lu, Theresa T

    Frontiers in immunology

    2019  Volume 10, Page(s) 519

    Abstract: Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the ...

    Abstract Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the pathophysiology of rheumatic autoimmune diseases. Here we review the current understanding of the role of lymphatics in the autoimmune diseases rheumatoid arthritis, scleroderma, lupus, and dermatomyositis and consider the possibility that manual therapies such as massage and acupuncture may be useful in improving lymphatic function in autoimmune diseases.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Humans ; Lymphatic Vessels/immunology ; Lymphatic Vessels/pathology
    Language English
    Publishing date 2019-03-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00519
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  10. Article ; Online: Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells.

    Dasoveanu, Dragos C / Shipman, William D / Chia, Jennifer J / Chyou, Susan / Lu, Theresa T

    Trends in immunology

    2016  Volume 37, Issue 11, Page(s) 764–777

    Abstract: During normal and pathologic immune responses, lymph nodes can swell considerably. The lymph node vascular-stromal compartment supports and regulates the developing immune responses and undergoes dynamic expansion and remodeling. Recent studies have ... ...

    Abstract During normal and pathologic immune responses, lymph nodes can swell considerably. The lymph node vascular-stromal compartment supports and regulates the developing immune responses and undergoes dynamic expansion and remodeling. Recent studies have shown that dendritic cells (DCs), best known for their antigen presentation roles, can directly regulate the vascular-stromal compartment, pointing to a new perspective on DCs as facilitators of lymphoid tissue function. Here, we review the phases of lymph node vascular-stromal growth and remodeling during immune responses, discuss the roles of DCs, and discuss how this understanding can potentially be used for developing novel therapeutic approaches.
    MeSH term(s) Animals ; Antigen Presentation ; Antigens/immunology ; Antigens/metabolism ; Cell Communication/immunology ; Dendritic Cells/immunology ; Humans ; Immunity ; Immunotherapy/methods ; Immunotherapy/trends ; Lymph Nodes/immunology ; Peptides/immunology ; Peptides/metabolism ; Stromal Cells/physiology ; Vascular Remodeling/immunology
    Chemical Substances Antigens ; Peptides
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2016.08.013
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