Article ; Online: Ion Microscope Imaging Mass Spectrometry Using a Timepix3-Based Optical Camera.
Journal of the American Society for Mass Spectrometry
2022 Volume 33, Issue 12, Page(s) 2328–2332
Abstract: Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that ...
| Abstract | Ion microscopy allows for high-throughput mass spectrometry imaging. In order to resolve congested mass spectra, a high degree of timing precision is required from the microscope detector. In this paper we present an ion microscope mass spectrometer that uses a Timepix3 hybrid pixel readout with an optimal 1.56 ns resolution. A novel triggering technique is also employed to remove the need for an external time-to-digital converter (TDC) and allow the experiment to be performed using a low-cost and commercially available readout system. Results obtained from samples of rhodamine B demonstrate the application of multimass imaging sensors for microscope mass spectrometry imaging with high mass resolution. |
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| MeSH term(s) | Microscopy |
| Language | English |
| Publishing date | 2022-11-16 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1073671-2 |
| ISSN | 1879-1123 ; 1044-0305 |
| ISSN (online) | 1879-1123 |
| ISSN | 1044-0305 |
| DOI | 10.1021/jasms.2c00223 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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