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  1. Article: SARS-CoV-2 Interaction with Human DNA Methyl Transferase 1: A Potential Risk for Increasing the Incidence of Later Chronic Diseases in the Survived Patients.

    Fakhrolmobasheri, Mohammad / Shiravi, Amirabbas / Zeinalian, Mehrdad

    International journal of preventive medicine

    2022  Volume 13, Page(s) 23

    Abstract: Currently, the COVID-19 pandemic is the most discussed subject in medical researches worldwide. As the knowledge is expanded about the disease, more hypotheses become created. A recent study on the viral protein interaction map revealed that SARS-CoV-2 ... ...

    Abstract Currently, the COVID-19 pandemic is the most discussed subject in medical researches worldwide. As the knowledge is expanded about the disease, more hypotheses become created. A recent study on the viral protein interaction map revealed that SARS-CoV-2 open reading frame 8 (ORF8) interacts with human DNA methyl transferase1 (DNMT1), an active epigenetic agent in DNA methylation. Moreover, DNMT1 is a contributor to a variety of chronic diseases which could cause some epigenetic dysregulation in infected cells, especially leukocytes, pancreatic beta, and endothelial cells. Regarding the fact that epigenetic alterations have a partial, but not completely reversible phenomena, it raises the question that if this interaction may cause long-term complications such as diabetes, atherosclerosis, cancer, and autoimmune diseases. Accordingly, long follow-up studies on the recovered patients from COVID-19 are recommended.
    Language English
    Publishing date 2022-02-08
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2574680-7
    ISSN 2008-8213 ; 2008-7802
    ISSN (online) 2008-8213
    ISSN 2008-7802
    DOI 10.4103/ijpvm.IJPVM_628_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thymus vulgaris, a natural pharmacy against COVID-19 and other similar infections

    Nadi Ali / Shiravi Amir-Abbas / Mohammadi Zahra / Aslani Amin / Zeinalian Mehrdad

    A molecular review

    2020  

    Abstract: This is a molecular review on the potential therapeutic effects of Thymus vulgaris against COVID-19 and other similar ... ...

    Abstract This is a molecular review on the potential therapeutic effects of Thymus vulgaris against COVID-19 and other similar infections
    Keywords Thymus vulgaris ; Thyme ; COVID-19 ; SARS-COV2 ; infection ; treatment ; covid19
    Language English
    Publishing date 2020-05-24
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Thymus vulgaris, a natural pharmacy against COVID-19 and other similar infections

    Nadi Ali / Shiravi Amir-Abbas / Mohammadi Zahra / Aslani Amin / Zeinalian Mehrdad

    A molecular review

    2020  

    Abstract: This is a molecular review on the potential therapeutic effects of Thymus vulgaris against COVID-19 and other similar ... ...

    Abstract This is a molecular review on the potential therapeutic effects of Thymus vulgaris against COVID-19 and other similar infections
    Keywords Thymus vulgaris ; Thyme ; COVID-19 ; SARS-COV2 ; infection ; treatment ; covid19
    Language English
    Publishing date 2020-05-24
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Vitamin D can be effective on the prevention of COVID-19 complications: A narrative review on molecular aspects.

    Shiravi, Amir-Abbas / Saadatkish, Milad / Abdollahi, Zeinab / Miar, Paniz / Khanahmad, Hossein / Zeinalian, Mehrdad

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2020  Volume 92, Issue 2, Page(s) 134–146

    Abstract: The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. In ... ...

    Abstract The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. In the current study, some molecular aspects of the potential effects of VD against COVID-19 side-effects have been discussed. An arguable role in autophagy or apoptosis control has been suggested for VD through calcium signaling at the mitochondrial and ER levels. 1,25(OH)2D3 is also an immunomodulator that affects the development of B-cells, T-cells, and NK cells in both innate and acquired immunity. The production of some anti-microbial molecules such as defensins and cathelicidins is also stimulated by VD. The overexpression of glutathione, glutathione peroxidase, and superoxide dismutase, and down-regulation of NADPH oxidase are induced by VD to reduce the oxidative stress. Moreover, the multi-organ failure due to a cytokine storm induced by SARS-CoV2 in COVID-19 may be prevented by the immunomodulatory effects of VD. It can also downregulate the renin-angiotensin system which has a protective role against cardiovascular complications induced by COVID-19. Given the many experimental and molecular evidences due to the potential protective effects of VD on the prevention of the COVID-19-induced morbidities, a VD supplementation is suggested to prevent the lethal side-effects of the infection. It is particularly recommended in VD-deficient patients or those at greater risk of serious or critical effects of COVID-19, including the elderly, and patients with pre-existing chronic diseases, especially those in nursing homes, care facilities, and hospitals.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/prevention & control ; Humans ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; Vitamin D/metabolism
    Chemical Substances RNA, Viral ; Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000676
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.210: Show issues Location:
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  5. Article ; Online: Cardiac fat pat change after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis.

    Sheikhbahaei, Erfan / Tavassoli Naini, Parsa / Agharazi, Mohammad / Pouramini, Alireza / Rostami, Sepehr / Bakhshaei, Sina / Valizadeh, Rohollah / Heshmat Ghahdarijani, Kiyan / Shiravi, Amirabbas / Shahabi, Shahab

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2022  Volume 19, Issue 6, Page(s) 653–664

    Abstract: Cardiac fat pad is a metabolically active organ that plays a role in energy homeostasis and cardiovascular diseases and generates inflammatory cytokines. Many studies have shown remarkable associations between cardiac fat thickness and cardiovascular ... ...

    Abstract Cardiac fat pad is a metabolically active organ that plays a role in energy homeostasis and cardiovascular diseases and generates inflammatory cytokines. Many studies have shown remarkable associations between cardiac fat thickness and cardiovascular diseases, making it a valuable target for interventions. Our meta-analysis aimed to investigate the effects of the 2 most popular bariatric surgeries (sleeve gastrectomy [SG] and Roux-en-Y gastric bypass [RYGB]) in cardiac fat pad reduction. A systematic review of the literature was done by searching in Scopus, Web of Science, Cochrane, and PubMed for articles published by September 16, 2022. This review followed the meta-analysis rules based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Nineteen studies met the inclusion criteria out of 128 potentially useful studies, including a total number of 822 patients. The results of subgroup analysis on the type of surgery showed that bariatric surgeries decreased the mean fat pad diameter, but the reduction was greater in SG than in RYGB. Epicardial and pericardial fat type showed a significant decrease of fat pad diameter. The results of subgroup analysis indicated RYGB had a significant reduction in mean fat pad volume. Computed tomography scan and cardiac magnetic resonance imaging showed a significant reduction of the mean cardiac fat pad volume. Epicardial and paracardial fat type showed a significant decrease in volume. The cardiac fat pad diameter and volume were significantly reduced after bariatric surgeries. SG showed greater reduction in fat pad diameter in comparison with RYGB, and RYGB had a significant reduction in mean fat pad volume.
    MeSH term(s) Humans ; Gastric Bypass/methods ; Cardiovascular Diseases ; Adipose Tissue ; Gastrectomy/methods ; Laparoscopy/methods ; Obesity, Morbid/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2022.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6572: Show issues Location:
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  6. Article: Vitamin D can be effective on the prevention of COVID-19 complications: A narrative review on molecular aspects

    Shiravi, Amir-Abbas / Saadatkish, Milad / Abdollahi, Zeinab / Miar, Paniz / Khanahmad, Hossein / Zeinalian, Mehrdad

    Int J Vitam Nutr Res

    Abstract: The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. In ... ...

    Abstract The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. In the current study, some molecular aspects of the potential effects of VD against COVID-19 side-effects have been discussed. An arguable role in autophagy or apoptosis control has been suggested for VD through calcium signaling at the mitochondrial and ER levels. 1,25(OH)2D3 is also an immunomodulator that affects the development of B-cells, T-cells, and NK cells in both innate and acquired immunity. The production of some anti-microbial molecules such as defensins and cathelicidins is also stimulated by VD. The overexpression of glutathione, glutathione peroxidase, and superoxide dismutase, and down-regulation of NADPH oxidase are induced by VD to reduce the oxidative stress. Moreover, the multi-organ failure due to a cytokine storm induced by SARS-CoV2 in COVID-19 may be prevented by the immunomodulatory effects of VD. It can also downregulate the renin-angiotensin system which has a protective role against cardiovascular complications induced by COVID-19. Given the many experimental and molecular evidences due to the potential protective effects of VD on the prevention of the COVID-19-induced morbidities, a VD supplementation is suggested to prevent the lethal side-effects of the infection. It is particularly recommended in VD-deficient patients or those at greater risk of serious or critical effects of COVID-19, including the elderly, and patients with pre-existing chronic diseases, especially those in nursing homes, care facilities, and hospitals.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #723272
    Database COVID19

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  7. Article ; Online: Vitamin D can be effective on the prevention of COVID-19 complications

    Shiravi, Amir-Abbas / Saadatkish, Milad / Abdollahi, Zeinab / Miar, Paniz / Khanahmad, Hossein / Zeinalian, Mehrdad

    International Journal for Vitamin and Nutrition Research

    A narrative review on molecular aspects

    2020  , Page(s) 1–13

    Abstract: Abstract. The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient ... ...

    Abstract Abstract. The widespread COVID-19 pandemic has been, currently, converted to a catastrophic human health challenge. Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. In the current study, some molecular aspects of the potential effects of VD against COVID-19 side-effects have been discussed. An arguable role in autophagy or apoptosis control has been suggested for VD through calcium signaling at the mitochondrial and ER levels. 1,25(OH)2D3 is also an immunomodulator that affects the development of B-cells, T-cells, and NK cells in both innate and acquired immunity. The production of some anti-microbial molecules such as defensins and cathelicidins is also stimulated by VD. The overexpression of glutathione, glutathione peroxidase, and superoxide dismutase, and down-regulation of NADPH oxidase are induced by VD to reduce the oxidative stress. Moreover, the multi-organ failure due to a cytokine storm induced by SARS-CoV2 in COVID-19 may be prevented by the immunomodulatory effects of VD. It can also downregulate the renin-angiotensin system which has a protective role against cardiovascular complications induced by COVID-19. Given the many experimental and molecular evidences due to the potential protective effects of VD on the prevention of the COVID-19-induced morbidities, a VD supplementation is suggested to prevent the lethal side-effects of the infection. It is particularly recommended in VD-deficient patients or those at greater risk of serious or critical effects of COVID-19, including the elderly, and patients with pre-existing chronic diseases, especially those in nursing homes, care facilities, and hospitals.
    Keywords Nutrition and Dietetics ; Medicine (miscellaneous) ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
    Language English
    Publisher Hogrefe Publishing Group
    Publishing country de
    Document type Article ; Online
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000676
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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