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  1. Article ; Online: Conquering the Synthesis and Functionalization of Bicyclo[1.1.1]pentanes.

    Shire, Bethany R / Anderson, Edward A

    JACS Au

    2023  Volume 3, Issue 6, Page(s) 1539–1553

    Abstract: Bicyclo[1.1.1]pentanes (BCPs) have become established as attractive bioisosteres ... ...

    Abstract Bicyclo[1.1.1]pentanes (BCPs) have become established as attractive bioisosteres for
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo.

    Allison, Simon J / Ashton, Gage P / Lynch, Hannah J / Shire, Bethany R / Phillips, Roger M / Parkes, Gareth M B / Pinder, Emma / Rice, Craig R / Teixeira, Ana A M / Volleman, Tibo / Wordsworth, Daisy A

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 30, Issue 3, Page(s) e202302803

    Abstract: Dipodal pyridylthiazole amine ligands ... ...

    Abstract Dipodal pyridylthiazole amine ligands L
    MeSH term(s) Metals ; Ions ; Anions ; Zinc ; Ligands ; Copper ; Neoplasms
    Chemical Substances Metals ; Ions ; Anions ; Zinc (J41CSQ7QDS) ; Ligands ; Copper (789U1901C5)
    Language English
    Publishing date 2023-11-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202302803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis of All-Carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling.

    Nugent, Jeremy / Shire, Bethany R / Caputo, Dimitri F J / Pickford, Helena D / Nightingale, Frank / Houlsby, Ian T T / Mousseau, James J / Anderson, Edward A

    Angewandte Chemie (International ed. in English)

    2020  Volume 59, Issue 29, Page(s) 11866–11870

    Abstract: 1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p-substituted arenes and alkynes. Access to all-carbon disubstituted BCPs via cross-coupling has to date been limited to use of the BCP as the ... ...

    Abstract 1,3-Disubstituted bicyclo[1.1.1]pentanes (BCPs) are important motifs in drug design as surrogates for p-substituted arenes and alkynes. Access to all-carbon disubstituted BCPs via cross-coupling has to date been limited to use of the BCP as the organometallic component, which restricts scope due to the harsh conditions typically required for the synthesis of metallated BCPs. Here we report a general method to access 1,3-C-disubstituted BCPs from 1-iodo-bicyclo[1.1.1]pentanes (iodo-BCPs) by direct iron-catalyzed cross-coupling with aryl and heteroaryl Grignard reagents. This chemistry represents the first general use of iodo-BCPs as electrophiles in cross-coupling, and the first Kumada coupling of tertiary iodides. Benefiting from short reaction times, mild conditions, and broad scope of the coupling partners, it enables the synthesis of a wide range of 1,3-C-disubstituted BCPs including various drug analogues.
    Language English
    Publishing date 2020-05-14
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202004090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.

    Frank, Nils / Nugent, Jeremy / Shire, Bethany R / Pickford, Helena D / Rabe, Patrick / Sterling, Alistair J / Zarganes-Tzitzikas, Tryfon / Grimes, Thomas / Thompson, Amber L / Smith, Russell C / Schofield, Christopher J / Brennan, Paul E / Duarte, Fernanda / Anderson, Edward A

    Nature

    2022  Volume 611, Issue 7937, Page(s) 721–726

    Abstract: Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly found para-substituted benzene rings in drug ... ...

    Abstract Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly found para-substituted benzene rings in drug design
    MeSH term(s) Anions/chemistry ; Benzene/chemistry ; Bridged Bicyclo Compounds/chemical synthesis ; Bridged Bicyclo Compounds/chemistry ; Drug Design ; Drug Discovery ; Heptanes/chemical synthesis ; Heptanes/chemistry ; Pentanes/chemical synthesis ; Pentanes/chemistry ; Solubility
    Chemical Substances Anions ; Benzene (J64922108F) ; Bridged Bicyclo Compounds ; Heptanes ; Pentanes ; bicyclo(1.1.1)pentane ; (3.1.1)propellane
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-05290-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal

    Bagum, Halima / Shire, Bethany R. / Christensen, Kirsten E. / Genov, Miroslav / Pretsch, Alexander / Pretsch, Dagmar / Moloney, Mark G.

    Synlett

    2020  Volume 31, Issue 04, Page(s) 378–382

    Abstract: Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S N -heterocycles are more stable than the corresponding O N -heterocycles but both are synthetic intermediates capable of further elaboration. ...

    Abstract Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S N -heterocycles are more stable than the corresponding O N -heterocycles but both are synthetic intermediates capable of further elaboration.
    Keywords lactams ; antibiotics ; cyclisation ; heterocycles
    Language English
    Publishing date 2020-01-21
    Publisher © Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0039-1691569
    Database Thieme publisher's database

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