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  1. Article ; Online: SIMVASTATIN INDUCED HISTOMORPHOLOGICAL CHANGES IN SKELETAL MUSCLE FIBER OF RATS AND PROTECTIVE EFFECT OF FORMOTEROL COADMINISTRATION

    Abdullah Qamar / Shoaib Naiyar Hashmi / Fareeha Mushtaq

    Pakistan Armed Forces Medical Journal, Vol 69, Iss 3, Pp 605-

    2019  Volume 610

    Abstract: Objective: To study Simvastatin induced, qualitative histomorphological changes in skeletal muscle fibers of rats and find protective effect of Formoterol co-administration in Simvastatin induced myopathy. Study Design: Laboratory based experimental ... ...

    Abstract Objective: To study Simvastatin induced, qualitative histomorphological changes in skeletal muscle fibers of rats and find protective effect of Formoterol co-administration in Simvastatin induced myopathy. Study Design: Laboratory based experimental randomized controlled trial. Place and Duration of Study: Study was conducted at the department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad and Armed forces institute of Pathology (AFIP) Rawalpindi, from Jan 2015 to Jun 2016. Material and Methods: Adult male Sprague-dawley rats were procured from NIH Islamabad. Their average approximate age was 70-80 days with weight as 250 ± 50 grams. The animals were randomly selected and divided into three groups. Group A was the control. Each rat of group B received Simvastatin dissolved in distilled water, by oral gavage (60mg/kg/day) once daily, for 12 weeks. Animals of Group C received simvastatin dissolved in distilled water (60mg/kg/day) once daily plus formoterol dissolved in distilled water (3μg/kg/day) once daily for 12 weeks. Both were administered with the help of oral gavage. The animals were sacrificed after three months of the experimental period. Extensor digitorum longus (EDL) tendon was isolated and dissected out. Tissue processing was done on the EDL muscle followed by Hematoxylin and Eosin staining. Fiber variability, inflammation, necrosis, shape of nuclei and location of nuclei were assessed per high power field in each specimen of all the groups. Results: Examination of H&E stained sections of the extensor digitorum longus muscle of the control group revealed the normal structure of skeletal muscle. Fiber variability, inflammation and necrosis were significantly higher in group B as compared to the control group A. Group C showed significantly decrease in myofiber variability, inflammation and necrosis in myofibers as compared to group B. Conclusion: Simvastatin induced the histomorphological changes in the skeletal muscle of experimental ...
    Keywords formoterol ; myopathy ; skeletal muscle ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 796 ; 630
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: CLINICOPATHOLOGICAL SPECTRUM OF SYNOVIAL SARCOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI, PAKISTAN

    Huma Saifullah / Iqbal Mohammad / Shoaib Naiyar Hashmi / Hafeez Ud Din / Rabia Ahmed / Mohammad Zubair

    Pakistan Armed Forces Medical Journal, Vol 68, Iss 3, Pp 455-

    2018  Volume 459

    Abstract: Objective: To analyse the clinicopathological spectrum of synovial sarcoma cases presenting in our institution. Study Design: Descriptive case series. Place and Duration of study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Jan 2010 to ... ...

    Abstract Objective: To analyse the clinicopathological spectrum of synovial sarcoma cases presenting in our institution. Study Design: Descriptive case series. Place and Duration of study: Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Jan 2010 to Jan 2015. Material and Methods: All cases of synovial sarcoma diagnosed on histopathological examination were recovered from the Armed Forces Institute of Pathology (AFIP) laboratory information management system.The inclusion criteria consisted of optimally processed Haematoxylin and Eosin stained slides. Positive immunohistochemistry for epithelial membrane antigen/cytokeratin and CD99. Both genders were included. Patients’ gender, age, tumour size, site, histological subtype, grade, microscopic margin status, depth and stage were noted. The data were analysed using SPSS Version 21. Frequencies and percentages were calculated for qualitative data and the standard deviation and mean for quantitative data. Results: Sixty-seven cases of synovial sarcoma (SS) were included in this study. The mean age of the patients was 35.1 years, with males at 55.2%. The most common site was the lower extremity 41.8%. The average size was 8.5 cm. The most common stage was pT2b (64.2%). Monophasic histological subtype was more common at 58.2%. Grade 2 tumours were 77.6%. Microscopic positive margins were 30.0%. Specimens that were fragmented or not oriented properly were 33.3%. Conclusion: The clinicopathological spectrum of synovial sarcoma in our institution is similar to that of other parts of the world. This study has highlighted that a significant proportion (33.3%) of resection specimens were fragmented or unmarked; therefore surgical margins could not be evaluated in these cases, increasing the chances of inadequate surgeries.
    Keywords clinicopathological spectrum ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER

    Fatima Qaiser / Abdul Khaliq Naveed / Sarah Sadiq / Palvasha Waheed / Iqbal Muhammad / Rubina Younis / Shoaib Naiyar Hashmi

    Khyber Medical University Journal, Vol 7, Iss 2, Pp 53-

    2015  Volume 59

    Abstract: Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical ... ...

    Abstract Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. χ 2 tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α Results: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p<0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p<0.0001). Conclusion: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.
    Keywords Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2015-07-01T00:00:00Z
    Publisher Khyber Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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