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Article: Risk factors for the development of stifle injuries in canine agility athletes.

Kieves, Nina R / Shoben, Abigail / Markley, Arielle Pechette

2024 Volume 11, Page(s) 1335939

Abstract: Objectives: Our aim was to determine risk factors for developing stifle injuries in canine agility athletes. We hypothesized that increased weight, increased frequency of competing, and greater number of runs/day would increase risk.: Study design: ... ...

Abstract	Objectives: Our aim was to determine risk factors for developing stifle injuries in canine agility athletes. We hypothesized that increased weight, increased frequency of competing, and greater number of runs/day would increase risk. Study design: Internet based survey, Methods: Individuals with at least one dog who had competed in agility in the past 3 years were eligible. Injury history was defined as an injury to the stifle that kept the dog from participating in agility for >1 week. Logistic regression models were used to estimate associations between variables of interest and injury history. Results: Handlers of 216 dogs reported a history of injury. The majority were cranial cruciate ligament (CCL) injury (101/216), and patella luxation (40/216). In the final model, five variables were independently associated with odds of stifle injury (in addition to age). Heavier dogs (adjusted for height), Border Collies, male dogs neutered <10 months, female dogs spayed before their first heat cycle, handlers aged 18-24, and teeter contact behavior were associated with increased risk. Conclusion: Heavier dogs were more likely to report injury, but there was no association with injury and increased number of competition days, or runs/day. The Border Collie breed was at the highest risk of injury. There was substantial risk for stifle injury with early spay/neuter. Additionally, a significant increase in risk of injury was reported for younger (18-24) vs. older handlers (65+). Athlete fitness level, conformation, and genetic predisposition to injury may play the most significant role in the development of injury.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2024.1335939
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Article ; Online: Reconsidering stepped wedge cluster randomized trial designs with implementation periods: Fewer sequences or the parallel-group design with baseline and implementation periods are potentially more efficient.

Westgate, Philip M / Nigam, Shawn R / Shoben, Abigail B

Clinical trials (London, England)

2024 , Page(s) 17407745241244790

Abstract: Background/aims: When designing a cluster randomized trial, advantages and disadvantages of tentative designs must be weighed. The stepped wedge design is popular for multiple reasons, including its potential to increase power via improved efficiency ... ...

Abstract	Background/aims: When designing a cluster randomized trial, advantages and disadvantages of tentative designs must be weighed. The stepped wedge design is popular for multiple reasons, including its potential to increase power via improved efficiency relative to a parallel-group design. In many realistic settings, it will take time for clusters to fully implement the intervention. When designing the HEALing (Helping to End Addiction Long-term Methods: We compare efficiencies of stepped wedge designs with implementation periods consisting of three to nine sequences with a variety of corresponding designs. The three-sequence design is compared to the two-sequence modified design and to the parallel-group design with baseline and implementation periods analysed via analysis of covariance. Stepped wedge designs with implementation periods consisting of four or more sequences are compared to modified designs that remove all or a subset of 'middle' sequences. Efficiencies are based on the use of linear mixed effects models. Results: In the studied settings, the modified design is more efficient than the three-sequence stepped wedge design with implementation periods. The parallel-group design with baseline and implementation periods with analysis of covariance-based analysis is often more efficient than the three-sequence design. With respect to stepped wedge designs with implementation periods that are comprised of more sequences, there are often corresponding modified designs that improve efficiency. However, use of only the first and last sequences has the potential to be either relatively efficient or inefficient. Relative efficiency is impacted by the strength of the statistical correlation among outcomes from the same cluster; for example, the relative efficiencies of modified designs tend to be greater for smaller cluster auto-correlation values. Conclusion: If a three-sequence stepped wedge design with implementation periods is being considered for a future cluster randomized trial, then a corresponding modified design using only the first and last sequences should be considered if sole focus is on efficiency. However, a parallel-group design with baseline and implementation periods and analysis of covariance-based analysis can be a practical, efficient alternative. For stepped wedge designs with implementation periods and a larger number of sequences, modified versions that remove 'middle' sequences should be considered. Due to the potential sensitivity of design efficiencies, statistical correlation should be carefully considered.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2138796-5
ISSN	1740-7753 ; 1740-7745
ISSN (online)	1740-7753
ISSN	1740-7745
DOI	10.1177/17407745241244790
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Article ; Online: Evaluation of variability in performance and paw placement patterns by dogs completing the dog walk obstacle in an agility competition.

DiMichele, Juli K / Pechette Markley, Arielle / Shoben, Abigail / Kieves, Nina R

PloS one

2024 Volume 19, Issue 3, Page(s) e0299592

Abstract: The objective of this study was to describe paw placement patterns for canine athletes completing the dog walk obstacle during canine agility trials. It was hypothesized that dogs would demonstrate defined sets of paw placement patterns as they complete ... ...

Abstract	The objective of this study was to describe paw placement patterns for canine athletes completing the dog walk obstacle during canine agility trials. It was hypothesized that dogs would demonstrate defined sets of paw placement patterns as they complete the dog walk obstacle and that those could be classified based on end contact behavior. Videos of 296 dogs attempting the dog walk obstacle at the 2021 UK Agility International (UKI) US Open were reviewed online. Data observed from video evaluation included front and rear limb paw placement across the dog walk and time to complete the obstacle. Results showed a high variability in obstacle performance. Mean time to complete the entire obstacle was 2.26 seconds (sd = 1.03). Mean and median completion times were qualitatively similar across all height classes. A slight majority of dogs hit the up ramp with their right foot first indicating running on their left lead (n = 185, 63%) with some variation observed between heights. Likewise, a slight majority (58%) of dogs hit the down ramp with their right front foot first (151/262). Given the high variation in completion times and paw placements, we could not identify clear patterns of dog walk performance. The large amount of variation observed with the dog walk obstacle suggests a need for future studies to employ alternative methods for objective gait analysis and to strategically select dogs to reflect the large variety in obstacle performance observed here.
MeSH term(s)	Humans ; Dogs ; Animals ; Walking ; Athletes ; Running ; Foot ; Gait Analysis ; Gait
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299592
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Article ; Online: Clinical features of prostate cancer by polygenic risk score.

Spears, Christina / Xu, Menglin / Shoben, Abigail / Dason, Shawn / Toland, Amanda Ewart / Byrne, Lindsey

Familial cancer

2024

Abstract: Genome-wide association studies have identified more than 290 single nucleotide variants (SNVs) associated with prostate cancer. These SNVs can be combined to generate a Polygenic Risk Score (PRS), which estimates an individual's risk to develop prostate ...

Abstract	Genome-wide association studies have identified more than 290 single nucleotide variants (SNVs) associated with prostate cancer. These SNVs can be combined to generate a Polygenic Risk Score (PRS), which estimates an individual's risk to develop prostate cancer. Identifying individuals at higher risk for prostate cancer using PRS could allow for personalized screening recommendations, improve current screening tools, and potentially result in improved survival rates, but more research is needed before incorporating them into clinical use. Our study aimed to investigate associations between PRS and clinical factors in affected individuals, including age of diagnosis, metastases, histology, International Society of Urological Pathology (ISUP) Grade Group (GG) and family history of prostate cancer, while taking into account germline genetic testing in known prostate cancer related genes. To evaluate the relationship between these clinical factors and PRS, a quantitative retrospective chart review of 250 individuals of European ancestry diagnosed with prostate cancer who received genetic counseling services at The Ohio State University's Genitourinary Cancer Genetics Clinic and a 72-SNV PRS through Ambry Genetics, was performed. We found significant associations between higher PRS and younger age of diagnosis (p = 0.002), lower frequency of metastases (p = 0.006), and having a first-degree relative diagnosed with prostate cancer (p = 0.024). We did not observe significant associations between PRS and ISUP GG, histology or a having a second-degree relative with prostate cancer. These findings provide insights into features associated with higher PRS, but larger multi-ancestral studies using PRS that are informative across populations are needed to understand its clinical utility.
Language	English
Publishing date	2024-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1502496-9
ISSN	1573-7292 ; 1389-9600
ISSN (online)	1573-7292
ISSN	1389-9600
DOI	10.1007/s10689-024-00369-0
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Article ; Online: Predictors of Stress Exposure in Hospitalized Preterm Infants.

Nist, Marliese Dion / Harrison, Tondi M / Shoben, Abigail B / Pickler, Rita H

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

2023 Volume 23, Issue 6, Page(s) 575–582

Abstract: Background: Stress exposure in the neonatal intensive care unit (NICU) is associated with poor outcomes in preterm infants. However, factors predicting subsequent NICU stress exposure have not been identified.: Purpose: To characterize NICU stressors ...

Abstract	Background: Stress exposure in the neonatal intensive care unit (NICU) is associated with poor outcomes in preterm infants. However, factors predicting subsequent NICU stress exposure have not been identified. Purpose: To characterize NICU stressors experienced by preterm infants during the first 2 weeks of life and identify demographic, perinatal, and institutional variables associated with stress exposure. Methods: A secondary analysis of data from a nonexperimental, prospective study was conducted using data from 60 very preterm infants born 28 to 31 weeks gestational age. Stress exposures during the first 2 weeks of life, operationalized as number of invasive procedures, were characterized by type and quantity for each infant using data extracted from electronic health records. Associations between number of invasive procedures and demographic, perinatal, or institutional variables were analyzed using linear regressions with robust standard errors. Results: Preterm infants experienced, on average, 98 (SD = 41.8) invasive procedures. Of these invasive procedures, nasal and/or oral suctioning episodes (58.1%), followed by skin-breaking procedures (32.6%), were most frequent. Differences in the number of invasive procedures were found for maternal race; infants born to Black mothers experienced fewer total invasive procedures than infants born to White mothers. The number of invasive procedures also varied across NICUs. Implications for practice and research: Preterm infant stress exposure differed by maternal race and NICU, consistent with research findings of differential treatment of diverse infants. Further research is needed to understand the reasons for these differences and to identify best practices to standardize neonatal care.
MeSH term(s)	Infant ; Female ; Infant, Newborn ; Humans ; Infant, Premature ; Prospective Studies ; Infant, Very Low Birth Weight ; Mothers ; Intensive Care Units, Neonatal
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171013-2
ISSN	1536-0911 ; 1536-0903
ISSN (online)	1536-0911
ISSN	1536-0903
DOI	10.1097/ANC.0000000000001099
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Article: Internet Survey of Risk Factors Associated With Training and Competition in Dogs Competing in Agility Competitions.

Pechette Markley, Arielle / Shoben, Abigail B / Kieves, Nina R

Frontiers in veterinary science

2022 Volume 8, Page(s) 791617

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.791617
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Article ; Online: Information growth for sequential monitoring of clinical trials with a stepped wedge cluster randomized design and unknown intracluster correlation.

Brown, Siobhan P / Shoben, Abigail B

Clinical trials (London, England)

2020 Volume 17, Issue 2, Page(s) 176–183

Abstract: Background/aims: In a stepped wedge study design, study clusters usually start with the baseline treatment and then cross over to the intervention at randomly determined times. Such designs are useful when the intervention must be delivered at the ... ...

Abstract	Background/aims: In a stepped wedge study design, study clusters usually start with the baseline treatment and then cross over to the intervention at randomly determined times. Such designs are useful when the intervention must be delivered at the cluster level and are becoming increasingly common in practice. In these trials, if the outcome is death or serious morbidity, one may have an ethical imperative to monitor the trial and stop before maximum enrollment if the new therapy is proven to be beneficial. In addition, because formal monitoring allows for the stoppage of trials when a significant benefit for new therapy has been ruled out, their use can make a research program more efficient. However, use of the stepped wedge cluster randomized study design complicates the implementation of standard group sequential monitoring methods. Both the correlation of observations introduced by the clustered randomization and the timing of crossover from one treatment to the other impact the rate of information growth, an important component of an interim analysis. Methods: We simulated cross-sectional stepped wedge study data in order to evaluate the impact of sequential monitoring on the Type I error and power when the true intracluster correlation is unknown. We studied the impact of varying intracluster correlations, treatment effects, methods of estimating the information growth, and boundary shapes. Results: While misspecified information growth can impact both the Type I error and power of a study in some settings, we observed little inflation of the Type I error and only moderate reductions in power across a range of misspecified information growth patterns in our simulations. Conclusion: Taking the study design into account and using either an estimate of the intracluster correlation from the ongoing study or other data in the same clusters should allow for easy implementation of group sequential methods in future stepped wedge designs.
MeSH term(s)	Analysis of Variance ; Cluster Analysis ; Cross-Over Studies ; Cross-Sectional Studies ; Humans ; Models, Statistical ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/statistics & numerical data ; Research Design ; Sample Size
Language	English
Publishing date	2020-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2138796-5
ISSN	1740-7753 ; 1740-7745
ISSN (online)	1740-7753
ISSN	1740-7745
DOI	10.1177/1740774520901488
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Article ; Online: Mindfulness-based Interventions Across the Cancer Continuum in the United States: A Scoping Review.

Emerson, Brent / Reddy, Menaka / Reiter, Paul L / Shoben, Abigail B / Klatt, Maryanna / Chakraborty, Subhankar / Katz, Mira L

American journal of health promotion : AJHP

2024 Volume 38, Issue 4, Page(s) 560–575

Abstract: Objective: To review mindfulness-based interventions (MBIs) tested in randomized controlled trials (RCT) across the cancer continuum.: Data source: Articles identified in PubMed, CINAHL, Web of Science, PsycINFO, and Embase.: Study inclusion and ... ...

Abstract	Objective: To review mindfulness-based interventions (MBIs) tested in randomized controlled trials (RCT) across the cancer continuum. Data source: Articles identified in PubMed, CINAHL, Web of Science, PsycINFO, and Embase. Study inclusion and exclusion criteria: Two independent reviewers screened articles for: (1) topic relevance; (2) RCT study design; (3) mindfulness activity; (4) text availability; (5) country (United States); and (6) mindfulness as the primary intervention component. Data extraction: Twenty-eight RCTs met the inclusion criteria. Data was extracted on the following variables: publication year, population, study arms, cancer site, stage of cancer continuum, participant demographic characteristics, mindfulness definition, mindfulness measures, mindfulness delivery, and behavioral theory. Data synthesis: We used descriptive statistics and preliminary content analysis to characterize the data and identify emerging themes. Results: A definition of mindfulness was reported in 46% of studies and 43% measured mindfulness. Almost all MBIs were tested in survivorship (50%) or treatment (46%) stages of the cancer continuum. Breast cancer was the focus of 73% of cancer-site specific studies, and most participants were non-Hispanic white females. Conclusion: The scoping review identified 5 themes: (1) inconsistency in defining mindfulness; (2) differences in measuring mindfulness; (3) underrepresentation of racial/ethnic minorities; (4) underrepresentation of males and cancer sites other than breast; and (5) the lack of behavioral theory in the design, implementation, and evaluation of the MBI.
MeSH term(s)	Male ; Female ; Humans ; United States ; Mindfulness ; Breast Neoplasms ; Research Design ; Text Messaging
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645160-3
ISSN	2168-6602 ; 0890-1171
ISSN (online)	2168-6602
ISSN	0890-1171
DOI	10.1177/08901171241227316
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Article ; Online: Internet-based survey of the frequency and types of orthopedic conditions and injuries experienced by dogs competing in agility.

Pechette Markley, Arielle / Shoben, Abigail B / Kieves, Nina R

Journal of the American Veterinary Medical Association

2021 Volume 259, Issue 9, Page(s) 1001–1008

Abstract: Objective: To describe the frequency and types of injuries experienced by dogs competing and training in agility and identify breed and geographic differences in frequency and types of injuries.: Sample: Surveys completed by owners of 4,701 dogs.: ... ...

Abstract	Objective: To describe the frequency and types of injuries experienced by dogs competing and training in agility and identify breed and geographic differences in frequency and types of injuries. Sample: Surveys completed by owners of 4,701 dogs. Procedures: The study involved an internet-based survey. Participants were asked whether their dog had ever had an injury that kept it from participating in agility for > 1 week and, if so, to identify the location and type of injury. Results: Owners of 1,958 (41.7%) dogs reported that their dogs had experienced an injury. The most common injury locations were the shoulder region (n = 589 [30.1% of all dogs with an injury]) and iliopsoas muscle (380 [19.4%]). The percentage of Border Collies sustaining an injury (549/1,052 [51.9%]) was significantly higher than percentages of other breeds. Percentage of dogs that sustained an injury varied by country, with the highest percentage reported in Australia (93/174 [53.4%]) and lowest percentage reported in the US (1,149/2,889 [39.8%]). Conclusions and clinical relevance: Results suggested that, among dogs competing and training in agility, injuries to the shoulder region were substantially more common than injuries in other anatomic locations, with iliopsoas muscle injuries second most common. The frequency and types of injuries varied among breeds and geographic regions. Findings may help guide clinical evaluations when agility dogs are seen in clinical practice for performance issues or lameness. Further studies regarding regional differences in injury rates are required.
MeSH term(s)	Animals ; Australia ; Dog Diseases/epidemiology ; Dogs ; Internet ; Musculoskeletal Diseases/veterinary ; Surveys and Questionnaires
Language	English
Publishing date	2021-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.259.9.1001
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Article ; Online: Forecasting Hepatitis C Virus Status for Children in the United States: A Modeling Study.

Hood, Robert B / Norris, Alison H / Shoben, Abigail / Miller, William C / Harris, Randall E / Pomeroy, Laura W

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: Background: Virtually all cases of hepatitis C virus (HCV) infection in children in the United States occur through vertical transmission, but it is unknown how many children are infected. Cases of maternal HCV infection have increased in the United ... ...

Abstract	Background: Virtually all cases of hepatitis C virus (HCV) infection in children in the United States occur through vertical transmission, but it is unknown how many children are infected. Cases of maternal HCV infection have increased in the United States, which may increase the number of children vertically infected with HCV. Infection has long-term consequences for a child's health, but treatment options are now available for children ≥3 years old. Reducing HCV infections in adults could decrease HCV infections in children. Methods: Using a stochastic compartmental model, we forecasted incidence of HCV infections in children in the United States from 2022 through 2027. The model considered vertical transmission to children <13 years old and horizontal transmission among individuals 13-49 years old. We obtained model parameters and initial conditions from the literature and the Centers for Disease Control and Prevention's 2021 Viral Hepatitis Surveillance Report. Results: Model simulations assuming direct-acting antiviral treatment for children forecasted that the number of acutely infected children would decrease slightly and the number of chronically infected children would decrease even more. Alone, treatment and early screening in individuals 13-49 years old reduced the number of forecasted cases in children and, together, these policy interventions were even more effective. Conclusions: Based on our simulations, acute and chronic cases of HCV infection are remaining constant or slightly decreasing in the United States. Improving early screening and increasing access to treatment in adults may be an effective strategy for reducing the number of HCV infected children in the United States.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae157
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