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  1. AU="Shokrollahi, Mitra"
  2. AU="Charles?Luce"
  3. AU="Denadai, Rafael"
  4. AU="Ambrosino, Teresa"
  5. AU=Antipova Tatiana
  6. AU="Moens, Pierre D J"
  7. AU="Abdel-Megied, Ahmed M."
  8. AU="Jain, Aseem"
  9. AU="Marcos, Jose F"
  10. AU="Furr-Stimming, Erin"
  11. AU="Schüle, Birgit"
  12. AU="Travieso-González, Alejandro"
  13. AU=Turilli Emily Samuela
  14. AU="Rueckert, Erroll H"
  15. AU=Keestra-Gounder A. Marijke
  16. AU="María José Endara"
  17. AU="Li, Lin-Zi"
  18. AU="Shirvanian, Moein"
  19. AU="Capaldo, Bianca D"
  20. AU="Matose, Takunda"
  21. AU=Plouffe Brian D.
  22. AU=Kuter David J
  23. AU="Moore, I D"
  24. AU="Schreibing, Felix"
  25. AU=Kang Keunsoo
  26. AU="de Pedro-Múñez, Álvaro"

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  1. Artikel ; Online: Interphase microtubules in nuclear organization and genome maintenance.

    Shokrollahi, Mitra / Mekhail, Karim

    Trends in cell biology

    2021  Band 31, Heft 9, Seite(n) 721–731

    Abstract: Microtubules are major cytoskeletal components mediating fundamental cellular processes, including cell division. Recent evidence suggests that microtubules also regulate the nucleus during the cell cycle's interphase stage. Deciphering such roles of ... ...

    Abstract Microtubules are major cytoskeletal components mediating fundamental cellular processes, including cell division. Recent evidence suggests that microtubules also regulate the nucleus during the cell cycle's interphase stage. Deciphering such roles of microtubules should uncover direct crosstalk between the nucleus and cytoplasm, impacting genome function and organismal health. Here, we review emerging roles for microtubules in interphase genome regulation. We explore how microtubules exert cytoplasmic forces on the nucleus or transport molecular cargo, including DNA, into or within the nucleus. We also describe how microtubules perform these functions by establishing transient or stable connections with nuclear envelope elements. Lastly, we discuss how the regulation of the nucleus by microtubules impacts genome organization and repair. Together, the literature indicates that interphase microtubules are critical regulators of nuclear structure and genome stability.
    Mesh-Begriff(e) Cell Nucleus ; Cytoskeleton ; Interphase ; Microtubules ; Nuclear Envelope
    Sprache Englisch
    Erscheinungsdatum 2021-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2021.03.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MG 25: Hefte anzeigen
    Zs.MO 113: Hefte anzeigen
    Zs.A 3410: Hefte anzeigen Standort:
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  2. Artikel ; Online: Intraluminal prucalopride increases propulsive motor activities via luminal 5-HT

    Shokrollahi, Mitra / Chen, Ji-Hong / Huizinga, Jan D

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2019  Band 31, Heft 10, Seite(n) e13598

    Abstract: Background: Activating luminal 5-HT: Methods: Colonic motor patterns were studied ex vivo using simultaneous spatiotemporal diameter mapping and pressure sensing.: Key results: Intraluminal prucalopride and intraluminal exogenous 5-HT strongly ... ...

    Abstract Background: Activating luminal 5-HT
    Methods: Colonic motor patterns were studied ex vivo using simultaneous spatiotemporal diameter mapping and pressure sensing.
    Key results: Intraluminal prucalopride and intraluminal exogenous 5-HT strongly evoked or enhanced the colonic motor complex at all levels of excitation beginning with generation of clusters of fast propagating contractions (FPCs), then development of long-distance contractions (LDCs) within the clusters, and finally forceful LDCs as the highest level of excitation. Intraluminal prucalopride and intraluminal exogenous 5-HT stimulated propulsive motor activity in a dose-dependent and antagonist-sensitive manner by increasing the contraction amplitude, intraluminal pressure, frequency, velocity, and degree of propagation of the colonic motor complex.
    Conclusions and inferences: Activating mucosal 5-HT
    Mesh-Begriff(e) Administration, Topical ; Animals ; Benzofurans/pharmacology ; Colon/drug effects ; Female ; Gastrointestinal Motility/drug effects ; Intestinal Mucosa/metabolism ; Male ; Myoelectric Complex, Migrating/drug effects ; Peristalsis/drug effects ; Rabbits ; Receptors, Serotonin, 5-HT4/metabolism ; Serotonin 5-HT4 Receptor Agonists/pharmacology
    Chemische Substanzen Benzofurans ; Serotonin 5-HT4 Receptor Agonists ; prucalopride (0A09IUW5TP) ; Receptors, Serotonin, 5-HT4 (158165-40-3)
    Sprache Englisch
    Erscheinungsdatum 2019-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.13598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.

    Shokrollahi, Mitra / Stanic, Mia / Hundal, Anisha / Chan, Janet N Y / Urman, Defne / Jordan, Chris A / Hakem, Anne / Espin, Roderic / Hao, Jun / Krishnan, Rehna / Maass, Philipp G / Dickson, Brendan C / Hande, Manoor P / Pujana, Miquel A / Hakem, Razqallah / Mekhail, Karim

    Nature structural & molecular biology

    2024  

    Abstract: Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs display such repositioning. Here we show that the human nuclear envelope localizes to DSBs in a manner ... ...

    Abstract Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs display such repositioning. Here we show that the human nuclear envelope localizes to DSBs in a manner depending on DNA damage response (DDR) kinases and cytoplasmic microtubules acetylated by α-tubulin acetyltransferase-1 (ATAT1). These factors collaborate with the linker of nucleoskeleton and cytoskeleton complex (LINC), nuclear pore complex (NPC) protein NUP153, nuclear lamina and kinesins KIF5B and KIF13B to generate DSB-capturing nuclear envelope tubules (dsbNETs). dsbNETs are partly supported by nuclear actin filaments and the circadian factor PER1 and reversed by kinesin KIFC3. Although dsbNETs promote repair and survival, they are also co-opted during poly(ADP-ribose) polymerase (PARP) inhibition to restrain BRCA1-deficient breast cancer cells and are hyper-induced in cells expressing the aging-linked lamin A mutant progerin. In summary, our results advance understanding of nuclear structure-function relationships, uncover a nuclear-cytoplasmic DDR and identify dsbNETs as critical factors in genome organization and stability.
    Sprache Englisch
    Erscheinungsdatum 2024-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-024-01286-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.

    Chen, Ji-Hong / Parsons, Sean P / Shokrollahi, Mitra / Wan, Andrew / Vincent, Alexander D / Yuan, Yuhong / Pervez, Maham / Chen, Wu Lan / Xue, Mai / Zhang, Kailai K / Eshtiaghi, Arshia / Armstrong, David / Bercik, Premsyl / Moayyedi, Paul / Greenwald, Eric / Ratcliffe, Elyanne M / Huizinga, Jan D

    Frontiers in physiology

    2018  Band 9, Seite(n) 1248

    Abstract: Simultaneous pressure waves (SPWs) in manometry recordings of the human colon have been associated with gas expulsion. Our hypothesis was that the SPW might be a critical component of most colonic motor functions, and hence might act as a biomarker for ... ...

    Abstract Simultaneous pressure waves (SPWs) in manometry recordings of the human colon have been associated with gas expulsion. Our hypothesis was that the SPW might be a critical component of most colonic motor functions, and hence might act as a biomarker for healthy colon motility. To that end, we performed high-resolution colonic manometry (HRCM), for the first time using an 84-sensor (1 cm spaced) water-perfused catheter, in 17 healthy volunteers. Intraluminal pressure patterns were recorded during baseline, proximal and rectal balloon distention, after a meal and following proximal and rectal luminal bisacodyl administration. Quantification was performed using software, based on Image J, developed during this study. Gas expulsion was always associated with SPWs, furthermore, SPWs were associated with water or balloon expulsion. SPWs were prominently emerging at the termination of proximal high amplitude propagating pressure waves (HAPWs); we termed this motor pattern HAPW-SPWs; hence, SPWs were often not a pan-colonic event. SPWs and HAPW-SPWs were observed at baseline with SPW amplitudes of 12.0 ± 8.5 mmHg and 20.2 ± 7.2 mmHg respectively. The SPW occurrence and amplitude significantly increased in response to meal, balloon distention and luminal bisacodyl, associated with 50.3% anal sphincter relaxation at baseline, which significantly increased to 59.0% after a meal, and 69.1% after bisacodyl. Often, full relaxation was achieved. The SPWs associated with gas expulsion had a significantly higher amplitude compared to SPWs without gas expulsion. SPWs could be seen to consist of clusters of high frequency pressure waves, likely associated with a cluster of fast propagating, circular muscle contractions. SPWs were occasionally observed in a highly rhythmic pattern at 1.8 ± 1.2 cycles/min. Unlike HAPWs, the SPWs did not obliterate haustral boundaries thereby explaining how gas can be expelled while solid content can remain restrained by the haustral boundaries. In conclusion, the SPW may become a biomarker for normal gas transit, the gastrocolonic reflex and extrinsic neural reflexes. The SPW assessment reveals coordination of activities in the colon, rectum and anal sphincters. SPWs may become of diagnostic value in patients with colonic dysmotility.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2018-09-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01248
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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