Article: Consecutive inoculations of influenza virus vaccine and poly(I:C) protects mice against homologous and heterologous virus challenge
Vaccine. 2017 Feb. 15, v. 35, no. 7
2017
Abstract: Mucosal immunity induced through natural infection by influenza virus has potent cross-protective activity, compared to subcutaneous vaccination-induced systemic immunity. Compared to natural infection with influenza virus, however, a single intranasal ... ...
| Abstract | Mucosal immunity induced through natural infection by influenza virus has potent cross-protective activity, compared to subcutaneous vaccination-induced systemic immunity. Compared to natural infection with influenza virus, however, a single intranasal vaccination with an inactivated influenza virus vaccine and poly(I:C) is not sufficient to induce primary immune response in naïve animals. The reasons for this moderate effect are not fully understood. Here, we demonstrated that intranasal vaccination with formalin-inactivated influenza virus vaccine and poly(I:C) for five consecutive days elicits high levels of virus-specific nasal IgA and serum IgG responses, while vaccination without poly(I:C) induced little response. Mice immunized with influenza virus vaccine and poly(I:C) for five consecutive days sustained high levels of virus-specific IgA in nasal wash and IgG in serum until at least 6months after vaccination. Furthermore, intranasal vaccination with influenza virus vaccine and poly(I:C) protected mice against homologous and heterologous influenza virus challenge. These results suggest that consecutive inoculations of influenza virus vaccine and poly(I:C) is an alternative method to induce primary immune responses in naïve subjects. |
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| Keywords | blood serum ; immune response ; immunoglobulin A ; immunoglobulin G ; mice ; mucosal immunity ; nose ; Orthomyxoviridae ; vaccination ; vaccines ; viruses | ||||||||||
| Language | English | ||||||||||
| Dates of publication | 2017-0215 | ||||||||||
| Size | p. 1001-1007. | ||||||||||
| Publishing place | Elsevier Ltd | ||||||||||
| Document type | Article | ||||||||||
| ZDB-ID | 605674-x | ||||||||||
| ISSN | 1873-2518 ; 0264-410X | ||||||||||
| ISSN (online) | 1873-2518 | ||||||||||
| ISSN | 0264-410X | ||||||||||
| DOI | 10.1016/j.vaccine.2017.01.025 | ||||||||||
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| Database | NAL-Catalogue (AGRICOLA) |
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