Article ; Online: Adhesion of mesenchymal stem cells to biomimetic polymers: A review.
Materials science & engineering. C, Materials for biological applications
2017 Volume 71, Page(s) 1192–1200
Abstract: The mesenchymal stem cells (MSCs) are promising candidates for cell therapy due to the self-renewal, multi-potency, ethically approved state and suitability for autologous transplantation. However, key issue for isolation and manipulation of MSCs is ... ...
| Abstract | The mesenchymal stem cells (MSCs) are promising candidates for cell therapy due to the self-renewal, multi-potency, ethically approved state and suitability for autologous transplantation. However, key issue for isolation and manipulation of MSCs is adhesion in ex-vivo culture systems. Biomaterials engineered for mimicking natural extracellular matrix (ECM) conditions which support stem cell adhesion, proliferation and differentiation represent a main area of research in tissue engineering. Some of them successfully enhanced cells adhesion and proliferation because of their biocompatibility, biomimetic texture, and chemistry. However, it is still in its infancy, therefore intensification and optimization of in vitro, in vivo, and preclinical studies is needed to clarify efficacies as well as applicability of those bioengineered constructs. The aim of this review is to discuss mechanisms related to the in-vitro adhesion of MSCs, surfaces biochemical, biophysical, and other factors (of cell's natural and artificial micro-environment) which could affect it and a review of previous research attempting for its bio-chemo-optimization. |
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| MeSH term(s) | Animals ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Cell Adhesion ; Cell Proliferation/drug effects ; Extracellular Matrix/chemistry ; Humans ; Mesenchymal Stromal Cells/metabolism |
| Language | English |
| Publishing date | 2017-02-01 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ZDB-ID | 2012160-X |
| ISSN | 1873-0191 ; 0928-4931 |
| ISSN (online) | 1873-0191 |
| ISSN | 0928-4931 |
| DOI | 10.1016/j.msec.2016.10.013 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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