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  1. Article: BclX

    Marola, Olivia J / Yablonski, Sarah E R / Shrager, Peter G / Nickells, Robert W / Libby, Richard T

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 331

    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01111-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fractionation Spares Mice From Radiation-Induced Reductions in Weight Gain But Does Not Prevent Late Oligodendrocyte Lineage Side Effects.

    Begolly, Sage / Shrager, Peter G / Olschowka, John A / Williams, Jacqueline P / O'Banion, M Kerry

    International journal of radiation oncology, biology, physics

    2016  Volume 96, Issue 2, Page(s) 449–457

    Abstract: Purpose: To determine the late effects of fractionated versus single-dose cranial radiation on murine white matter.: Methods and materials: Mice were exposed to 0 Gy, 6 × 6 Gy, or 1 × 20 Gy cranial irradiation at 10 to 12 weeks of age. Endpoints were ...

    Abstract Purpose: To determine the late effects of fractionated versus single-dose cranial radiation on murine white matter.
    Methods and materials: Mice were exposed to 0 Gy, 6 × 6 Gy, or 1 × 20 Gy cranial irradiation at 10 to 12 weeks of age. Endpoints were assessed through 18 months from exposure using immunohistochemistry, electron microscopy, and electrophysiology.
    Results: Weight gain was temporarily reduced after irradiation; greater loss was seen after single versus fractionated doses. Oligodendrocyte progenitor cells were reduced early and late after both single and fractionated irradiation. Both protocols also increased myelin g-ratio, reduced the number of nodes of Ranvier, and promoted a shift in the proportion of small, unmyelinated versus large, myelinated axon fibers.
    Conclusions: Fractionation does not adequately spare normal white matter from late radiation side effects.
    MeSH term(s) Animals ; Cell Lineage/radiation effects ; Cells, Cultured ; Cranial Irradiation/adverse effects ; Dose Fractionation ; Dose-Response Relationship, Radiation ; Mice ; Oligodendroglia/pathology ; Oligodendroglia/radiation effects ; Organ Sparing Treatments/methods ; Organs at Risk/radiation effects ; Radiation Dosage ; Radiation Protection/methods ; Weight Gain/radiation effects ; White Matter/pathology ; White Matter/radiation effects
    Language English
    Publishing date 2016-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2016.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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